Abstracts Archive - Page 441 of 2607 - ACR Meeting Abstracts

Abstract Number: 1736 • ACR Convergence 2023
The Effect of Resolvin E1 and Resolvin D1 Specialised Pro-resolving Mediators on the Inhibition of Osteoclastogenesis
Patricia Riedlova¹, Kieran Woolcock², Cecilia Ansalone² and Carl Goodyear², ¹University of Glasgow - School of Infection & Immunity, Glasgow, United Kingdom, ²University of Glasgow, Glasgow, United Kingdom
Background/Purpose: Osteoclasts (OCs) are multinucleated bone-resorbing cells playing a key role in rheumatoid arthritis (RA). Under physiological conditions, OCs are in balance with bone-forming osteoblasts,…
Abstract Number: 2182 • ACR Convergence 2023
Mitochondrial Alterations in Primary Sjögren´s Syndrome
Pavlina Javorova¹, Johannes Fessler¹, Melanie Zeiler¹, Angelika Lackner¹, Josef Hermann², Sabine Zenz³, Jens Thiel⁴ and Martin Stradner¹, ¹Medical University of Graz, Graz, Austria, ²Division of Rheumatology and Immunology, Department of Internal Medicine, Medical University Graz, Graz, Austria, ³Medical University Graz, Graz, Austria, ⁴University Hospital Freiburg, Freiburg, Germany
Background/Purpose: Primary Sjögren's Syndrome (pSS) is a systemic autoimmune disorder characterized by lymphocytic infiltrations in exocrine glands. T-cells are considered major players in the pathogenesis…
Abstract Number: 2181 • ACR Convergence 2023
Secretagogue Effect of PDE4 Inhibitor Apremilast on Human Salivary Gland Organoids Obtained from Primary Sjögren’s Syndrome Patients
Valeria Manfrè¹, Salvatore Parisi², Isabella Caligiuri², Ombretta Repetto³, Alen Zabotti¹, Enrico Pegolo⁴, Cinzia Fabro¹, Salvatore De Vita¹, Vincenzo Canzonieri², Carla Di Loreto⁴, Flavio Rizzolio² and Luca Quartuccio¹, ¹Division of Rheumatology, Department of Medicine, University of Udine, Udine, Italy, ²Pathology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy, ³Facility of Bio-Proteomics, Immunopathology and Cancer Biomarkers, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy, ⁴Institute of Pathology, Azienda Sanitaria Universitaria Friuli Centrale c/o Università degli studi di Udine, Udine, Italy
Background/Purpose: In primary Sjögren's syndrome (pSS), salivary epithelial cells show an active role in the initiation and reiteration of the immunomediated damage. Epithelial saliva production…
Abstract Number: 1738 • ACR Convergence 2023
Identification of Homeostatic and Inflammatory Synovial Fibroblast Signatures in Synovial Tissue Biopsies of Healthy Controls and Patients with Rheumatoid Arthritis
Brianne Barker¹, Órla Tynan², Conor Smith³, Dumitru Anton⁴, Carl Orr⁵, Mary Canavan⁶, Douglas Veale⁷ and Ursula Fearon⁸, ¹Molecular Rheumatology, Trinity Biomedical Sciences Institute, Trinity College Dublin, EULAR Centre for Rheumatic and Arthritic Diseases, St Vincent's University Hospital, University College Dublin, Dublin, Ireland, ²Molecular Rheumatology Department, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland, EULAR Centre for Arthritis and Rheumatic Diseases, St Vincent University Hospital, University College Dublin, Dublin, Ireland, ³Translational Immunology, Trinity Biomedical Sciences Institute, Dublin, Ireland, ⁴Molecular Rheumatology Department, Trinity Biomedical Sciences Institute, Trinity College Dublin, EULAR Centre for Arthritis and Rheumatic Diseases, St Vincent University Hospital, University College Dublin, Dublin, Ireland, ⁵EULAR Centre for Arthritis and Rheumatic Diseases, St Vincent University Hospital, University College Dublin, Dublin, Ireland, ⁶Molecular Rheumatology Department, Trinity Biomedical Sciences Institute, Trinity College Dublin, EULAR Centre for Arthritis and Rheumatic Diseases, St Vincent University Hospital, University College Dublin, School of Biochemistry & Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, ⁷St.Vincent's University Hosp, Dublin, Ireland, ⁸Trinity College Dublin, Dublin, Ireland
Background/Purpose: Recent literature has identified different synovial fibroblast (FLS) populations within RA synovium with distinct inflammatory profiles. Despite current advances in classifying heterogeneity of FLS…
Abstract Number: 1742 • ACR Convergence 2023
Sputum Citrullinated Proteins and Sputum Anti-Cit-S100A8/A9 IgG Antibodies Are Increased in Serum Anti-CCP-IgG Positive Individuals Who Developed RA
Rachna Talluri¹, Sudeshna Sen², Timothy Wilson³, Adam Savage⁴, Mark Gillespie⁴, Tom Bumol⁴, Marie Feser¹, Jill Norri⁵, Michael Holer¹, kevin Deane¹, Paul Thompson² and Kristen Demoruelle¹, ¹University of Colorado Anschutz Medical Campus, Aurora, CO, ²University of Massachusetts Chan Medical School, Worcester, MA, ³Thomas Jefferson University, Philadelphia, PA, ⁴Allen Institute for Immunology, Seattle, WA, ⁵Colorado School of Public Health, Denver, CO
Background/Purpose: The presence of anti-CCP-IgG in the blood identifies individuals who are "at-risk" of developing RA. Our group has reported that in a cohort of…
Abstract Number: 1562 • ACR Convergence 2023
Behcet’s Disease Coagulopathy in a Racially Diverse Patient Population
Sundus Mian¹, Talia Meisel², Hussain Md¹, Xianhong Xie³, Tamara Tanner¹, Anand Kumthekar⁴ and Bibi Ayesha⁴, ¹Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, ²Montefiore Medical Center, Bronx, NY, ³Albert Einstein College of Medicine, Bronx, NY, ⁴Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY
Background/Purpose: Behcet's disease (BD) is a vasculitis with both thrombotic and bleeding complications which can make management challenging. Thrombosis is due to direct vascular inflammation,…
Abstract Number: 1713 • ACR Convergence 2023
Prevention of Arthritis Development by Mechanical Unloading Through Inhibition of CCL2 and YAP-mediated Inflammation in the Rat Adjuvant-induced Arthritis Model
Elisa Dalix¹, Mathieu Maalouf¹, Robin Caire², Guillaume Courbon¹, Virginie Dumas³, Sylvie Peyroche¹, Marie-Thérèse Linossier¹, Mireille Thomas¹, Charles-Antoine Arthaud¹, Arnaud Vanden-Bossche¹ and Hubert Marotte⁴, ¹Université Jean Monnet Saint-Étienne, Mines Saint-Etienne, INSERM, Saint-Etienne, France, ²Department of Molecular Medicine, University of Padua School of Medicine, Padua, Italy, ³Laboratory of Tribology and Systems Dynamics, Ecole Nationale d'Ingénieurs de Saint Etienne, Ecole Centrale de Lyon, University of Lyon, Saint-Etienne, France, ⁴CHU Saint-Etienne, Saint-Etienne, France
Background/Purpose: Rheumatoid arthritis (RA) is the most common chronic inflammatory rheumatic disease, characterized by synovitis associated with progressive bone loss and joint degradation. The adjuvant-induced…
Abstract Number: 2183 • ACR Convergence 2023
Evolution of Lymphoma Predictors in Primary Sjogren’s Syndrome by Data Driven Analysis in Harmonized Patients
Andreas Goules¹, Loukas Chatzis², Vasileios pezoulas³, Francesco Ferro⁴, Valeria Manfrè⁵, Dimitrios Fotiadis³, Luca Quartuccio Quartuccio⁶, Chiara Baldini⁷, Salvatore De Vita⁵ and Athanasios Tzioufas¹, ¹Dept. of Pathophysiology, School of Medicine, University of Athens, Athens, Greece, ²Dept. of Pathophysiology, School of Medicine, University of Athens, Cholargos Athens, Greece, ³Unit of Medical Technology and Intelligent Information Systems, Dept. of Materials Science and Engineering, University of Ioannina, Ioannina, Greece, ⁴Clinical and Experimental Medicine Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy, ⁵Clinic of Rheumatology, Dept. of Medical and Biological Sciences, Udine University, Udine, Italy, ⁶Rheumatology Division, Department of Medicine, University of Udine, Udine, Italy, ⁷University of Pisa, Pisa, Italy
Background/Purpose: Lymphoma is the most serious complication of primary Sjogren'ssyndrome (pSS), occurring as a late sequel during disease course. So far, lymphomapredictors have been identified…
Abstract Number: 1746 • ACR Convergence 2023
Smoking as a Risk Factor for Rheumatoid Arthritis: Exclusive Association with IgA Autoantibodies
Tineke van Wesemael¹, Anna Svärd², Annemarie Dorjee¹, Thomas Huizinga¹, René Toes¹ and Diane van der Woude¹, ¹Leiden University Medical Center, Leiden, Netherlands, ²Centre for Clinical Research Dalarna, Uppsala, Sweden
Background/Purpose: Rheumatoid arthritis (RA) is characterized by autoantibodies to anti-modified protein autoantibodies (AMPAs) like anti-citrullinated protein antibodies (ACPA) and anti-acetylated protein antibodies (AAPA). Smoking is…
Abstract Number: 1678 • ACR Convergence 2023
Comparative Safety of Biologic and Targeted Synthetic Disease Modifying Anti-Rheumatic Drugs for Cancer in Rheumatoid Arthritis
Xavier Sendaydiego¹, Laura Gold², Jean liew³, K Wysham⁴, Maureen Dubreuil⁵, James Andrews¹, Pankti Reid⁶, David Liew⁷, Radjiv Goulabchand⁸, Abha Singh⁹, Grant Hughes¹, Mathilde Pioro¹, Jeffrey Sparks¹⁰, Jeffrey Jarvik², Siddharth Singh⁹ and Namrata Singh¹¹, ¹University of Washington, Seattle, WA, ²Department of Radiology and University of Washington Clinical Learning, Evidence, and Research (CLEAR) Center for Musculoskeletal Disorders, Seattle, WA, ³Boston University, Boston, MA, ⁴VA Puget Sound/University of Washington, Seattle, WA, ⁵Department of Rheumatology, Boston University School of Medicine, Milton, MA, ⁶University of Chicago Medical Center, Chicago, IL, ⁷Austin Health, Heidelberg, Australia, ⁸St. Eloi Hospital, Department of Internal Medicine and Multi-Organic Diseases, Montpellier, France, ⁹University of California San Diego, San Diego, CA, ¹⁰Division of Rheumatology, Inflammation, and Immunity, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, ¹¹University of Washington, Bellevue, WA
Background/Purpose: In the ORAL Surveillance trial, cancer risk was higher among patients with rheumatoid arthritis (RA) on tofacitinib, a Janus kinase inhibitor (JAKi), compared to…
Abstract Number: 1565 • ACR Convergence 2023
Baseline Vascular Ultrasound of Polymyalgia Rheumatica Patients at Time of Diagnosis Predicts Clinical Outcomes at 3 Months
Sharon Cowley¹, Colm Kirby², Patricia Harkins³, Richard Conway⁴ and David Kane⁵, ¹Tallaght University Hospital, Dublin, Dublin, Ireland, ²Tallaght University Hospital, Dublin, Ireland, ³St James's Hospital, Dublin, Ireland, ⁴Trinity College Dublin, Dublin, Ireland, ⁵Tallaght University Hospital & Trinity College Dublin, Dublin, Ireland
Background/Purpose: It has been reported that up to a quarter of patients with polymyalgia rheumatica (PMR) have subclinical giant cell arteritis (GCA). It is currently…
Abstract Number: 2184 • ACR Convergence 2023
Development of Salivary Gland Organoids to Study Sjögren Syndrome
Loïc Meudec¹, Negaar Goudarzi², Juliette Pascaud³, Fanny Jaulin², Xavier Mariette⁴ and Gaetane Nocturne⁵, ¹CHU Kremlin-Bicêtre, Rheumatology, Le Kremlin-Bicêtre, France, ²INSERM UMR 981, Institut Gustave Roussy, Villejuif, France, Villejuif, France, ³Center for Immunology of Viral Infections and Autoimmune Diseases, INSERM UMR 1184, FHU CARE, Université Paris-Saclay, Le Kremlin-Bicêtre, France, ⁴Université Paris-Saclay, Le Kremlin-Bicêtre, France, ⁵APHP, Le Kremlin-Bicêtre, France
Background/Purpose: Sjögren disease (Sjo) is an autoimmune disease characterized by the infiltration of exocrine glands by immune cells, especially salivary glands (SG). SG epithelial cells…
Abstract Number: 1566 • ACR Convergence 2023
Exposure-Response Analysis of Sarilumab in Patients with Polymyalgia Rheumatica
Christine Xu¹, Ying Liu¹, Jennifer Sloane², Remco Diab³, Hubert van Hoogstraten¹, Hisham Abdallah⁴, Sreeraj Macha¹ and Bhaskar Dasgupta⁵, ¹Sanofi, Bridgewater, NJ, ²Sanofi, Cambridge, MA, ³Sanofi, Rotkreuz, Switzerland, ⁴Regeneron Pharmaceuticals, Inc., Tarrytown, NY, ⁵Anglia Ruskin University, East Anglia, United Kingdom
Background/Purpose: Sarilumab blocks interleukin-6 (IL-6) from binding to the membrane-bound and soluble IL-6 receptor-α subunit (IL-6Rα). Sarilumab is now approved for both rheumatoid arthritis (RA)…
Abstract Number: 1578 • ACR Convergence 2023
Impact of Anxiety or Depression Status and Fibromyalgia on Adherence to Treatment of Patients with Takayasu Arteritis
Alejandra Espinosa-Orantes¹, David Vera-Bustamante², Jessica Roldan Ortega³, Maria Mejia-Avila⁴, Jose Raul Molina⁵, Evelyn Aranda Cano⁵, Adriana Miguel-Alvarez⁵, Ismael Valenzuela⁵, Viridiana Del Río-Guerrero⁶, Paloma Rodriguez⁵, Mauricio Mora-Ramirez⁵, Nilda Espinola-Zavaleta⁴, Luis H Silveira-torre⁶, Angélica Vargas Guerrero⁷ and Laura A Martínez-Martínez⁸, ¹Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico, ²BENEMERITA UNIVERSIDAD AUTONOMA DE PUEBLA, Mexico City, Mexico, ³INSTITUTO NACIONAL DE CARDIOLOGIA, Ciudad de México, Mexico, ⁴Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico, ⁵Instituto Nacional de Cardiologia, Mexico City, Mexico, ⁶Instituto Nacional de Cardiología, Mexico City, Mexico, ⁷Instituto Nacional de Cardiología, Mexico City, Mexico, ⁸Universidad Nacional Autónoma de México - Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
Background/Purpose: Takayasu arteritis (TAK) is a chronic, granulomatous large-vessel vasculitis. As TAK has a chronic course, higher frequency rates of anxiety and depression are reported…
Abstract Number: 1157 • ACR Convergence 2023
Experience of Pain in Adults with Idiopathic Inflammatory Myopathies, Myositis
Helene Alexanderson¹, Masoumeh Tasaroffi², Henrik Pettersson³ and Malin Regardt³, ¹Karolinska Institutet, Stockholm, Sweden, ²Danderyds Hospital, Stockholm, Sweden, ³Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Knowledge of pain in myositis is limited. Recent research suggest that pain is a common symptom in adults with myositis and deemed as one…

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