ACR Meeting Abstracts

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  • Abstract Number: 0747 • ACR Convergence 2024

    Clofutriben to Improve the Benefit-Risk Profile of Prednisolone in Patients with Polymyalgia Rheumatica

    FRANK HARTMUT DR. BUTTGEREIT1, Andrea Everding2, Ioana Andreica3, Herbert Kellner4, Florian Schuch5, Tonya K Marmon6, Frank S Czerwiec7, Ketan Desai8 and David A Katz9, 1Charité University Medicine Berlin, Berlin, Germany, 2Hamburger Rheuma Forschungszentrum II, Hamburg, Germany, 3Rheumazentrum Ruhrgebiet, Bochum, Germany, 4Schwerpunktpraxis f�r Rheumatologie und Gastroenterologie, Munich, Germany, 5PGRN, Erlangen, Germany, 6Marmon Biostatistics, Seattle, WA, 7Sparrow Pharmaceuticals, Portand, OR, 8IMC, Easton, PA, 9Sparrow Pharmaceuticals, Portland, OR

    Background/Purpose: 11β-hydroxysteroid dehydrogenase type 1 (HSD-1) differentially regulates intracellular glucocorticoid levels in the immune system and glucocorticoid toxicity target organs. Clofutriben is a potent HSD-1…
  • Abstract Number: 0809 • ACR Convergence 2024

    The Utility of the sFlt1:PlGF Ratio to Rule out and Predict Preeclampsia in Women with Lupus

    Megan Clowse1, Kateena Addae-Konadu2, Jerome Federspiel3, Jennifer Gilner2, Andra James2, Eugene Kovalik2, Anika Lucas3, Laura Neil2, Catherine Sims4, Amanda Snyderman2, Samir Soneji2 and Amanda Eudy5, 1Duke University, Chapel Hill, NC, 2Duke University School of Medicine, Durham, 3Duke University School of Medicine, Durham, NC, 4Duke University, Knightdale, NC, 5Duke University, Raleigh, NC

    Background/Purpose: Women with SLE have high rates of preeclampsia caused by poor placental vascularization. The FDA recently approved the ratio of two angiogenic factors, soluble…
  • Abstract Number: 0790 • ACR Convergence 2024

    CoLchicine for Treatment of OsteoArthritis of the Knee: Clinical Outcomes from a 90-day Double-Blind, Placebo-Controlled Study

    Jonathan Samuels1, Katherine Tse2, Wei David2, maryfe Coronel2, Fernando Bomfim2, Renata La Rocca Vieira3, Nicole Leung4, Svetlana Krasnokutsky Samuels5, Michael Toprover6 and Michael Pillinger7, 1NYU Langone, Rye Brook, NY, 2NYU Langone Health, new york, NY, 3NYU., New York, NY, 4New York University Langone Medical Center, New York, NY, 5Summit Health, Rye Brook, NY, 6New York University Langone Health, New York, NY, 7New York University Grossman School of Medicine, New York,, NY

    Background/Purpose: Knee osteoarthritis (OA) leads to progressive disability, but approved pharmacologic treatments target analgesia without affecting disease course. Colchicine is well-tolerated and inhibits inflammation thought…
  • Abstract Number: 0819 • ACR Convergence 2024

    The Assessment of SpondyloArthritis International Society (ASAS) Definition of Difficult-to-Manage Axial Spondyloarthritis

    Denis Poddubnyy1, Xenofon Baraliakos2, Victoria Navarro Compán3, Murat Torgutalp4 and Desiree van der Heijde5, and ASAS Difficult-to-Manage Axial Spondyloarthritis Task Force, 1Charite-Universitatsmedizin Berlin, Berlin, Germany, 2Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, 3La Paz University Hospital, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain, 4Charite Universitatsmedizin - Berlin, Berlin, Germany, 5Department of Rheumatology, Leiden University Medical Center, Meerssen, Netherlands

    Background/Purpose: Non-response to standard treatments represents a management challenge in axial Spondyloarthritis (axSpA). The Assessment of SpondyloArthritis international Society (ASAS) seeks to define 'difficult-to-manage axSpA'…
  • Abstract Number: 0588 • ACR Convergence 2024

    Sex-Related Differences in Baseline Patient and Disease Characteristics: Post Hoc Analyses of Three Phase 3, Randomized, Double-blind, Placebo-Controlled Studies in Patients with Active Psoriatic Arthritis

    Laura Coates1, Carlo Selmi2, Philip Mease3, Alexis Ogdie4, Francois Nantel5, Frederic Lavie6, Mohamed Sharaf7, Oyediran Adelakun8, Emmanouil Rampakakis9, Laura Pina Vegas10 and Lihi Eder11, 1University of Oxford, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford, United Kingdom, 2Department of Biomedical Sciences, Humanitas University, Rozzano, Italy, 3Swedish Medical Center/Providence St. Joseph Health; University of Washington School of Medicine, Seattle, WA, 4Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 5Nantel MedSci Consult, Montreal, QC, Canada, 6Janssen Cilag Global Medical Affairs, Immunology Global Medical Affairs, Issy les Moulineaux, France, 7Johnson & Johnson, Middle East FZ LLC, Dubai, UAE, Dubai, United Arab Emirates, 8Janssen Research & Development, LLC, Titusville, NJ, 9McGill University, Department of Pediatrics / Scientific Affairs, JSS Medical Research Inc., Montreal, QC, Canada, 10Leiden University Medical Center, Leiden, Netherlands, 11University of Toronto, Women’s College Hospital and Department of Medicine, Toronto, ON, Canada

    Background/Purpose: Although PsA occurs in males and females at similar rates, clinical manifestations and outcomes differ between sexes. Findings from real-world evidence (RWE) studies have…
  • Abstract Number: 0824 • ACR Convergence 2024

    The Effect of Intranasal Niclosamide on Nasal Symptoms in Patients with ENT Manifestations of ANCA-Associated Vasculitis (AAV): Post Hoc Analysis of Subset of Patients Recruited to the PROTECT-V Trial

    Benjamin Lim1, Wendi Qian1, Francis Dowling2, Michael Chen-Xu1, Alan Salama3 and Rona Smith4, 1University of Cambridge, Cambridge, 2Cambridge University Hospitals NHS Foundation Trust, Cambridge, 3University College London, London, 4University of Cambridge, Cambridge, United Kingdom

    Background/Purpose: Ear, nose and throat (ENT) manifestations are common in ANCA associated vasculitis (AAV), particularly the PR3 (proteinase 3) sub type.  There is unmet need…
  • Abstract Number: 0378 • ACR Convergence 2024

    Disparate Disease Activity Outcomes Associated with Demographic Variables in Patients with Juvenile Idiopathic Arthritis in the Pediatric Rheumatology Care and Outcomes Improvement Network Registry

    Julia Harris1, Catherine Bingham2, Sheetal Vora3, Cagri Yildirim-Toruner4, Kerry Ferraro5, Erik Friedrichsen6, Michelle Batthish7, Jon Burnham8, Danielle Fair9, Suhas Ganguli10, Mileka Gilbert11, Beth Gottlieb12, Tzielan Lee13, Daniel Lovell14, Melissa Mannion15, Edward Oberle16, Nancy Pan17, Linda Ray18, Michael Shishov19, Mary Toth20 and Esi Morgan21, 1Children's Mercy Kansas City, Overland Park, KS, 2Penn State Children’s Hospital, Hershey, 3Atrium Health Levine Children's Hospital, Charlotte, NC, 4Baylor College of Medicine/ Texas Children's Hospital, Houston, TX, 5JIA parent and CHOP volunteer, Lower Gwynedd, PA, 6Seattle Children's Hospital, Seattle, 7McMaster Children's Hospital, Hamilton, ON, Canada, 8Children's Hospital of Philadelphia, Philadelphia, PA, 9Medical College of Wisconsin/Children's Wisconsin, Wauwatosa, WI, 10Hackensack University Medical Center, Hackensack, 11Medical University of South Carolina, Charleston, SC, 12Cohen Children's Medical Center, Lake Success, NY, 13Stanford University School of Medicine, Palo Alto, CA, 14Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 15University of Alabama at Birmingham, Birmingham, AL, 16Nationwide Children's Hospital, Columbus, OH, 17Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, 18University of Mississippi Medical Center, Jackson, MS, 19Phoenix Children's Hospital, Phoenix, AZ, 20Nemours Foundation, Orlando, FL, 21Seattle Children's Hospital, Seattle, WA

    Background/Purpose: The Pediatric Rheumatology Care and Outcomes Improvement Network (PR-COIN) is a North American learning health network focused on improving outcomes in patients with juvenile…
  • Abstract Number: 0395 • ACR Convergence 2024

    Assessment of Enthesitis by Pediatric Rheumatology Providers

    Erin Treemarcki1, Shirley Tse2, Marisa Klein-Gitelman3, Adam Mayer4, Hemalatha Srinivasalu5, Heather Walters6 and Melissa Oliver7, and the CARRA Juvenile Spondyloarthritis Workgroup and the CARRA investigators, 1University of Utah, Salt Lake City, UT, 2SickKids, Toronto, ON, Canada, 3Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 4University of Pennsylvania/Children's Hospital of Philadelphia, Philadelphia, PA, 5Children's National Hospital, Washington, DC, 6Northwell Health, New Hyde Park, NY, 7Indiana University, Indianapolis, IN

    Background/Purpose: Enthesitis is a characteristic feature of enthesitis related arthritis (ERA) but can be found in other juvenile idiopathic arthritis (JIA) subtypes. It occurs with…
  • Abstract Number: 0605 • ACR Convergence 2024

    Guselkumab Binding to CD64+ IL-23–Producing Myeloid Cells Enhances Potency for Neutralizing IL-23 Signaling

    Dennis McGonagle1, Raja Atreya2, Maria Abreu3, James Krueger4, Kilian Eyerich5, Robert Bissonnette6, Carrie Greving7, He Li8, Tom C. Freeman9, Amy Hart8, Brice Keyes7, Brian Stoveken8, John Hartman8, Kristin Leppard8, Jenna Parrett10, Joshua Wertheimer8, Indra Sarabia7, Janise Deming7, Kristen Kohler7, Christopher Ritchlin11, Iain McInnes12, Matthieu Allez13, Anne Fourie7 and Kacey Sachen7, 1National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds Teaching Hospitals, Leeds, UK, Leeds, England, United Kingdom, 2Department of Medicine I, Gastroenterology, Endocrinology and Pneumology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany, 3Leonard M. Miller School of Medicine, University of Miami, Miami, FL, 4The Rockefeller University, Laboratory for Investigative Dermatology, New York, NY, 5Karolinska Institute, Department of Medicine – Division of Dermatology and Venereology, Stockholm, Sweden; Medical Center, University of Freiburg, Freiburg, Germany, 6Innovaderm Research Inc., Montréal, QC, Canada, 7Janssen Research & Development, LLC, Immunology, San Diego, CA, 8Janssen Research & Development, LLC, Therapeutics Discovery, Spring House, PA, 9Janssen Research & Development, LLC, Spring House, PA, USA, Spring House, PA, 10Janssen Scientific Affairs, LLC, Horsham, PA, 11Department of Medicine, Allergy, Immunology, and Rheumatology Division, University of Rochester Medical School, Canandaigua, NY, 12University of Glasgow, College of Medical Veterinary and Life Sciences, Glasgow, United Kingdom, 13Hôpital Saint-Louis, Université Paris Cité, Paris, France

    Background/Purpose: IL-23 is implicated in the pathogenesis of psoriasis (PsO), and myeloid cells that express FcγRI (CD64) have been identified as a primary source of…
  • Abstract Number: 0739 • ACR Convergence 2024

    One Year Outcomes in Those with Isolated PMR Recruited via a Fast Track PMR Clinic

    Patricia Harkins1, Sharon Cowley2, Robert Harrington3, seoidin McKittrick4, David Kane5 and Richard Conway6, 1Trinity College Dublin, Dublin 8, Dublin, Ireland, 2Tallaght University Hospital, Dublin, Dublin, Dublin, Ireland, 3St. James's Hospital, Dublin, Dublin, Ireland, 4University of Limerick, Limerick, Ireland, 5Tallaght University Hospital & Trinity College Dublin, D24, Ireland, 6Trinity College Dublin, Dublin, Ireland

    Background/Purpose: To date the longitudinal outcomes of those with isolated Polymyalgia Rheumatica (PMR) are poorly understood, owing largely to the fact that in the majority…
  • Abstract Number: 0387 • ACR Convergence 2024

    Absolute Agreement and Inter-rater Reliability of a Web-based Standardized Scoring Tool for Magnetic Resonance Images from Children with Chronic Nonbacterial Osteomyelitis (CNO) Amongst Radiologists

    Farzana Nuruzzaman1, T. Shawn Sato2, Jennifer Stimec3, Ramesh S. Iyer4, Andrew Carbert5, Joel Paschke5, Lauren Potts6, Xiaoyue Zhang7, Walter Maksymowych8, Polly Ferguson9 and Yongdong (Dan) Zhao10, and CARRA CRMO Workgroup, 1Stony Brook Children's Hospital, Stony Brook, NY, 2University of Iowa, Iowa City, 3Hospital for Sick Children, Toronto, ON, Canada, 4Seattle Children's Hospital, Seattle, WA, 5CARE Arthritis, Edmonton, AB, Canada, 6Artist, Long Beach, CA, 7Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, 8University of Alberta, Edmonton, AB, Canada, 9University of Iowa Carver College of Medicine, Iowa City, IA, 10University of Washington, Redmond, WA

    Background/Purpose: The web-based ChRonic nonbacterial Osteomyelitis Magnetic Resonance Imaging Scoring (CROMRIS) portal was developed to assess specific features of bone and soft tissue inflammation in…
  • Abstract Number: 0799 • ACR Convergence 2024

    Peripheral Biomarker Signatures and a Genetic Risk Score Improve the Identification of RA-ILD Beyond Clinical Risk Factors

    Austin Wheeler1, Thomas Riley2, Joshua Baker3, Yangyuna Yang1, Punyasha Roul4, Katherine Wysham5, grant Cannon6, Gary Kunkel7, Gail Kerr8, Dana Ascherman9, Paul Monach10, Andreas Reimold11, Jill Poole1, Tony Merriman12, Ted Mikuls1 and Bryant England1, 1University of Nebraska Medical Center, Omaha, NE, 2Hopsital of the University of Pennsylvania, Philadelphia, PA, 3University of Pennsylvania, Philadelphia, PA, 4UNMC, Omaha, NE, 5VA PUGET SOUND/UNIVERSITY OF WASHINGTON, Seattle, WA, 6University of Utah and Salt Lake City VA, Salt Lake City, UT, 7University of Utah and George E Wahlen VAMC, Salt Lake City, UT, 8Washington DC VAMC/Georgetown and Howard Universities, Washington, DC, 9Division of Rheumatology and Clinical Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA, 10VA Boston Healthcare System, Boston, MA, 11Dallas VA Medical Center, Dallas, TX, 12University of Alabama at Birmingham, Homewood, AL

    Background/Purpose: Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is an extra-articular manifestation of RA that causes substantial morbidity and mortality. Despite the paucity of known risk…
  • Abstract Number: 0818 • ACR Convergence 2024

    Defining BASDAI Cut-offs for Disease Activity States in Axial Spondylarthritis – Results from the EuroSpA Collaboration

    Stylianos Georgiadis1, Lykke Oernbjerg1, Brigitte Michelsen2, Tore K. Kvien3, Simon Horskjær Rasmussen4, Jakub Závada5, Kristýna Bubová6, Bente Glintborg7, Anne Gitte Loft8, Ana Maria Rodrigues9, Maria Jose Santos10, Adrian Ciurea11, Michael Nissen12, Laura Kuusalo13, Jarno Rutanen14, Ziga Rotar15, Katja Perdan-Pikmajer15, Bjorn Gudbjornsson16, Olafur Palsson17, Daniela DiGuiseppe18, Mikkel Ostergaard19 and Merete Hetland20, 1Rigshospitalet Glostrup, Glostrup, Hovedstaden, Denmark, 2Rigshospitalet Glostrup, Diakonhjemmet Hospital and Sørlandet Hospital, Copenhagen, Denmark, 3Center for treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway and University of Oslo (UiO), Institute of Clinical Medicine, Oslo, Norway, Oslo, Norway, 4Rigshospitalet Glostrup, Glostrup, Denmark, 5Institute of Rheumatology and Charles University, Praha, Czech Republic, 6Institute of Rheumatology and Charles University, Prague, Czech Republic, 7DANBIO, Rigshospitalet Glostrup and University of Copenhagen, Virum, Denmark, 8Aarhus University Hospital and Aarhus University, Horsens, Denmark, 9Nova Medical School and Hospital dos Lusíadas, Lisbon, Portugal, 10Hospital Garcia de Orta and Centro Académico de Medicina de Lisboa, Lisboa, Portugal, 11University Hospital Zurich, Zürich, Switzerland, 12Geneva University Hospital, Geneva, Switzerland, 13University of Turku and Turku University Hospital, Turku, Finland, 14Tampere University Hospital, Tampere, Finland, 15University Medical Centre Ljubljana and University of Ljubljana, Ljubljana, Slovenia, 16Landspitali University Hospital and University of Iceland, Reykjavik, Iceland, 17University of Iceland and Skåne University Hospital, Reykjavik, Iceland, 18Karolinska Institutet, Stockholm, 19Department of Clinical Medicine, University of Copenhagen and Center for Rheumatology, Copenhagen Center for Arthritis Research, Glostrup, Denmark, 20Rigshospitalet Glostrup and University of Copenhagen, Glostrup, Denmark

    Background/Purpose: While the Axial Spondyloarthritis Disease Activity Score based on C-reactive protein (ASDAS) is recommended for assessment of disease activity in patients with axial spondyloarthritis…
  • Abstract Number: 0826 • ACR Convergence 2024

    Plasma Exchange for Severe Alveolar Hemorrhage in ANCA-Associated Vasculitis: Emulation of a Target Trial

    Anne-Claire Sanna1, Ségolène Gendreau2, Cyrielle Desnos3, Dimitri Titeca-Beauport4, Jolan Malherbe5, Florian Reizine6, Kladoum Nassarmadji7, Louis Guillaume8, Alban Deroux9, Eddine Bendiab10, Jennifer Catano11, Julien Campagne12, Marc Pineton de Chambrun13, Valentin Coirier14, Clara Vigneron11, Maxime SAMSON15, Antoine Neel16, Benoît Brilland17, Jean-Philippe Martellosio18, Maxim Desgrouas19, Olivier Simon20, Perrine SMETS21, Romain Paule22, Stanislas Faguer23, Stéphane Giorgiutti24, Thylbert Deltombe20, François Arrive18, Ingrid Masson25, Thomas Quemeneur26, Cécile Audrey Durel27, Etienne de Montmollin11, François Perrin28, Herve Lobbes29, Quentin Lajoye30, Rafik Mesbah31, Rodéreau Outh32, Adeline Lacraz33, Damien Contou34, Fabien Parazols35, Florian Garo36, Grégoire Ducoux37, Halil Yildiz38, Isabelle Rey39, Viviane Queyrel40, Rita Eid11, Robin Arcani41, Xavier Puéchal42, Raphael Porcher43, Nicolas de Prost11 and Benjamin Terrier44, and French Vasculitis Study Group (FVSG); Groupe de Recherche en Réanimation Respiratoire du patient d'Onco-Hématologie (GrrrOH), 1Cochin Hospital, Paris, France, 2Mondor Hospital, Paris, 3Tenon Hospital, Paris, France, 4CHU Amiens, Amiens, France, 5CHU Caen, Caen, France, 6CHU Vannes, Vannes, 7APHP, Paris, 8Hopital de Metz, Metz, France, 9Clinique Universitaire de Médecine Interne, Department of Internal Medicine, Grenoble University Hospital, Grenoble, France, 10CHU Montpellier, Montpellier, France, 11APHP, Paris, France, 12Hôpital Robert Schuman - Competence center for autoimmune diseases, Internal Medicine, Metz, France, 13Sorbonne Université, Paris, France, 14CHU Rennes, Rennes, France, 15Dijon University Hospital, Dijon, France, 16Department of Internal Medicine, CHU Nantes, Nantes, France, 17CHU Angers, Angers, France, 18CHU Poitiers, Poitiers, France, 19CHU Orléans, Orleans, France, 20CHU Réunion, Réunion, France, 21Clermont Ferrand University Hospital - National reference center for autoimmune disease, Internal Medicine, Clermont-Ferrand, France, 22Foch Hospital, Suresnes, France, 23CHU Toulouse, Toulouse, France, 24CHRU Strasbourg, Strasbourg, France, 25CHU Saint Etienne, Saint Etienne, France, 26CH Valenciennes, Valenciennes, France, 27HCL, Lyon, France, 28CH Saint Nazaire, Saint Nazaire, France, 29CHU Clermont-Ferrand, Clermont-Ferrand, France, 30CHU Bordeaux, Bordeaux, France, 31CH Boulogne, Boulogne, France, 32CH, Perpignan, France,, Perpignan, France, 33CH Bayonne, Bayonne, France, 34CH Argenteuil, Argenteuil, France, 35CH Perpignan, Perpignan, France, 36CHU Nimes, Nimes, France, 37CHU Lyon, Lyon, France, 38Université de Louvain, Louvain, Belgium, 39CH Annecy, Annecy, France, 40CHU Nice, Nice, France, 41APHM, Marseille, France, 42National Referral Center For Rare Systemic Autoimmune Diseases, Paris, France, 43Department of Rheumatology, Bicêtre AP-HP Hôpital, Université Paris-Saclay, Paris, Ile-de-France, France, 44Service de Médecine interne, Hôpital Cochin, AP-HP, Paris, Ile-de-France, France

    Background/Purpose: Mortality is high in patients with diffuse alveolar hemorrhage (DAH) associated with ANCA-associated vasculitis (AAV). In the PEXIVAS study, plasma exchange (PLEX) did not have a…
  • Abstract Number: 0728 • ACR Convergence 2024

    Glomerular Proteomic Signature in ANCA-associated Glomerulonephritis

    Ivana Stojkic1, Arnon Arazi2, Huijuan Song3, Pearlly Yan4, Estela Puchulu-Campanella4, Hubao Wang3, Lynn Fussner3, Brad Rovin3, Samir Parikh5 and Salem Almaani6, 1Nationwide, Columbus, OH, 2Feinstein Institutes for Medical Research, Melrose, MA, 3The Ohio State University, Columbus, OH, 4The Ohio State University, Columbus, 5Ohio State University, Columbus, OH, 6The Ohio State University Medical Center, Columbus, OH

    Background/Purpose: Crescentic glomerulonephritis (AAGN) is a common manifestation of ANCA-associated vasculitis (AAV) but does not occur in all patients. It is unclear whether the immune…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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