ACR Meeting Abstracts

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  • Abstract Number: 2189 • ACR Convergence 2022

    Impact of a Fatigue and Energy Management Program for Persons with Systemic Sclerosis (FAME-iSS): A Pilot Study

    Janet Poole1, Deirdre Connolly2, Jessica Salazar3 and Kristine Carandang4, 1University of New Mexico, Albuquerque, NM, 2School of Medicine, Trinity College, Dublin, Ireland, 3University of New Mexico, Occupational Therapy Graduate Program, Albuquerque, NM, 4Young Patients' Autoimmune Research & Empowerment Alliance, San Diego, CA

    Background/Purpose: Fatigue is one of the most prevalent and disabling symptom reported by people with systemic sclerosis (SSc). No fatigue-specific programs exist for people with…
  • Abstract Number: 2156 • ACR Convergence 2022

    Clinical Benefits of Lung Transplantation in Systemic Sclerosis-related Interstitial Lung Disease; A Single-Center Retrospective Study

    Yoichi Nakayama1, Ran Nakashima1, Tomohiro Handa2, Kiminobu Tanizawa2, Akihiro Ohsumi3, Mirei Shirakashi1, Ryosuke Hiwa1, Hideaki Tsuji1, Koji Kitagori1, Shuji Akizuki4, Hajime Yoshifuji5, Hiroshi date3 and Akio Morinobu5, 1Kyoto University Graduate School of Medicine, Department of Rheumatology and Clinical Immunology, Kyoto, Japan, 2Kyoto University Graduate School of Medicine, Department of Respiratory Medicine, Kyoto, Japan, 3Kyoto University Graduate School of Medicine, Department of Thoracic Surgery, Kyoto, Japan, 4Kyoto universtiy hospital, Kyoto City, Japan, 5Kyoto University, Kyoto, Japan

    Background/Purpose: Systemic sclerosis (SSc) is a chronic autoimmune disorder with microangiopathy and fibrosis affecting the skin and visceral organs. Interstitial lung disease (ILD) is a…
  • Abstract Number: 2208 • ACR Convergence 2022

    Diagnostic Performance of Hip Ultrasound in Calcium Pyrophosphate Deposition Disease

    Carina Soto-Fajardo1, Fabian Carranza-Enriquez2, Sinthia Solorzano Flores2, Abish Angeles2, Paola Flores2, Raul Pichardo-Bahena2, Luis Javier Jara Quezada2, Angélica Peña Ayala2, Victor-Manuel Ilizaliturri-Sanchez2, Georgios Filippou3 and Carlos Pineda2, 1Instituto Nacional de Rehabilitacion "Luis Guillermo Ibarra Ibarra", Ciudad de México, Mexico, 2Instituto Nacional de Rehabilitacion, Ciudad de México, Mexico, 3Rheumatology Department, Luigi Sacco University Hospital, Siena, Italy

    Background/Purpose: Calcium Pyrophosphate Deposition Disease (CPPD) is a chronic and potentially incapacitating disease. The reference standard for its diagnosis is the identification of calcium pyrophosphate…
  • Abstract Number: 2210 • ACR Convergence 2022

    Baricitinib in Juvenile Idiopathic Arthritis: A Phase 3, Double-Blind, Placebo-Controlled, Withdrawal, Efficacy and Safety Study

    Athimalaipet Ramanan1, Pierre Quartier Dit Maire2, Nami Okamoto3, Gabriella Meszaros4, Joana Araujo4, Zhongkai Wang4, Ran Liao4, Brenda Crowe4, Xin Zhang4, Rodney Decker4, Stuart Keller4, Hermine Brunner5 and Nicola Ruperto6, 1Bristol Royal Hospital for Children, Bristol, United Kingdom, 2Necker hospital, Paris Cedex 15, France, 3Osaka Medical College, Takatsuki-city, Japan, 4Eli Lilly and Company, Indianapolis, IN, 5Division of Rheumatology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Department of Pediatrics, Cincinnati, OH, 6IRCCS Istituto Giannina Gaslini; PRINTO, Clinica Pediatrica e Reumatologia, Genova, Italy

    Background/Purpose: Baricitinib is a JAK1/2 selective inhibitor approved for the treatment of rheumatoid arthritis. Juvenile idiopathic arthritis (JIA) is a group of diseases characterized by…
  • Abstract Number: 2195 • ACR Convergence 2022

    Pre-exposure Prophylaxis for SARS-CoV-2 with Subcutaneous Casirivimab/Imdevimab in Vaccine-refractory Patients with Immune-mediated Inflammatory Diseases

    Filippo Fagni1, Katja Schmidt2, Daniela Bohr3, Larissa Valor Mendez4, Ioanna Minopoulou2, Melek Yalcin Mutlu2, Fabian Hartmann2, Koray Tascilar4, Karin Manger5, Bernhard Manger2, Arnd Kleyer4, David Simon4, Georg Schett6 and Thomas Harrer2, 1University Hospital Erlangen; Department of Internal Medicine 3 - Rheumatology and Immunology, Erlangen, Germany, 2University Hospital Erlangen, Department of Internal Medicine 3 - Rheumatology and Immunology, Erlangen, Germany, 3Department of Internal Medicine 3, Rheumatology & Immunology, Friedrich-Alexander-University (FAU) Erlangen-Nurnberg and University Hospital Erlangen, Erlangen, Germany, 4Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054 Erlangen, Germany; Deutsches Zentrum Immuntherapie, Friedrich-Alexander-UniversityErlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, 5Rheumatology Practice Bamberg, Bamberg, Germany, 6Universitätsklinikum Erlangen, Erlangen, Germany

    Background/Purpose: Humoral responses to SARS-CoV-2 vaccination are reduced in patients with immune-mediated inflammatory diseases (IMID), especially when treated with B-cell depletion therapies, leading to increased…
  • Abstract Number: 2201 • ACR Convergence 2022

    Increased Economic Burden of Uveitis Among Patients with Psoriasis and Psoriatic Arthritis – a Retrospective Study Using Claims Data, 2009-2022

    M. Elaine Husni1, Jennifer Thorne2, Steve Peterson3, Natalie Shiff4, Shanti Neff-Baro5, Iris Lin5, Rachel Teneralli5, Oluwakayode Adejoro5 and Joseph Merola6, 1Cleveland Clinic, Cleveland, OH, 2Johns Hopkins Medicine, Baltimore, MD, 3Department of Immunology, Janssen Global Services, LLC, Horsham, PA, 4Janssen Scientific Affairs, LLC; Community Health and Epidemiology, University of Saskatchewan, Philadelphia, PA, 5Janssen, Horsham, PA, 6Harvard Medical School, Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Uveitis occurs more frequently in patients (pts) with psoriatic disease than in the general population,1-2 yet little is known about the increased burden associated…
  • Abstract Number: 2207 • ACR Convergence 2022

    Structural Ultrasound Features of Joints and Tendons of Healthy Children: Development of Normative Data

    Ruth Wittoek1, Céline Decock2, Nele Dewaele2, Lara Arnold3, Pieter baeyens4, Ignace Deschrijver4, Lisa Pardaens5, Ioannis Raftakis6, Thomas Renson7, Alexander D.J. Thooft8, Charline Rinkin9, Tine Vanhaverbeke5 and Caroline Verbist10, 1Dept. of Rheumatology, Ghent University Hospital, Ghent University, Gent, Belgium, 2Ghent University, Faculty of Medicine, Ghent, Belgium, 3Dept. Of Rheumatology, Maastricht UMC+, Maastricht, Netherlands, 4Dept. of Radiology, Clinique de Flandre, Coudekerque-Branche, France, 5Ghent University, Faculty of Internal Medicine and Pediatrics, Gent, Belgium, 6Dept. of Rheumatology, CHU-Brugmann Hospital Brussels, Brussels, Belgium, 7Ghent University Hospital, Ghent, Belgium, 8Ghent University, Faculty of Internal Medicine and Pediatrics, Ghent, Belgium, 9Dept. of Rheumatology, CHU Liège, Liège, Belgium, 10Dept. of Rheumatology, AZ Delta, Roeselare, Belgium, Roeselare, Belgium

    Background/Purpose: Ultrasound is a highly valuable imaging modality to study joints in patients with rheumatic diseases. In children, the applicability is hampered because of lack…
  • Abstract Number: 2203 • ACR Convergence 2022

    Changes in Tophus Composition During Urate-Lowering Therapy: A Dual Energy CT Study

    Leanne Chen1, Gregory Gamble1, Anne Horne1, Jill Drake2, Anthony Doyle1, Till Uhlig3, Lisa Stamp2 and Nicola Dalbeth1, 1University of Auckland, Auckland, New Zealand, 2University of Otago, Christchurch, New Zealand, 3Diakonhjemmet Hospital, Oslo, Norway

    Background/Purpose: The gouty tophus is an organized structure composed of monosodium urate (MSU) crystals and chronic inflammatory soft tissue. Long-term urate-lowering therapy leads to gradual…
  • Abstract Number: 2148 • ACR Convergence 2022

    Analysis of Serum Proteomics Data Identifies Beta-Defensin 2 as a Predictive Biomarker of Clinical Response to IL-17 Blockade in Psoriatic Arthritis

    Mathias Cardner1, Danny Tuckwell2, Anna Kostikova2, Pascal Forrer3, Richard Siegel2, Alain Marti3, Marc Vandemeulebroecke3 and Enrico Ferrero2, 1Novartis Global Drug Development and Novartis Institutes for BioMedical Research, Basel, Switzerland, 2Novartis Institutes for BioMedical Research, Basel, Switzerland, 3Novartis Global Drug Development, Basel, Switzerland

    Background/Purpose: Despite several effective targeted therapies, biomarkers that predict whether a patient with psoriatic arthritis (PsA) will respond to a particular treatment are currently lacking.Methods:…
  • Abstract Number: 2149 • ACR Convergence 2022

    Cycling versus Swapping Strategies in Psoriatic Arthritis: Results from the Rheumatic Diseases Portuguese Register

    Francisca Guimarães1, Maria Pontes-Ferreira1, Catarina Soares1, Hugo Parente2, Carolina Ochôa Matos3, Roberto Costa3, Daniela Oliveira4, Catarina Abreu5, Rafaela teixeira6, Sofia Ferreira Azevedo7, João Madruga-Dias8, Filipe Araújo9, Carla Campinho Ferreira10, Daniela Santos-Faria2 and José Tavares-Costa2, 1Rheumatology department, Unidade Local de Saúde do Alto Minho, Ponte de Lima, Viana do Castelo, Portugal, 2Rheumatology department, Unidade Local de Saúde do Alto Minho, Ponte de Lima, Portugal, 3Rheumatology Department, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal, 4Rheumatology Department, Centro Hospitalar Universitário São João, Porto, Portugal, 5Rheumatology Department, Hospital Garcia de Orta, Lisboa, Portugal, 6Rheumatology department, Centro Hospitalar Tondela-Viseu, Viseu, Portugal, 7Rheumatology Department, Centro Hospitalar do Baixo Vouga, Aveiro, Portugal, 8Rheumatology Service, Centro Hospitalar Médio Tejo, Tomar, Portugal, 9Rheumatology and Osteoporosis Unit, Hospital de Sant´Ana, SCML, Lisboa, Portugal, 10Rheumatology Department, Hospital de Braga, Braga, Portugal

    Background/Purpose: This study aimed to compare the effectiveness and safety of switching to a second tumour necrosis factor alfa inhibitor (TNFi) – "cycling group" -…
  • Abstract Number: 2193 • ACR Convergence 2022

    Invasive Fungal Diseases in Patients with Autoimmune Diseases: Prospective Data from a Nationwide French Registry

    Simon Galmiche1, Benjamin Thoreau2, Stéphane Bretagne3, Alexandre Alanio3, André Paugam4, Valérie Bru5, Sophie Cassaing6, Jean-Pierre Gangneux7, Hélène Guégan7, Loïc Favennec8, Alida Minoza9, Florent Morio10, Julie Bonhomme11, Guillaume Desoubeaux12, Odile Eloy13, Lilia Hasseine14, Milène Sasso15, Laurence Millon16, Anne-Pauline Bellanger16, Philippe Poirier17, Maxime Moniot17, Taieb Chouaki18, Antoine Huguenin19, Frédéric Dalle20, Bernard Bouteille21, Muriel Nicolas22, Nicole Desbois-Nogard23, Marie-Elisabeth Bougnoux24, François Danion25, Vincent Poindron26, Antoine Néel27, Karine Boukris-Sitbon28, Fanny Lanternier29 and Benjamin Terrier30, 1Institut Pasteur, Paris, France, 2AP-HP, Université Paris Cité, INSERM U1016, CNR UMR 8104, Paris, France, 3Institut Pasteur, Université Paris Cité, Centre National de Référence Mycoses Invasives et Antifongiques, UMR 2000, AP-HP, Paris, France, 4Parasitologie – Mycologie, Université Paris Cité, Cochin Hospital, AP-HP, Paris, France, 5Institut de parasitologie et de pathologie tropicale, Hôpitaux universitaires de Strasbourg, Université de Strasbourg, Strasbourg, France, 6Parasitologie - Mycologie, Université de Toulouse, CHU de Toulouse, Toulouse, France, 7Université de Rennes, CHU, INSERM, Irset: Institut de Recherche en Santé, Environnement et Travail, UMR_S 1085, Rennes, France, 8French National Cryptosporidiosis Reference Center, Rouen University Hospital, Rouen, France, 9Département des agents infectieux, Service de Mycologie-Parasitologie, CHU de Poitiers, Poitiers, France, 10Parasitologe – Mycologie, CHU de Nantes, Nantes, France, 11Microbiologie, CHU de Caen, Caen, France, 12Parasitologie - Mycologie - Médecine tropicale, CHU de Tours, Tours, France, 13Microbiologie, Hôpital de Versailles, Le Chesnay, France, 14Parasitologie – Mycologie, hôpital de l'Archet, CHU Nice, Nice, France, 15Laboratoire de Parasitologie-Mycologie, CHU Nîmes, Université de Montpellier, CNRS, IRD, MiVEGEC, Nîmes, France, 16Laboratoire de Parasitologie – Mycologie, CHU Besançon, Besançon, France, 17Parasitologie – Mycologie, CHU de Clermont-Ferrand, Clermont-Ferrand, France, 18Mycologie – parasitologie, CHU d’Amiens, Amiens, France, 19Parasitologie – Mycologie, hôpital Maison-Blanche, CHU de Reims, Reims, France, 20Parasitologie – Mycologie, Plateforme de Biologie Hospitalo-Universitaire Gérard Mack, Dijon, France, 21Parasitologie – Mycologie, Centre de Biologie et de Recherche en Santé, CHU Dupuytren, Limoges, France, 22Mycologie – Parasitologie, CHU de Pointe-à-pitre/Abymes, Pointe-à-Pitre, France, 23Parasitologie – Mycologie, CHU de la Martinique, Fort-de-France, France, 24Institut Pasteur, Unité Biologie et Pathogénicité Fongiques, Département Mycologie, Laboratoire de Parasitologie – Mycologie, Service de Microbiologie, Necker-Enfants Malades University Hospital, AP-HP, Paris, France, 25Maladies infectieuses et tropicales, Hôpitaux universitaires de Strasbourg, Strasbourg, France, 26Immunologie clinique et médecine interne, Hôpitaux universitaires de Strasbourg, Strasbourg, France, 27CHU de Nantes, Nantes, France, 28Institut Pasteur, Université Paris Cité, CNRS, Mycologie Moléculaire, Centre National de Référence Mycoses Invasives et Antifongiques, UMR 2000, Paris, France, 29Infectious Diseases Unit, Necker-Enfants Malades University Hospital, AP-HP, Institut Pasteur, Université Paris Cité, Centre National de Référence Mycoses Invasives et Antifongiques, CNRS UMR 2000, Paris, France, 30National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris, France

    Background/Purpose: Patients with autoimmune diseases (AIDs) display a risk of invasive fungal diseases (IFDs), because of the underlying disease or treatments used. Our objective was…
  • Abstract Number: 2146 • ACR Convergence 2022

    Efficacy of Upadacitinib in Patients with Psoriatic Arthritis and Prior Exposure to Anti-TNF Therapy in the SELECT-PsA 2 Trial Through 2 Years

    Philip J Mease1, Rodrigo Luppino Assad2, Shigeyoshi Tsuji3, Pascal Richette4, Arathi Setty5, Erin McDearmon-Blondell6, Tianming Gao5, Sandra Ciecinski6 and Filip Van den bosch7, 1Swedish Medical Center/Providence St. Joseph Health, Seattle, WA, 2Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil, 3Department of Orthopaedics and Rheumatology, Nippon Life Hospital, Osaka, Japan, 4Department of Rheumatology, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France, 5AbbVie, Inc., North Chicago, IL, 6AbbVie, Inc., Mettawa, IL, 7Department of Internal Medicine and Paediatrics, Ghent University and VIB Centre for Inflammation Research, Ghent, Belgium

    Background/Purpose: Patients with psoriatic arthritis (PsA) who experience anti-TNF failure and switch to another TNF inhibitor as second- or third-line therapy typically show poorer responses…
  • Abstract Number: 1782 • ACR Convergence 2022

    Sociocultural and Moral Factors Influencing the Decision to Vaccinate Among Rheumatic Patients: A Qualitative Study

    Tirsa Colmenares-Roa1, Amaranta ManriquedeLara2, Virginia Pascual Ramos3, JOSE FRANCISCO MOCTEZUMA RIOS4, Irazu Contreras-Ibañez5, Everardo Alvarez-Hernandez6, Guillermo Guaracha Basañez7, Graciela Meza-LópezyOlguin4 and Ingris Pelaez-Ballestas1, 1Hospital General de México "Dr. Eduardo Liceaga", Ciudad de México, Mexico, 2Hospital General de México "Dr. Eduardo Liceaga,", Ciudad de México, Mexico, 3Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de México, Mexico, 4HOSPITAL GENERAL DE MEXICO "Dr. Eduardo Liceaga", Ciudad de México, Mexico, 5Instituto Nacional de Nutricion Salvador Zubirán, Ciudad de México, Mexico, 6Hospital General de Mexico "Dr.Eduardo Liceaga", Ciudad de México, Mexico, 7Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirn", Ciudad de México, Mexico

    Background/Purpose: Vaccination is a process that involves individual, social and moral aspects, beyond public governance of vaccines or vaccination as a public health concern. The…
  • Abstract Number: 1785 • ACR Convergence 2022

    PROs and Sociodemographic Factors in Year Prior to COVID Predict Trajectories of Depressive Symptoms in Adults with RA in First 2 Years of Pandemic: Data from the Canadian Early Arthritis Cohort

    Susan Bartlett1, orit schieir2, Marie-France Valois2, Janet Pope3, Louis Bessette4, Gilles Boire5, Carol Hitchon6, Edward Keystone7, Carter Thorne8, Diane Tin9, Glen Hazlewood10 and Vivian Bykerk11, 1McGill University, Montreal, QC, Canada, 2McGill University, Montréal, QC, Canada, 3University of Western Ontario, London, ON, Canada, 4Centre de l'Ostoporose et de Rhumatologie de Québec, Québec, QC, Canada, 5Universite de Sherbrooke, Sherbrooke, QC, Canada, 6University of Manitoba, Winnipeg, MB, Canada, 7Keystone Consulting Enterprises Inc., Toronto, ON, Canada, 8Southlake Regional Health Centre, Newmarket, ON, Canada, 9The Arthritis Program Research Group, Newmarket, ON, Canada, 10University of Calgary, Calgary, AB, Canada, 11Hospital for Special Surgery, New York, NY

    Background/Purpose: Growing evidence points to considerable mental health impacts of the prolonged COVID-19 pandemic, though data from longitudinal studies in rheumatic diseases are sparse. We…
  • Abstract Number: 2152 • ACR Convergence 2022

    Depression and Other Neurological Disorders Are Associated with Biologic DMARD Failure in Psoriatic Arthritis

    Nicoletta Luciano1, Elisa Barone2, Enrico Brunetta1, Maria De Santis3, Angela Ceribelli4, Marta Caprioli5, Giacomo Maria Guidelli1, Arianna Sonaglia1, Daniela Renna6, Francesca Motta7, Natasa Isailovic7, Matteo Vecellio3 and Carlo Selmi8, 1IRCCS Humanitas Research Hospital, Rheumatology and Clinical Immunology, Rozzano, Italy, 2IRCCS Humanitas Research Hospital, Rheumatology and Clinical Immunology, Rozzano (MI), Lombardia, Italy, 3Humanitas University, IRCCS Humanitas Research Hospital, Rheumatology and Clinical Immunology, Pieve Emanuele, Italy, 4Humanitas Research Hospital, Humanitas University, Rozzano (MI) Italy, Borgo San Giacomo, Italy, 5IRCCS Humanitas Research Hospital, Rheumatology and Clinical Immunology, Pavia, Italy, 6IRCCS Humanitas Research Hospital, Rheumatology and Clinical Immunology, Milano, Italy, 7Humanitas University, IRCCS Humanitas Research Hospital, Rheumatology and Clinical Immunology, Rozzano (MI), Italy, 8Humanitas University, IRCCS Humanitas Research Hospital, Rheumatology and Clinical Immunology, Rozzano, Italy

    Background/Purpose: The management of patients with psoriasis and psoriatic artrhitis (PsA) has been recently enriched and has thus become more challenging by the wide armamentarium…
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