Abstracts Archive - Page 361 of 2607 - ACR Meeting Abstracts

Abstract Number: 0839 • ACR Convergence 2024
Comprehensive Single-cell Analysis Reveals Interferon Pathway Activation and Aberrant B Cell Dynamics in APS Autoimmunity
Haoyu Pan, Xiaohan Wei, Jinyi Qian, Shuyi Yu, Zhixia Yang, Zetao Ding, Chengde Yang and Hui Shi, Department of Rheumatology and lmmunology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, Shanghai, China (People's Republic)
Background/Purpose: Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized with the presence of pathogenic antiphospholipid antibodies (aPL) by autoreactive B cells. However, it remains…
Abstract Number: 0820 • ACR Convergence 2024
The Classification in Axial Spondyloarthritis Inception Cohort Study: Performance of the 2009 Assessments in Spondyloarthritis International Society Classification Criteria
Walter Maksymowych¹, Desiree van der Heijde², Liron Caplan³, Robert Landewé⁴, Lianne S Gensler⁵, Pedro M. Machado⁶, Alexandre Sepriano⁷, Floris van Gaalen⁸, Miranda van Lunteren⁹, Ben Vandermeer¹⁰, Joachim Sieper¹¹, Atul Deodhar¹² and Martin Rudwaleit¹³, and on behalf of CLASSIC Study investigators, ¹University of Alberta, Edmonton, AB, Canada, ²Department of Rheumatology, Leiden University Medical Center, Meerssen, Netherlands, ³Rocky Mountain Regional VAMC, Aurora, CO, ⁴Amsterdam University Medical Center, Meerssen, Netherlands, ⁵Department of Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ⁶Department of Rheumatology, University College London Hospitals NHS Foundation Trust; and Department of Rheumatology, Northwick Park Hospital, London North West University Healthcare NHS Trust; and Centre for Rheumatology & Department of Neuromuscular Diseases, University College London, London, United Kingdom, ⁷Leiden University Medical Centre, Portela Loures, Portugal, ⁸LUMC, Leiden, Zuid-Holland, Netherlands, ⁹Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands, ¹⁰University of Alberta, Edmonton, Canada, ¹¹Charité University Medicine Berlin, Berlin, Germany, ¹²Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University, Portland, OR, ¹³University of Bielefeld, Klinikum Bielefeld, Bielefeld, Germany
Background/Purpose: The 2009 ASAS classification criteria had sensitivity of 83% and specificity of 84% for a rheumatologist diagnosis of axSpA. However, their implementation revealed varying…
Abstract Number: 0849 • ACR Convergence 2024
Effectiveness of Tocilizumab in Aortitis and Aneurysms Associated with Giant Cell Arteritis. Multicenter Open-label Study
Adrián Martín-Gutiérrez¹, Javier Loricera², Carmen Secada Gómez³, Iñigo Hernández-Rodríguez⁴, Susana Romero Yuste⁵, Eugenio De Miguel⁶, Eva Galindez-Agirregoikoa⁷, ivan Ferraz-Amaro⁸, Julio Sánchez-Martín⁹, Patricia Moya Albarado¹⁰, Cristina Campos Fernández¹¹, Fernando Lopez-Gutierrez¹², Santos Castañeda¹³ and Ricardo Blanco-Alonso¹⁴, and the Tocilizumab in Giant Cell Arteritis Spanish Collaborative Group, ¹Hospital Universitario Marques de Valdecilla, IDIVAL, Renedo de Piélagos, Cantabria, Spain, ²Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, ³Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, ⁴Complejo Hospitalario Universitario de Vigo, Vigo, Spain, ⁵Department of Rheumatology, University Hospital Complex of Pontevedra, Pontevedra, Spain, ⁶Hospital Universitario La Paz, Madrid, Spain, ⁷BASURTO UNIVERSITY HOSPITAL, BILBAO, Spain, ⁸Rheumatology, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Canarias, Spain, ⁹Hospital Universitario 12 de Octubre, Madrid, Spain, ¹⁰Hospital de San Pau, Barcelona, Spain, ¹¹Escuela de Doctorado, Universidad Católica de Valencia San Vicente Mártir, Valencia, Spain, ¹²Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Cantabria, Spain, ¹³Hospital Universitario de la Princesa, Madrid, Spain, ¹⁴Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain
Background/Purpose: Giant Cell Arteritis (GCA) was initially described involving mainly the extracranial branches of the carotid arteries. However, GCA also may involve the aorta (GCA-aortitis)…
Abstract Number: 0618 • ACR Convergence 2024
Comparison of Cell Type-Specific Polygenic Risk in Systemic Lupus Erythematosus Patient and Healthy Controls
Liyoung Kim¹, Vitor Aguiar², Daniela Fernandez-Salinas³, Jeffrey Sparks⁴, Peter Nigrovic¹, Joyce Chang² and Maria Gutierrez-Arcelus², ¹Boston Children's Hospital, Brookline, MA, ²Boston Children's Hospital, Boston, MA, ³Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, ⁴Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Boston, MA
Background/Purpose: Polygenic risk scores quantify the composite impact of numerous genetic variants to predict disease risk. However, conventional polygenic risk scores have limitations in revealing…
Abstract Number: 0854 • ACR Convergence 2024
The OMERACT GCA Phantom Project: Validation of 3D Printed Ultrasound Training Models for Giant Cell Arteritis
Valentin Sebastian Schäfer¹, Tobias Schremmer², Florian Recker³, Wolfgang Hartung⁴, Christina Duftner⁵, Sara Monti⁶, Alojzija Hocevar⁷, Rositsa Karalilova⁸, Annamaria Iagnocco⁹, pierluigi macchioni¹⁰, Giuseppe Antonio Germano¹¹, ESPERANZA NAREDO¹², Eugenio De Miguel¹³, Luca Seitz¹⁴, Thomas Daikeler¹⁵, Dennis Boumans¹⁶, Chetan Mukhtyar¹⁷, Kate Smith¹⁸, Richard Wakefield¹⁸, Andreas Diamantopoulos¹⁹, Stavros Chrysidis²⁰, Berit Dalsgaard Nielsen²¹, Kresten Keller²², Uffe Moller Dohn²³, Lene Terslev²⁴, Marcin Milchert²⁵, Wolfgang Schmidt²⁶, George A. W. Bruyn²⁷, Aaron Juche²⁸ and Christian Dejaco²⁹, ¹Clinic of Internal Medicine III, Department of Rheumatology, University Hospital of Bonn, Bonn, Germany, 53127 Bonn, Nordrhein-Westfalen, Germany, ²Helios Klinikum Bonn/Rhein-Sieg, Bonn, Germany, ³Department for Gynecology and Obstetrics, University Hospital Bonn, Germany, Bonn, Germany, ⁴Asklepios Clinic, Tegernheim, Germany, ⁵Medical University Innsbruck/Tirol Kliniken GmbH, Innsbruck, Austria, ⁶IRCCS Istituto Auxologico Italiano, Milan, Italy, ⁷University Medical Center Ljubljana, LJUBLJANA, Slovenia, ⁸Medical University of Plovdiv, Bulgaria, Plovdiv, Bulgaria, ⁹University of Turin, Italy, Roma, Italy, ¹⁰SERVIZIO REUMATOLOGIA IRCCS REGGIO EMILIA, Reggio Emilia, Italy, ¹¹Rheumatology Unit- Arcispedale Santa Maria Nuova Reggio Emilia-Italy, Reggio Emilia, Italy, ¹²Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain, ¹³Hospital Universitario La Paz, Madrid, Spain, ¹⁴Inselspital, Liebefeld, Switzerland, ¹⁵university hospital, Basel, Switzerland, ¹⁶Ziekenhuisgroep Twente (Hospital Group Twente), Borne, Netherlands, ¹⁷Norfolk and Norwich University Hospital, Norwich, United Kingdom, ¹⁸NIHR Leeds Biomedical Research Centre, Leeds, UK., Leeds, United Kingdom, ¹⁹Akershus University Hospital, Lørenskog, Norway, ²⁰Department of Rheumatology, University Hospital of Southern Denmark, Esbjerg, Denmark, ²¹Department of Rheumatology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, Vejle, Denmark, ²²Aarhus University Hospital, Aarhus, Denmark, ²³Rigshospitalet-Glostrup, Glostrup, Denmark, ²⁴Rigshospitalet-Glostrup & COPECARE, Glostrup, Denmark, ²⁵Department of Rheumatology, Internal Medicine, Geriatrics and Clinical Immunology, Pomeranian Medical University, Szczecin, Poland., Szczecin, Poland, ²⁶Immanuel Krankenhaus Berlin, Berlin, Germany, ²⁷Reumakliniek Lelystad, Loenga, Netherlands, ²⁸Immanuel Krankenhaus Berlin, Medical Centre for Rheumatology Berlin-Buch, Berlin, Germany, Berlin, Germany, ²⁹Azienda Sanitaria Alto Adige, Brunico, Italy
Background/Purpose: Ultrasonography has been validated as a diagnostic tool for giant cell arteritis (GCA). Due to the urgent need for glucocorticoid treatment in acute GCA…
Abstract Number: 0393 • ACR Convergence 2024
Effectiveness of Secukinumab in TMJ Symptoms in Children with JPsA and ERA: A Secondary Data Analysis of JUNIPERA
Marianne Kerski¹, Smriti Mohan¹, Cynthia Vizcaya², Reema Sutariya³, Weibin Bao³ and Matthew Stoll⁴, ¹University of Michigan, Ann Arbor, MI, ²Novartis Pharmaceutical Corporation, East Hanover, NJ, ³Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁴University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Early recognition and treatment of temporomandibular joint (TMJ) arthritis in children with juvenile idiopathic arthritis (JIA) is of high importance given its impact on…
Abstract Number: 0395 • ACR Convergence 2024
Assessment of Enthesitis by Pediatric Rheumatology Providers
Erin Treemarcki¹, Shirley Tse², Marisa Klein-Gitelman³, Adam Mayer⁴, Hemalatha Srinivasalu⁵, Heather Walters⁶ and Melissa Oliver⁷, and the CARRA Juvenile Spondyloarthritis Workgroup and the CARRA investigators, ¹University of Utah, Salt Lake City, UT, ²SickKids, Toronto, ON, Canada, ³Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁴University of Pennsylvania/Children's Hospital of Philadelphia, Philadelphia, PA, ⁵Children's National Hospital, Washington, DC, ⁶Northwell Health, New Hyde Park, NY, ⁷Indiana University, Indianapolis, IN
Background/Purpose: Enthesitis is a characteristic feature of enthesitis related arthritis (ERA) but can be found in other juvenile idiopathic arthritis (JIA) subtypes. It occurs with…
Abstract Number: 0635 • ACR Convergence 2024
Medical Record Natural Language Processing and Patient Biometric and Self-Reported Measures Inform an Artificial Intelligence Augmented Remote Care Management Strategy for Lupus Patients
Gerald Lushington¹, Bruce Wang², Mohan Purushothaman³, Melissa Munroe⁴, Vijay R. Nadipelli⁵, Bernard Rubin², Jessica Crawley², Beth Valashinas⁶, Reshma Khan⁷, Anil Warrier⁸, Joseph Huffstutter⁹, Jennifer Murphy¹⁰, Lizeth Santamaria², Sneha Nair², Georg Armstrong², Sandeep Nair², Daniele DeFreese³, Adrian Holloway³, Arif Sorathia², Brett Adelman², Fabricio Pautasso² and Eldon Jupe³, ¹Progentec Diagnostics, Inc, Oklahoma City, OK, ²Progentec Diagnostics, Inc., Oklahoma City, OK, ³Progentec Diagnostics, Inc., Oklahoma City, ⁴Oklahoma Medical Research Foundation; Progentec Diagnostics, Inc., Oklahoma City, OK, ⁵GSK, Medical Evidence Generation, Philadelphia, PA, ⁶Physicians Alliance of Connecticut, Milford, CT, ⁷Palm Beach Rheumatology and Wellness Center, Jupiter, FL, ⁸Millennium Rheumatology, Conroe, TX, ⁹Arthritis Associates PLLC, Signal Mountain, TN, ¹⁰Articularis Healthcare, Summerville, SC
Background/Purpose: Systemic lupus erythematosus (SLE) is one of several rheumatologic disorders that presents frequent healthcare challenges, particularly for socioeconomic and geographically disadvantaged patients. Due to…
Abstract Number: 0769 • ACR Convergence 2024
Baseline Evaluation of Diagnoses and Prescribing Patterns in Polymyalgia Rheumatica
Laura Stradford¹, Shilpa Venkatachalam², Kelly Gavigan³, Angela Degrassi³, Emily Holladay⁴, Fenglong xie⁵, Yujie Su⁶, Shanette Daigle⁷ and Jeffrey Curtis⁸, ¹Global Healthy Living Foundation, Nyack, NY, ²Global Healthy Living Foundation, New York, NY, ³Global Healthy Living Foundation, Upper Nyack, NY, ⁴University of Alabama at Birmingham, Birmingham, AL, ⁵University of Alabama at Birmingham; Illumination Health, Birmingham, AL, ⁶Illumination Health, Hoover, AL, ⁷FASTER, Birmingham, AL, ⁸University of Alabama at Birmingham, Hoover, AL
Background/Purpose: Polymyalgia rheumatica (PMR) is a chronic inflammatory rheumatic condition that affects approximately 800,000 people in the U.S., occurring almost exclusively after age 50. Moreover,…
Abstract Number: 0402 • ACR Convergence 2024
Reporting of Clinical Features and Outcome Measures in Still’s Disease: A Systematic Literature Review of sJIA and AOSD Cohorts
Mariana Correia Marques¹, Erin Balay-Dustrude², Claudia Bracaglia³, Marinka Twilt⁴, Karen Onel⁵, Simone Appenzeller⁶, Fatma Dedeoglu⁷, Esraa Eloseily⁸, Penelope Martinez Jimenez⁹, Rebecca Trachtman¹⁰, Francesca Minoia¹¹ and Susan Shenoi¹², and on behalf of the MAS/sJIA WP of PReS and CARRA sJIA Workgroup, ¹National Institutes of Health, Bethesda, MD, ²University of Washington, Seattle, WA, ³IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, ⁴Alberta Children's Hospital, University of Calgary, Cumming School of Medicine, Calgary, Alberta, Canada, Calgary, AB, Canada, ⁵HSS, New York, NY, ⁶Department of Orthopedics, Rheumatology and Traumatology. University of Campinas, Campinas, Brazil, ⁷Boston Children's Hospital, Boston, MA, ⁸Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁹Icahn School of Medicine at Mount Sinai- Elmhurst Hospital Center, Rego Park, NY, ¹⁰Icahn School of Medicine at Mount Sinai, New York, NY, ¹¹Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy, Milan, Italy, ¹²Seattle Children's Hospital and Research Center, Mercer Island, WA, WA
Background/Purpose: Multinational research is essential to globally improve the management of systemic juvenile idiopathic arthritis (sJIA), improve recognition of rare complications like lung disease, and…
Abstract Number: 0829 • ACR Convergence 2024
Epstein-Barr Virus Infection Triggers Hyperinflammation and Cytokine Storm in Healthy Children
Kailey Brodeur¹, Meng Liu², Rachel Weng², Evan Hsu², Lauren Henderson³, Fatma Dedeoglu², Jane Newburger³, Peter Nigrovic⁴, Mary Beth Son⁴ and Pui Lee⁵, ¹Boston Children's Hospital, Cumberland, RI, ²Boston Children's Hospital, Boston, MA, ³Boston Children's Hospital, Watertown, MA, ⁴Boston Children's Hospital, Brookline, MA, ⁵Boston Children's Hospital, Newton, MA
Background/Purpose: Epstein-Barr virus (EBV) is common pathogen responsible for infectious mononucleosis but also triggers hemophagocytic lymphohistiocytosis (HLH). This variation in the immune response to EBV…
Abstract Number: 0848 • ACR Convergence 2024
Impact of SGLT2i Initiation on the Need for Urate-Lowering Therapy and Colchicine Among Gout Patients with Type 2 Diabetes:Propensity-Score Matched, Active Comparator, New User Design Study
Gregory Challener¹, kevin sheng-kai ma¹, Minna Kohler¹, Chio Yokose², Janeth Yinh¹, Natalie McCormick¹ and Hyon K. Choi³, ¹Massachusetts General Hospital, Boston, MA, ²Massachusetts General Hospital, Waltham, MA, ³Massachusetts General Hospital, Lexington, MA
Background/Purpose: Sodium-glucose cotransporter-2 inhibitors (SGLT2is), initially approved for type 2 diabetes (T2D), have been demonstrated to reduce serum urate levels [1-4] and are associated with…
Abstract Number: 0856 • ACR Convergence 2024
Comparative Effectiveness of Disease Modifying Antirheumatic Drugs for Cardiac Sarcoidosis
Michael Putman¹, Lisbeth Brooks², William Kivlin², Divyanshu Mohananey² and Viktoriya Sabchyshyn², ¹The Medical College of Wisconsin, Milwaukee, WI, ²Medical College of Wisconsin, Milwaukee, WI
Background/Purpose: No studies to date have evaluated the comparative efficacy of disease modifying antirheumatic drugs (DMARDs) for cardiac sarcoidosis. Methods: We performed a retrospective cohort…
Abstract Number: 0758 • ACR Convergence 2024
Difficult to Treat Takayasu Arteritis: Comparative Efficacy of Colchicine and Tofacitinib
Ravi Kumar¹, Prabhu Vasanth², Ramya Janardhana³, Arvind Ganapati⁴, Abhishek Patil⁵, Avinash Jain⁶, Benzeeta Pinto⁷, Ramesh Jois⁸, Shivraj Padiyar⁹, John Mathew⁹, Vineeta Shobha³, George Joseph² and Ruchika goel⁹, ¹Christian Medical college , Vellore , India, Bangalore, India, ²Christian Medical college , Vellore , India, Vellore, Tamil Nadu, India, ³St. John’s Medical College, Bengaluru , India, Bangalore, India, ⁴Kasturba Medical College, Rheumatology Division, Manipal , India, Vellore, Tamil Nadu, India, ⁵Manipal Hospital, Rheumatology, Bengaluru, India, Bengaluru, India, ⁶SMS Medical College and Hospital, Jaipur ,India, JAIPUR, India, ⁷St. John’s Medical College, Bengaluru , India, Bengaluru, India, ⁸Manipal Hospital ,Rheumatology, Millers Road, Bengaluru, India, Bengaluru, India, ⁹Christian Medical college , Vellore , India, Vellore, India
Background/Purpose: Biologic DMARDs (bDMARDs) are mainstay in management of patients with difficult to treat Takayasu Arteritis (D2TTAK). The cost of long-term biologics is prohibitory in…
Abstract Number: 0673 • ACR Convergence 2024
BCMA-CD19 Compound CAR-T (cCAR) Safely Provides a Complete Humoral Reset Eliminating All Autoantibodies Resulting in Long-term Medication-Free Complete Remission Among Systemic Lupus Erythematosus (SLE) and Lupus Nephritis (LN) Patients
Yong Yuan¹, Shanzhi He², Wenli Zhang³, Hongyu Zhang⁴, Vincent M DeStefano⁵, Masayuki Wada⁵, Kevin Pinz⁵, Greg Deener⁵, Yu Ma⁶, Min Wang², Fugui Li⁷, Ming Hong¹, Chanjuan Zou², Mingxia Wang², Ling Ding², Yingwen Liang⁸, Yupo Ma⁵ and Weija Wang⁹, ¹Department of Translational Medicine, Zhongshan people's Hospital, Zhongshan, China (People's Republic), ²Department of Rheumatoid Immunology, Zhongshan people's Hospital, Zhongshan, China (People's Republic), ³Department of Hematology, Peking University Shenzhen Hosptial, Shenzhen, China (People's Republic), ⁴Department of Hematology, Peking University Shenzhen Hospital, Shenzhen, China (People's Republic), ⁵iCell Gene Therapeutics, Inc., Stony Brook, NY, ⁶iCAR Bio Therapeutics Ltd, Zhongshan, China (People's Republic), ⁷Department of Translational Medicine. Zhongshan people's Hospital, Zhongshan, China (People's Republic), ⁸Department of Translational Medicine, Zhongshan's people Hospital, Zhongshan, China (People's Republic), ⁹Department of Translational Research, Zhongshan people's Hospital, Zhongshan, China (People's Republic)
Background/Purpose: Medication free complete remission (CR) has been elusive in SLE. An open label investigator-initiated trial (IIT) infused SLE/LN patients with a novel cCAR targeting…

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