ACR Meeting Abstracts

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  • Abstract Number: 2200 • ACR Convergence 2022

    Reliability of Medication Information Derived from EHR Data Compared to Insurance Claims: An Analysis of Biologic Medications in RISE and Medicare

    Rahaf Baker1, Jing Li2, Rachael Stovall3, Jeffrey Curtis4, Fenglong Xie5, Jinoos Yazdany6 and Gabriela Schmajuk7, 1Alameda Highland Internal Medicine Residency, Oakland, CA, 2University of California, San Francisco, San Francisco, CA, 3University of California San Francisco, San Francisco, CA, 4University of Alabama at Birmingham, Hoover, AL, 5University of Alabama at Birmingham, Birmingham, AL, 6UCSF, San Francisco, CA, 7UCSF / SFVA, San Francisco, CA

    Background/Purpose: Health services studies increasingly rely on Electronic Health Record (EHR) data to capture medication use. However, the reliability of medication information derived from EHR…
  • Abstract Number: 2204 • ACR Convergence 2022

    Interosseous Tendon Inflammation in the Hands: A Novel Feature of Developing Rheumatoid Arthritis? Results from a Large MRI Study in Clinically Suspect Arthralgia

    Bastiaan van Dijk1, Hanna van Steenbergen1, Monique Reijnierse2, Sarah J.H. Khidir2, Lambertus Wisse1, Marco deRuiter1 and Annette van der Helm-van Mil3, 1Leiden University Medical Centre (LUMC), Leiden, Netherlands, 2Leiden University Medical Center, Leiden, Netherlands, 3Leiden University Medical Center, Erasmus Medical Center, Leiden, Netherlands

    Background/Purpose: Inflammation around the tendons of hand interosseous muscles (interosseous tendon inflammation; ITI) on MRI was recently reported for the first time in rheumatoid arthritis…
  • Abstract Number: 2205 • ACR Convergence 2022

    Non-Invasive in Vivo Metabolic Profiling of Inflammation in Joints and Entheses by Optoacoustic Imaging

    Koray Tascilar1, Filippo Fagni2, Arnd Kleyer1, Sara Bayat2, Robert Heidemann3, Florian Steiger3, Gerhard Kroenke1, Daniela Bohr4, Andreas Ramming1, Melek Yalcin Mutlu3, Ioanna Minopoulou3, Fabian Hartmann3, Daniel Klett5, Anna Federle5, Adrian Regensburger6, Alexandra L. Wagner6, Ferdinand Knieling6, Markus Neurath5, Georg Schett7, Maximilian Waldner5 and David Simon1, 1Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054 Erlangen, Germany; Deutsches Zentrum Immuntherapie, Friedrich-Alexander-UniversityErlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, 2University Hospital Erlangen; Department of Internal Medicine 3 - Rheumatology and Immunology, Erlangen, Germany, 3University Hospital Erlangen, Department of Internal Medicine 3 - Rheumatology and Immunology, Erlangen, Germany, 4Department of Internal Medicine 3, Rheumatology & Immunology, Friedrich-Alexander-University (FAU) Erlangen-Nurnberg and University Hospital Erlangen, Erlangen, Germany, 5University Hospital Erlangen; Department of Internal Medicine 1 - Gastroenterology, Pulmonology and Immunology, Erlangen, Germany, 6University Hospital Erlangen; Department of Pediatrics and Adolescent Medicine, Erlangen, Germany, 7Universitätsklinikum Erlangen, Erlangen, Germany

    Background/Purpose: For individuals with inflammatory arthritis, a detailed metabolic characterization of joints and entheses at the tissue level can aid in early diagnosis and treatment…
  • Abstract Number: 2199 • ACR Convergence 2022

    Primary Non-adherence to Biologics and Immunomodulatory Therapies for Rheumatoid Arthritis, Psoriatic Arthritis, and Spondyloarthritis Using Linked EHR and Pharmacy Claims Data

    Jeffrey Curtis1, Yujie Su2, Cassie Clinton2, Patrick Stewart3, Bryant England4, Tim Buekelman5 and Fenglong Xie2, 1Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 2University of Alabama at Birmingham, Birmingham, AL, 3Bendcare, Boca Raton, FL, 4University of Nebraska Medical Center, Omaha, NE, 5FASTER, Hoover, AL

    Background/Purpose: Many patients with autoimmune and inflammatory conditions discontinue biologics and other immunomodulatory medications prematurely, but many fail to even start (primary non-adherence). We examined…
  • Abstract Number: 2081 • ACR Convergence 2022

    COVID-19 Infections, Morbidity, and Seroreactivity in SLE Patients Following Initial Vaccination Series and Additional Dose Through the New York City Omicron BA.1 Wave

    Amit Saxena1, Alexis Engel2, Brittany Banbury1, Ghadeer Hasan3, Nicola Fraser1, Devyn Zaminski1, Mala Masson4, Rebecca Haberman5, Jose Scher2, Gary Ho6, Jammie Law3, Paula Rackoff1, Chung-E Tseng5, H Michael Belmont1, Robert Clancy1, Jill Buyon7 and Peter Izmirly7, 1NYU School of Medicine, New York, NY, 2New York University School of Medicine, New York, NY, 3NYU Langone, New York, NY, 4NYU Langone Medical Center- Division of Rheumatology, New York, NY, 5NYU Langone Health, New York, NY, 6New York University Grossman School of Medicine, VA New York Harbor Health Care System, Brooklyn, NY, 7NYU Grossman School of Medicine, New York, NY

    Background/Purpose: Patients with systemic lupus erythematosus (SLE) are at high risk for severe disease from COVID-19 and decreased vaccine efficacy, due to inherent immune perturbations…
  • Abstract Number: 2146 • ACR Convergence 2022

    Efficacy of Upadacitinib in Patients with Psoriatic Arthritis and Prior Exposure to Anti-TNF Therapy in the SELECT-PsA 2 Trial Through 2 Years

    Philip J Mease1, Rodrigo Luppino Assad2, Shigeyoshi Tsuji3, Pascal Richette4, Arathi Setty5, Erin McDearmon-Blondell6, Tianming Gao5, Sandra Ciecinski6 and Filip Van den bosch7, 1Swedish Medical Center/Providence St. Joseph Health, Seattle, WA, 2Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil, 3Department of Orthopaedics and Rheumatology, Nippon Life Hospital, Osaka, Japan, 4Department of Rheumatology, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France, 5AbbVie, Inc., North Chicago, IL, 6AbbVie, Inc., Mettawa, IL, 7Department of Internal Medicine and Paediatrics, Ghent University and VIB Centre for Inflammation Research, Ghent, Belgium

    Background/Purpose: Patients with psoriatic arthritis (PsA) who experience anti-TNF failure and switch to another TNF inhibitor as second- or third-line therapy typically show poorer responses…
  • Abstract Number: 2191 • ACR Convergence 2022

    Long-term Outcomes of Children Born to Mothers with Systemic Lupus Erythematosus: A Nationwide Population-based Study in Korea

    In Ah Choi1, Ji Hyoun Kim2, Sung Hae Chang3, Hyun Jung Kim4 and Hyeong Sik Ahn4, 1Chungbuk National University, Cheongju, Republic of Korea, 2Chungbuk National University Hospital, Cheongju, Republic of Korea, 3Soonchunhyang University College of Medicine, Bongmyeong-dong, Dongnam-gu, Cheonan-si, Republic of Korea, 4Institute for Evidence-based Medicine, Cochrane Korea, Seoul, Republic of Korea

    Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease that primarily affects women of childbearing age, and epidemiologic studies have shown poor maternal and fetal…
  • Abstract Number: 2031 • ACR Convergence 2022

    Efficacy and Safety of Telitacicept in Primary Sjögren’s Syndrome: A Randomized, Double-blind, Placebo-controlled, Phase 2 Trial

    Dong Xu1, Shangzhu Zhang1, Cibo Huang2, Chenghui Huang3, Li Qin4, Xiaomei Li5, Meiqing Chen6, Xiumei Liu7, Yi Liu8, Zhijun Li9, Jiankang Hu10, Chunde Bao11, wei Wei12, Jing Tian13, Xinwang Duan14, Jianmin Fang15 and Xiaofeng Zeng16, 1Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, 2Beijing Hospital, Beijing, China, 3The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China, 4Huzhou Third Municipal Hospital, Huzhou, China, 5Anhui Provincial Hospital, Hefei, China, 6The First Affiliated Hospital of Xiamen University, Xiamen, China, 7The First Hospital of Shanxi Medical University, Taiyuan, China, 8West China Hospital of Sichuan University, Chengdu, China, 9The First Affiliated Hospital of Bengbu Medical College, Bengbu, China, 10Jiangxi Pingxiang People’s Hospital, Shanghai, China, 11Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China, 12Tianjin Medical University General Hospital, Tianjin, China, 13Second Xiangya Hospital of Central South University, Changsha, China, 14The Second Affiliated Hospital of Nanchang University, Nanchang, China, 15Shanghai Tongji Hospital, Shanghai, China, 16Department of Rheumatology, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China

    Background/Purpose: To evaluate the efficacy and safety of telitacicept in adult patients with primary Sjögren’s syndrome (pSS) in a phase II randomized double-blind placebo-controlled trial.Methods:…
  • Abstract Number: 1706 • ACR Convergence 2022

    Clinical and Immunological Factors Associated with Chronic Post-COVID19 Syndrome 12 Months After Acute Infection

    Emmanuel Abimelec Camacho-Morán1, jiram torres-Ruiz1, Jaquelin Lira-Luna1, Ana Sofía Vargas-Castro2, Alfredo Pérez-Fragoso1, Miroslava Nuñez-Aguirre2, Beatriz Alcalá-Carmona3, Abdiel Absalón-Aguilar3 and Diana Gómez-Martín1, 1INCMNSZ, Ciudad de México, Mexico, 2Instituto Nacional de Ciencias Medicas y Nutricion "Salvador Zubiran", Ciudad de México, Mexico, 3Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, Mexico

    Background/Purpose: Post-COVID19 syndrome has been defined as the persistence of symptoms and/or organic damage for more than three weeks after the presence of clinical infection…
  • Abstract Number: 2177 • ACR Convergence 2022

    Familial Clustering of Systemic Sclerosis, Autoimmunity, and Cancer History

    Mariana Bombini1, Nailú Sinicato1, Jacqueline Paredes2, Theresa Wampler Muskardin2, Tiago Nardi Amaral1, Ana Paula Del Rio1, Joao Marques Neto3, Timothy Niewold2 and Simone Appenzeller4, 1State University of Campinas, Campinas, São Paulo, Brazil, 2Hospital for Special Surgery, New York, NY, 3State University of Campinas, São Paulo, Brazil, 4Unicamp, Campinas, São Paulo, Brazil

    Background/Purpose: Systemic sclerosis (SSc) is a complex disease characterized by chronic inflammation, fibrosis, and vasculopathy. Genetic factors contribute to pathogenesis, but because it is a…
  • Abstract Number: 2202 • ACR Convergence 2022

    Association of Visit-based Retention and Receipt of Serologic Testing with Acute Care Use Among Young Adults with Lupus: A Medicare Cohort Study

    Maria Schletzbaum1, Brad C. Astor2, W. Ryan Powell3, Shivani Garg4, Andrea Gilmore-Bykovskyi5, Joseph A. Kramer6, Amy J. Kind7 and Christie Bartels8, 1University of Wisconsin School of Medicine and Public Health, Department of Population Health Sciences, Middleton, WI, 2University of Wisconsin School of Medicine and Public Health, Department of Medicine, Nephrology Division and Department of Population Sciences, Madison, WI, 3University of Wisconsin School of Medicine and Public Health, Center for Health Disparities Research, Thousand Oaks, CA, 4University of Madison, School of Medicine and Public Health, Madison, WI, 5University of Wisconsin School of Medicine and Public Health, Department of Emergency Medicine; and the Center for Health Disparities Research, Madison, WI, 6University of Wisconsin School of Medicine and Public Health, Department of Medicine & Center for Health Disparities Research,, Madison, WI, 7University of Wisconsin School of Medicine and Public Health, Department of Medicine, Geriatrics Division & Center for Health Disparities Research, Madison, WI, 8University of Wisconsin School of Medicine and Public Health, Madison, WI

    Background/Purpose: While high quality lupus care is associated with less damage, the impact of care use patterns and care quality on lupus outcomes remains unclear,…
  • Abstract Number: 2187 • ACR Convergence 2022

    Decision-Making Around Vaccination and Other Public Health Measures During the COVID-19 Pandemic: Experiences of Individuals with Rheumatoid Arthritis

    Jenny leese1, Stephanie Therrien2, Smruthi Ramachandran3, Catherine L. Backman3, Jasmin Ma4, Kelly English5, Eileen Davidson6, Shanon McQuitty7, Alison Hoens5, Cheryl Koehn8, James Gavin9, jo Adams9 and Linda Li3, 1University of Ottawa, Ottawa, ON, Canada, 2Arthritis Research Canada, Vancouver, BC, Canada, 3University of British Columbia, Vancouver, BC, Canada, 4Arthritis Research Canada/University of British Columbia, Richmond, BC, Canada, 5Arthritis Patient Advisory Board of Arthritis Research Canada, Vancouver, BC, Canada, 6Arthritis Patient Advisory Board of Arthritis Research Canada, Burnaby, BC, Canada, 7Arthritis Patient Advisory Board of Arthritis Research Canada, Richmond, BC, Canada, 8Arthritis Consumer Experts, Vancouver, BC, Canada, 9University of Southampton, Southampton, United Kingdom

    Background/Purpose: The spectrum of individual decisions about adopting public health measures (e.g., vaccination programs, physical distancing, mask wearing) to reduce COVID-19 transmission has important implications…
  • Abstract Number: 2155 • ACR Convergence 2022

    Sclerodermoid Reaction Following Immune Checkpoint Inhibitor Therapy: A Case Series from MD Anderson Cancer Center

    Julia Chernis1 and Maryam Buni2, 1McGovern Medical School at the UTHSC Houston, Houston, TX, 2MD Anderson Cancer Center, Bellaire, TX

    Background/Purpose: Immune checkpoint inhibitors (ICIs) have proven to be efficacious in the treatment of multiple malignancies.[1] they are associated immunologic activation has been implicated in…
  • Abstract Number: 2094 • ACR Convergence 2022

    Predictors of Health-Related Quality of Life (HRQoL) in Adults with Juvenile- and Adult-onset Systemic Lupus Erythematosus: Results from a Multiethnic US Cohort (LUMINA)

    R. Ezequiel Borgia1, Manuel Ugarte-Gil2, Luis Vilá3, John Reveille4, Gerald McGwin5 and Graciela Alarcón6, 1UH Rainbow Babies & Children's Hospital, Cleveland, OH, 2Universidad Cientifica del Sur/Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, 3University of Puerto Rico Medical Sciences Campus, San Juan, PR, 4University of Texas McGovern Medical School, Houston, TX, 5Department of Epidemiology, School of Public Health, The University of Alabama at Birmingham, Birmingham, AL, 6The University of Alabama at Birmingham, Oakland

    Background/Purpose: To examine and compare baseline predictors of improvement in HRQoL in adults with systemic lupus erythematosus (SLE) with disease onset occurring before age 24…
  • Abstract Number: 2042 • ACR Convergence 2022

    Sjögren’s Disease and Mitochondrial Function

    Biji T Kurien1, Pharaoh Gavin2, Joshua Cavett1, Valerie Lewis3, Ambre Chambers1, Bhaskaran Shylesh4, Anjum Juvaria1, Brittany Karfonta1, Lida Radfar1, Astrid Rasmussen4, Christopher Lessard4, Darise Farris4, Kathy Sivils5, Kristi A Koelsch4, Holly Van Remmen4 and R. Hal Scofield1, 1University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2University of Washington, Seattle, WA, 3Veterans Affairs Medical Center, Oklahoma City, OK, 4Oklahoma Medical Research Foundation, Oklahoma City, OK, 5Janssen Research and Development, LLC, Spring House, PA

    Background/Purpose: Sjögren's disease (SjD) is a chronic inflammatory, autoimmune disorder with reduced lacrimal/salivary gland secretion resulting in keratoconjunctivitis sicca and xerostomia, respectively. Also, SjD patients…
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