Abstracts Archive - Page 450 of 2607 - ACR Meeting Abstracts

Abstract Number: 0131 • ACR Convergence 2023
Identifying Antinuclear Antibody Positive Individuals at Risk for Systemic Autoimmune Disease: Development and Validation of a Real-Time Risk Model
April Barnado, Ryan Moore, Hank Domenico, Sarah Green, Alex Camai, Ashley Suh, Bryan Han, Katherine Walker, Audrey Anderson, Lannawill Caruth, Anish Katta, Allison McCoy and Daniel W. Byrne, Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Up to 20% of the general population has a positive ANA without having autoimmune disease. Currently, no tools exist to help clinicians interpret the…
Abstract Number: 0130 • ACR Convergence 2023
Association of HLA-DRB1 Alleles with Coronary Artery Calcium, Abdominal Aortic Calcium, and Carotid Intima-media Thickness in a Multi-ethnic Community-living Population
Manmeet Kaur¹, Ronit Katz², Michael H. Criqui¹, Maripat Corr³, Wendy S. Post⁴, Matthew Budoff⁵, Gerald P. Morris³ and Jan M. Hughes-Austin³, ¹University of California San Diego, San Diego, CA, ²University of Washington, Seattle, WA, ³University of California San Diego, La Jolla, CA, ⁴Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Harbor-UCLA Medical Center, Torrance, CA
Background/Purpose: Human leukocyte antigen (HLA) DRB1 alleles with specific common amino acids referred to as the shared epitope (SE) have been linked to endothelial dysfunction…
Abstract Number: 0125 • ACR Convergence 2023
Decreasing Ischemic Heart Disease, but Increasing Cancer Among the Underlying Causes of Death in Decedents with Lupus Nephritis
snehin Rajkumar¹ and Ram Singh², ¹University of California Los Angeles, Irvine, CA, ²UCLA David Geffen School of Medicine, Los Angeles, CA
Background/Purpose: Patients with lupus nephritis may die of active systemic lupus erythematosus (SLE) disease, end-stage renal disease (ESRD) and its complications as well as of…
Abstract Number: 0113 • ACR Convergence 2023
Serum Myeloperoxidase (MPO)-DNA Complexes and Serum Calprotectin Differentiate Isolated Thrombotic Antiphospholipid Syndrome from Isolated Obstetric Antiphospholipid Syndrome
Ruyu Liang¹, Ranran Yao², Ziye Wang³, Wenwen Pei², Renge Liang³ and Chun Li⁴, ¹Peking University, XiCheng, China, ²Peking University, Beijing, China, ³Peking University People's Hospital, Beijing, China, ⁴Peking University People’s Hospital, Beijing, China
Background/Purpose: There is a lack of serum markers to differentiate thrombotic APS (tAPS) and obstetric APS (oAPS). Neutrophil extracellular traps (NETs) are involved in the…
Abstract Number: 0072 • ACR Convergence 2023
Circulating T-cell Immunosenescence Is High in Patients with Immune-Mediated Inflammatory Diseases (IMIDs) and Is Associated with Interferons
Marie Naingeon¹, Samuel Bitoun², Matthieu roulleaux Dugage¹, Caroline de Oliveira¹, Caroline Berthot¹, Xavier Mariette³, Nathalie Chaput¹ and Gaetane Nocturne⁴, ¹LIO, Department of Medicine, Gustave Roussy Université Paris Saclay, Villejuif, France, ²CHU Bicêtre APHP, Le Kremlin-Bicêtre, France, ³Université Paris-Saclay, Le Kremlin-Bicêtre, France, ⁴APHP, Le Kremlin-Bicêtre, France
Background/Purpose: Immunosenescence is a global remodeling of immune functions that has been first described with aging. It can also occur in pathologies associated with chronic…
Abstract Number: 0104 • ACR Convergence 2023
Cluster Analysis of Antiphospholipid Antibodies Associated Adverse Pregnancy Outcome Patients: Based on a 13-year Longitudinal Cohort Study
Yin Long¹, Jiuliang zhao², Mengtao Li², Xinping Tian² and xiaofeng Zeng³, ¹Peking Union Medical College Hospital Department of Rheumatology and Clinical Immunology, Beijing, China, ²Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, ³Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
Background/Purpose: Antiphospholipid antibodies (aPLs) play a pivotal role in the etiology of adverse pregnancy outcomes (APOs). (1) Women with persistently aPLs positivity present heterogeneous clinical…
Abstract Number: 0132 • ACR Convergence 2023
Feasibility of a Real-Time Risk Model to Identify Antinuclear Antibody Positive Individuals at Risk for Systemic Autoimmune Disease
April Barnado, Ryan Moore, Hank Domenico, Sarah Green, Alex Camai, Ashley Suh, Bryan Han, Katherine Walker, Audrey Anderson, Lannawill Caruth, Anish Katta, Allison McCoy and Daniel W. Byrne, Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Positive antinuclear antibodies (ANAs) cause diagnostic dilemmas for clinicians across multiple specialties. We previously developed and validated a risk model using a de-identified electronic…
Abstract Number: 0138 • ACR Convergence 2023
Prevalence and Incidence of Sjögren’s Syndrome: A Systematic Literature Review
Jiyoon Choi¹, Kimberly Hofer², Nishu Gaind², Mir Sohail Fazeli², Robert Carroll³, Antoine G Sreih³ and Antonia Christodoulou³, ¹Bristol Myers Squibb, Lawrenceville, NJ, ²Evidinno Outcomes Research Inc., Vancouver, BC, Canada, ³Bristol Myers Squibb, Princeton Pike, NJ
Background/Purpose: Sjögren's syndrome (SjS) is a chronic autoimmune disease that has been historically categorized into primary (manifesting alone; pSjS) or secondary (appearing alongside another underlying…
Abstract Number: 0137 • ACR Convergence 2023
Incidence of and Risk Factors for Myelodysplastic Syndromes in Patients with Rheumatologic Diseases
YoungEun Kim¹, Hansun Song¹, Wook Jang Seo², Jinseok Kim³, Soo Min Ahn¹, Seokchan Hong⁴, Ji-Seon Oh⁵, Chang-Keun Lee⁶, Bin Yoo⁶ and Yong-Gil Kim¹, ¹Department of Rheumatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea, ²Department of Rheumatology, Veteran Health Service Medical Center, Seoul, South Korea, ³Department of Rheumatology, Jeju National University Hospital, Jeju National University School of Medicine, Jeju-si, Jeju-do, South Korea, La Jolla, CA, South Korea, ⁴Department of Rheumatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea, ⁵Department of Information Medicine, Big Data Research Center, Asan Medical Center, University of Ulsan College of Medicine, Ulsan, South Korea, ⁶Asan Medical Center, Seoul, South Korea
Background/Purpose: Myelodysplastic syndrome (MDS) is a hematologic disorder characterized by dysplasia of bone marrow, leading to ineffective hematopoiesis and cytopenia. Despite sporadic reports of associations…
Abstract Number: 0141 • ACR Convergence 2023
In-patient Outcome Difference in Systemic Lupus Erythematous Patient Between Medicare and Non-Medicare Group, a Nationwide Analysis
Mishouri Paul, Prodip Paul, Birendra Amgai and Julio Ramos, Geisinger Community Medical Center, Scranton, PA
Background/Purpose: Systemic lupus erythematosus is a chronic inflammatory disorder that significantly burdens our health system. The study aimed to understand the difference in in-patient outcomes…
Abstract Number: 0142 • ACR Convergence 2023
New-Onset Systemic Autoimmune Diseases Following COVID-19 Vaccination – Results from the COVAD Study
Russka Shumnalieva¹, Jennifer Hannah², DEBADITYA ROY³, Naveen R⁴, Mahnoor Javaid⁵, Daniel Gonzalez⁶, Mrudula Joshi⁷, Abraham Edgar Gracia-Ramos⁸, Lorenzo Cavagna⁹, Parikshit Sen¹⁰, Jessica Day¹¹, Sreoshy Saha¹², Ioannis Parodis¹³, Elena Nikiphorou¹⁴, Esha Kadam¹⁵, Johannes Knitza¹⁶, Rohit Aggarwal¹⁷, Vikas Agarwal⁴ and Latika Gupta¹⁸, ¹Clinic of Rheumatology, Department of Rheumatology, Medical University, Sofia, Bulgaria, ²King's College London, London, United Kingdom, ³Institute of Post Graduate Medical Education and Research Kolkata (IPGMER), Kolkata, India, ⁴Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, India, ⁵The Aga Khan University, Karachi, Pakistan, ⁶Department of Rheumatology, University of Texas Medical Center, Galveston, TX, ⁷Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals, Pune, India, ⁸Department of Internal Medicine, General Hospital, National Medical Center "La Raza", Instituto Mexicano del Seguro Social, Av. Jacaranda S/N, Col. La Raza, Del. Azcapotzalco, C.P. 02990, Mexico City, Mexico, ⁹Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, ¹⁰Maulana Azad Medical College, 2-Bahadurshah Zafar Marg, New Delhi, Delhi-110002, India., Dalhi, India, ¹¹Walter and Eliza Hall Institute, Melbourne, Australia, ¹²Mymensingh Medical College, Faridpur, Bangladesh, ¹³Karolinska Institutet, Stockholm, Sweden, ¹⁴King's College London, London, United Kingdom, ¹⁵Seth Gordhandhas Sunderdas Medical College and King Edwards Memorial Hospital, Mumbai, India, ¹⁶Department of Internal Medicine 3 Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg, University Hospital Erlangen, Erlangen, Germany, ¹⁷University of Pittsburgh, Pittsburgh, PA, ¹⁸Royal Wolverhampton Trust, Wolverhampton/University of Manchester, United Kingdom
Background/Purpose: We aim to describe the profile of new-onset systemic autoimmune diseases (SAID) developed in individuals following COVID-19 vaccination and to characterize the potential risk…
Abstract Number: 0128 • ACR Convergence 2023
Incidence, Trends, and Determinants of Multimorbidity in Systemic Sclerosis: Data from a Population-based Cohort
Anukul Karn¹, Sara Achenbach², Alicia Hinze³, Cynthia Crowson¹ and Ashima Makol², ¹Mayo Clinic, Rochester, MN, ²Mayo Clinic, Rochester, MN, Rochester, MN, ³Mayo Clinic - Rochester, MN, Rochester, MN
Background/Purpose: To evaluate the burden, longitudinal trends, and drivers of multimorbidity (MM; the presence of ≥2 morbidities) in patients with Systemic Sclerosis (SSc) vs. age-…
Abstract Number: 0119 • ACR Convergence 2023
Mortality-related Health Metrics in Systemic Autoimmune Diseases: An Epidemiological Analysis of a Nationwide Register-based Cohort
Mucong Li¹, Chanyuan Wu², Peng Yin³, Qian Wang⁴, Dong Xu⁵, Xiaomei Leng², Xinping Tian¹, Ali Duarte-Garcia⁶, Mengtao Li¹, xiaofeng Zeng⁴ and Maigeng Zhou³, ¹Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, ²Peking Union Medical College Hospital, Beijing, China, ³Chinese Center for Disease Control and Prevention, Beijing, China, ⁴Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, ⁵Department of Rheumatology, Peking Union Medical College, Beijing, China, ⁶Mayo Clinic, Rochester, MN
Background/Purpose: Systemic autoimmune diseases (sAIDs) have become leading contributors to premature death. Meanwhile, regional disparities exist in capacity of rheumatology healthcare services delivery. However, no…
Abstract Number: 0088 • ACR Convergence 2023
SLAMF4 Orchestrates the Pathological Cytotoxic Response of CD4+ T Cells in Rheumatoid Arthritis
Megane Lacaud¹, Houda-Ghozlane Bouzidi¹, Magali breckler¹, Delphine Lemeiter², Luca Semerano³, Marie-Christophe Boissier³, Natacha Bessis⁴ and Jerome Biton², ¹Inserm UMR 1225, Université Sorbonne Paris Nord, Bobigny, France, ²Inserm UMR 1125, Université Sorbonne Paris Nord, Bobigny, France, ³Inserm UMR 1125, Université Sorbonne Paris Nord; Assistance Publique-Hôpitaux de Paris, Rheumatology department, Avicenne Hospital, Bobigny, France, ⁴Inserm UMR 1125, Université Sorbonne Paris Nord, Bobigny, France
Background/Purpose: CD4+ Foxp3- conventional T cells (Tconv) play a key role in the inflammatory process involved in rheumatoid arthritis (RA). Recent studies, aided by a…
Abstract Number: 0092 • ACR Convergence 2023
Multi-omics Immune Profiling of Cytotoxic T Cells from Ankylosing Spondylitis Patients Identified a Subset of Clonally Exapnded CTLs That Evade Immune Exhaustion
Michael Tang¹, Zoya Qaiyum², Melissa Lim¹ and Robert Inman¹, ¹University Health Network, Toronto, ON, Canada, ²Krembil Research Institute, Toronto, ON, Canada
Background/Purpose: Sustained chronic inflammation in the spine and of the sacroiliac joints is a key feature in Ankylosing Spondylitis (AS). A central role of CTL…

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