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  • Abstract Number: 2274 • ACR Convergence 2022

    Factors Associated with Disease Flare Following SARS-CoV-2 Vaccination in People with Inflammatory Rheumatic and Musculoskeletal Diseases – Results from the Physician-Reported EULAR Coronavirus Vaccine (COVAX) Registry

    Bayram Farisoğulları1, Saskia Lawson-Tovey2, Kimme Hyrich3, Laure Gossec4, Loreto Carmona5, Anja Strangfeld6, Elsa Mateus7, Martin Schaefer8, Ana Maria Rodrigues9, Eric Hachulla10, Jose A Gomez-Puerta11, Marta Mosca12, Patrick Durez13, Ludovic Trefond14, Tiphaine Goulenok15, Martina Cornalba16, Emoke Šteňová17, Inita Bulina18, Eva Strakova19, Julija Zepa20, Nicolas Roux21, Olivier Brocq22, Viellard Eric23, Bernd Raffeiner24, Gerd Burmester25, Xavier Mariette26 and Pedro Machado27, 1Hacettepe University Faculty of Medicine Division of Rheumatology, Ankara, Turkey, 2Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, the University of Manchester, Manchester, UK AND National Institute of Health Research Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom, 3The University of Manchester, Manchester, United Kingdom, 4Sorbonne Université, Paris, France, 5Instituto de Salud Musculoesquelética (InMusc), Madrid, Spain, 6Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany, 7EULAR, Lisboa, Portugal, 8German Rheumatism Research Center, Berlin, Germany, 9Reuma.pt, Sociedade Portuguesa de Reumatologia, Lisbon, Portugal, 10University of Lille, LILLE, France, 11Hospital Clínic de Barcelona, Barcelona, Spain, 12Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, 13Rheumatology, Cliniques Universitaires Saint-Luc – Université catholique de Louvain (UCLouvain) – Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, 14Université Clermont Auvergne, CHU Clermont-Ferrand, Service de Médecine Interne, Hôpital Gabriel Montpied, INSERM U1071, Clermont-Ferrand, France, 15APHP, Paris, France, 16Dipartimento di Reumatologia e Scienze Mediche, ASST Gaetano Pini-CTO, Milano, Italy, 17University Hospital, Bratislava, Slovakia, 18Center of Rheumatology, Paul Stradins Clinical University hospital, Riga, Latvia, Riga, Latvia, 19Department of Internal Medicine, Faculty Hospital Prešov, Presov, Slovakia, 20Riga Stradins University, Latvia, Pauls Stradins Clinical University Hospital, Centre of Rheumatology, Riga, Latvia, Riga, Latvia, 21Service de Rhumatologie, Hôpital Robert Schuman, Metz, France, 22Rheumatology- CH Princesse Grace, Monaco, Monaco, 23Private practice, St. Malo, France, 24Department of Rheumatology, Central Hospital of Bolzano, Bolzano, Italy, 25Charité University Medicine Berlin, Berlin, Germany, 26Paris-Saclay University, Rueil Malmaison, Ile-de-France, France, 27University College London, London, United Kingdom

    Background/Purpose: To investigate the frequency and factors associated with disease flare following vaccination against SARS-CoV-2 in people with inflammatory/autoimmune rheumatic and musculoskeletal diseases (I-RMD).Methods: The…
  • Abstract Number: 2154 • ACR Convergence 2022

    An Exploratory Phosphoproteomic and Immunohistochemical Analysis of Receptor Tyrosine Kinases and Downstream Signaling Pathways in Systemic Sclerosis Skin

    Elizabeth Bundschuh1, Rebecca Fine2, Miruna Carnaru3, Sanchit Kumar4, Francis Perry Wilson2, Alyssa Williams1, Shannon Teaw4, Ian Odell4 and Monique Hinchcliff5, 1Yale University, New Haven, CT, 2Yale School of Medicine, New Haven, CT, 3Hartford Healthcare Medical Group, Rocky Hill, CT, 4Yale University School of Medicine, New Haven, CT, 5Yale School of Medicine, Westport, CT

    Background/Purpose: Receptor tyrosine kinases (RTK) such as epidermal growth factor receptor (EGFR) and others including PDGFRs, FGFRs, and VEGFRs are implicated in systemic sclerosis (SSc)…
  • Abstract Number: 2221 • ACR Convergence 2022

    The Molecular Endotypes of Type 1 and Type 2 SLE

    Robert Robl1, Amanda Eudy2, Prathyusha Bachali3, Jennifer L Rogers4, Megan Clowse5, David Pisetsky6 and Peter lipsky1, 1AMPEL BioSolutions, Charlottesville, VA, 2Duke University, Raleigh, NC, 3AMPEL BioSolutions, Redmond, WA, 4Duke University School of Medicine, Division of Rheumatology & Immunology, Durham, NC, 5Duke University, Durham, NC, 6Duke University Medical Center, Durham, NC

    Background/Purpose: To characterize the molecular landscape of patients with Type 1 and Type 2 systemic SLE erythematosus (SLE) by analyzing gene expression profiles from peripheral…
  • Abstract Number: 2266 • ACR Convergence 2022

    Platelet-selectin Prime Lupus Neutrophils to Produce Mitochondrial ROS and Participate in SLE Pathogenesis

    Marc Scherlinger1, Pierre Vacher2, Vivien Guillotin3, Isabelle Douchet4, Christophe Richez5 and Patrick Blanco4, 1BIDMC Harvard University, Boston, MA, 2INSERM U1218, Bordeaux, France, 3CHU de Bordeaux, Bordeaux, France, 4UMR-CNRS 5164 Immunoconcept, Bordeaux, France, 5CHRU Bordeaux, Bordeaux, France

    Background/Purpose: In patients with active systemic lupus erythematosus (SLE), circulating platelets have an activated phenotype characterized by the expression of P-selectin (CD62P). We have shown…
  • Abstract Number: 2032 • ACR Convergence 2022

    Major Salivary Gland Ultrasound and Elastography for Assessment of Disease Activity in Patients of Primary Sjögren’s Syndrome

    Kunal Chandwar1, Juhi Dixit1, Kriti Kishor1, DOGGA PRASANNA KUMAR2, DIGVIJAY EKBOTE3, PUNEET KUMAR1 and Urmila Dhakad1, 1King George's Medical University, Lucknow, India, 2KGMU, LUCKNOW, Uttar Pradesh, India, 3KING GEORGE MEDICAL UNIVERSITY, LUCKNOW, Uttar Pradesh, India

    Background/Purpose: To assess major salivary gland involvement by ultrasonography and elastography in patients with Sjögren's syndrome , compare it with controls and correlate the severity…
  • Abstract Number: 1652 • ACR Convergence 2022

    Long-term Safety and Efficacy of Anifrolumab in Adult Patients with Systemic Lupus Erythematosus: A Multicenter, Randomized, Double-blind, Placebo-controlled 3-year TULIP Extension Study

    Kenneth C. Kalunian1, Richard A. Furie2, Eric F. Morand3, Ian N. Bruce4, Susan Manzi5, Yoshiya Tanaka6, Kevin Winthrop7, Gabriel Abreu8, Ihor Hupka9, Lijin Zhang10, Shanti Werther11, Micki Hultquist12, Raj Tummala10 and Catharina Lindholm11, 1UC San Diego, La Jolla, CA, 2Northwell Health, Great Neck, NY, 3Monash University, Melbourne, Australia, 4The University of Manchester, Manchester, United Kingdom, 5Allegheny Health Network, Pittsburgh, PA, 6University of Occupational and Environmental Health, Kitakyusyu Fukuoka, Japan, 7Oregon Health & Science University, Portland, OR, 8AstraZeneca, Mölndal, Sweden, 9AstraZeneca, Warsaw, Poland, 10AstraZeneca, Gaithersburg, MD, 11AstraZeneca, Gothenburg, Sweden, 12AstraZeneca, Bethesda, MD

    Background/Purpose: Anifrolumab is a fully human IgG1 κ monoclonal antibody that binds to the type I IFN receptor and inhibits type I IFN signaling.1 In…
  • Abstract Number: 1649 • ACR Convergence 2022

    Five-Year Cardiovascular Event Risk in Early Rheumatoid Arthritis Patients Who Received Treat-to-Target Management

    Lai-shan Tam1, Tsz On Lam2 and Man Choi Wan3, 1The Chinese University of Hong Kong, Hong Kong, China, 2Prince of Wales Hospital, Hong Kong, Hong Kong, 3Ruttonjee Hospital, Hong Kong, Hong Kong, Hong Kong

    Background/Purpose: Rheumatoid arthritis (RA) is known to cause increased risk of cardiovascular (CV) disease (CVD) due to the underlying inflammation. The year of 2010 revolutionised…
  • Abstract Number: 1928 • ACR Convergence 2022

    Idiopathic Pulmonary Capillaritis Within the Spectrum of Pediatric Diffuse Alveolar Hemorrhage

    Angela Chun1, Tiphanie vogel1, Andrea Ramirez1, Marietta De Guzman2, Eyal Muscal1 and Manuel Silva-Carmona3, 1Baylor College of Medicine, Houston, TX, 2Baylor College of Medicine/ Texas Children's Hospital, Houston, TX, 3Baylor College of Medicine, Texas Children's Hospital, Houston, TX

    Background/Purpose: Diffuse alveolar hemorrhage (DAH) is a life-threatening syndrome with bleeding from the pulmonary microvasculature. It is classified as pulmonary capillaritis if histology shows neutrophilic…
  • Abstract Number: 2253 • ACR Convergence 2022

    Sputum Cytokines Are Elevated in Rheumatoid Arthritis-Associated Interstitial Lung Disease

    Timothy Wilson1, Kevin D Deane2, Jonathan Dekermanjian2, Joyce Lee2, Marie Feser3, Stephen Humphries4, Joshua Solomon4 and Kristen Demoruelle3, 1University of Colorado Denver Anschutz Medical Campus, Aurora, CO, 2University of Colorado Denver Anschutz Medical Campus, Denver, CO, 3University of Colorado Anschutz Medical Campus, Aurora, CO, 4National Jewish Health, Denver, CO

    Background/Purpose: Interstitial lung disease (ILD) is a well-recognized comorbidity in rheumatoid arthritis (RA) that contributes significantly to morbidity and mortality. ILD is diagnosed in up…
  • Abstract Number: PP02 • ACR Convergence 2022

    Patient Mobilization for Vaccine Access and Improved Care During the COVID Pandemic

    Marie-Claude Beaulieu1, Ines Colmegna2, Nathalie Amiable3, Jean Légaré4 and Paul Fortin5, 1Universite de Sherbrooke, Sherbrooke, QC, Canada, 2The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 3CHU de Québec, Quebec, QC, Canada, 4QC, Canada, 5CHU de Quebec - Universite Laval, Quebec, QC, Canada

    Background/Purpose: The COVID pandemic was particularly difficult for persons like me living with rheumatoid arthritis and immunosuppressed. I had to impose myself months of isolation…
  • Abstract Number: 2262 • ACR Convergence 2022

    Albumin-hitchhiking MMP13 siRNA Conjugate (siMMP13< (EG18L)2) for the Treatment of Rheumatic Disease

    Juan Colazo1, Ella Hoogenboezem1, Fang Yu1, Veeraj Shah1, Justin Lo1, Hongsik Cho2, Karen Hasty2, Leslie Crofford3 and Craig Duvall1, 1Department of Biomedical Engineering, Vanderbilt University, Nashville, Nashville, TN, 2Department of Orthopaedic Surgery and Biomedical Engineering, Memphis VA Medical Center, Memphis, TN, 3Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: Osteoarthritis (OA) and rheumatoid arthritis (RA) decrease quality of life due to joint destruction, pain, and decreased function. Multiple joint osteoarthritis (MJOA) can occur…
  • Abstract Number: 2230 • ACR Convergence 2022

    Ultra-Rare Genetic Variation in Relapsing Polychondritis: A Whole-Exome Sequencing Study

    Yiming Luo1, Marcela Ferrada1, Keith Sikora2, Daniel Kastner3, Zuoming Deng4, Mengqi Zhang5, Hugh Alessi1, Virginia Kraus6, Andrew Allen6 and Peter Grayson7, 1National Institutes of Health, Bethesda, MD, 2National Institutes of Health Clinical Center, Bethesda, MD, 3National Human Genome Research Institute, Bethesda, MD, 4National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 5University of Pennsylvania, Philadelphia, PA, 6Duke University, Durham, NC, 7National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD

    Background/Purpose: Relapsing polychondritis (RP) is a rare rheumatic disease of unknown etiology characterized by inflammations of cartilaginous structures and other tissues, particularly the ears, nose,…
  • Abstract Number: 2169 • ACR Convergence 2022

    Cardiac Rhythm and Conduction Abnormalities in Systemic Sclerosis-meta-analysis

    Drashti Antala1, Angkawipa Trongtorsak1, Qingqing Meng1, Akshaya Ramachandran1, Aanshi Patel2, Pabitra Adhikari1, Prasun Pudasainee1 and Krutarth Pandya3, 1Ascension Saint Francis hospital, Evanston, IL, 2B.J. Medical College, Ahmedabad, Ahmedabad, India, 3Trumbull Regional Medical Centre, Warren, OH

    Background/Purpose: Systemic sclerosis( SSc) can primarily cause repeated focal ischaemic insults in the myocardium and result in irreversible myocardial fibrosis. Myocardial involvement, when becomes clinically…
  • Abstract Number: 2039 • ACR Convergence 2022

    The Tubarial Glands Resemble the Palatal Salivary Glands Based on Further Histological Characterization, and May Represent an Organ of Interest in Primary Sjögren’s Syndrome

    Sarah Pringle1, Floris Bikker2, Wouter Vogel3, Ingrid Hofland3, Bert van der Vegt4, Hendrika Bootsma1, Frans Kroese1, Arjan Vissink5 and Matthijs Valstar3, 1University Medical Center Groningen, Groningen, Netherlands, 2ACTA, Amsterdam, Netherlands, 3NKI, Amsterdam, Netherlands, 4University Medical Center Groningen, University of Groningen, Groningen, Netherlands, 5UMCG, Leek, Netherlands

    Background/Purpose: Primary Sjögren's syndrome (pSS) often results in dysfunction of the salivary glands (hyposalivation and xerostomia) and substantial decrease in patient quality of life. High…
  • Abstract Number: 2038 • ACR Convergence 2022

    Single Cell RNA Sequencing Points to a Role for Fibroblasts Early in Salivary Gland Dysfunction in Primary Sjögren’s Syndrome

    Sarah Pringle1, Fred Spijkervet1, Arjan Vissink2, Hendrika Bootsma1 and Frans Kroese1, 1University Medical Center Groningen, Groningen, Netherlands, 2UMCG, Leek, Netherlands

    Background/Purpose: Salivary gland (SG) dysfunction is commonly associated with the autoimmune disease primary Sjögren's syndrome (pSS). Whilst the more advanced stages of the disease are…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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