ACR Meeting Abstracts

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  • Abstract Number: 1746 • ACR Convergence 2021

    Baricitinib Decreases Anti-dsDNA and IgG Antibodies in Adults with Systemic Lupus Erythematosus from a Phase 2 Double-Blind, Randomized, Placebo-Controlled Trial

    Thomas Dörner1, Ronald Van Vollenhaven2, Andrea Doria3, Bochao Jia4, Damiano Fantini4, Jorge Ross Terres4, Maria Silk5, Stephanie de Bono4, Peter Fischer6 and Daniel Wallace7, 1Charite Universitätsmedizin Berlin and Deutsches Rheumaforschungszentrum (DRFZ), Berlin, Germany, 2University Medical Center, Amsterdam, Netherlands, 3University of Padova, Padova, Italy, 4Eli Lilly and Company, Indianapolis, IN, 5Eli Lilly and Company, Carmel, IN, 6Eli Lilly and Company, North Easton, MA, 7Cedars-Sinai, Los Angeles, CA

    Background/Purpose: Baricitinib (BARI), an oral, selective Janus kinase (JAK)1 and JAK2 inhibitor, improved disease activity in adults with systemic lupus erythematosus (SLE) receiving standard background…
  • Abstract Number: 1738 • ACR Convergence 2021

    Uveitis Status in Patients with Ankylosing Spondylitis or Psoriatic Arthritis Under Secukinumab Treatment – Real World Data from a German Observational Study

    Uta Kiltz1, Jan Brandt-Jrgens2, Peter Kästner3, Elke Riechers4, Daniel Peterlik5, Annika Boas6 and Hans-Peter Tony7, 1Rheumazentrum Ruhrgebiet Herne, Ruhr-Universität Bochum, Herne, Germany, 2Rheumatologische Schwerpunktpraxis, Berlin, Germany, 3Ambulantes Rheumazentrum Erfurt, Erfurt, Germany, 4Department for Rheumatology and Immunology, Hannover Medical University, Hannover, 5Novartis Pharma GmbH, Nürnberg, Germany, 6Novartis Pharma GmbH, Nuernberg, Germany, 7Universitätsklinikum Würzburg, Wuerzburg, Germany

    Background/Purpose: Uveitis is a well-known non-musculoskeletal manifestation of spondyloarthropathies. Patients typically suffer from blurred vision, pain, and photophobia and have an increased risk of ocular…
  • Abstract Number: 1629 • ACR Convergence 2021

    Effect of Drug Withdrawal on Interleukin-1 or Interleukin-6 Inhibitor Associated Diffuse Lung Disease

    Vivian Saper1, Sampath Prahalad2, Scott Canna3, Rabheh Abdul-Aziz4, Marcela Alvarez5, Catherine Bingham6, Brigitte Bader-Meunier7, Imelda Balboni8, Roberta Berard9, Roxana Bolaria10, Alexis Boneparth11, Alicia Casey12, Elaine Cassidy13, Joyce C. Chang14, Michal Cidon15, Kathleen Collins16, Aileen M. Dickenson17, Graciela Espada5, Martha Fishman12, Elaine Flanagan18, Timothy Hahn19, Ankur K. Jindal20, Ozgur Kasapcopur21, Marisa Klein-Gitelman22, Timothy Klouda12, Mikhail Kostik23, Carol Lake24, Mariana Marques25, Michael Ombrello26, Karen Onel27, Omkar Phadke28, Angelo Ravelli29, Adam Reinhardt30, Amanda D. Robinson31, Kelly Rouster-Stevens32, Nadine Saad27, Grant Schulert33, Susan Shenoi34, Cory Stingl14, Anjali Sura35, Melissa Tesher36, Jessica Tibaldi37, Kathryn Torok38, Cathy Tsin39, Natalia Vasquez-Canizares40, D. Sofia Villacis-Nunez41, Ben Whitehead42, Holly Wobma12, Lawrence Zemel43 and Elizabeth Mellins1, 1Stanford University, Stanford, CA, 2Emory + Children's Pediatric Institute, Atlanta, GA, 3Children's Hospital of Philadelphia, Philadelphia, PA, 4University at Buffalo, Buffalo, NY, 5Hospital de Niños Dr Ricardo Gutierrez, Buenos Aires, Argentina, 6Penn State Children's Hospital, Allentown, PA, 7Pediatric Immuno-hematology, Necker Hospital, APHP, Paris, France, 8Stanford University, Palo Alto, CA, 9London Health Sciences Centre, London, ON, Canada, 10Self, Victoria, BC, Canada, 11Columbia University Medical Center, New York, NY, 12Boston Children's Hospital, Boston, MA, 13University of Pittsburgh Medical Center Medical Education, Pittsburgh, PA, 14Children's Hospital of Phildelphia, Philadelphia, PA, 15Children's Hospital Los Angeles, Los Angeles, CA, 16LeBonheur Children's Hospital, Memphis, TN, 17Children's Hospital of Los Angeles, Los Angeles, CA, 18Emory University and Children's Healthcare of Atlanta, Atlanta, GA, 19Penn State Childrens Hospital, Hershey, PA, 20Postgraduate Institute of Medical Education and Research, Chandigarh, India, 21Istanbul University-Cerrahpasa, Cerrahpasa Medical School, İstanbul, Turkey, 22Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 23Saint-Petersburg State Pediatric Medical University, Saint Petersburg, Russia, 24National Institutes of Health, Gaithersburg, MD, 25UPMC Children’s Hospital of Pittsburgh, Pittsburgh, PA, 26National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 27Hospital for Special Surgery, New York, NY, 28EMORY, Atlanta, GA, 29Istituto Giannina Gaslini, Genoa, Italy, 30Boys Town National Research Hospital, Omaha, NE, 31UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, 32Emory University/Children's Healthcare of Atlanta, Atlanta, GA, 33Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 34Seattle Children's Hospital, Seattle, WA, 35SUNY Upstate Medical University, Syracuse, NY, 36University of Chicago, Chicago, IL, 37IRCSS Istituto G. Gaslini University of Genoa, Genoa, Italy, 38University of Pittsburgh, Pittsburgh, PA, 39Stanford University, Stanford, 40Children's Hospital at Montefiore, Bronx, NY, 41Children's Healthcare of Atlanta - Emory University, Atlanta, GA, 42Queensland Children's Hospital, Brisbane, Australia, 43CCMC, Hartford, CT

    Background/Purpose: Severe delayed hypersensitivity reactions (DHR) are under-recognized in inflammatory conditions, particularly drug reaction with eosinophilia and systemic symptoms (DRESS). Previous work has shown this…
  • Abstract Number: 1693 • ACR Convergence 2021

    Lower Adverse Event and Infection Rates During Tocilizumab Therapy Without Concomitant GC: An Analysis of the ICHIBAN Study

    Christof Specker1, Martin Aringer2, Gerd Burmester3, Marvin A. Peters4, Michael W. Hofmann5, Herbert Kellner6, Frank Moosig7, Hans-Peter Tony8 and Gerhard Fliedner9, 1Evangelisches Krankenhaus, Kliniken Essen-Mitte, Essen, Germany, 2Rheumatology, Medicine III, University Medical Center & Faculty of Medicine, TU Dresden, Dresden, Germany, 3Charité University Medicine Berlin, Berlin, Germany, 4Roche Pharma AG, Grenzach-Wyhlen, Germany, 5Chugai Pharma Germany GmbH, Frankfurt am Main, Germany, 6Hospital Neuwittelsbach, Center for Rheumatology and Gastroenterology, Munich, Germany, Munich, Germany, 7Rheumatology Center Schleswig-Holstein Middle, Neumünster, Germany, 8Universitätsklinikum Würzburg, Wuerzburg, Germany, 9Rheumatology Practice, Osnabrueck, Germany

    Background/Purpose: To limit the risk of serious infections, guidelines recommend short term (< 3 months) or low-dose (≤10 mg/day) adjunct glucocorticoids (GCs) to control rheumatoid…
  • Abstract Number: 1753 • ACR Convergence 2021

    Hydroxychloroquine Blood Levels Are Associated with Reduced SLE Disease Activity and Improvements in Cardiovascular Risk Factors

    Laurence Magder1, Michelle Petri2 and Daniel Goldman2, 1University of Maryland, Baltimore, Baltimore, MD, 2Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: In SLE, treatment with hydroxychloroquine (HCQ) has been shown to be associated with reduced SLE flares and reduced risk of damage in several different…
  • Abstract Number: 1725 • ACR Convergence 2021

    Higher Prevalence of Aspirin Use with a Specific Educational Tool in SLE Pregnancies: Preliminary Results

    Joo Young (Esther) Lee1, Arielle Mendel2, Isabelle Malhamé2, Sasha Bernatsky1 and Evelyne Vinet3, 1McGill University, Montréal, QC, Canada, 2McGill University Health Centre, Montréal, QC, Canada, 3McGill University Health Centre, Mont Royal, QC, Canada

    Background/Purpose: Pregnant women with SLE are at substantial risk of preeclampsia. Best international practice guidelines recommend aspirin (ASA) in this population, as it reduces preeclampsia…
  • Abstract Number: 1743 • ACR Convergence 2021

    Whole Blood Hydroxychloroquine Levels Do Not Correlate with QTc Intervals in a Cohort of 84 SLE Patients: Evidence That Antimalarials Are Not Associated with Cardiac Conduction System Toxicity

    Mayce Haj-Ali1 and H. Michael Belmont2, 1NYU Grossman School of Medicine, New York, NY, 2NYU School of Medicine, New York, NY

    Background/Purpose: Hydroxychloroquine (HCQ) is an antimalarial drug used in the treatment of systemic lupus erythematous (SLE). There is limited data assessing cardiac toxicity as arrhythmias…
  • Abstract Number: 1707 • ACR Convergence 2021

    A Bioengineered Probiotic for the Oral Delivery of an Immunomodulator in Rheumatoid Arthritis

    Yuqing Wang1, Duolong Zhu1, Laura Ortiz-Velez2, Jacob Perry1, Michael Pennington3, Joseph Hyser1, Robert Britton1 and Christine Beeton1, 1Baylor College of Medicine, Houston, TX, 2TMC Innovation, Houton, 3AmbioPharm Inc., North Augusta, SC

    Background/Purpose: CCR7- effector memory T (TEM) lymphocytes are targets for immunomodulation for the treatment of rheumatoid arthritis (RA). Following activation, TEM cells upregulate the expression…
  • Abstract Number: 1649 • ACR Convergence 2021

    Parameters by FDG-PET/CT Are Useful for Predicting Spontaneous Regression in MTX Associated Lymphoproliferative Disorder

    Tomohiro Kameda1, Shusaku Nakashima1, Hiromi Shimada1, Risa Wakiya1, Mai Fahmy Mansour1, Mikiya Kato1, Koichi Sugihara1, Rina Semba1, Mao Mizusaki1, Norimitsu Kadowaki1 and Hiroaki Dobashi2, 1Kagawa University, Takamatsu, Japan, 2Department of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Kita-gun, Japan

    Background/Purpose: Methotrexate associated lymphoproliferative disorder (MTX-LPD) has various histological types from benign and malignant. Some MTX-LPDs spontaneously regress after discontinuation of MTX, even though they…
  • Abstract Number: 1522 • ACR Convergence 2021

    Potential Predictors of Persistence in Immune Check Point Inhibitor Induced Arthritis

    Anu Desai1, Lakshmi Priya Shadananan1, Adam Croft2, Lalit Pallan1, Neil Steven3 and Benjamin Fisher4, 1University of Birmingham, Birmingham, United Kingdom, 2University of Birmingham, Halesowen, United Kingdom, 3Institute of Immunology and Immunotherapy/University of Birmingham, Birmingham, United Kingdom, 4Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham; National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre and Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom

    Background/Purpose: Immune Check Point Inhibitors (ICIs) are widely used in Oncology and are associated with multiple autoimmune and systemic inflammatory reactions called immune-related adverse events.…
  • Abstract Number: 0003 • ACR Convergence 2021

    Clinically Identifiable Autoreactivity Is Common in Severe SARS-CoV-2 Infection

    Richard Ramonell1, Matthew Woodruff2, Mark Rudolph3, F. Eun-Hyung Lee1 and Iñaki Sanz4, 1Emory University, Atlanta, GA, 2Emory University, Decatur, GA, 3Exagen Inc., Vista, CA, 4Emory University School of Medicine, Atlanta, GA

    Background/Purpose: A massive expanson of plasmablasts or antibody secreting cells (ASC) have been shown in severe patients with SARS-CoV-2 infection and in patients with autoimmune…
  • Abstract Number: 0002 • ACR Convergence 2021

    Salivary Sodium Levels in the Parotid Salivary Gland of SS Patients Suggest B-cell Mediated Epithelial Sodium Channel Disruption

    Sarah Pringle1, Bas Berkhof1, Martha S. van Ginkel2, Silvia Liefers1, Bert van der vegt2, Fred Spijkervet2, Hendrika Bootsma1, Arjan Vissink1 and Frans Kroese1, 1University Medical Center Groningen, Groningen, Netherlands, 2University of Groningen, University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: Patients with Sjögren’s syndrome (SS) suffer from significantly reduced saliva production. Saliva is important for oral health. A careful of sodium, chloride, potassium and…
  • Abstract Number: 0004 • ACR Convergence 2021

    Unappreciated Systemic Metabolic Functions of the Canonical B Cell Cytokines, BAFF and APRIL: Regulation of Lipolysis and Non-shivering Thermogenesis and Protection from Obesogenic Diet Induced Weight Gain

    Isaac Harley1, Calvin Chan2, Paul Pfluger3, Trompette Aurelien4, Traci Stankiewicz5, Jessica Allen5, Maria Moreno-Fernandez5, Michelle Damen5, Jarren Oates5, Pablo Alarcon5, Jessica Doll6, Matthew Flick7, Leah Flick8, Juan Sanchez-Gurmaches9, Rajib Mukherjee9, Rebekah Karns10, Michael Helmrath11, Thomas Inge12, Stuart Weisberg13, Sunje Pamp14, David Relman15, Randy Seeley16, Matthias Tschoep17, Chris Karp18 and Senad Divanovic8, 1University of Colorado Anschutz Medical Campus, Aurora, CO, 2University of Cincinnati, Cincinnati, OH, 3Technical University of Munich, Munich, Germany, 4Le Centre hospitalier universitaire vaudois, Lausanne, Switzerland, 5Cincinnati Children's Hospital Medical Center, Division of Immunobiology, Cincinnati, OH, 6Cincinnati Children's Hospital Medical Center, Division of Immunobiology, Cincinn, OH, 7Division of Experimental Hematology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 8Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 9Division of Endocrinology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 10Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 11Pediatric General and Thoracic Surgery, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 12Department of Surgery, Children’s Hospital Colorado, Aurora, CO, 13Columbia University Medical Center, New York, NY, USA, New York, NY, 14Danmarks Tekniske Universitet, Lyngby, Denmark, 15Department: Medicine - Med/Infectious Diseases - Stanford University, Stanford, 16Department of Surgery, Internal Medicine and Nutritional Sciences, University of Michigan, Ann Arbor, MI, 17Division of Metabolic Diseases, Technische Universität München, Munich, Germany, 18Division of Molecular Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati

    Background/Purpose: The impact of immune mediators on weight homeostasis and systemic metabolism remains underdefined. Interrogation of resistance to diet-induced obesity in mice lacking a negative…
  • Abstract Number: 0006 • ACR Convergence 2021

    Metabolic Characteristics of Age-related B Cells in Lupus-prone Mice and Effects on Follicular Helper T Cells

    Ivan Ramirez1, Betty Diamond2 and Sun Jung Kim3, 1Northwell, Little Neck, NY, 2Northwell Health, Manhasset, NY, 3Feinstein Institutes for Medical Research, Manhasset, NY

    Background/Purpose: Since the description of age-associated B cells (ABC), there has been a growing interest in the role of these cells in autoimmunity. Evidence suggests…
  • Abstract Number: 0005 • ACR Convergence 2021

    Maturation and Dysfunction of Autoreactive B Cell Clones in Tissues of Patients with Sjögren’s Syndrome

    Mathijs Broeren1, Giulia Balzaretti2, Jing Wang3, Patricia Groenen1, Barbera van Schaik4, Tim Chataway3, Charlotte Kaffa1, Sander Bervoets1, Konnie Hebeda1, Gergana Bounova5, Ger Pruijn1, Tom Gordon3, Niek De Vries6 and Rogier Thurlings7, 1Radboud University Medical Center, Nijmegen, Netherlands, 2Amsterdam, Netherlands, 3Flinders University, Adelaide, Australia, 4Amsterdam University Medical Centers, Amsterdam, Netherlands, 5Enpicom BV, Den Bosch, Netherlands, 6Amsterdam UMC, Amsterdam, Netherlands, 7Radboud University Medical Centre, Nijmegen, Netherlands

    Background/Purpose: Sjögren's syndrome (SjS) involves chronic inflammation of exocrine glands that can be complicated by extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT). We…
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