Abstracts Archive - Page 448 of 2607 - ACR Meeting Abstracts

Abstract Number: 2285 • ACR Convergence 2023
Vaccine Uptake in Women with Systemic Lupus Erythematosus (SLE) – Study Update
J. Patricia Dhar¹, Hannah Forsythe², Louis Saravolatz¹ and Susanna Szpunar³, ¹Ascension St. John Hospital and Wayne State University School of Medicine, Detroit, MI, ²Michigan Department of Human and Health Services, Lansing, MI, ³Ascension St. John Hospital, Detroit, MI
Background/Purpose: Infections are a major cause of morbidity & mortality in patients with systemic lupus erythematosus (SLE), including vaccine-preventable infections. SLE patients are considered to…
Abstract Number: 1721 • ACR Convergence 2023
The Therapeutic Effects of Gingival Mesenchymal Stem Cells and Their Exosomes in a Chimeric Model of Rheumatoid Arthritis
shane Bruckner¹, Braden Zeno², Vittoria Capria¹, William Willis³, Latha Prabha Ganesan¹ and wael Jarjour¹, ¹Ohio State University, Columbus, OH, ²Ohio State University, Upper Arlington, OH, ³Ohio State University, Reynoldsburg, OH
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that leads to progressive joint destruction involving multiple joints. There is a large body of…
Abstract Number: 2289 • ACR Convergence 2023
Short and Long Term Outcomes of Patients with Pure Membranous Lupus Nephritis Compared to Patients with Proliferative Disease
Fadi Kharouf¹, Juan Pablo Diaz Martinez², Dafna Gladman³ and Zahi Touma⁴, ¹University Health Network and University of Toronto, Toronto, ON, Canada, ²Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada, ³Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Department of Medicine, University of Toronto, Toronto, ON, Canada, ⁴University of Toronto, Toronto, ON, Canada
b>Background/Purpose: Patients with pure membranous lupus nephritis (LN) are known to have a different disease course than those with proliferative disease. The aim of this…
Abstract Number: 1738 • ACR Convergence 2023
Identification of Homeostatic and Inflammatory Synovial Fibroblast Signatures in Synovial Tissue Biopsies of Healthy Controls and Patients with Rheumatoid Arthritis
Brianne Barker¹, Órla Tynan², Conor Smith³, Dumitru Anton⁴, Carl Orr⁵, Mary Canavan⁶, Douglas Veale⁷ and Ursula Fearon⁸, ¹Molecular Rheumatology, Trinity Biomedical Sciences Institute, Trinity College Dublin, EULAR Centre for Rheumatic and Arthritic Diseases, St Vincent's University Hospital, University College Dublin, Dublin, Ireland, ²Molecular Rheumatology Department, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland, EULAR Centre for Arthritis and Rheumatic Diseases, St Vincent University Hospital, University College Dublin, Dublin, Ireland, ³Translational Immunology, Trinity Biomedical Sciences Institute, Dublin, Ireland, ⁴Molecular Rheumatology Department, Trinity Biomedical Sciences Institute, Trinity College Dublin, EULAR Centre for Arthritis and Rheumatic Diseases, St Vincent University Hospital, University College Dublin, Dublin, Ireland, ⁵EULAR Centre for Arthritis and Rheumatic Diseases, St Vincent University Hospital, University College Dublin, Dublin, Ireland, ⁶Molecular Rheumatology Department, Trinity Biomedical Sciences Institute, Trinity College Dublin, EULAR Centre for Arthritis and Rheumatic Diseases, St Vincent University Hospital, University College Dublin, School of Biochemistry & Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, ⁷St.Vincent's University Hosp, Dublin, Ireland, ⁸Trinity College Dublin, Dublin, Ireland
Background/Purpose: Recent literature has identified different synovial fibroblast (FLS) populations within RA synovium with distinct inflammatory profiles. Despite current advances in classifying heterogeneity of FLS…
Abstract Number: 1731 • ACR Convergence 2023
A Competitive Inhibitor of MOART Showed Potent Therapeutic Effects in a Mouse Model of Collagen-induced Arthritis
Sujin Park¹, DongWoo Kang², Haein An¹, Eunji Hong¹, Kwiyeom Yoon², MinWoo Kim², Hwajung Kim² and Seong Jin Kim², ¹GILO Institute, GILO Foundation, Seoul, South Korea, ²Medpacto Inc., Seoul, South Korea
Background/Purpose: Despite tumor necrosis factor (TNF) inhibitors and Jak kinase inhibitors (JKI) have shown a significant advance in the treatment of rheumatoid arthritis (RA) however,…
Abstract Number: 2283 • ACR Convergence 2023
Anti-SARS-CoV-2 Vaccination Among Patients Living with Systemic Lupus Erythematosus in Sweden: Coverage and Clinical Effectiveness
Arthur Mageau¹, Julia Simard², Elisabet Svenungsson³ and Elizabeth Arkema⁴, ¹Department of Medicine Solna, Clinical Epidemiology Division, Karolinska Institutet, Stockholm, Sweden / Internal Medicine Unit, Hopital Bichat, Paris, France, ²Department of Epidemiology & Population Health, Stanford University School of Medicine, Stanford, CA, ³Department of Medicine Solna, Unit of Rheumatology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden, ⁴Department of Medicine Solna, Clinical Epidemiology Division, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Real-world data assessing the effectiveness of the anti-SARS-CoV2 vaccination in patients living with systemic lupus erythematosus (SLE) are currently lacking. We aimed to describe…
Abstract Number: 2284 • ACR Convergence 2023
Effect of Air Pollutant Exposure on Disease Activity of Systemic Lupus Erythematous: A Prospective Longitudinal Study from Korea
Ji-Hyoun Kang¹, Hyemin Jeong², Sung-Eun Choi², Dong-Jin Park², Han Joo Baek³, Hyo-Jin Choi⁴, Jae Hyun Jung⁵ and Shin-Seok Lee², ¹Chonnam National University Hospital, Gwangju, South Korea, ²Chonnam National University Medical School & Hospital, Gwangju, South Korea, ³Gil Medical Center, Gachon University College of Medicine, Inchon, South Korea, ⁴Gil Medical Center, Gachon University College of Medicine, Incheon, South Korea, ⁵Korea University Ansan Hospital, Ansan-si, South Korea
Background/Purpose: Exposure to air pollutants is associated with an increased risk of pulmonary and cardiovascular disease and death. Because few studies have investigated the effects…
Abstract Number: 2288 • ACR Convergence 2023
Scoping Literature Review and Focus Groups Interviews to Identify Candidate Domains for the SLE OMERACT Core Domain Set
Wils Nielsen¹, Vibeke Strand², Lee Simon³, Maya Desai⁴, Ioannis Parodis⁵, Alfred Kim⁶, Daniel Wallace⁷, Yashaar Chaichian⁸, Sandra Navarra⁹, Cynthia Aranow¹⁰, Meggan MacKay¹⁰, Kimberly Trotter¹¹, Oshrat Tayer-Shifman¹², Ali Duarte-Garcia¹³, Lai-Shan Tam¹⁴, Manuel Ugarte-Gil¹⁵, Guillermo Pons-Estel¹⁶, John Reynolds¹⁷, Mandana Nikpour¹⁸, Danae Papachristos¹⁹, Alberta Hoi²⁰, Alison Hendry²¹, Juanita Romero-Diaz²², Rosalind Ramsey-Goldman²³, Hanan Alrayes²⁴, Ibrahim Almaghlouth²⁵, Aarabi Thayaparan²⁶, Carolina Munoz-Grajales²⁷, Aaron Howe²⁸, Behdin Nowrouzi-Kia²⁸, Melanie Anderson²⁹, Dennisse Bonilla²⁹, Julian Thumboo³⁰, Marta Mosca³¹, Martin Aringer³², Sindhu Johnson³³, Aaron Drucker³⁴, Eric Morand³⁵, Ian Bruce³⁶ and Zahi Touma²⁸, ¹University of Toronto, Markham, ON, Canada, ²Stanford University, Portola Valley, CA, ³SDG LLC, West Newton, MA, ⁴OCAD University, Toronto, ON, Canada, ⁵Karolinska Institutet, Stockholm, Sweden, ⁶Washington University School of Medicine, St. Louis, MO, ⁷Cedars-Sinai/David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁸Stanford University, San Mateo, CA, ⁹University of Santo Tomas Hospital, Joint and Bone Center, Manila, Philippines, ¹⁰Feinstein Institutes for Medical Research, Manhasset, NY, ¹¹University of Chicago, Chicago, IL, ¹²Meir Medical Center, Raanana, Israel, ¹³Mayo Clinic, Rochester, MN, ¹⁴The Chinese University of Hong Kong, New Territories, China, ¹⁵Universidad Cientifica del Sur, Lima, Peru, ¹⁶RELESSAR, Rosario, Argentina, ¹⁷University of Birmingham, Birmingham, United Kingdom, ¹⁸The University of Melbourne at St. Vincent’s Hospital Melbourne, Departments of Medicine and Rheumatology, Melbourne, Australia, ¹⁹Mater Hospital, Brisbane, Australia, ²⁰Monash University, Department of Medicine, Sub-faculty of Clinical and Molecular Medicine, Melbourne, Australia, ²¹Te Whatu Ora, Counties Manukau District, Middlemore Hospital, Auckland, New Zealand, ²²Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ²³Northwestern University, Chicago, IL, ²⁴Riyadh Military - Prince Soltan Military Medical City ( PSMMC ) - Olaya, Riyadh, Saudi Arabia, ²⁵King Saud University, Riyadh, Saudi Arabia, ²⁶Schroeder Arthritis Institute, Krembil Research Institute, Markham, ON, Canada, ²⁷UHN/TWH, Toronto, ON, Canada, ²⁸University of Toronto, Toronto, ON, Canada, ²⁹University Health Network, Toronto, ON, Canada, ³⁰Singapore General Hospital; Duke-NUS Medical School, Singapore, Singapore, ³¹Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, ³²Faculty of Medicine TU Dresden, Dresden, Germany, ³³Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, ON, Canada, ³⁴Women's College Hospital, Toronto, ON, Canada, ³⁵Monash University, Centre for Inflammatory Diseases, Melbourne, Australia, ³⁶University of Manchester, Manchester, United Kingdom
Background/Purpose: We established the OMERACT SLE Working Group in 2021 which includes over 150 members representing over 25 countries and 5 continents to develop a…
Abstract Number: 1723 • ACR Convergence 2023
3,3-dimethyl-1-butanol and Its Metabolite 3,3-dimethylbutyrate Ameliorate Arthritis Severity in CIA Independent of Choline TMA Lyase Activity
Brendan Allen¹, Sabrina Fechtner², Meagan Chriswell³, Widian Jubair¹, M. Aaron Vrolijk¹, V. Michael Holers⁴ and kristine Kuhn¹, ¹University of Colorado School of Medicine, Aurora, CO, ²University of Colorado Anschutz Medical Campus, Aurora, CO, ³University of Colorado Anschutz SOM, Denver, CO, ⁴University of Colorado, Denver, CO
Background/Purpose: Both human and animal studies associate specific microbiota and microbial metabolic pathways with the development of RA and autoimmune arthritis, thereby providing a novel…
Abstract Number: 1683 • ACR Convergence 2023
Moving the ACR’s Reproductive Health Guidelines into Practice: Assessment of a Novel Reproductive Rheumatology ECHO
Megan Clowse¹, Teresa Swezey², Jerome (Jeff) Federspiel², Catherine Sims², Amanda Snyderman², Amy Corneli², Sarahn Wheeler² and JoAnn Zell³, ¹Duke University, Chapel Hill, NC, ²Duke University School of Medicine, Durham, NC, ³University of Colorado Anschutz Medical Campus, Denver, CO
Background/Purpose: Project ECHO™ in an education model that links experts with community providers through a series of video teleconferences. Each conference involves a brief didactic…
Abstract Number: 1667 • ACR Convergence 2023
Characterization of the Vascular Niches in Systemic Sclerosis (SSc) as a Prototypical Immune-mediated Fibrotic Disease with Prominent Vasculopathy Using Imaging Mass Cytometry
Minrui Liang¹, Aleix Rius Rigau², yi-nan Li¹ and Joerg Distler¹, ¹Clinic for Rheumatology University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University, Düsseldorf, Germany; Hiller Research Center, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University, Düsseldorf, Germany, ²Department of Internal Medicine 3, Rheumatology and Clinical Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany; Deutsches Zentrum Immuntherapie (DZI), FAU Erlangen-Nürnberg and University Hospital Erlangen, Erlangen, Germany
Background/Purpose: Systemic sclerosis (SSc) is a prototypical collagen-vascular disease with prominent vasculopathy. Although microvascular changes are the earliest histopathologic manifestation of SSc, the vascular dysregulation…
Abstract Number: 1669 • ACR Convergence 2023
High Incidence of Immune-mediated Inflammatory Diseases in Sepsis Survivors: A Nationwide Exposed-non-exposed Epidemiological Study
Arthur Mageau¹, Alois Helary², Stephane Ruckly³, Andrey Strukov², Thomas Papo¹, Jean-Francois Timsit¹ and Karim Sacre¹, ¹Université Paris Cité, Paris, France, ²Assistance Publique Hopitaux de Paris, Paris, France, ³INSERM, Paris, France
Background/Purpose: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Previous studies have shown that immune dysregulation associated with severe…
Abstract Number: 1670 • ACR Convergence 2023
Exacerbation of Immune-mediated Inflammatory Diseases in COVID19 Sequelae
CAMILA CAETANO¹, Tamiris Azamor¹, Nikki M. Meyer¹, Cassandra Calabrese², Leonard Calabrese², Nicolas Piuzzi³, M. Elaine Husni², Suan-Sin Foo¹ and Weiqiang Chen¹, ¹Cleveland Clinic / Infection Biology Program, Global Center for Pathogen Research and Human Health, Lerner Research Institute, Cleveland, OH, ²Cleveland Clinic / Department of Rheumatic and Immunologic Diseases, Cleveland, OH, ³Cleveland Clinic / Department of Orthopedic Surgery, Cleveland, OH
Background/Purpose: Patients with underlying immune-mediated inflammatory diseases (IMIDs), such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), have a higher susceptibility to severe COVID19…
Abstract Number: 1682 • ACR Convergence 2023
Prospective Evaluation of Anti-SSA/Ro Pregnancies Supports the Utility of High Titer Antibodies and Fetal Home Monitoring for the Detection of Fetal Atrioventricular Block
Bettina Cuneo¹, Mala Masson², Colin Phoon³, Ashley Roman³, Peter Izmirly⁴, Amit Saxena⁵, Michael Belmont⁶, Christina Penfield³, Young Mi Lee³, Julie Nusbaum⁷, Ruben Acherman⁸, Elena Sinkovskaya⁹, Alfred Abuhamad¹⁰, Majd Makhoul¹¹, Gary Satou¹², Whitnee Hogan¹³, Nelangi Pinto¹³, Anita Moon-Grady¹⁴, Lisa Howley¹⁵, Mary Donofrio¹⁶, Anita Krishnan¹⁶, Homa Ahmadzia¹⁷, Stephanie Levasseur¹⁸, Erin Paul¹⁹, Sonal Owens²⁰, Kristopher Cumberback²¹, Jyothi Matta²², Gary Joffe²³, Christopher Lindblade²⁴, Andrew Rubenstein²⁵, Caitlin Haxel²⁶, Katherine Kohari²⁷, Joshua Copel²⁷, James Strainic²⁸, Tam Doan²⁹, Karla Bermudez-Wagner²⁹, Shreya Sheth²⁹, Stacy Killen³⁰, Theresa Tacy³¹, Michelle Kaplinski³¹, Lisa Hornberger³², Nicola Fraser³, Robert Clancy³ and Jill Buyon³³, ¹University of Colorado, Denver, Denver, CO, ²New York University, New York, NY, ³NYU Grossman School of Medicine, New York, NY, ⁴New York University School of Medicine, New York, NY, ⁵NYU Langone, New York, NY, ⁶New York University Langone Medical Center, New York, NY, ⁷NYU Long Island School of Medicine, Mineola, NY, ⁸Children's Heart Center, Las Vegas, NV, ⁹East Virginia Medical School, East Virginia Medical School, VA, ¹⁰East Virginia Medical School, Norfolk, VA, ¹¹Atrium Health Levine Children's Hospital, Charlotte, NC, ¹²University of California Los Angeles, Los Angeles, CA, ¹³University of Utah, Salt Lake City, UT, ¹⁴University of California San Francisco, San Francisco, CA, ¹⁵Midwest Fetal Care Center, Children's Minnesota/Allina Health, Minneapolis, MN, ¹⁶Children's National Hospital, Washington, DC, ¹⁷George Washington University, Washington, DC, ¹⁸Columbia University, New York, NY, ¹⁹Mount Sinai, New York, NY, ²⁰University of Michigan, Ann Arbor, MI, ²¹University of Kentucky, Lexington, KY, ²²University of Louisville, Louisville, KY, ²³Perinatal Associates of New Mexico, Albuquerque, NM, ²⁴Phoenix Children's Hospital, Phoenix, AZ, ²⁵Dignity Health, Phoenix, AZ, ²⁶University of Vermont Children's Hospital, Burlington, VT, ²⁷Yale University, New Haven, CT, ²⁸UH Rainbow Babies, Cleveland, OH, ²⁹Baylor School of Medicine, Houston, TX, ³⁰Vanderbilt University, Nashville, TN, ³¹Stanford University, Stanford, CA, ³²Stollery Children's Hospital, Edmonton, AB, Canada, ³³Department of Medicine, NYU Grossman School of Medicine, New York, NY
Background/Purpose: The management of fetuses exposed to maternal anti-SSA/Ro autoantibodies is challenging as the clinician weighs the rarity of fetal atrioventricular block (AVB) against the…
Abstract Number: 1262 • ACR Convergence 2023
“Somebody Who’s Been There and Can Understand the Challenges That You’re Going Through”: Participant Perspectives of a Resilience-Based Energy Management Online Intervention for Systemic Sclerosis with Peer Health Coaches
Yen Chen¹, Alexandra Harper², Tiffany Phanhdone³, Mary Alore¹, Sheri Hicks¹, Adam Pape¹, Gina Jay¹, Shannen Bolde¹, Jennie Feldpausch¹, Dinesh Khanna¹ and Susan Murphy⁴, ¹University of Michigan, Ann Arbor, MI, ²University of Michigan, Ypsilanti Charter Twp, MI, ³Northwestern University, Chicago, IL, ⁴University of Michigan, Plymouth, MI
Background/Purpose: People with systemic sclerosis (SSc) often experience fatigue, which impacts daily life functioning and quality of life. We developed a 12-week, resilience-based energy management…

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