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  • Abstract Number: 2025 • ACR Convergence 2022

    Natural History of Sjögren’s Disease from the National Institutes of Health Cohort

    Brandon Law1, Margaret Beach2, Eileen Pelayo2, Ilias Alevizos2, Zohreh Khavandgar2, Blake Warner2 and Alan Baer1, 1Johns Hopkins University School of Medicine, Baltimore, MD, 2National Institutes of Health, Bethesda, MD

    Background/Purpose: The objectives of this study were to assess the natural history of Sjögren's disease (SjD) over an interval reaching up to 32 years among…
  • Abstract Number: 2027 • ACR Convergence 2022

    Labial and Parotid Salivary Gland Histopathology in Primary Sjögren’s Syndrome

    Uzma Nakshbandi1, Martha S. van Ginkel1, Silvia Liefers2, Hendrika Bootsma2, Fred Spijkervet2, Arjan Vissink1, Bert van der Vegt1 and Frans Kroese2, 1University Medical Center Groningen, University of Groningen, Groningen, Netherlands, 2University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: Salivary gland involvement is a hallmark of disease in primary Sjögren's syndrome (pSS). This is reflected by the prominent role of a positive biopsy…
  • Abstract Number: 2016 • ACR Convergence 2022

    Safety and Efficacy Associated with Long-Term Low Dose Glucocorticoids in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials

    Andriko Palmowski1, Sabrina Mai Nielsen2, Zhivana Boyadzhieva3, Abelina Schneider3, Anne Pankow3, Linda Hartman4, Jose Pereira da Silva5, John Kirwan6, Siegfried Wassenberg7, Christian Dejaco8, Robin Christensen9, Maarten Boers10 and Frank Buttgereit11, 1Department of Rheumatology and Clinical Immunology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, 2The Parker Institute, Section for Biostatistics and Evidence-Based Research, Bispebjerg-Frederiksberg Hospital, Frederiksberg, Denmark, 3Charité-Universitätsmedizin Berlin, Berlin, Germany, 4Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam, Netherlands, 5University of Coimbra, Rheumatology, Columbia, Portugal, 6University of Bristol, Bristol, United Kingdom, 7Rheumazentrum Ratingen, Ratingen, Germany, 8Department of Rheumatology, Hospital of Brunico (SABES-ASDAA), Brunico, Italy, and Department of Rheumatology and Immunology, Medical University of Graz, Graz, Austria, 9Musculoskeletal Statistics Unit, The Parker Institute, Copenhagen, Denmark, 10Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands, 11Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin / DRFZ Berlin, Berlin, Germany

    Background/Purpose: There is ongoing controversy about the safety and efficacy of long-term low dose glucocorticoids (GCs) in rheumatoid arthritis (RA). Our aim was to study…
  • Abstract Number: 2022 • ACR Convergence 2022

    Outcome of Pregnancy in Women with Primary Sjögren’s Syndrome Compared to the General Population: The French Multicenter Prospective GR2 Study

    Gregoire Martin de Fremont1, Nathalie Costedoat-Chalumeau2, Rakiba Belkhir3, Gaelle Guettrot-Imbert4, Nathalie Morel4, Gaetane Nocturne5, Anna Molto6, Tiphaine Goulenok7, Elisabeth Diot8, Estibaliz Lazaro9, Laurent Perard10, Nicole Ferreira11, Maelle Le Besnerais12, Nicolas Limal7, Nihal Martis13, Noémie Abisror14, Odile Debouverie15, Christophe Richez16, Vincent Sobanski17, Francois Maurier18, Gaetan Sauvetre12, Herve Levesque12, Marie Agnes Timsit19, Nathalie Tieule13, Pauline Orquevaux20, GEFA Collaborative group21, Matthieu Mahevas22, Celine Lartigau Roussin23, Elodie Chauvet24, Emilie Berthoux25, Francoise Sarrot Reynauld26, Loic Raffray27, Marion Couderc28, Nicolas Martin Silva29, Noemie Jourde Chiche30, Nicolas Belhomme31, Thierry Thomas32, Vincent Poindron33, Viviane Queyrel13, Juliette Delforge34, Camille Le Ray35, Emmanuelle Pannier35, Xavier Mariette36, Veronique Le Guern4 and Raphaèle Seror37, 1Rheumatology department, Kremlin Bicêtre hospital, APHP, Paris, France, 2Inserm DR Paris 5, Paris, France, 3Rheumatology departement, Bicêtre, Paris-Saclay university, Le Kremlin Bicêtre, France, 4Hôpital Cochin, Paris, France, 5APHP, Le Kremlin Bicêtre, France, 6Rheumatology Department, Cochin Hospital, APHP, Paris, France, 7APHP, Paris, France, 8CHU Tours, Tours, France, 9Bordeaux Hospital University, Bordeaux, France, 10CHU Lyon, Lyon, France, 11department of Internal Medecine, CHU de Tours, Tours, France, 12CHU Rouen, Rouen, France, 13CHU Nice, Nice, France, 14Hopital Saint Antoine, Paris, France, 15CHU Poitiers, Poitiers, France, 16Université de Bordeaux, Bordeaux, France, 17Université de Lille, Lille, France, 18Hôpitaux privés de Metz, Metz, France, 19CHU Brest, Brest, France, 20CHU Reims, Reims, France, 21Saint Joseph Hospital, Marseille, France, 22CHU Mondor, Creteil, France, 23CH La Réunion, CH la Réunion, France, 24CH Cabestany, Cabestany, France, 25CH Saint Joseph Saint Luc, Lyon, France, 26CHU Grenoble, CHU Grenoble, France, 27CH St Denis Reunion, Saint Denis Reunion, France, 28University Hospital, Clermont-Ferrand, France, 29CHU Caen, Caen, France, 30APHM, Marseille, France, 31CHU Rennes, Rennes, France, 32CHU Saint Etienne, Saint Etienne, France, 33Immunologie clinique et médecine interne, Hôpitaux universitaires de Strasbourg, Strasbourg, France, 34Jean Verfier, Bobigny, France, 35Port Royal, Paris, France, 36Paris-Saclay University, Rueil Malmaison, Ile-de-France, France, 37University Hospital Paris-Saclay, Le Kremlin Bicêtre, France

    Background/Purpose: In the context of primary Sjögren's syndrome (pSS), only a few retrospective studies using heterogeneous methods have investigated the risk of adverse pregnancy outcomes…
  • Abstract Number: 2026 • ACR Convergence 2022

    Serum and Tear Autoantibodies from nor Mice as Potential Diagnostic Indicators of Local and Systemic Inflammation in Sjögren’s Syndrome

    Shruti Singh Kakan1, Yaping Ju2, Maria Edman2 and Sarah Hamm-Alvarez3, 1Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California; Department of Ophthalmology, Keck School of Medicine, Roski Eye Institute, University of Southern California, Los Angeles, CA, 2Department of Ophthalmology, Keck School of Medicine, Roski Eye Institute, University of Southern California, Los Angeles, CA, 3Department of Ophthalmology, Keck School of Medicine, Roski Eye Institute, University of Southern California; Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA

    Background/Purpose: Sjögren's Syndrome (SS) is an autoimmune disease characterized by infiltration of lymphocytes into lacrimal (LG) and salivary (SG) glands and their concurrent loss of…
  • Abstract Number: 2028 • ACR Convergence 2022

    The Value of FDG-PET/CT in the Detection of Lymphomas Associated with Primary Sjögren’s Syndrome

    Martha S. van Ginkel1, Andor WJM Glaudemans1, Bert van der Vegt1, Arjan Vissink1, Frans Kroese2 and Hendrika Bootsma2, 1University Medical Center Groningen, University of Groningen, Groningen, Netherlands, 2University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: Primary Sjögren's syndrome (pSS) patients have an increased risk of developing a lymphoma. PSS-associated lymphomas are mostly of the mucosa associated lymphoid tissue (MALT)…
  • Abstract Number: 1991 • ACR Convergence 2022

    Mice Do Not Develop CIA: Knocking out of Kv1.3 Renders CD4+TEMCells Resistant to Activation

    Siba Raychaudhuri1, Smriti Raychaudhuri2 and Heike Wulff3, 1UC Davis, School of Medicine/ VA Medical Center, Sacramento, CA, 2VA Medical Center, Sacramento, CA, 3UC Davis, Davis, CA

    Background/Purpose: Engagement of the TCR triggers Ca++ influx through Ca++ channels. Ca++ influx is only possible with a counterbalancing K+ efflux through Kv1.3 and/or KCa3.1.…
  • Abstract Number: 1990 • ACR Convergence 2022

    Artificial Intelligence Applied to Transcriptomics Profiling of Synovial Tissue Biopsies Accurately Predicts Rheumatoid Arthritis Patients Who Will Respond or Be Refractory to Standard Biological Treatments

    Giorgio CASABURI, Todd Holscher and Ming-Chou Lee, Exagen, Inc., Vista, CA

    Background/Purpose: In recent years, biological therapies have revolutionized treatments of Rheumatoid Arthritis (RA). However, about 40% of RA patients do not respond to given biologics…
  • Abstract Number: 2014 • ACR Convergence 2022

    Difficult to Treat Rheumatoid Arthritis: Prevalence of Different Objective Patterns, Predictive Characteristics, and Associated Factors in 1-Year Follow-Up

    Einer Sanchez-Prado, ronald Perez, Laura Cuellar, jonatan mareco, Santiago Ruta, Sebastian Magri and Rodrigo Garcia Salinas, Hospital Italiano de La Plata, La Plata, Argentina

    Background/Purpose: Difficult-to-Treat Rheumatoid Arthritis (RA) (D2T), is a concept recently defined by EULAR, it refers to patients who do not achieve the therapeutic target, who…
  • Abstract Number: 1989 • ACR Convergence 2022

    Predictors of Flare in the RHEUmatoid Arthritis Medication TAPering (RHEUMTAP) Cohort

    Nada Alrifai1, Mohamed Tageldin2, Malavikalakshmi Attur2, Nicholas Wilson2, Rebecca schorr2 and Tarun Sharma2, 1Allegheny Health Network, Pittsburgh, 2Allegheny Health Network, Pittsburgh, PA

    Background/Purpose: Long term use of conventional synthetic DMARDs (csDMARDs) and biologics in RA has clinical risks including infection and malignancy. Few RCTs and real-world studies…
  • Abstract Number: 1455 • ACR Convergence 2022

    Immune Thrombocytopenic Purpura and Subsequent Development of Systemic Lupus Erythematosus

    Gelsomina Alle1, Marina Scolnik1, VALERIA SCAGLIONI1, John Fredy Jaramillo Gallego1, Mayra Alejandra Tobar Jaramillo1, Rodolfo Alvarado1, Enrique R Soriano2 and Javier Eduardo Rosa1, 1Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 2Rheumatology Unit and University Institute, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

    Background/Purpose: The aim of this study is to assess the incidence of Systemic Lupus Erythematosus (SLE) in a cohort of patients with Immune Thrombocytopenic Purpura…
  • Abstract Number: 1460 • ACR Convergence 2022

    Neuropsychiatric Lupus in Late and Early Onset Systemic Lupus Erythematosus Patients: A Systemic Review and Meta-analysis

    Omer Pamuk1, Saja Ali2 and Sarfaraz Hasni2, 1NIH/NIAMS, Bethesda, MD, 2NIAMS/NIH, Bethesda, MD

    Background/Purpose: The diagnosis of neuropsychiatric lupus (NPSLE) is challenging due to its variegated presentation, absence of diagnostic biomarkers and radiological imaging. The NPSLE is further…
  • Abstract Number: 1985 • ACR Convergence 2022

    The BEGIN Study: A Double-blind, Multi-center, Two-part, Randomized, Placebo-controlled Study of the Safety, Tolerability, and Efficacy of 4 Weeks of Treatment with AP1189 in Early Rheumatoid Arthritis (RA) Patients with Active Joint Disease

    Thomas Jonassen1, Irene Sandholdt2, Birgitte Telmer2 and Ellen-Margrethe Hauge3, 1SynAct Pharma, Holte, Denmark, 2CroxxMed, Hørsholm, Denmark, 3Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark

    Background/Purpose: Melanocortin (MC) type 1 and type 3 receptor stimulation is associated with anti-inflammatory activity and the promotion of inflammatory resolution. AP1189 is novel biased…
  • Abstract Number: 2021 • ACR Convergence 2022

    Early Histopathological Changes of the Salivary Glands Associated with the Development of Primary Sjögren’s Syndrome

    Xiaomei Shan1, Clara Reichardt1, Jeeshan Singh1, Anne Zeitler2, Christine Schauer1, Jasmin Knopf1, Martin Herrmann1, Gerhard Grossmayer1, Georg Schett1 and Luis Munoz1, 1Universitätsklinikum Erlangen, Erlangen, Germany, 2Friedrich-Alexander University Erlangen Nürnberg, Erlangen, Germany

    Background/Purpose: Primary Sjögren's syndrome (PSS) is a chronic inflammatory disease affecting exocrine glands including salivary and lacrimal glands that leads to dry eyes and mouth…
  • Abstract Number: 1453 • ACR Convergence 2022

    Prevalence and Associations of Myositis in an Indian Inception Cohort of Lupus

    Liza Rajasekhar1, Vineetha Shobha2, Meenakshi Ponnana3, Chengappa Kavadichanda4, Ashish J Mathew5, Saumya Ranjan Tripathy6, Manish Rathi7, Parasar Ghosh8, Ranjan Gupta9, Avinash Jain10 and Amita Aggarwal11, 1Nizam's Institute of Medical Sciences, Madhapur, India, 2St. John’s Medical College Hospital, Bangalore, India, 3Nizam's Institute of Medical Sciences, Hyderabad, India, 4JIPMER, Pondicherry, Puducherry, India, 5Rigshospitalet, Copenhagen, Denmark, 6SCB medical college, Cuttack, India, 7PGIMER Chandigarh, Chandigarh, India, 8Govt of West Bengal, Kolkata, India, Kolkata, West Bengal, India, 9All India Institute of Medical Sciences, New Delhi, India, 10SMS Medical College, Lucknow, India, 11Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

    Background/Purpose: Muscle inflammation in systemic lupus erythematosus (SLE) usually presents as generalised myalgia in the presence of active disease elsewhere and responds well to treatment.…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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