ACR Meeting Abstracts

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  • Abstract Number: 1911 • ACR Convergence 2022

    Baseline Bone Curvature a Biomarker for the Prediction of Knee Osteoarthritis Cartilage Volume Loss at One-Year. Use of Machine Learning

    Johanne Martel-Pelletier1, Hossein Bonakdari1, Jean-Pierre Pelletier1 and François Abram2, 1Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montréal, QC, Canada, 2ArthroLab Inc., Montréal, QC, Canada

    Background/Purpose: The hallmark of osteoarthritis is the loss of cartilage. At present, we cannot discriminate, early during the osteoarthritis process, patients for whom cartilage will…
  • Abstract Number: 2115 • ACR Convergence 2022

    Early Skin and Early Enthesitis Responses in Psoriatic Arthritis Patients Treated with Guselkumab Associate with Long-term Response: Post Hoc Analysis Through 2 Years of a Phase 3 Study

    Laura Coates1, Julio Ramírez2, Dennis McGonagle3, Sibel Aydin4, Miriam Zimmermann5, Francois Nantel6, May Shawi7, Emmanouil Rampakakis8, Peter Nash9 and Philip J Mease10, 1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK, Oxford, England, United Kingdom, 2Arthritis Unit, Rheumatology Department, Hospital Clinic, Barcelona, Spain, 3University of Leeds, Leeds, UK, Leeds, United Kingdom, 4University of Ottawa, Ottawa Hospital Research Institute, Ottawa, ON, Canada, 5Immunology, Janssen Scientific Affairs, LLC, Zug, Switzerland, 6Nantel MedSci Consult, Montréal, QC, Canada, 7Immunology Global Medical Affairs, Janssen Pharmaceutical Companies of Johnson & Johnson, Horsham, PA, 8McGill University, Department of Pediatrics and JSS Medical Research, Montréal, QC, Canada, 9School of Medicine, Griffith University, Sunshine Coast, Australia, 10Swedish Medical Center/Providence St. Joseph Health, Seattle, WA

    Background/Purpose: Guselkumab (GUS), an IL-23p19 inhibitor, has demonstrated efficacy in PsA across key Group for Research and Assessment of Psoriasis (PsO) and Psoriatic Arthritis (GRAPPA)-recommended…
  • Abstract Number: 2248 • ACR Convergence 2022

    Prevalence and Mortality of Interstitial Lung Abnormalities in Rheumatoid Arthritis and non-RA Comparators in a Multicenter Prospective Cohort

    Gregory McDermott1, Keigo Hayashi2, Kazuki Yoshida1, Matthew Moll1, Michael Cho1, Tracy Doyle1, Paul Dellaripa1, Rachel Putman1, Raul San Jose Estepar1, George Washko1, Elizabeth Regan3, Hiroto Hatabu1, Gary M Hunninghake1, Edwin Silverman1 and Jeffrey Sparks4, 1Brigham and Women's Hospital, Boston, MA, 2Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, 3National Jewish Health, Denver, CO, 4Brigham and Women's Hospital and Harvard Medical School, Boston, MA

    Background/Purpose: Subpleural interstitial lung abnormalities (ILA) may be a form of subclinical or preclinical interstitial lung disease (ILD) and have been reported in up to…
  • Abstract Number: 1784 • ACR Convergence 2022

    Gait Alterations Associated with Worsening Physical Function over 2 Years: A Machine-learning Approach in the Multicenter Osteoarthritis (MOST) Study

    Kathryn Bacon1, David Felson1, S. Reza Jafarzadeh2, Vijaya Kolachalama2, Jeffrey Hausdorff3, Eran Gazit4, Joshua Stefanik5, Patrick Corrigan6, Neil Segal7, Cora E. Lewis8, Michael Nevitt9 and Deepak Kumar1, 1Boston University, Boston, MA, 2Boston University School of Medicine, Boston, MA, 3Tel Aviv University, Tel Aviv, Israel, 4Tel Aviv Suarasky Medical Center, Tel Aviv, Israel, 5Northeastern University, Boston, MA, 6Saint Louis University, St. Louis, MO, 7University of Kansas, Kansas City, KS, 8University of Alabama at Birmingham, Birmingham, AL, 9University of California at San Francisco, Orinda, CA

    Background/Purpose: Altered gait is related to pathogenesis of knee osteoarthritis (OA). For people with knee OA, in addition to pain, declines in physical function are…
  • Abstract Number: 2200 • ACR Convergence 2022

    Reliability of Medication Information Derived from EHR Data Compared to Insurance Claims: An Analysis of Biologic Medications in RISE and Medicare

    Rahaf Baker1, Jing Li2, Rachael Stovall3, Jeffrey Curtis4, Fenglong Xie5, Jinoos Yazdany6 and Gabriela Schmajuk7, 1Alameda Highland Internal Medicine Residency, Oakland, CA, 2University of California, San Francisco, San Francisco, CA, 3University of California San Francisco, San Francisco, CA, 4University of Alabama at Birmingham, Hoover, AL, 5University of Alabama at Birmingham, Birmingham, AL, 6UCSF, San Francisco, CA, 7UCSF / SFVA, San Francisco, CA

    Background/Purpose: Health services studies increasingly rely on Electronic Health Record (EHR) data to capture medication use. However, the reliability of medication information derived from EHR…
  • Abstract Number: PP20 • ACR Convergence 2022

    ‘It Is Due to Stress’ – But Which Type of Stress? Cumulative childhood stress is a risk factor for autoimmune disease

    Melissa Allman, Michigan State University, Meridian Charter Township, MI

    Background/Purpose: Trauma can have profound detrimental influences on our health and well-being. I am tangibly familiar with how trauma can impact the individual due to…
  • Abstract Number: 2263 • ACR Convergence 2022

    Nanotherapeutic Approaches for the Treatment of Post-traumatic Osteoarthritis

    Luke Springer1, Kelsey Collins2, Huimin Yan2, Ying Hu3, Farshid Guilak2, Samuel Wickline4, Hua Pan2 and Christine Pham2, 1Washington University School of Medicine, St. Louis, MO, 2Washington University School of Medicine, Saint Louis, MO, 3Washington University, Saint Louis, MO, 4University of South Florida, Tampa, FL

    Background/Purpose: Osteoarthritis (OA) represents the most common form of arthritis and is a major cause of morbidity in the aging population. Post-traumatic OA (PTOA) is…
  • Abstract Number: 2223 • ACR Convergence 2022

    Transcriptome Profiling and Autoimmunity-related Serological Markers Identify Tumour Protein P53 and Complement C3a Receptor 1 as Drug Targets in Neuropsychiatric Systemic Lupus Erythematosus

    Julius Lindblom1, Daniel Toro-Domínguez2, Elena Carnero-Montoro2, Maria Orietta Borghi3, Jessica Castillo4, Ellen Iacobaeus1, Yvonne Enman5, Chandra Mohan4, Marta Alarcon-Riquelme2, Guillermo Barturen2 and Ioannis Parodis1, 1Karolinska Institutet, Stockholm, Sweden, 2Center for Genomics and Oncological Research (GENYO), Granada, Spain, 3Università degli Studi di Milano and Istituto Auxologico Italiano, Milano, Italy, 4University of Houston, Houston, TX, 5Karolinska Institutet, Sundbyberg, Sweden

    Background/Purpose: Involvement of the nervous system is a common but poorly understood manifestation of SLE, termed NPSLE. Although studies have reported varying prevalence estimates (Unterman…
  • Abstract Number: 2145 • ACR Convergence 2022

    Efficacy and Safety of Risankizumab for Active Psoriatic Arthritis: 100-Week Results from the KEEPsAKE 1 and KEEPsAKE 2 Trials

    Lars Erik1, Kim Papp2, Douglas White3, Cecilia Asnal4, Wenjing Lu5, Ahmed Soliman5, Byron Padilla6, Michael Chen5 and Andrew Ostor7, 1Bispebjerg-Frederiksberg Hospital, Vedbæk, Denmark, 2K Papp Clinical Research and Probity Medical Research, Waterloo, ON, Canada, 3Rheumatology Department, Waikato Hospital, and Waikato Clinical School, University of Auckland, Hamilton, New Zealand, 4Hospital Alemán, Buenos Aires, Argentina, 5AbbVie, Inc., North Chicago, IL, 6AbbVie, Inc., Waukegan, IL, 7Cabrini Hospital, Monash University & Emeritus Research, Melbourne, Australia

    Background/Purpose: PsA is a chronic, systemic inflammatory disease with a variety of clinical manifestations including arthritis, enthesitis, and dactylitis and is associated with skin and…
  • Abstract Number: 2137 • ACR Convergence 2022

    Impact of Patient Characteristics, Including Sex, on the Efficacy of Upadacitinib Compared with Adalimumab in Patients with Psoriatic Arthritis

    Lihi Eder1, Laura Coates2, Peter Nash3, Uta Kiltz4, Ennio Lubrano5, Erin McDearmon-Blondell6, Tianming Gao7 and Alexis Ogdie8, 1Women’s College Research Institute, Department of Medicine, University of Toronto, Toronto, ON, Canada, 2Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK, Oxford, England, United Kingdom, 3School of Medicine, Griffith University, Brisbane, Australia, 4Rheumazentrum Ruhrgebiet, Herne, Germany, 5Academic Rheumatology Unit, Dipartimento di Medicina e Scienze della Salute ‘‘Vincenzo Tiberio’’, Università degli Studi del Molise, Campobasso, Italy, 6AbbVie, Inc., Mettawa, IL, 7AbbVie, Inc., North Chicago, IL, 8Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Evidence suggests that response to treatment in PsA may vary with patient (pt) characteristics, such as sex.1 This post hoc analysis of the Phase…
  • Abstract Number: 2139 • ACR Convergence 2022

    Sustained Response to Guselkumab Regardless of Baseline Demographic, Disease, and Medication Characteristics in Patients with Active Psoriatic Arthritis and an Inadequate Response to TNF Inhibitors: Results from a Phase 3b Trial

    Iain B McInnes1, Philipp Sewerin2, Mohamed Sharaf3, Michela Efficace4, May Shawi5, Michelle Perate6, Miriam Zimmermann7 and Laura Coates8, 1Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom, 2Rheumazentrum Ruhrgebiet, Ruhr-Universität-Bochum, Herne, Germany, 3Johnson & Johnson, Middle East FZ LLC, Dubai, United Arab Emirates, 4Janssen Cilag SpA, Imperia, Italy, 5Immunology Global Medical Affairs, Janssen Pharmaceutical Companies of Johnson & Johnson, Horsham, PA, 6Janssen Scientific Affairs, LLC, Horsham, PA, 7Janssen Scientific Affairs, LLC, Zug, Switzerland, 8Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK, Oxford, England, United Kingdom

    Background/Purpose: Guselkumab (GUS) is a human monoclonal antibody targeting the IL-23 p19 subunit. In the Phase 3b COSMOS trial (NCT03796858), GUS significantly improved disease signs/symptoms…
  • Abstract Number: PP26 • ACR Convergence 2022

    Chronically Catherine: A Sex and the City-Inspired Autobiographical Column for Disabled Young Adults on Subjects We Really Care About – Like Disabled Dating and How Hot Cheetos Saved My Life

    Catherine Ames1, Courtney Wells2 and Kristine Carandang1, 1Young Patients' Autoimmune Research & Empowerment Alliance, San Diego, CA, 2University of Wisconsin-River Falls; Young Patients' Autoimmune Research and Empowerment Alliance, St. Paul, MN

    Background/Purpose: What if Carrie Bradshaw, sex advice columnist, fashionsta, and all around icon from Sex and the City were chronically ill? Or disabled? That's the…
  • Abstract Number: PP21 • ACR Convergence 2022

    What Lies Beneath: Making Rheumatoid Arthritis Visible for the Seronegative Patient Through Blood Work

    Shilpa Venkatachalam, Global Healthy Living Foundation, New York, NY

    Background/Purpose: When I first received my Rheumatoid Arthritis (RA) diagnosis 5 years ago, I experienced a combination of relief and disbelief. Relief because now all…
  • Abstract Number: PP24 • ACR Convergence 2022

    Planting Seeds of Self-Advocacy: Increasing Healthcare Engagement in Children and Adolescents Through Arthritis Camp

    Kaye Anderson1, Kristine Carandang2 and Courtney Wells3, 1Young Patients' Autoimmune Research & Empowerment Alliance, River Falls, WI, 2Young Patients' Autoimmune Research & Empowerment Alliance, San Diego, CA, 3University of Wisconsin-River Falls; Young Patients' Autoimmune Research and Empowerment Alliance, St. Paul, MN

    Background/Purpose: I was diagnosed with Juvenile Idiopathic Arthritis at the age of ten. The constant battle between doctor appointments, pain, and medication side effects left…
  • Abstract Number: 1785 • ACR Convergence 2022

    PROs and Sociodemographic Factors in Year Prior to COVID Predict Trajectories of Depressive Symptoms in Adults with RA in First 2 Years of Pandemic: Data from the Canadian Early Arthritis Cohort

    Susan Bartlett1, orit schieir2, Marie-France Valois2, Janet Pope3, Louis Bessette4, Gilles Boire5, Carol Hitchon6, Edward Keystone7, Carter Thorne8, Diane Tin9, Glen Hazlewood10 and Vivian Bykerk11, 1McGill University, Montreal, QC, Canada, 2McGill University, Montréal, QC, Canada, 3University of Western Ontario, London, ON, Canada, 4Centre de l'Ostoporose et de Rhumatologie de Québec, Québec, QC, Canada, 5Universite de Sherbrooke, Sherbrooke, QC, Canada, 6University of Manitoba, Winnipeg, MB, Canada, 7Keystone Consulting Enterprises Inc., Toronto, ON, Canada, 8Southlake Regional Health Centre, Newmarket, ON, Canada, 9The Arthritis Program Research Group, Newmarket, ON, Canada, 10University of Calgary, Calgary, AB, Canada, 11Hospital for Special Surgery, New York, NY

    Background/Purpose: Growing evidence points to considerable mental health impacts of the prolonged COVID-19 pandemic, though data from longitudinal studies in rheumatic diseases are sparse. We…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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