Abstracts Archive - Page 49 of 2607 - ACR Meeting Abstracts

Abstract Number: 0857 • ACR Convergence 2025
CD14-dependent MAP kinase signaling is required for pathogenic neutrophil extracellular trap formation in APS
Thalia Newman¹, NaveenKumar Somanathapura¹, Chao Liu², Srilakshmi Yalavarthi¹, Pooja Kapoor¹, Ajay Tambralli¹, Jacqueline Madison¹, Yu (Ray) Zuo¹ and Jason S. Knight¹, ¹University of Michigan, Ann Arbor, MI, ²University of Michigan, Superior Charter Twp, MI
Background/Purpose: Antibodies targeting beta-2-glycoprotein I (anti-β2GPI) promote inflammation and thrombosis in antiphospholipid syndrome (APS). It has been shown that anti-β2GPI activate neutrophils through Toll-like receptor…
Abstract Number: 0871 • ACR Convergence 2025
The gut microbiome shapes MTX pharmacology and is linked to treatment outcomes
Vanya Sofia Villa Soto¹, Diego Orellana², Erin Reilly³, Chloe Heath², Alexandra Degraeve², Mohana Mukherjee², darren Dumlao², Rebecca Blank⁴, steven Yu², Noah Perlmutter², Judith Ashouri², Jose Scher⁵, andrew Patterson³, Peter Turnbaugh² and Renuka Nayak⁶, ¹University of California, San Francisco, San Francics, CA, ²University of California, San Francisco, San Francisco, CA, ³Pennsylvania State University, University Park, PA, ⁴NYU Langone Health, New York, NY, ⁵New York University School of Medicine, New York, NY, ⁶University of California, San Francisco (UCSF), San Francisco, CA
Background/Purpose: Despite advances in targeted therapeutics, methotrexate (MTX) remains the first-line therapy in the treatment of rheumatoid arthritis (RA) and other inflammatory arthritides. However, more…
Abstract Number: 0854 • ACR Convergence 2025
The Assessments in Spondyloarthritis International Society (ASAS) and Spondyloarthritis Research and Treatment Network (SPARTAN) Revised Classification Criteria for Axial Spondyloarthritis: Development and Validation in the Classification of Axial SpA Inception Cohort Study
Walter P. Maksymowych¹, Désirée van der Heijde², Liron Caplan³, Robert Landewé⁴, Lianne S. Gensler⁵, Pedro Machado⁶, Alexandre Sepriano⁷, Floris A. van Gaalen², Miranda van Lunteren², Ben Vandermeer⁸, Servet Akar⁹, Sibel Aydin¹⁰, Xenofon Barliakos¹¹, Wilson bautista molano¹², Stephanie Bernard¹³, RUBEN BURGOS-VARGAS¹⁴, John Carrino¹⁵, Alberto Cauli¹⁶, Jonathan Chan¹⁷, Abhijeet Danve¹⁸, Torsten Diekhoff¹⁹, Maxime Dougados²⁰, iris Eshed²¹, Warren Fong²², Rodrigo García Salinas²³, Hildrun Haibel²⁴, Nigil Haroon²⁵, Kay-Geert Hermann²⁶, Lennart Jans²⁷, Anne Jurik²⁸, Uta Kiltz²⁹, Tae-Jong Kim³⁰, Robert G. W. Lambert³¹, Clementina López Medina³², Ennio Lubrano³³, Marina Magrey³⁴, Vikas Majithia³⁵, Helena Marzo-Ortega³⁶, Philip J. Mease³⁷, Victoria Navarro-Compan³⁸, John O'Neill³⁹, Mikkel Ostergaard⁴⁰, Salih Ozgocmen⁴¹, Susanne Pedersen⁴², Fernando Pimentel-Santos⁴³, Denis Poddubnyy⁴⁴, Fabian Proft⁴⁵, Sofia Ramiro⁴⁶, Monique Reijnierse⁴⁷, John Reveille⁴⁸, Ruxandra Elena Schiotis⁴⁹, Hasan Tahir⁵⁰, Michael Tuite⁵¹, Filip Van den Bosch⁵², Runshen Wang⁵³, Ulrich Weber⁵⁴, James Cheng-Chung⁵⁵, Joachim Sieper⁵⁶, Atul Deodhar⁵⁷, and Martin Rudwaleit⁵⁸, ¹Department of Medicine, University of Alberta, 568 Heritage Building, Edmonton, AB, Canada, ²Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Medicine Service, Rocky Mountain Regional VAMC, Aurora, CO, ⁴Department of Rheumatology, Amsterdam University Medical Center, Amsterdam, Netherlands; and Zuyderland Medical Center, Heerlen, Netherlands, ⁵Department of Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ⁶Department of Rheumatology, University College London, and Department of Rheumatology, Northwick Park Hospital, London North West University Healthcare NHS Trust, Centre for Rheumatology & Department of Neuromuscular Diseases, University College London, London, United Kingdom, ⁷Department of Rheumatology, Leiden University Medical Centre, Portela Loures, Portugal, ⁸Department of Medicine, University of Alberta, Edmonton, AB, Canada, ⁹Department of Medicine, Izmir Katip Çelebi University School of Medicine, Izmir, Turkey, ¹⁰Department of Medicine, University of Ottawa, The Ottawa Hospital Research Institute, Ottawa, ON, Canada, ¹¹Ruhr-University Bochum, Rheumazentrum Ruhrgebiet, Herne, Germany, ¹²University Hospital Fundacion Santa Fe de Bogota, Bogota, Colombia, ¹³Department of Radiology, Brooke Army Medical Center, Fort Sam Houston, TX, ¹⁴Department of Rheumatology, Hospital General de Mexico, Faculty of Medicine, Universidad Nacional Autonoma de Mexico, Ciudad de México, Mexico, ¹⁵Department of Radiology and Imaging, Hospital for Special Surgery, New York, NY, ¹⁶Rheumatology Unit, Department of Medicine and Public Health, AOU and University of Cagliari, Cagliari, Italy, ¹⁷Department of Medicine, University of British Columbia, Vancouver, BC, Canada, ¹⁸Section of Rheumatology, Department of Medicine, Yale School of Medicine, New Haven, CT, ¹⁹Department of Radiology, Immanuel Clinic Ruedersdorf, Brandenburg Medical School, Ruedersdorf, Germany, ²⁰Department of Medicine, Hopital Cochin, Universite de Paris, Paris, France, ²¹Department of Diagnostic Imaging, Sheba Medical Center, Tel Hashomer affiliated with School of Medicine, Tel Aviv University, Tel Aviv, Israel, ²²Department of Medicine, Singapore General Hospital, Singapore, Singapore, ²³Hospital Italiano La Plata, La Plata, Argentina, ²⁴Charite- University Medicine Berlin Campus Benjamin Franklin, Berlin, Germany, ²⁵Department of Medicine/Rheumatology, University Health Network, Schroeder Arthritis Institute, University of Toronto, Toronto, ON, Canada, ²⁶Department of Radiology, Charité – Universitätsmedizin Berlin, Berlin, Germany, ²⁷Department of Radiology, Ghent University Hospital, Ghent, Belgium, ²⁸Department of Radiology, Aarhus University Hospital, Aarhus, Denmark, ²⁹Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, ³⁰Department of Medicine, Chonnam National University Hospital, Seoul, Republic of Korea, ³¹University of Alberta, Department of Radiology & Diagnostic Imaging, Edmonton, AB, Canada, ³²Department of Medicine, Hospital Universitario Reina Sofia, University of Cordoba, IMIBIC, Cordoba, Spain, ³³Department of Medicine, Università deglia Studi del Molise, Campobasso, Italy, ³⁴Case Western Reserve University School of Medicine/University Hospitals Cleveland, Richfield, OH, ³⁵Mayo Clinic Hospital, Jacksonville, FL, ³⁶NIHR Leeds Biomedical Research Centre, The Leeds Teaching Hospitals NHS Trust and Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, Leeds, United Kingdom, ³⁷Department of Rheumatology, Providence-Swedish Medical Center and University of Washington, Seattle, WA, ³⁸Department of Rheumatology, La Paz University Hospital, IdiPaz, Madrid, Spain, ³⁹Department of Radiology, McMaster University, Hamilton, ON, Canada, ⁴⁰Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark, and Copenhagen Center for Arthritis Research, Center for Rheumatology, Rigshospitalet, Glostrup, Denmark, ⁴¹Department of Rheumatology, Istinye University/Faculty of Medicine, Istanbul, Turkey, ⁴²Department of Medicine, Rigshopital, University of Copenhagen, Copenhagen, Denmark, ⁴³NOVA Medical School, Universidade NOVA e Lisboa, Lisboa, Portugal, ⁴⁴Division of Rheumatology, Department of Medicine, University Health Network and University of Toronto, Toronto, Ontario, Canada, and Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité – Universitätsmedizin Berlin, Berlin, Germany; Department of Epidemiology, German Rheumatism Research Centre, Berlin, Germany, ⁴⁵Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, ⁴⁶Leiden University Medical Center, Zuyderland Medical Center, Netherlands, ⁴⁷Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁴⁸Department of Medicine, University of Texas Medical Center, Houston, TX, ⁴⁹Clinical Hospital of Infectious Diseases, Rheumatology Department, Cluj-Napoca, Romania, ⁵⁰Department of Medicine, Royal Free NHS Foundation Trust, London, United Kingdom, ⁵¹Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI ⁵²Department of Internal Medicine and Pediatrics, Ghent University and VIB Center for Inflammation Research, Ghent, Belgium, ⁵³Division of Rheumatology, Columbia University Irving Medical Center and Garden State Rheumatology Consultants, Union, NJ, ⁵⁴Medical Centre of Zenit, Department of Rheumatology, Schaffhausen, Switzerland, ⁵⁵Department of Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan (Republic of China), ⁵⁶Department of Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany ⁵⁷Division of Arthritis and Rheumatic Diseases, Oregon Health & Sciences University, Portland, OR, ⁵⁸Bielefeld University, Medical School and University Medical Centre OWL, Klinikum Bielefeld, Department of Rheumatology, Bielefeld, Germany

Background/Purpose: The 2009 ASAS classification criteria had sensitivity (Sn) of 83% and specificity (Sp) of 84% for a rheumatologist diagnosis of axial spondyloarthritis (axSpA). Given…
Abstract Number: 0846 • ACR Convergence 2025
A Longitudinal Transcriptomic Study of Mycophenolate Mofetil in Systemic Sclerosis Skin with Clinical and Molecular Stratification
Rezvan Parvizi¹, Zhiyun Gong², Natania Field³, Helen Jarnagin², Dillon Popovich², Monica Yang⁴, Kathleen Aren⁵, Mary Carns⁶, Isaac Goldberg⁷, Lorinda Chung⁸, Vivien Goh⁹, Zsuzsanna McMahan¹⁰, Tammara Wood¹¹, Dinesh Khanna¹², Monique Hinchcliff¹³ and Michael Whitfield¹⁴, ¹Dartmouth, lebanon, NH, ²Dartmouth College, Lebanon, NH, ³Northwestern Memorial Hospital, Chicago, IL, ⁴UCSF, San Francisco, CA, ⁵Northwestern University Division of Rheumatology, Chicago, IL, ⁶Northwestern University, Chicago, IL, ⁷Wayne State University, Detroit, ⁸Stanford University, Stanford, CA, ⁹Northwestern, Chicago, ¹⁰UT Health Houston, Houston, TX, ¹¹Dartmouth, Hanover, NH, ¹²University of Michigan, Ann Arbor, MI, ¹³Yale School of Medicine, Westport, CT, ¹⁴Geisel School of Medicine, Lebanon, NH
Background/Purpose: Mycophenolate Mofetil (MMF) is the most commonly prescribed immunosuppressive treatment for patients diagnosed with diffuse cutaneous systemic sclerosis (dcSSc). Here, we analyzed skin gene…
Abstract Number: 0837 • ACR Convergence 2025
Risk of New Proteinuria in Next Ten Years in SLE
Michelle Petri¹, Ilayda Demirayak², Andrea Fava³, Daniel Goldman¹ and Laurence Magder⁴, ¹Johns Hopkins University School of Medicine, Timonium, MD, ²Istanbul University, Istanbul, Turkey, ³Johns Hopkins University, Baltimore, MD, ⁴University of Maryland, Baltimore, Baltimore, MD
Background/Purpose: The current 2024 ACR Lupus Nephritis guidelines recommend checking the urine protein to creatinine ratio (UPCR) every 6-12 months. Early recognition of lupus nephritis…
Abstract Number: 0789 • ACR Convergence 2025
Short Form 36 (SF-36) Health Survey Questionnaire in Health-Related Quality of Life Assessment in Patients with Inflammatory Myopathies
Almurtada Razok¹, Jasmin Taylor², Ethan Ritz³, Kristin Wipfler⁴, Kaleb Michaud⁵ and Didem Saygin⁶, ¹John H Stroger Jr Hospital of Cook County, Chicago, IL, ²Rush Medical College, Chicago, IL, ³Rush Research Informatics Core, Rush University Medical Center, Chicago, IL, ⁴FORWARD, The National Databank for Rheumatic Diseases, Omaha, NE, ⁵University of Nebraska Medical Center, Omaha, NE, ⁶Rush University Medical Center, Chicago, IL
Background/Purpose: Patients with idiopathic inflammatory myopathies (IIM) experience significant impairment in their health-related quality of life (QoL); however, there are currently no validated measures to…
Abstract Number: 0842 • ACR Convergence 2025
Association of urinary biomarkers with histological features in diagnostic and per-protocol repeat kidney biopsies in lupus nephritis
Andrea Fava¹, CHEN-YU LEE¹, Carla Guthridge², Dionysis Nikolopoulos³, Julius Lindblom⁴, Farah Tamirou⁵, Michelle Petri⁶, Joel Guthridge², Frederic Houssiau⁷ and Ioannis Parodis⁸, ¹Johns Hopkins University, Baltimore, MD, ²Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Karolinska Institutet and Karolinska University Hospital, Division of Rheumatology, Department of Medicine Solna, Stockholm, Sweden, ⁴Karolinska Institutet, Stockholm, Sweden, ⁵Cliniques universitaires Saint-Luc, Brussels, Belgium, ⁶Johns Hopkins University School of Medicine, Timonium, MD, ⁷CUSL, BRUSSELS, Belgium, ⁸Karolinska Institutet and Karolinska University Hospital, Department of Medicine Solna, Division of Rheumatology, Stockholm, Sweden
Background/Purpose: Persistent intrarenal inflammation despite immunosuppression drives kidney damage and functional decline in lupus nephritis (LN). Yet, current guidelines do not recommend repeat biopsy to…
Abstract Number: 0869 • ACR Convergence 2025
PD-1 inhibitor unleashes pathogenic CD8+ T cells and induce arthritis in collagen-primed mice
Clement Adedeji¹, Muhammad Hamdan¹, Hong-Jai Park², Kelsey Wang¹ and Sang Kim³, ¹Yale University, New Haven, ²Yale University, New Haven, CT, ³Yale University, Branford, CT
Background/Purpose: Background/Purpose: Immune checkpoint inhibitors (ICIs) are associated with immune-related adverse events, including inflammatory arthritis (ICI-arthritis). The pathophysiology of ICI-arthritis, particularly the role of T…
Abstract Number: 0025 • ACR Convergence 2025
Expansion and Transcriptional Reprogramming of CD14⁺ and CD16⁺ Monocytes in Behçet’s Disease
Elio Carmona¹, Rabia Deniz², Cemal Bes³, Haner Direskeneli⁴, Ahmet Gul⁵ and Amr Sawalha⁶, ¹Division of Pediatric Rheumatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA, Pittsburgh, ²University of Health Sciences Basaksehir Çam and Sakura City Hospital, Istanbul, Turkey, ³University of Health Sciences, Basaksehir Çam and Sakura City Hospital, Istanbul, Turkey, ⁴Marmara University, ISTANBUL, Turkey, ⁵Istanbul University, Istanbul, Turkey, ⁶University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Behçet’s disease (BD) is a chronic, relapsing inflammatory disease characterized by complex immunopathogenesis and limited treatment options. Monocytes are known to play a significant…
Abstract Number: 0020 • ACR Convergence 2025
Bulk RNA-sequencing of Leukocytoclastic Vasculitis Skin Biopsies Show Upregulation of Leukocyte Migration Genes
Anne Carlton, Lam Tsoi, Joseph Kirma, Jennifer Fox, Paul Harms and Johann Gudjonsson, University of Michigan, Ann Arbor, MI
Background/Purpose: Vasculitis encompasses multiple conditions united by end-organ damage due to an immune-mediated reaction against the vasculature. Leukocytoclastic vasculitis (LCV) is a subtype of cutaneous…
Abstract Number: 0848 • ACR Convergence 2025
Spatial Frequency Domain Imaging (SFDI) for Skin Assessment in Systemic Sclerosis: Insights from Histology and Clinical Correlates
Hung Vo¹, Aarohi Mehendale², Martin Azzam³, Fatima-Ezzahrae El Adili⁴, Rutvi Patel³, Marcin TROJANOWSKI³, Michael York⁵, Eugene Kissin⁶, Jeffrey Browning⁷, Jag Bhawan³, Darren Roblyer⁵ and Andreea Bujor⁵, ¹Boston Medical Center, Peabody, MA, ²Department of Biomedical Engineering, Boston University, Boston, MA, ³Boston University School of Medicine, Boston, MA, ⁴Boston University School of Medicine, Revere, MA, ⁵Boston University, Boston, MA, ⁶Boston University, Newton, MA, ⁷Boston University School of Medicine, Cambridge, MA
Background/Purpose: Assessing skin involvement in systemic sclerosis (SSc) is complex, with no single method capturing all pathological changes. The modified Rodnan Skin Score (mRSS) is…
Abstract Number: 2284 • ACR Convergence 2025
Cardiovascular Outcomes in Diabetic Rheumatoid Arthritis Patients: TNF-α Inhibitors versus IL-6 Inhibitors
Sila Mateo Faxas¹, Godbless Ajenaghughrure¹, Gurjot Singh², Kim Nguyen², Nirys Mateo Faxas³, Nicole Tejeda⁴, Kimberly Ramirez Bonetti⁵ and Erick Perez Mejias⁴, ¹Trihealth Good Samaritan Hospital, Cincinnati, OH, ²Trihealth Good Samaritan Hospital, Cincinnati, ³Independent Author, Santo Domingo, Dominican Republic, ⁴Independent Author, Cincinnati, ⁵Independent Author, cincinnati, OH
Background/Purpose: Patients with rheumatoid arthritis (RA) and type 2 diabetes mellitus (T2DM) face increased cardiovascular risk. Different biologic disease-modifying antirheumatic drugs (bDMARDs) may have varying…
Abstract Number: 0839 • ACR Convergence 2025
Precision Liquid Biopsy for Lupus Nephritis: cfDNA Methylation and Fragmentomic Signatures Enable Non-Invasive Diagnosis and Dynamic Disease Tracking
Qiuyu Jing¹, Qiang Li², Chiu Wai Shirley Chan³, Weixin Chen⁴, Fung Yu Nick choi⁴, Iris Tang⁵, Chak Sing Lau⁶, Heidi Ling⁶, Jason Wong⁷ and Philip Li², ¹Center for Oncology & Immunology, Hong Kong, Hong Kong, ²Department of Medicine, The University of Hong Kong, Hong Kong, Hong Kong, ³Division of Rheumatology and Clinial Immunology, Department of Medicine, the University of Hong Kong, Hong Kong, Hong Kong, China, ⁴School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong, ⁵Department of Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong, ⁶The University of Hong Kong, Hong Kong, Hong Kong, ⁷School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hing Kong, Hong Kong
Background/Purpose: Lupus nephritis (LN), a severe complication of systemic lupus erythematosus (SLE), lacks reliable non-invasive biomarkers for early detection and monitoring. This study investigates plasma…
Abstract Number: 0852 • ACR Convergence 2025
LEVI-04 Significantly Reduces Bone Marrow Lesions and Symptoms in Knee Osteoarthritis: Results from a Phase II RCT
Simon Westbrook¹, Ali Guermazi² and Philip Conaghan³, ¹Levicept Ltd, Sandwich, United Kingdom, ²Boston University, West Roxbury, MA, ³University of Leeds, Leeds, United Kingdom
Background/Purpose: Bone marrow lesions (BMLs), detectable on MRI as areas of ill-defined high signal intensity on fluid-sensitive sequences, are a common feature of osteoarthritis (OA),…
Abstract Number: 0811 • ACR Convergence 2025
SSc Skin Cell Atlas: a Scalable Web Portal for scRNA-Seq Analysis
Helen Jarnagin¹, Zhiyun Gong¹, Rachael Bogle², Alex Tsoi², Rezvan Parvizi³, Madeline Morrisson⁴, Dinesh Khanna⁵, Johann Gudjonsson⁵ and Michael Whitfield⁶, ¹Dartmouth College, Lebanon, NH, ²University of Michigan, Holland, OH, ³Dartmouth, lebanon, NH, ⁴Geisel School of Medicine at Dartmouth College, Hanover, NH, ⁵University of Michigan, Ann Arbor, MI, ⁶Geisel School of Medicine, Lebanon, NH
Background/Purpose: Despite the recent popularity and utility of modern high-resolution sequencing technologies, leveraging publicly available single-cell studies remains hampered by the need for substantial computational…

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