ACR Meeting Abstracts

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  • Abstract Number: 2027 • ACR Convergence 2022

    Labial and Parotid Salivary Gland Histopathology in Primary Sjögren’s Syndrome

    Uzma Nakshbandi1, Martha S. van Ginkel1, Silvia Liefers2, Hendrika Bootsma2, Fred Spijkervet2, Arjan Vissink1, Bert van der Vegt1 and Frans Kroese2, 1University Medical Center Groningen, University of Groningen, Groningen, Netherlands, 2University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: Salivary gland involvement is a hallmark of disease in primary Sjögren's syndrome (pSS). This is reflected by the prominent role of a positive biopsy…
  • Abstract Number: 2029 • ACR Convergence 2022

    Distinctive Clinical Profiles Associated with anti-SSA/Ro60, anti-Ro52/TRIM21 and Anti-SSB/La Reactivity

    Liselotte Deroo1, Helena Achten2, Kristel De Boeck2, Eva Genbrugge2, Wouter Bauters2, Dimitri Roels2, Frederick Dochy2, David Creytens2, Filip Van den bosch3, Dirk Elewaut4 and isabelle peene5, 1Ghent University, Gent, Belgium, 2Ghent University Hospital, Gent, Belgium, 3Department of Internal Medicine and Paediatrics, Ghent University and VIB Centre for Inflammation Research, Ghent, Belgium, 4Department of Rheumatology, Ghent University Hospital, Belgium, VIB-UGent Center for Inflammation Research, Ghent University, Heusden, Belgium, 5Ghent University Hospital, Ghent, Belgium

    Background/Purpose: Presence of anti-SSA/Ro antibodies is one of the 2016 ACR-EULAR classification criteria for primary Sjögren's Syndrome (pSS). Anti-SSA/Ro antibodies comprise reactivity against Ro52 and/or…
  • Abstract Number: 2018 • ACR Convergence 2022

    Five Year Follow-up of Systemic Disease Activity Measured with the ESSDAI in a Standard of Care Cohort of Patients with Primary Sjögren’s Syndrome

    Liseth de Wolff1, Suzanne Arends2, Alja Stel3, Greetje van Zuiden3, Jolien van Nimwegen2, Arjan Vissink4, Frans Kroese2, Gwenny Verstappen2 and Hendrika Bootsma2, 1UMCG, Zwolle, Netherlands, 2University Medical Center Groningen, Groningen, Netherlands, 3University of Groningen, University Medical Centre Groningen, Groningen, Netherlands, 4University Medical Center Groningen, University of Groningen, Groningen, Netherlands

    Background/Purpose: The EULAR Sjögren's Syndrome Disease Activity Index (ESSDAI) is often used as primary endpoint in randomised clinical trials (RCTs) in patients with primary Sjögren's…
  • Abstract Number: 2024 • ACR Convergence 2022

    Salivary Gland Ultrasound May Lead to a More Accurate Stratification of Patients with the Same Serological Profile in Sjögren’s Syndrome: Towards a Personalized Approach

    Silvia Fonzetti1, Francesco Ferro2, Gaetano La Rocca3, Giovanni Fulvio4, Inmaculada Concepción Navarro García5, Gianmaria Governato6, Valentina Donati7, Marta Mosca8 and Chiara Baldini4, 1Azienda Ospedaliera Universitaria Pisana, Pisa, Italy, 2Clinical and Experimental Medicine Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Pisa, Italy, 3University of Pisa, Rheumatology Unit, Palermo, Palermo, Italy, 4University of Pisa, Pisa, Pisa, Italy, 5Clinical and Experimental Medicine Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy, 6Azienda Ospedaliera Universitaria Pisana, Pisa, Pisa, Italy, 7Pathology Unit, University of Pisa, Pisa, Italy, 8Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

    Background/Purpose: Salivary gland ultrasound (SGUS) abnormalities have been increasingly recognized as possible biomarkers for Sjögren's Syndrome (SS) phenotypic stratification. However, to date few studies have…
  • Abstract Number: 2028 • ACR Convergence 2022

    The Value of FDG-PET/CT in the Detection of Lymphomas Associated with Primary Sjögren’s Syndrome

    Martha S. van Ginkel1, Andor WJM Glaudemans1, Bert van der Vegt1, Arjan Vissink1, Frans Kroese2 and Hendrika Bootsma2, 1University Medical Center Groningen, University of Groningen, Groningen, Netherlands, 2University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: Primary Sjögren's syndrome (pSS) patients have an increased risk of developing a lymphoma. PSS-associated lymphomas are mostly of the mucosa associated lymphoid tissue (MALT)…
  • Abstract Number: 2030 • ACR Convergence 2022

    Designing of a Phase 2, Multicenter, Randomized, Placebo-Controlled, Double-Blind Study to Assess the Efficacy and Safety of Nipocalimab, an FcRn Inhibitor, in Adults with Primary Sjögren’s Syndrome

    Jonathan Hubbard1, Kim Campbell1, Kathy Sivils1, Robert Hoffman1, Kim Hung Lo1, Jocelyn Leu1, Sophia Liva1, Qing Zuraw1, Anne Stevens1, Leona Ling2, Keith Karcher3, Sindhu Ramchandren3, Hong Sun3, Hal Scofield4, Daniel Wallace5 and Raphaèle Seror6, 1Janssen Research and Development, LLC, Spring House, PA, 2Janssen Research & Development, LLC, Cambridge, MA, 3Janssen Research & Development, LLC, Titusville, NJ, 4Oklahoma Medical Research Foundation, Oklahoma City, OK, 5Cedars-Sinai Medical Center, Los Angeles, CA, 6University Hospital Paris-Saclay, Le Kremlin Bicêtre, France

    Background/Purpose: Dysregulated humoral immunity is a hallmark of primary Sjögren's Syndrome (pSS). This dysregulation involves aberrant B-lymphocyte activity resulting in abnormally high immunoglobulin G (IgG)…
  • Abstract Number: 1992 • ACR Convergence 2022

    Burden of Pain for Patients in the CorEvitasTM Rheumatoid Arthritis Registry

    Joshua Baker1, J Morel Symons2, Jud C Janak3, Page Moore3, Elizabeth Kohl3, Bernice Gershenson3, Oksana Pugach3, Dave Webb4, Alan A Martin4, Didier Saurigny5 and Marguerite Bracher5, 1University of Pennsylvania and Corporal Michael J. Crescenz VA Medical Center, Philadelphia, 2GlaxoSmithKline, Collegeville, PA, 3CorEvitas, LLC, Waltham, MA, 4GlaxoSmithKline, Brentford, United Kingdom, 5GlaxoSmithKline, Stevenage, United Kingdom

    Background/Purpose: Pain is a hallmark symptom of RA that impacts patients' quality of life and informs therapeutic decisions that aim to reduce joint inflammation and…
  • Abstract Number: 1991 • ACR Convergence 2022

    Mice Do Not Develop CIA: Knocking out of Kv1.3 Renders CD4+TEMCells Resistant to Activation

    Siba Raychaudhuri1, Smriti Raychaudhuri2 and Heike Wulff3, 1UC Davis, School of Medicine/ VA Medical Center, Sacramento, CA, 2VA Medical Center, Sacramento, CA, 3UC Davis, Davis, CA

    Background/Purpose: Engagement of the TCR triggers Ca++ influx through Ca++ channels. Ca++ influx is only possible with a counterbalancing K+ efflux through Kv1.3 and/or KCa3.1.…
  • Abstract Number: 2016 • ACR Convergence 2022

    Safety and Efficacy Associated with Long-Term Low Dose Glucocorticoids in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials

    Andriko Palmowski1, Sabrina Mai Nielsen2, Zhivana Boyadzhieva3, Abelina Schneider3, Anne Pankow3, Linda Hartman4, Jose Pereira da Silva5, John Kirwan6, Siegfried Wassenberg7, Christian Dejaco8, Robin Christensen9, Maarten Boers10 and Frank Buttgereit11, 1Department of Rheumatology and Clinical Immunology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, 2The Parker Institute, Section for Biostatistics and Evidence-Based Research, Bispebjerg-Frederiksberg Hospital, Frederiksberg, Denmark, 3Charité-Universitätsmedizin Berlin, Berlin, Germany, 4Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam, Netherlands, 5University of Coimbra, Rheumatology, Columbia, Portugal, 6University of Bristol, Bristol, United Kingdom, 7Rheumazentrum Ratingen, Ratingen, Germany, 8Department of Rheumatology, Hospital of Brunico (SABES-ASDAA), Brunico, Italy, and Department of Rheumatology and Immunology, Medical University of Graz, Graz, Austria, 9Musculoskeletal Statistics Unit, The Parker Institute, Copenhagen, Denmark, 10Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands, 11Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin / DRFZ Berlin, Berlin, Germany

    Background/Purpose: There is ongoing controversy about the safety and efficacy of long-term low dose glucocorticoids (GCs) in rheumatoid arthritis (RA). Our aim was to study…
  • Abstract Number: 1990 • ACR Convergence 2022

    Artificial Intelligence Applied to Transcriptomics Profiling of Synovial Tissue Biopsies Accurately Predicts Rheumatoid Arthritis Patients Who Will Respond or Be Refractory to Standard Biological Treatments

    Giorgio CASABURI, Todd Holscher and Ming-Chou Lee, Exagen, Inc., Vista, CA

    Background/Purpose: In recent years, biological therapies have revolutionized treatments of Rheumatoid Arthritis (RA). However, about 40% of RA patients do not respond to given biologics…
  • Abstract Number: 1522 • ACR Convergence 2022

    The Collaborative National Quality and Efficacy Registry for Scleroderma: Association of Medication Use on Gastrointestinal Tract Symptoms in Early Disease

    Sarah Luebker1, Tracy Frech1, Shervin Assassi2, Jessica Gordon3, Elana Bernstein4, Virginia Steen5, Ami Shah6, Laura Hummers7, Carrie Richardson8, Dinesh Khanna9, Flavia Castelino10, Lorinda Chung11, Faye Hant12, Vicki Shanmugam13, John VanBuren14, Jessica Alvey14, Monica Harding14, Luke Evnin15 and Nora Sandorfi16, 1Vanderbilt University Medical Center, Nashville, TN, 2McGovern Medical School, University of Texas, Houston, TX, 3Hospital for Special Surgery, New York, NY, 4Columbia University, New York, NY, 5Georgetown University School of Medicine, Washington, DC, 6Johns Hopkins Rheumatology, Baltimore, MD, 7Johns Hopkins Univerisity, Baltimore, MD, 8Northwestern University, Chicago, IL, 9Division of Rheumatology, Department of Internal Medicine, Scleroderma Program, University of Michigan, Ann Arbor, MI, 10Massachusetts General Hospital, Boston, MA, 11Stanford University, Stanford, CA, 12Medical University of South Carolina, Charleston, SC, 13George Washington University, Washington, DC, 14University of Utah, Salt Lake City, UT, 15Scleroderma Research Foundation, Brisbane, CA, 16University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Gastrointestinal tract (GIT) symptoms are common amongst systemic sclerosis (SSc) patients.1 The Scleroderma Clinical Trials Consortium University of California Los Angeles Gastrointestinal Tract Questionnaire…
  • Abstract Number: 1519 • ACR Convergence 2022

    Using Galacetin-3 (Gal-3) and Cardiotrophin-1 (CT-1) for Early Detection of Primary Heart Involvement in Systemic Sclerosis as Seen on Cardiac MRI

    Erin Chew1, Sarah Wood1, Bibin Varghese1, Christopher Chew2, erin wilfong1 and Tracy Frech1, 1Vanderbilt University Medical Center, Nashville, TN, 2University of North Carolina at Chapel Hill, Chapel Hill, NC

    Background/Purpose: Primary heart involvement in systemic sclerosis (SSc-pHI) is characterized by myocardial inflammation with resultant fibrosis that is not secondary to ischemic heart disease or…
  • Abstract Number: 1986 • ACR Convergence 2022

    Early-stage Rheumatoid Arthritis Patients with High Levels of Type III Collagen Are Less Likely to Respond to Anti-IL6R Treatment

    Sofie Falkenløve Madsen1, Dovile Sinkeviciute2, Christian Thudium2, Morten Karsdal2 and Anne-Christine Bay-Jensen2, 1University of Copenhagen / Nordic Bioscience, Herlev, Denmark, 2Nordic Bioscience, Herlev, Denmark

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic, autoimmune disease, which normally is characterized by inflammation and thickening of the synovial membrane leading to swollen and…
  • Abstract Number: 2023 • ACR Convergence 2022

    Salivary Autoantibodies in Sicca Patients Are Associated with Dry Symptoms

    Martha Tsaliki1, Joshua Cavett1, Biji T. Kurien2, Christina Bruxvoort1, Robert Hal Scofield2 and Kristi A Koelsch3, 1University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2University of Oklahoma Health Sciences Center, Oklahoma, OK, 3Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Sjögren’s Syndrome (SS) diagnosis depends on clinic examinations that involve measurements of serum levels of anti-Ro\SSA, anti-La\SSB, and rheumatoid factor antibodies; the first is…
  • Abstract Number: 1530 • ACR Convergence 2022

    Scleroderma Renal Crisis: Time to Initiation of Therapy Does Not Affect Mortality

    Aditi Patel1, Chao Zhang1 and Soumya Chatterjee2, 1Cleveland Clinic, Cleveland, OH, 2Cleveland Clinic, Richmond Heights, OH

    Background/Purpose: Scleroderma renal crisis (SRC) is a rare complication in patients with systemic sclerosis (SSc), characterized by accelerated hypertension and acute kidney injury. ACE inhibitors…
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