ACR Meeting Abstracts

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  • Abstract Number: 2417 • ACR Convergence 2023

    Influence of Histological Tempol Artery Biopsy Findings on Outcomes of Biopsy-proven Giant Cell Arteritis in Italian Patients : A Long Single Center Follow-up Study

    LUIGI BOIARDI1, PIERLUIGI MACCHIONI2, Francesco Muratore3, Elena Galli4, chiara marvisi4, caterina Ricordi4, federica Macaluso1, alberto cavazza4, Stefania Croci4 and Carlo Salvarani5, 1IRCCS REGGIO EMILIA, Reggio Emilia, Italy, 2Azienda USL -IRCCS di Reggio Emilia, Reggio Emilia, Italy, 3IRCCS di Reggio Emilia, Reggio Emilia, Italy, 4Azienda Unità Sanitaria Locale-IRCCS Di Reggio Emilia, Reggio Emilia, Italy, 5Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy

    Background/Purpose: Few studies have evaluted the influence of histological features of temporal artery biopsy (TAB) on disease outcome in giant cell arteritis (GCA) patients. Our…
  • Abstract Number: 2270 • ACR Convergence 2023

    Factors Associated with Discordance Between Patient and Physician Perception of Disease Activity Among Patients with Systemic Lupus Erythematosus: An International Collaborative Study

    Shounak Ghosh1, Rajagopal Sankara Narayanan2, Katie Bechman3, Ioannis Parodis4, Esha Kadam5, Wanruchada Katchamart6, Phonpen Akarawatcharangura Goo7, Abraham Edgar Gracia-Ramos8, Parikshit Sen9, Elena Nikiphorou3, Sreoshy Saha10, Ai Lyn Tan11, Tsvetelina Velikova12, Marcin Milchert13, Johannes Knitza14, Carlo Caballero15, Dey Dzifa16, Hector Chinoy17, COVAD Study Group18, Rohit Aggarwal19, Vikas Agarwal20, Latika Gupta21 and Chris Wincup22, 1CMRI Hospital, Kolkata, India, 2Narayana Medical College, Nellore, India, 3King's College London, London, United Kingdom, 4Karolinska Institutet, Stockholm, Sweden, 5Seth Gordhandhas Sunderdas Medical College and King Edwards Memorial Hospital, Mumbai, India, 6Mahidol University, Bangkok, Thailand, 7Department of Medicine, Queen Savang Vadhana Memorial Hospital, Chonburi, Thailand, 8Department of Internal Medicine, General Hospital, National Medical Center "La Raza", Instituto Mexicano del Seguro Social, Av. Jacaranda S/N, Col. La Raza, Del. Azcapotzalco, C.P. 02990, Mexico City, Mexico, 9Maulana Azad Medical College, 2-Bahadurshah Zafar Marg, New Delhi, Delhi-110002, India., Dalhi, India, 10Mymensingh Medical College, Faridpur, Bangladesh, 11University of Leeds, Leeds, United Kingdom, 12Department of Clinical Immunology, Medical Faculty, University Hospital "Lozenetz", Sofia University St. Kliment Ohridski, Sofia, Bulgaria, 13Department of Internal Medicine, Rheumatology, Diabetology, Geriatrics and Clinical Immunology, Pomeranian Medical University in Szczecin, Szczecin, Poland, 14Department of Internal Medicine 3 Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg, University Hospital Erlangen, Erlangen, Germany, 15Universidad del Norte, Barranquilla, Colombia, 16Department of Medicine and Therapeutics, University of Ghana School of Medicine and Dentistry, College of Health Sciences, Korle-Bu, Accra, Ghana, 17The University of Manchester, Sale, United Kingdom, 18-, -, 19University of Pittsburgh, Pittsburgh, PA, 20Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, India, 21Royal Wolverhampton Trust, Wolverhampton/University of Manchester, United Kingdom, 22King's College Hospital, London, United Kingdom

    Background/Purpose: The management of SLE relies on regular assessment of disease activity. However, patient perception of disease activity can be highly variable and may be…
  • Abstract Number: 2256 • ACR Convergence 2023

    The Impact of Clinical Trial Metrics in Psoriatic Arthritis

    Maxine Yarnall and Kara Murray, Spherix Global Insights, Exton, PA

    Background/Purpose: Rheumatologists have access to a plethora of advanced biologic and small molecule agents for the treatment of psoriatic arthritis (PsA). Prior to FDA approval,…
  • Abstract Number: 2414 • ACR Convergence 2023

    Relapse in Giant Cell Arteritis Treated with Tocilizumab. Predictive Factors

    Fernando López1, Javier Loricera2, Ivan Ferraz Amaro3, Santos Castañeda4, Clara Moriano Morales5, Javier Narvaez6, Vicente Aldasoro7, Olga Maiz8, Rafael Benito Melero-Gonzalez9, Juan I. Villa10, PALOMA VELA11, Susana Romero Yuste12, Jose L. Callejas13, Eugenio De Miguel14, Eva Galindez-Agirregoikoa15, Francisca Sivera16, Jesús Carlos Fernández López17, Arturo Llobell18, Julio Sánchez-Martín19, Calderon Goercke2, Lara Sanchez-Bilbao20, Jose L. Hernández21 and Ricardo Blanco22, 1Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 2Hospital Universitario Marqués de Valdecilla, Santander, Spain, 3Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, 4Hospital Universitario de la Princesa, Madrid, Spain, 5Rheumatology, Hospital Universitario de León, León, Spain, 6Hospital Universitario de Bellvitge, Barcelona, Spain, 7Hospital Universitario de Navarra, Pamplona, Spain, 8Hospital Universitario de Donostia. San Sebastián, Spain., Donosti, Spain, 9CHU Vigo, O Carballino, Spain, 10Department of Rheumatology, Hospital Sierrallana, Torrelavega, Torrelavega, Spain, 11Rheumatology, Hospital General Universitario Alicante, Alicante, Spain, 12Complexo Hospitalario Universitario, Pontevedra, Spain, 13Unit of Systemic Autoimmune Diseases, Hospital San Cecilio, Granada, Spain, 14Hospital Universitario La Paz, Madrid, Spain, 15Basurto University Hospital, Bilbao, Spain, 16Elda General University Hospital, Elda, Spain, 17Rheumatology department, Complexo Hospitalario Universitario A Coruña (CHUAC). Instituto de Investigación Biomédica A Coruña (INIBIC), A Coruña, Spain, 18Parc Tauli University Hospital, Barcelona, Spain, 19Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Immunopathology Group, Santander, Spain, 20Hospital Universitario Marques de Valdecilla, Santander, Spain, 21Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 22Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain

    Background/Purpose: Tocilizumab (TCZ) is the only biologic therapy approved for giant cell arteritis (GCA). Clinical trial with TCZ in GCA was performed with intravenous (iv)…
  • Abstract Number: 2395 • ACR Convergence 2023

    Recommendations for Early Referral of Patients with Suspected Polymyalgia Rheumatica: An Initiative from the International Giant Cell Arteritis and Polymyalgia Rheumatica Study Group

    Kresten Keller1, Chetan Mukhtyar2, Andreas Wiggers Nielsen3, Andrea Hemmig4, Sarah Mackie5, Sebastian Sattui6, Ellen Margrethe Hauge3, Anisha Dua7, Toby Helliwell8, Lorna Neil9, Daniel Blockmans10, Valerie Devauchelle11, eric Hayes3, Annett Jansen Venneboer12, Sara Monti13, Cristina Ponte14, Eugenio De Miguel15, Mark Matza16, Kenneth Warrington17, Kevin Byram18, Kinanah Yaseen19, Christine Peoples20, Mike Putman21, Lindsay Lally22, Michael Finikiotis20, Simone Appenzeller23, Ugo Carmori23, CARLOS ENRIQUE TORO GUTIERREZ24, Elisabeth Backhouse25, Maria Camila Guerrero26, Victor Pimentel-Quiroz27, Helen Keen25, Claire Owen28, Thomas Daikeler29, Annette De Thurah3, Wolfgang Schmidt30, Elisabeth Brouwer12 and Christian Dejaco31, 1Department of Rheumatology, Aarhus University Hospital; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, 2Vasculitis service, Rheumatology department, Norfolk and Norwich University Hospital, Norwich, United Kingdom, 3Aarhus University Hospital, Aarhus, Denmark, 4University of Basel, Basel, Switzerland, 5Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK; Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 6University of Pittsburgh, Pittsburgh, PA, 7Northwestern University, Chicago, IL, 8Keele University, Keele, United Kingdom, 9Polymyalgia Rheumatica and Giant Cell Arteritis Scotland, Perth, United Kingdom, 10Department of General Internal Medicine, University Hospitals Leuven, Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium, 11UBO, Brest, France, 12University Medical Center Groningen, Groningen, Netherlands, 13Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Internal Medicine and Therapeutics, Università di Pavia, Pavia, Italy, 14Department of Rheumatology, Centro Hospitalar Universitário Lisboa Norte, Centro Académico de Medicina de Lisboa, Lisbon, Portugal; Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Centro Académico de Medicina de Lisboa, Lisbon, Portugal, 15Hospital Universitario La Paz, Madrid, Spain, 16Massachusetts General Hospital, Newton, MA, 17Mayo Clinic, Rochester, MN, 18Vanderbilt University Medical Center, Nashville, TN, 19Cleveland Clinic, Cleveland, OH, 20University of Pittsburgh Medical Center, Pittsburgh, PA, 21Division of Rheumatology, Medical College of Wisconsin, Milwaukee, WI, 22Hospital for Special Surgery, New York, NY, 23UNICAMP, Campinas, Brazil, 24Centro de Estudios de Reumatología y Dermatología SAS, Cali, Colombia, 25University of Western Australia, Daglish, Australia, 26General practice, Cali, Colombia, 27Universidad Cientifica del Sur/Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Peru, 28Austin Health, Malvern East, Australia, 29Clinic for Rheumatology, University Hospital Basel, Basel, Switzerland, 30Rheumatology, Immanuel Krankenhaus Berlin, Medical Centre for Rheumatology Berlin-Buch, Berlin, Germany, 31Azienda Sanitaria Alto Adige, Brunico, Italy

    Background/Purpose: Existing EULAR/ACR guidelines on polymyalgia rheumatica (PMR) are focused on the management by rheumatologists. However, there is no consensus regarding early referral and evaluation…
  • Abstract Number: 2422 • ACR Convergence 2023

    Magnetic Resonance Imaging Reflects Disease Activity in the “Giant Cell Arteritis Treatment with Ultra-short Glucocorticoids and Tocilizumab” Trial (The GUSTO Trial)

    Lisa Christ1, Harald Bonel2, Jennifer Cullmann3, Luca Seitz4, Lukas Butikofer5, Franca Wagner6 and Peter Villiger7, 1Department of Rheumatology and Immunology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland, 2Department of Diagnostic, Interventional and Pediatric Radiology (DIPR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Campusradiologie, Lindenhofspital Bern, Bern, Switzerland, 3Campusradiologie, Lindenhofspital Bern, Bern, Switzerland, 4Rheumatology and Immunology, Inselspital University Hospital Bern, Bern, Switzerland, 5CTU Bern, University of Bern, Bern, Switzerland, Bern, Switzerland, 6University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland, 7Medical Center Monbijou, Rheumatology and Immunology, Bern, Switzerland

    Background/Purpose: Magnetic resonance imaging (MRI) is well established for diagnosing giant cell arteritis (GCA). Its role in monitoring disease activity has yet to be determined.…
  • Abstract Number: 2421 • ACR Convergence 2023

    Optic Nerve Sheath Measurement on Ultrasound: A Novel Diagnostic Test for Giant Cell Arteritis

    Hussein Baalbaki1, David Dube1, Carolyn Ross2, Stephanie Ducharme-Benard3, Samer Hussein4, Rosalie-Selene Meunier4, Christian Pagnoux5 and Jean-Paul Makhzoum2, 1Hopital du Sacre-Coeur de Montreal, University of Montreal, Montreal, QC, Canada, 2Vasculitis Clinic, Canadian Network for Research on Vasculitides, Hopital du Sacre-Coeur de Montreal, Montreal, QC, Canada, 3Vasculitis Clinic, Hopital du Sacre-Coeur de Montreal, Montreal, QC, Canada, 4Vasculitis Clinic, Hopital du Sacre-Coeur de Montreal, Montreal, QC, Canada, 5Mount Sinai Hospital, Toronto, ON, Canada

    Background/Purpose: Confirming the diagnosis of giant cell arteritis (GCA) remains challenging. Available diagnostic tests have limited accuracy and availability. Recently, optic nerve sheath enhancement on…
  • Abstract Number: 2416 • ACR Convergence 2023

    Comparison of Clinical, Laboratory and Imaging Features of Relapses Between Takayasu and LV-GCA Patients. an Italian Monocentric Study

    LUIGI BOIARDI1, PIERLUIGI MACCHIONI2, Francesco Muratore3, Elena Galli4, chiara marvisi4, Giulia Besutti1, Lucia Spaggiari1, Annibale Versari1 and Carlo Salvarani5, 1IRCCS REGGIO EMILIA, Reggio Emilia, Italy, 2Azienda USL -IRCCS di Reggio Emilia, Reggio Emilia, Italy, 3IRCCS di Reggio Emilia, Reggio Emilia, Italy, 4Azienda Unità Sanitaria Locale-IRCCS Di Reggio Emilia, Reggio Emilia, Italy, 5Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy

    Background/Purpose: No previous study has compared clinical, laboratory and imaging features of relapses in Takayasu (TAK) and large vessel giant cell arteritis (LV-GCA). The aim…
  • Abstract Number: 2407 • ACR Convergence 2023

    Immuno-permissive Antigen-presenting Cells in Giant Cell Arteritis

    Shozo Ohtsuki1, Chenyao Wang2, Ryu Watanabe3, Hui Zhang3, Mitsuhiro Akiyama3, Kenneth Warrington4, Gerald J. Berry3, Jorg Goronzy4 and Cornelia M. Weyand5, 1Mayo Clinic College of Medicine and Science, Stanford University School of Medicine, Rochester, MN, 2Mayo Clinic College of Medicine and Science, Rochester, MN, 3Stanford University School of Medicine, Stanford, CA, 4Mayo Clinic, Rochester, MN, 5Mayo Clinic School of Medicine and Stanford University, Rochester, MN

    Background/Purpose: Giant cell arteritis (GCA) is a medium and large vessel vasculitis with pathognomonic granulomatous infiltrates in the vessel wall. During the early stages of…
  • Abstract Number: 2415 • ACR Convergence 2023

    Giant Cell Arteritis Is Associated with Worse Hospital Outcomes in Aortic Aneurysm/Dissection Hospitalizations: A Nationwide United States Population-Based Study

    Artem Minalyan1, Christopher Hino1, Emily He1, Osahon Idolor2, Chinenye Osuorji3, Nneka Chukwu4, Ehizogie Edigin1 and Vaneet Sandhu5, 1Loma Linda University Health, Loma Linda, CA, 2Piedmont Athens Regional Hospital, Atlanta, GA, 3Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, 4Nuvance Health Internal Medicine Residency, Poughkeepsie, NY, 5Loma Linda University, Loma Linda, CA

    Background/Purpose: Giant Cell Arteritis (GCA) is a known risk factor for Aortic Aneurysm/Dissection (AAD). However, it is unclear if patients with GCA have worse hospital…
  • Abstract Number: 2266 • ACR Convergence 2023

    Direct Health Care Costs Differ by SLE Autoantibody Machine Learning Clusters in an International Inception

    May Choi1, Karen Costenbader2, Marvin Fritzler1, Yvan St. Pierre3, Murray Urowitz4, John G. Hanly5, Caroline Gordon6, Sang-Cheol Bae7, Juanita Romero-Diaz8, Jorge Sanchez-Guerrero9, Sasha Bernatsky3, Daniel Wallace10, David Isenberg11, Anisur Rahman12, Joan Merrill13, Paul R. Fortin14, Dafna Gladman15, Ian Bruce16, Michelle Petri17, Ellen Ginzler18, Mary Anne Dooley19, Rosalind Ramsey-Goldman20, Susan Manzi21, Andreas Jonsen22, Graciela S Alarcón23, Ronald van Vollenhoven24, Cynthia Aranow25, Meggan MacKay25, Guillermo Ruiz-Irastorza26, S. Sam Lim27, Murat Inanc28, Kenneth Kalunian29, Soren Jacobsen30, Christine Peschken31, Diane L. Kamen32, Anca Askanase33, Jill Buyon34 and Ann Clarke35, 1University of Calgary, Calgary, AB, Canada, 2Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 3Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 4Schroeder Arthritis Institute, Krembil Research Institute; University of Toronto Lupus Clinic; Division of Rheumatology, Toronto, ON, Canada, 5Dalhousie University, Halifax, NS, Canada, 6Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, 7Hanyang University Hospital for Rheumatic Diseases and Hanyang University Institute for Rheumatology Research, Department of Rheumatology, Seoul, South Korea, 8Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, 9University Health Network, Toronto, ON, Canada, 10Cedars-Sinai Medical Center, Los Angeles, CA, 11University College London, London, United Kingdom, 12Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom, 13Oklahoma Medical Research Foundation, Oklahoma City, OK, 14Centre ARThrite - CHU de Québec - Université Laval, Quebec City, QC, Canada, 15Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Department of Medicine, University of Toronto, Toronto, ON, Canada, 16University of Manchester, Manchester, United Kingdom, 17Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Timonium, MD, 18SUNY Downstate Health Sciences University, Brooklyn, NY, 19Raleigh Neurology Associates, Chapel Hill, NC, 20Northwestern University, Chicago, IL, 21Lupus Center of Excellence, Autoimmunity Institute, Allegheny Health Network, Pittsburgh, PA, 22Rheumatology, Department of Clinical Sciences, Lund University, Lund, Sweden, 23Heersink School of Medicine. The University of Alabama at Birmingham, Birmingham, AL, 24Amsterdam University Medical Centers, Amsterdam, Netherlands, 25Feinstein Institutes for Medical Research, Manhasset, NY, 26Hospital Universitario Cruces, Barakaldo, Spain, 27Emory University, Atlanta, GA, 28Division of Rheumatology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey, 29University of California San Diego, La Jolla, CA, 30Rigshospitalet, Copenhagen, Denmark, 31University of Manitoba, Winnipeg, MB, Canada, 32Medical University of South Carolina, Charleston, SC, 33Columbia University Medical Center, New York, NY, 34NYU Grossman School of Medicine, New York, NY, 35University of Calgary, Division of Rheumatology, Cumming School of Medicine, Calgary, AB, Canada

    Background/Purpose: Using machine learning, we identified 4 patient clusters based on longitudinal autoantibody profiles in an international SLE inception cohort, which were predictive of disease…
  • Abstract Number: 2280 • ACR Convergence 2023

    The LFA-REAL Clinician Reported Outcome Predicts Damage in Patients with Systemic Lupus Erythematosus (SLE). Data from a Prevalent Latin American Lupus Cohort

    Manuel Ugarte-Gil1, Rocío Gamboa-Cárdenas2, Victor Pimentel-Quiroz2, Cristina Reategui-Sokolova3, Claudia Elera-Fitzcarrald4, Erika Noriega5, Cesar Pastor-Asurza6, Zoila Rodriguez-Bellido6, Risto Perich-Campos6 and Graciela S Alarcón7, 1Universidad Cientifica del Sur, Lima, Peru, 2Universidad Cientifica del Sur/Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Peru, 3Hospital Guillermo Almenara Irigoyen, EsSalud/Universidad San Ignacio de Loyola, Lima, Peru, 4Hospital Guillermo Almenara Irigoyen, EsSalud/Universidad Privada San Juan Bautista, Lima, Peru, 5Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Peru, 6Hospital Guillermo Almenara Irigoyen, EsSalud/Universidad Nacional Mayor de San Marcos, Lima, Peru, 7Heersink School of Medicine. The University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: The Lupus Foundation of America Rapid Evaluation of Activity in Lupus (LFA-REAL) clinican-reported outcome (ClinRO) correlates well with other disease activity indices such us…
  • Abstract Number: 2401 • ACR Convergence 2023

    A Study Defining the Optimal Sonographic Parameters for Intima-Media Thickness in Diagnosing Giant Cell Arteritis

    Colm Kirby1, Sharon Cowley2, Rachael Flood1, Ronan Mullan1, Grainne Murphy3 and David Kane4, 1Tallaght University Hospital, Dublin, Ireland, 2Tallaght University Hospital, Dublin, Dublin, Ireland, 3Cork University Hospital, Cork, Ireland, 4Tallaght University Hospital & Trinity College Dublin, Dublin, Ireland

    Background/Purpose: In recent years, Temporal Artery US (TAUS) incorporating Axillary Artery US (AAUS) has become a reliable alternative to biopsy for diagnosing GCA but studies…
  • Abstract Number: 2408 • ACR Convergence 2023

    The Use of the Southend GCA Probability Score (GCAPS) in Assessing the Risk of Giant Cell Arteritis in Australian Ophthalmological and General Medical Hospital Cohorts

    Eloise Norman1, Clare Fraser2, Mitchell Lawlor3 and Anthony Sammel4, 1Prince of Wales Hospital, Randwick, Australia, 2Save Sight Institute, The University of Sydney, Sydney, Australia, 3Sydney and Sydney Eye Hospital, Sydney, Australia, 4The Prince of Wales Hospital, Sydney, Australia

    Background/Purpose: The rate of positive temporal artery biopsies (TAB) in patients with suspected giant cell arteritis (GCA) varies widely, indicating the need for better pre-test…
  • Abstract Number: 2429 • ACR Convergence 2023

    Romosozumab versus Denosumab in High-risk Patients Treated with Glucocorticoids: Interim 12-month Results from a Pilot Randomized Controlled Trial

    Chi Chiu Mok1, SAU MEI TSE2, Kar Li Kelly Chan3 and Wai Han Ma1, 1Tuen Mun Hospital, Hong Kong, Hong Kong, 2Tuen Mun Hospital, Hong Kong, China, 3Tuen Mun Hospital, Shatin, China

    Background/Purpose: To compare the efficacy and safety of romozosumab (ROMO) and denosumab (DEN) in high-risk patients treated with glucocorticoids (GCs). Methods: Adult patients (≥18 years)…
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