Abstracts Archive - Page 443 of 2607 - ACR Meeting Abstracts

Abstract Number: 2209 • ACR Convergence 2023
Prevalence and Clinical Characteristics of Late Onset Axial Spondyloarthritis: Results from a Multicentre Nationwide Study
Margarida Lucas Rocha¹, Rita Torres², Sofia Ramiro³, Alice Morais Castro⁴, Alice Neves⁵, Ana Martins⁶, Ana Teodósio Chícharo¹, Beatriz Mendes⁷, Carolina Ochôa Matos⁸, Catarina Soares⁹, Cláudia Miguel¹⁰, Cláudia Pinto Oliveira¹¹, Hugo Parente¹², J. A. Melo Gomes¹³, Mariana Luís¹⁴, Mariana Santos¹⁵, Maura Couto¹⁶, Miguel Bernardes¹⁷, Paula Valente¹⁸, Roberto Costa¹⁹, Sandra Sousa⁴, Jaime Branco²⁰, Fernando Pimentel-Santos²¹ and Alexandre Sepriano²², ¹Rheumatology Department, Centro Hospitalar Universitário do Algarve, Faro, Portugal, ²Hospital Egas Moniz, Lisboa, Portugal, ³Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Departamento de Reumatologia, Hospital Garcia de Orta, Almada, Portugal, ⁵Instituto Português de Reumatologia, Lisboa, Portugal, ⁶Serviço de Reumatologia, Centro Hospitalar Universitário São João; Serviço de Medicina, Faculdade de Medicina da Universidade do Porto, Porto, Portugal, ⁷Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal, ⁸Centro Académico de Medicina de Lisboa, Lisbon, Portugal, ⁹Centro Unidade Local de Saúde do Alto Minho, Viana do Castelo, Portugal, ¹⁰Instituto Português de Reumatologia, Lisbon, Portugal, ¹¹Serviço de Reumatologia, Centro Hospitalar do Baixo Vouga, Aveiro, Portugal, ¹²Serviço de Reumatologia do Centro Unidade Local de Saúde do Alto Minho, Viana do Castelo, Portugal, ¹³Clínica Reumatológica Dr. Melo Gomes, Lisboa, Portugal, ¹⁴Serviço de Reumatologia – Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal, ¹⁵Serviço de Reumatologia do Centro Hospitalar Lisboa Ocidental, Hospital de Egas Moniz EPE, Lisboa, Portugal, ¹⁶Unidade de Reumatologia, Centro Hospitalar Tondela-Viseu, Viseu, Portugal, ¹⁷Rheumatology Department, Centro Hospitalar e Universitário de São João, Porto, Portugal, ¹⁸Serviço de Reumatologia, Centro Hospitalar Entre o Douro e o Vouga, Santa Maria da Feira, Portugal, ¹⁹Centro Hospitalar Lisboa Norte, Lisboa, Portugal, ²⁰CHLO, EPE - Hospital Egas Moniz, Lisbon, Portugal, ²¹NOVA Medical School; Universidade NOVA e Lisboa, Lisboa, Portugal, ²²Leiden University Medical Centre, Portela Loures, Portugal
Background/Purpose: Axial spondyloarthritis (axSpA) typically starts before the fourth decade of life. Consistent with that, the Assessment of SpondyloArthritis international Society (ASAS) classification criteria for…
Abstract Number: 1734 • ACR Convergence 2023
Serum PDGF-BB Levels Correlate with Lung Fibrosis in Mice Injected with Malondialdehyde-Acetaldehyde and/or Citrulline Modified Vimentin
Nozima Aripova¹, Michael Duryee¹, Carlos Hunter¹, Amy Nelson¹, Breanna Butler¹, Jill Poole¹, Bryant England¹, Geoffrey Thiele¹ and Ted R Mikuls², ¹University of Nebraska Medical Center, Omaha, NE, ²Division of Rheumatology and Immunology, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Pulmonary manifestations of rheumatoid arthritis (RA), such as interstitial lung disease (RA-ILD), are a major contributor to morbidity and mortality. The mechanism of pulmonary…
Abstract Number: 1731 • ACR Convergence 2023
A Competitive Inhibitor of MOART Showed Potent Therapeutic Effects in a Mouse Model of Collagen-induced Arthritis
Sujin Park¹, DongWoo Kang², Haein An¹, Eunji Hong¹, Kwiyeom Yoon², MinWoo Kim², Hwajung Kim² and Seong Jin Kim², ¹GILO Institute, GILO Foundation, Seoul, South Korea, ²Medpacto Inc., Seoul, South Korea
Background/Purpose: Despite tumor necrosis factor (TNF) inhibitors and Jak kinase inhibitors (JKI) have shown a significant advance in the treatment of rheumatoid arthritis (RA) however,…
Abstract Number: 1744 • ACR Convergence 2023
Histological and Molecular Comparison in the Synovial Tissue of Patients with Active Rheumatoid Arthritis to Remission
Selina Ohl¹, Klaus Frommer¹, Markus Rickert², Stefan Rehart³, Ulf Müller-Ladner¹ and Elena Neumann¹, ¹Justus Liebig University Gießen, Campus Kerckhoff, Bad Nauheim, Germany, ²Dept. of Orthopaedics and Orthopaedic Surgery, University Hospital Giessen and Marburg, Giessen, Germany, ³Dept. of Orthopaedics and Trauma Surgery, Agaplesion Markus Hospital Frankfurt, Frankfurt, Germany
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease which leads to local and systemic manifestations. Subsequently, the inflamed synovium drives the destruction of…
Abstract Number: 2207 • ACR Convergence 2023
Knowledge, Awareness, and Attitudes Regarding Inflammatory Back Pain Among Non-Rheumatology Physicians in the United States
William Odell¹, Swetha Ann Alexander², Nicolas Page³, Narinder Maheshwari⁴ and Abhijeet Danve⁵, ¹Yale University, Wethersfield, CT, ²University of Utah Health, Salt Lake City, UT, ³Yale University, New Haven, CT, ⁴UCONN Health, Farmington, CT, ⁵Yale University School of Medicine, Glastonbury, CT
Background/Purpose: Inflammatory back pain (IBP) is the defining feature of axial spondyloarthritis (axSpA). However, it may be difficult for non-rheumatology physicians (non-rheums) to distinguish between…
Abstract Number: 1733 • ACR Convergence 2023
Platelet-Derived Growth Factor Is a Mediator of Disease in an Animal Model of Rheumatoid-Associated Interstitial Lung Disease
Nozima Aripova¹, Michael Duryee¹, Amy Nelson¹, Carlos Hunter¹, Breanna Butler¹, Bryant England¹, Jill Poole¹, Geoffrey Thiele¹ and Ted R Mikuls², ¹University of Nebraska Medical Center, Omaha, NE, ²Division of Rheumatology and Immunology, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a leading cause of mortality in RA with limited treatment options as well as lack of available…
Abstract Number: 1740 • ACR Convergence 2023
Exploring Disease-Associated DNA Methylome Alterations in Rheumatoid Arthritis: Potential Diagnostic and Prognostic Biomarkers
Arkaitz Mucientes¹, Martín-Núñez Gracia María², José Lisbona-Montañez³, Patricia Ruiz-Limon⁴, Rocío Redondo-Rodríguez⁵, SARA MANRIQUE⁶, Inmaculada Ureña⁵, Laura Cano-García⁵, Isabel Moreno-Indias¹, Natalia Mena Vazquez⁷ and Antonio Fernandez-Nebro⁸, ¹IBIMA Plataforma BIONAND, Málaga, Spain, ²Universidad de Málaga, Departamento de Medicina y Dermatología, Málaga, Spain, ³Universidad de Málaga, Departamento de Medicina y Dermatología, Moclinejo, Spain, ⁴IBIMA Plataforma BIONAND, Cordoba, Spain, ⁵Division of Rheumatology, Hospital Regional Universitario Carlos Haya, Málaga, Spain, ⁶Division of Rheumatology, Hospital Regional Universitario Carlos Haya, Malaga, Spain, ⁷IBIMA, Málaga, Spain, ⁸Hospital Regional Universitario de Málaga, Malaga, Spain
Background/Purpose: The etiology of rheumatoid arthritis (RA) is not fully understood. It is accepted that RA results from the interplay of genetic and environmental factors.…
Abstract Number: 2211 • ACR Convergence 2023
A Two-year Comparison of Back Pain and Morning Stiffness in Axial Spondyloarthritis and Non-axial Spondyloarthritis Chronic Back Pain Patients in the Spondyloarthritis Caught Early (SPACE) Cohort
Ana Bento da Silva¹, Miranda Van Lunteren², Mary Lucy marques³, Karen Fagerli⁴, Sofia Ramiro⁵, Désirée van der Heijde⁵ and Floris Van Gaalen², ¹Leiden University Medical Center, Leiden, Netherlands, ²Leiden University Medical Center, Department of Rheumatology, Leiden, Netherlands, ³Leiden University Medical Center; Centro Hospitalar e Universitário de Coimbra (Department of Rheumatology), Coimbra, Portugal, ⁴Diakonhjemmet Hospital, Oslo, Norway, ⁵Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Treatment of axial spondyloarthritis (axSpA) has been shown to improve symptoms of the disease such as back pain (BP) and morning stiffness (MS). As…
Abstract Number: 1592 • ACR Convergence 2023
Memantine Attenuates the Development of Osteoarthritis by Blocking NMDA Receptor Mediated Calcium Overload and Chondrocyte Senescence
Ning Wang¹, Qingmei Cheng¹, Xiaoxiao Li², ke he¹, Junyu Zhu¹, Hui Li³ and Jie Wei⁴, ¹中南大学湘雅医院, Changsha, China, ²Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China, ³Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China, ⁴Health Management Center, Xiangya Hospital Central South University, Changsha, China
Background/Purpose: Memantine is an FDA proved drug utilized for the treatment of dementia and exerts its function by blocking the NMDA (N-methyl-D-aspartate) receptor, a calcium…
Abstract Number: 1742 • ACR Convergence 2023
Sputum Citrullinated Proteins and Sputum Anti-Cit-S100A8/A9 IgG Antibodies Are Increased in Serum Anti-CCP-IgG Positive Individuals Who Developed RA
Rachna Talluri¹, Sudeshna Sen², Timothy Wilson³, Adam Savage⁴, Mark Gillespie⁴, Tom Bumol⁴, Marie Feser¹, Jill Norri⁵, Michael Holer¹, kevin Deane¹, Paul Thompson² and Kristen Demoruelle¹, ¹University of Colorado Anschutz Medical Campus, Aurora, CO, ²University of Massachusetts Chan Medical School, Worcester, MA, ³Thomas Jefferson University, Philadelphia, PA, ⁴Allen Institute for Immunology, Seattle, WA, ⁵Colorado School of Public Health, Denver, CO
Background/Purpose: The presence of anti-CCP-IgG in the blood identifies individuals who are "at-risk" of developing RA. Our group has reported that in a cohort of…
Abstract Number: 1708 • ACR Convergence 2023
In Cis SOCS1 Variants Illustrate the Precise Regulation of Interferon Signaling Needed to Prevent Autoimmunity
Yan Du¹, Evan Hsu², Kailey Brodeur³, Meng Liu⁴, Mindy Lo⁵, Craig Platt³ and Pui Lee⁵, ¹Harvard medical school, Boston, MA, ²Wesleyan University, Newton, MA, ³Boston Children's Hospital, Boston, MA, ⁴Southern Medical University, Boston, MA, ⁵Division of Immunology, Boston Children's Hospital, Boston, MA
Background/Purpose: Systemic autoimmunity can be driven by monogenic or polygenic risk variants. We aimed to characterize the genetic basis of disease in a family with…
Abstract Number: 1595 • ACR Convergence 2023
Pharmacological Modulation of Krüppel-like Factor 4 Reduces the Severity of Experimental Osteoarthritis via Tissue Protection and Regeneration
Manabu Kawata¹, Merissa Olmer², Kristen Johnson³ and Martin K Lotz², ¹Scripps Research Institute, San Diego, CA, ²Scripps Research Institute, La Jolla, CA, ³CALIBR, La Jolla, CA
Background/Purpose: Krüppel-like factors (KLFs) are members of the zinc finger family of transcription factors, which includes 17 members in mammals. We found that expression of…
Abstract Number: 1596 • ACR Convergence 2023
A Cell and Transcriptomic Atlas of the Infrapatellar Fat Pad from Patients with Knee Osteoarthritis: Identification of an Obesity-Associated Transcriptomic Signature
Hayley Peters¹, Pratibha Potla¹, Jason Rockel¹, Keemo Delos Santos¹, Shabana Vohra¹, starlee lively², Kim Perry³, Anthony Perruccio¹, Nizar Mahomed⁴, Raja Rampersaud¹, Rajiv Gandhi⁵ and Mohit Kapoor⁶, ¹Schroeder Arthritis Institute, Toronto, ON, Canada, ²University Health Network, Toronto, ON, Canada, ³Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada, ⁴Division of Orthopaedics, Osteoarthritis Research Program, Schroeder Arthritis Institute, Krembil Research Institute, and Toronto Western Hospital, University Health Network, Toronto, ON, Canada, ⁵Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and Division of Orthopaedics, Department of Surgery, University of Toronto, Toronto, ON, Canada, ⁶Schroeder Arthritis Institute, University Health Network and Department of Surgery, University of Toronto, Toronto, ON, Canada
Background/Purpose: Knee osteoarthritis (KOA) is the most common form of arthritis that affects multiple knee joint tissues. The infrapatellar fat pad is the largest fat…
Abstract Number: 1608 • ACR Convergence 2023
Plasma Proteomic Profiling in Antiphospholipid Antibody-positive Patients with Different Clinical Phenotypes: Results from the Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) Registry
Ayesha Butt¹, Rolando Garcia Milian¹, George Goshua¹, Sean Gu¹, Eugenia Chock², Valentina Restrepo¹, John Hwa¹, Hyung Chun¹, H Michael Belmont³, Kello Nina⁴, D. Ware Branch⁵, Michelle Petri⁶, Jason Knight⁷, Rohan Willis⁸, Maria Laura Bertolaccini⁹, Doruk Erkan¹⁰, Alfred lee¹, Anish Sharda¹ and Alexander Pine¹¹, ¹Yale School of Medicine, New Haven, CT, ²Yale School of Medicine, Greenwich, CT, ³NYU School of Medicine, New York, NY, ⁴Northwell Health, Brooklyn, NY, ⁵University of Utah, Salt Lake City, UT, ⁶Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Timonium, MD, ⁷University of Michigan, Ann Arbor, MI, ⁸University of Texas Medical Branch, Galveston, TX, ⁹King's College London, London, United Kingdom, ¹⁰Hospital for Special Surgery, New York, NY, ¹¹VA Connecticut/Yale School of Medicine, West Haven, CT
Background/Purpose: Antiphospholipid syndrome (APS) is an autoimmune disease with thrombotic and obstetric complications arising via a model of immunothrombosis. Patients may present with a spectrum…
Abstract Number: 1187 • ACR Convergence 2023
Post-hoc Analysis of Individual Questions from the Australian/Canadian Osteoarthritis Hand Index from a Randomized, Double-blind, Placebo-controlled Trial of Patients with Hand OA
Karin Nicholson¹, Edwin Sanchez¹, Wendy Wright², Joel Block³ and Richard Petruschke¹, ¹Haleon, Warren, NJ, ²Wright & Associates Family Healthcare, Amherst, NH, ³Rush University Medical Center, Chicago, IL
Background/Purpose: Hand osteoarthritis (OA) is a frequently occurring form of OA characterized by symptoms including joint pain, stiffness, and swelling which affect performance of activities…

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