Abstracts Archive - Page 426 of 2605 - ACR Meeting Abstracts

Abstract Number: 1961 • ACR Convergence 2023
Anti-PM/Scl Autoantibodies in Juvenile Myositis Are Associated with a Distinct Phenotype Resembling Anti-synthetase Syndrome
Matthew Sherman¹, Payam Noroozi Farhad², Edward Trieu³, Katherine Pak⁴, Iago Pinal-Fernandez⁴, Kakali Sarkar², Megan Neely⁵, Ira Targoff⁶, Frederick Miller⁷, Andrew Mammen⁸ and Lisa Rider⁹, ¹NIAMS/NIH, Washington, DC, ²Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, ³Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴National Institutes of Health, Bethesda, MD, ⁵Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, ⁶Veterans Affairs Medical Center, University of Oklahoma Health Sciences Center, and Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁷NIH, NIEHS, Chapel Hill, NC, ⁸NIH, Bethesda, MD, ⁹NIEHS, NIH, Bethesda, MD
Background/Purpose: Anti-PM/Scl autoantibodies (Abs) are an uncommon myositis-associated autoantibody (MAA) in juvenile myositis. The clinical features and outcomes associated with anti-PM/Scl Abs in juvenile myositis…
Abstract Number: 1711 • ACR Convergence 2023
CD14+ Monocytes Demonstrate a Unique Transcriptional Signature in Macrophage Activation Syndrome, Highlighting a Role for Interferons and Identifying Putative Hemophagocytes in Circulation
Susan Canny¹, Hannah DeBerg², Griffin Gessay², Ailing Lu³, Mary Eckert⁴, Andrea La Bella⁵, Susan Shenoi⁶, Joyce Hui-Yuen⁷, Betsy Barnes⁸ and Jessica Hamerman², ¹Seattle Children's Hospital/University of Washington, Seattle, WA, ²Benaroya Research Institute, Seattle, WA, ³Feinstein Institutes for Medical Research, Manhasset, NY, ⁴Seattle Children's Hospital, Seattle, WA, ⁵Cohen Children's Medical Center, Queens, NY, ⁶Seattle Childrens Hospital, Mercer Island, WA, ⁷Division of Pediatric Rheumatology, Cohen Children's Medical Center, Lake Success, NY, ⁸Northwell Health, Manhasset, NY
Background/Purpose: Macrophage activation syndrome (MAS) is a potentially fatal complication of rheumatic diseases. MAS is characterized by a dysfunctional hyperinflammatory response in which there is…
Abstract Number: 1956 • ACR Convergence 2023
Rituximab Treatment in Adult Patients with Idiopathic Inflammatory Myositis (IIM): A Systematic Review and Meta-analysis
Lilian Otalora Rojas¹, Karishma Ramsubeik², Luis Sanchez-Ramos², Shastri Motilal³, Jasvinder Singh⁴ and Gurjit S Kaeley⁵, ¹University of Florida, Ponte Vedra Beach, FL, ²University of Florida, Jacksonville, FL, ³The University of the West Indies, St. Augustine, Trinidad and Tobago, ⁴University of Alabama at Birmingham, Birmingham, AL, ⁵University of Florida College of Medicine – Jacksonville, Ponte Vedra Beach, FL
Background/Purpose: Autoimmune myositis involves a spectrum of rare autoimmune disorders characterized by inflammation and damage to skeletal muscles. The management of these challenging conditions often…
Abstract Number: 1958 • ACR Convergence 2023
Validity, Responsiveness and Minimal Clinically Important Difference of EQ-5D-5L in Inflammatory Myositis: A Longitudinal Study
Chengappa Kavadichanda¹, Parthibane S¹, Mamatha Gorijavolu¹, Sai Kumar Dunga¹, Amrita Nayak¹, Sitanshu Sekhar¹ and Rohit Aggarwal², ¹Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India, ²University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Idiopathic inflammatory myositis (IIM) significantly impacts health-related quality of life (HRQoL). EQ5D-5L is a widely used and validated tool to measure HRQoL. The health…
Abstract Number: 1757 • ACR Convergence 2023
Quantitative Assessment of Synovial Vascularity Using Power Doppler Index in Rheumatoid Arthritis and Psoriatic Arthritis Patients with High Disease Activity
Michał Jakubaszek, Maria Maślińska and Brygida Kwiatkowska, National Institute of Geriatrics Rheumatology and Rehabilitation, Warsaw, Poland
Background/Purpose: Usefulness of quantitative assessment of synovial vascularity in ultrasound (US) imaging in patients with active RA and PsA (peripheral arthritis). Additionally the assessment of…
Abstract Number: 1755 • ACR Convergence 2023
Unique Pattern of Cadherin 6 Localization in Fibroblast-Like Synoviocytes
Camilla R. L. Machado¹, David Boyle¹, Narayanan B. Perumal², Robert J. Benschop³ and Gary Firestein¹, ¹University of California San Diego, San Diego, CA, ²Eli Lilly and Company, San Diego, CA, ³Eli Lilly and Company, Indianapolis, IN
Background/Purpose: The synovial lining of rheumatoid arthritis (RA) is formed by a network of fibroblast-like synoviocytes (FLS). Cadherins are type I transmembrane proteins and participate…
Abstract Number: 1959 • ACR Convergence 2023
Quantitative Scoring of High Resolution Chest Computed Tomography (HRCT) Images in Myositis and Antisynthetase Syndrome Related Interstitial Lung Disease in Comparison to Scleroderma Related Interstitial Lung Disease
Sangmee Bae¹, Fereidoun Abtin², Grace Kim³, Siamak Moghadam-Kia⁴, Chester V. Oddis⁵, Lila Pourzand², Didem Saygin⁵, Daniel Sullivan⁶, Koichi Yamaguchi⁷, Donald Tashkin³, Christina Charles-Schoeman⁸, Jonathan Goldin³ and Rohit Aggarwal⁵, ¹UCLA Rheumatology, Los Angeles, CA, ²UCLA Radiological Sciences, Los Angeles, CA, ³University of California Los Angeles, Los Angeles, CA, ⁴University of Pittsburgh Medical Center, Pittsburgh, PA, ⁵University of Pittsburgh, Pittsburgh, PA, ⁶UCLA Pulmonology, Pittsburgh, PA, ⁷University of Pittsburgh Medical Center Rheumatology, Pittsburgh, PA, ⁸UCLA Medical Center, Santa Monica, CA
Background/Purpose: High resolution computed tomography (HRCT) of the chest has become an important modality in the evaluation of interstitial lung disease (ILD). A quantitative CT…
Abstract Number: 1955 • ACR Convergence 2023
Responsiveness and Minimal Important Difference of PROMIS Pain Interference, Fatigue, and Physical Function Forms in Adults with Idiopathic Inflammatory Myopathies
Didem Saygin¹, Dana Direnzo², Joost Raaphorst³, Jin Kyun Park⁴, Ingrid de Groot⁵, Clifton Bingham⁶, Ingrid Lundberg⁷, Malin Regardt⁸, catherine Sarver⁹, Marianne de Visser¹⁰, lara maxwell¹¹, Dorcas Beaton¹², Ju Yeon Kim¹³, Merrilee Needham¹⁴, Helene Alexanderson¹⁵, Lisa Christopher-Stine⁶ and Christopher Mecoli¹⁶, ¹University of Pittsburgh, Pittsburgh, PA, ²University of Pennsylvania, Bala Cynwyd, PA, ³Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands, ⁴Seoul National University Hospital and College of Medicine, Seoul, South Korea, ⁵N/A, Amsterdam, Netherlands, ⁶Johns Hopkins University, Baltimore, MD, ⁷Division of Rheumatology, Department of Medicine, Karolinska Institutet; Department of Gastroenterology, Dermatotology, Rhematology, Karolinska Universitetssjukhuset, Stockholm, Sweden, ⁸Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, ⁹N/A, Baltimore, MD, ¹⁰University of Amsterdam, Amsterdam, Netherlands, ¹¹University of Ottawa, Ottawa, ON, Canada, ¹²Institute for Work & Health, Toronto, ON, Canada, ¹³Seoul National University Hospital, Seoul, South Korea, ¹⁴IIID Murdoch University and University of Notre Dame, Perth, Australia, ¹⁵Karolinska Institutet, Stockholm, Sweden, ¹⁶Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Patient reported outcome measures (PROMs) are critical in assessing clinical outcomes. There is a paucity of PROMs for use in patients with adult idiopathic…
Abstract Number: 1762 • ACR Convergence 2023
Single-cell RNA Sequencing Analysis and Immune Profiling of Antigen-specific T Cells in Patients with Rheumatoid Arthritis and Healthy Controls
JING SONG¹, Cliff Rims¹, Matthew Dufort¹, Peter Linsley¹, Eddie James² and Jane Buckner², ¹Benaroya Research Institute, Seattle, WA, ²Benaroya Research Institute at Virginia Mason, Seattle, WA
Background/Purpose: Single-cell analysis has emerged as a powerful tool for investigating the transcriptomics and T-cell receptor (TCR) diversity in patients with rheumatoid arthritis (RA). However,…
Abstract Number: 1962 • ACR Convergence 2023
Toll-Like Receptor 7/8 Activation of Immune and Non-Immune Cells in Muscle by RNA-Containing Immune Complexes Can Contribute to Inflammation and the Pathogenesis of Myositis
Yin Wu¹, Aditee Deshpande¹, Nicholas Geraci¹, Vera Sellers², Phanindra Velisetty², David Fiorentino³, Kavita Y. Sarin³ and Andrew Bender¹, ¹Research Unit – Neurology and Immunology, EMD Serono, Billerica, MA, ²Discovery Technologies, EMD Serono, Billerica, MA, ³Department of Dermatology, Stanford University, Redwood City, CA
Background/Purpose: Tissue inflammation is a major disease driver in idiopathic inflammatory myopathies (IIM), leading to muscle weakness and, in the case of dermatomyositis (DM), a…
Abstract Number: 1622 • ACR Convergence 2023
Myositis-associated Autoantibodies in Juvenile Myositis Are Associated with Severe Disease Features and Mortality
Matthew Sherman¹, Payam Noroozi Farhad², Katherine Pak³, Iago Pinal-Fernandez³, Kakali Sarkar², Megan Neely⁴, Ira Targoff⁵, Frederick Miller⁶, Andrew Mammen⁷ and Lisa Rider⁸, ¹NIAMS/NIH, Washington, DC, ²Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, ³National Institutes of Health, Bethesda, MD, ⁴Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, ⁵Veterans Affairs Medical Center, University of Oklahoma Health Sciences Center, and Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶NIH, NIEHS, Chapel Hill, NC, ⁷NIH, Bethesda, MD, ⁸NIEHS, NIH, Bethesda, MD
Background/Purpose: Myositis-associated autoantibodies (MAAs), such as anti-Ro52 autoantibodies (Abs), have been found to be associated with interstitial lung disease (ILD) and worse prognosis in the…
Abstract Number: 1764 • ACR Convergence 2023
Antibody Responses to Citrullinated Type II Collagen and Vimentin Modified with Malondialdehyde-Acetaldehyde Differ in Rheumatoid Arthritis and Rheumatoid Arthritis-Interstitial Lung Disease
Breanna Butler¹, Jill Poole¹, Michael Duryee¹, Nozima Aripova¹, Carlos Hunter¹, Bridget Kramer¹, James O'Dell¹, Geoffrey Thiele¹, Bryant England¹ and Ted R Mikuls², ¹University of Nebraska Medical Center, Omaha, NE, ²Division of Rheumatology and Immunology, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Interstitial lung disease (ILD) causes significant complications and mortality in patients with rheumatoid arthritis (RA). We have previously shown that patients with RA-ILD had…
Abstract Number: 1732 • ACR Convergence 2023
Immunopathogenesis and Preclinical Trials in a Humanized Mouse Model of Rheumatoid Arthritis(RA)
Huiyi Wang¹, Kangkang Luo¹, Shuxin Xu¹, Jiayin Zhou¹, Santi Chen², Jun wang², Wenzhao Li², Jing Zhao¹ and Cunxiang Ju¹, ¹GemPharmatech CO., Ltd., Nanjing, China, ²GemPharmatech LLC, La Jolla, CA
Background/Purpose: The differences between human and mouse immune systems make it challenging to accurately reflect the immunopathogenesis of autoimmune diseases in patients. Therefore, translational research…
Abstract Number: 1631 • ACR Convergence 2023
Comparison of Peripheral Biomarker Profiles Across Unique Multimorbidity Patterns in Rheumatoid Arthritis
Chloe Peyton¹, Tate Johnson¹, Joshua Baker², Yangyuna Yang¹, Punyasha Roul¹, Michael Duryee¹, Jill Poole¹, Geoffrey Thiele¹, Ted R Mikuls³ and Bryant England¹, ¹University of Nebraska Medical Center, Omaha, NE, ²University of Pennsylvania, Philadelphia, PA, ³Division of Rheumatology and Immunology, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Rheumatoid arthritis (RA) predisposes affected individuals to develop multiple chronic conditions (i.e., multimorbidity). Mechanisms underlying multimorbidity onset in RA are incompletely understood, particularly for…
Abstract Number: 1430 • ACR Convergence 2023
A Proof-of-concept Study Evaluating the Use of Functional Brain Magnetic Resonance Imaging in Assessing Treatment Response in Psoriatic Arthritis Patients
Esther Espartal López¹, Xabier Michelena Vegas², Sara Marsal Barril¹, Alex Rovira³, Deborah Pareto³ and Alba Erra Duran¹, ¹Vall Hebron University Hospital, Rheumatology Department, Barcelona, Spain, ²Hospital Universitari Vall Hebron, Barcelona, Spain, ³Vall Hebron University Hospital, Section of Neuroradiology (Department of Radiology, IDI), Barcelona, Spain
Background/Purpose: Inflammatory cytokines can alter the way the central nervous system processes pain as shown in patients with rheumatoid arthritis. However, the relationship between TNFα…

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