ACR Meeting Abstracts

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  • Abstract Number: 1716 • ACR Convergence 2022

    The Transcriptomic Landscape of Nephritic Kidneys Reveals Mechanisms for End Organ Resistance to Damage in Lupus-prone Mice

    Andrea Daamen1, Hongyang Wang2, Prathyusha Bachali3, Shu Man Fu2, Amrie Grammer4 and Peter Lipsky1, 1AMPEL BioSolutions, Charlottesville, VA, 2University of Virginia, Charlottesville, VA, 3AMPEL BioSolutions, Redmond, WA, 4AMPEL LLC, Charlottesville, VA

    Background/Purpose: Pathologic inflammation is a major driver of kidney damage in lupus nephritis (LN), but the immune mechanisms of disease progression and risk factors for…
  • Abstract Number: 1699 • ACR Convergence 2022

    Arthritis-associated Synovial CD64-Ly6c- myeloid Cells Comprise 2 Subpopulations

    Yidan Wang1, Miranda Gurra1, Carla Cuda1, Hadijat Makinde1, Shangyang Chen1, Gaurav Gadhvi1, Salina Dominguez1, Caroline Shah1, Deborah Winter2 and Harris Perlman1, 1Northwestern University, Chicago, IL, 2Northwestern University, Skokie, IL

    Background/Purpose: Monocytes are critical for the pathogenesis of rheumatoid arthritis (RA). However, depletion of circulating monocytes – either classical or non-classical monocytes – is not…
  • Abstract Number: 1687 • ACR Convergence 2022

    A Core Inflammation Program Conserved Across Human and Murine Neutrophils

    Nicolaj hackert1, Felix Radtke1, Tarik Exner1, Carsten Müller-Tidow1, Hanns-Martin Lorenz1, Peter Nigrovic2, Guido Wabnitz1 and Ricardo Grieshaber-Bouyer1, 1Heidelberg University Hospital, Heidelberg, Germany, 2Boston Children's Hospital, Boston, MA

    Background/Purpose: Neutrophils mediate a range of homeostatic and inflammatory processes and display substantial phenotypic and functional heterogeneity. While animal models enable important mechanistic discoveries, differences…
  • Abstract Number: 1707 • ACR Convergence 2022

    Exploring the Role of Lipocalin-2 in Neuropsychiatric SLE

    Chaim Putterman1, Sayra Garcia-Murillo2 and Elise Mike3, 1Albert Einstein College of Medicine, Bronx, NY, 2Albert Einstein College of Medicine, New York, NY, 3John Hopkins University, Baltimore, MD

    Background/Purpose: While the etiology of neuropsychiatric lupus (NPSLE) is not fully understood, blood brain barrier (BBB) disruption and localized neuroinflammation are potential mechanisms that contribute…
  • Abstract Number: 1676 • ACR Convergence 2022

    Sarilumab in Patients with Relapsing Polymyalgia Rheumatica: A Phase 3, Multicenter, Randomized, Double Blind, Placebo Controlled Trial (SAPHYR)

    Robert Spiera1, Sebastian Unizony2, Kenneth J. Warrington3, Jennifer Sloane Lazar4, Angeliki Giannelou5, Michael C Nivens6, Bolanle Akinlade5, Wanling Wong4, Yong Lin4, Frank Buttgereit7, Valerie Devauchelle8, Andrea Rubbert-Roth9 and Bhaskar Dasgupta10, 1Hospital for Special Surgery, New York, NY, 2Massachusetts General Hospital, Winchester, MA, 3Mayo Clinic, ROCHESTER, MN, 4Sanofi, Bridgewater, NJ, 5Regeneron Pharmaceuticals, Inc., Tarrytown, NY, 6Regeneron Pharmaceuticals, Inc., Tarrytown, NY, NY, 7Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin / DRFZ Berlin, Berlin, Germany, 8Université de Bretagne Occidentale, Brest, France, 9Division of Rheumatology, Cantonal Clinic St Gallen, St.Gallen, Switzerland, 10Anglia Ruskin University, East Anglia, United Kingdom

    Background/Purpose: IL-6 is elevated in patients with active PMR and is associated with disease activity, relapse and severity. Clinical trials with IL-6 receptor (IL-6R) inhibitors…
  • Abstract Number: 1725 • ACR Convergence 2022

    Sex Differences in Autoimmune Pathogenesis and Systemic Response to High Fat Diet in Lupus-prone Mice

    Gitanjali Lobo1, Juan Meng2, Xuhua Shi2, Ronak Patel3, Laura Rivers4, Chad Hille5, Robert Quinet6, William Davis7, Jerald Zakem8, Chandana Keshavamurthy9, Tamika Webb-Detiege10, Zongbing You2 and Xin Zhang11, 1Ochsner Clinic Foundation, Metairie, LA, 2Tulane University, New Orleans, LA, 3Ochsner, New Orleans, LA, 4Ochsner Medical Center, River Ridge, LA, 5Ochsner Clinic Foundation, New Orleans, LA, 6Ochsner Health, River Ridge, LA, 7Ochsner Medical Center, New Orleans, LA, 8Ochsner Health Systems, Metairie, LA, 9ochsner medical center, Metairie, LA, 10University of Queensland/Ochsner Clinical School, New Orleans, LA, 11Institution of Translational Research, Ochsner Health System, New Orleans, LA

    Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by chronic inflammation and the production of autoantibodies, leading to systemic multiorgan damage. SLE has…
  • Abstract Number: 1452 • ACR Convergence 2022

    Patterns of Outpatient and Acute Care Use Among Patients with SLE on Long-Term Moderate to High Dose Glucocorticoid Medication: A 1 Year Retrospective Analysis

    James Sullivan1 and Emily Littlejohn2, 1Cleveland Clinic Lerner College of Medicine, Cleveland Heights, OH, 2Cleveland Clinic, Cleveland, OH

    Background/Purpose: Long-term glucocorticoid use can lead to adverse outcomes independent of SLE disease activity. Identifying factors associated with long-term glucocorticoids is an important step towards…
  • Abstract Number: 1516 • ACR Convergence 2022

    How Disease Activity Can Affect Workability in Spondyloarthropaties: A Monocentric Cohort Analysis

    Federico Fattorini1, Cosimo Cigolini2, Gabriele Marchetti3, Andrea Delle Sedie4, Linda Carli5 and Marta Mosca5, 1Rheumatology Unit, University of Pisa, Pisa, Italy, 2Rheumatology Unit, University of Pisa, Pisa, Toscana, Italy, 3University of Pisa, Pisa, Toscana, Italy, 4University of Pisa, Pisa, Pisa, Italy, 5Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, PISA, Italy

    Background/Purpose: Spondyloarthropathies (SpA) may compromise the working ability (WA) of patients, often affected by the disease during their productive life. The Work Productivity and Activity…
  • Abstract Number: 1325 • ACR Convergence 2022

    The Risks of Osteoporotic Fracture After Lung Transplant: A Retrospective Cohort Study at an International Transplant Center

    Adil Vural1, Sarah Keller2, Neel Tapryal3, Komal Mushtaq4, Hassan Shaheen1, Chao Zhang2, Marie Budev2, Abby Abelson2 and Chad Deal5, 1Cleveland Clinic, Westlake, OH, 2Cleveland Clinic, Cleveland, OH, 3Cleveland Clinic, Rocky River, OH, 4Cleveland Clinic, Fairview Park, OH, 5Cleveland Clinic, Shaker Heights, OH

    Background/Purpose: Osteoporotic fractures are a well-known complication of lung transplant (LT) and can significantly impact the quality of life of LT recipients. Although much is…
  • Abstract Number: 1741 • ACR Convergence 2022

    Mutated Nod2 Controls T Cell Function and Promotes Uveitis in a Blau Syndrome Mouse Model

    Leah Huey1, Kylie Koney1, Emily Vance1, Chia-Feng Tsai2, Rosalie K. Chu2, Marina A. Gritsenko2, Ellen Lee1, Holly Rosenzweig1 and Ruth Napier1, 1Oregon Health & Science University and VA Portland Health Care System, Portland, OR, 2Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA

    Background/Purpose: Mutations in the microbial signaling molecule NOD2 cause granulomatous uveitis, arthritis, and dermatitis in Blau Syndrome. We previously showed a novel role for Nod2…
  • Abstract Number: 1742 • ACR Convergence 2022

    Shared Epitope Allomorphs Directly Influence Antigen-specific T-cell Responses in RA

    Ravi Kumar1, Anatoly Dubnovitsky1, Christina Gerstner1, Niyaz Yoosuf2, Sara Turcinov1, Sanjay Boddul1, Fredrik Wermeling1, Lars Klareskog1, Leonid Padyukov1 and vivianne malmström1, 1Karolinska Institutet, Stockholm, Sweden, 2Bioinvent International AB, Lund, Sweden

    Background/Purpose: The products of rheumatoid arthritis (RA)-associated MHC class II risk alleles HLA-DRB1*04:01 and *04:04 (DR4) differ only by two amino acids in the peptide…
  • Abstract Number: 1715 • ACR Convergence 2022

    Ezh2 Knockout in B Cells Impairs Plasmablast Differentiation and Ameliorates Lupus-like Disease in MRL/lpr Mice

    Xiaoqing Zheng1, Mikhail Dozmorov2, Colleen Strohlein1, Sheldon Bastacky1 and Amr Sawalha1, 1University of Pittsburgh, Pittsburgh, PA, 2Virginia Commonwealth University, Richmond, VA

    Background/Purpose: Enhancer of zeste homolog 2 (EZH2) has been shown to regulate early B cell development and the differentiation of antibody secreting cells (ASCs). We…
  • Abstract Number: 1689 • ACR Convergence 2022

    Oral Ginger Supplementation Counteracts NETosis in Autoimmune Mouse Models and in Healthy Humans

    Ramadan Ali1, Miela Zahavi2, Christine Rysenga1, Cyrus Sarosh3, Claire Hoy1, Kristen Demoruelle4 and Jason S Knight5, 1University of Michigan, Ann Arbor, MI, 2Universtiy of Michigan, Ann Arbor, MI, 3University of Michigan, Temperance, MI, 4University of Colorado Anschutz Medical Campus, Aurora, CO, 5University of Michigan, Division of Rheumatology, Ann Arbor, MI

    Background/Purpose: It has previously been reported that 6-gingerol, the most abundant phytochemical in ginger root, inhibits neutrophil phosphodiesterase activity and thereby counteracts neutrophil hyperactivity in…
  • Abstract Number: 1648 • ACR Convergence 2022

    Risk of Vascular Events Under the Treatments with Janus Kinase Inhibitors in Patients with Rheumatoid Arthritis: An Analysis Using Japanese Health Insurance Database

    Eiichi Tanaka1, Ryoko Sakai2, Eisuke Inoue3 and Masayoshi Harigai1, 1Division of Rheumatology, Department of Internal Medicine, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan, 2Meiji Pharmaceutical University, Tokyo, Japan, 3Research Administration Center, Showa University, Shinagawa-ku, Japan

    Background/Purpose: Janus kinase inhibitors (JAKIs) have shown positive therapeutic impacts on treatments for rheumatoid arthritis (RA), whereas, concerns have been raised about the risk of…
  • Abstract Number: 1650 • ACR Convergence 2022

    Systemic Immune Inflammation Index Predict All-Cause and Cardiovascular Mortality in Rheumatoid Arthritis

    Jose felix Restrepo Suarez1, Inmaculada Del Rincon1, Carlos Lorenzo2 and Agustin Escalante3, 1University of Texas Health Science center at San Antonio, San Antonio, TX, 2University of Texas Health Sciences Center San Antonio, San antonio, TX, 3University of Texas Health Science Center at San Antonio, San Antonio, TX

    Background/Purpose: The systemic immune inflammation index (SII) is an inflammation-based biomarker that is an influential prognostic factor in diseases with an inflammation-related etiology. This index…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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