ACR Meeting Abstracts

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  • Abstract Number: 2181 • ACR Convergence 2023

    Secretagogue Effect of PDE4 Inhibitor Apremilast on Human Salivary Gland Organoids Obtained from Primary Sjögren’s Syndrome Patients

    Valeria Manfrè1, Salvatore Parisi2, Isabella Caligiuri2, Ombretta Repetto3, Alen Zabotti1, Enrico Pegolo4, Cinzia Fabro1, Salvatore De Vita1, Vincenzo Canzonieri2, Carla Di Loreto4, Flavio Rizzolio2 and Luca Quartuccio1, 1Division of Rheumatology, Department of Medicine, University of Udine, Udine, Italy, 2Pathology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy, 3Facility of Bio-Proteomics, Immunopathology and Cancer Biomarkers, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy, 4Institute of Pathology, Azienda Sanitaria Universitaria Friuli Centrale c/o Università degli studi di Udine, Udine, Italy

    Background/Purpose: In primary Sjögren's syndrome (pSS), salivary epithelial cells show an active role in the initiation and reiteration of the immunomediated damage. Epithelial saliva production…
  • Abstract Number: 2223 • ACR Convergence 2023

    Relationship Between Sleep Quality, Disease Activity, and Psychological Factors in Patients with Axial Spondyloarthritis: A Cross Sectional Study

    Srujana Budumuru, Rohini Handa, Sundeep Kumar Upadhyaya, Sirinder Jit Gupta, Meera H Shah, Meera P Shah and Anushka Aggarwal, Indraprastha Apollo Hospital, Delhi, India

    Background/Purpose: Sleep problems are prevalent in 30-70% of patients with axial Spondyloarthritis (SpA), negatively impacting their quality of life. Poor sleep quality in these patients…
  • Abstract Number: 2224 • ACR Convergence 2023

    Difficult to Treat Axial Spondyloarthritis. Predictors of Poor Outcomes

    FERNANDO MONTERO1, Laura Berbel Arcobé2, Karen Carpio Astudillo1, Jose Maria Bellón3 and Xavier Juanola Roura4, 1Hospital General Universitario Gregorio Marañón, Madrid, Spain, 2H.U. Bellvitge, Barcelona, Spain, 3Gregorio Marañón Health Research Institute, Madrid, Spain, 4Hospital Universitari de Bellvitge, Barcelona, Spain

    Background/Purpose: The term "Difficult-to-Treat" (D2T) defines those patients who remain active despite having undergone various treatments within the established recommendations. This concept is defined by…
  • Abstract Number: 2182 • ACR Convergence 2023

    Mitochondrial Alterations in Primary Sjögren´s Syndrome

    Pavlina Javorova1, Johannes Fessler1, Melanie Zeiler1, Angelika Lackner1, Josef Hermann2, Sabine Zenz3, Jens Thiel4 and Martin Stradner1, 1Medical University of Graz, Graz, Austria, 2Division of Rheumatology and Immunology, Department of Internal Medicine, Medical University Graz, Graz, Austria, 3Medical University Graz, Graz, Austria, 4University Hospital Freiburg, Freiburg, Germany

    Background/Purpose: Primary Sjögren's Syndrome (pSS) is a systemic autoimmune disorder characterized by lymphocytic infiltrations in exocrine glands. T-cells are considered major players in the pathogenesis…
  • Abstract Number: 2177 • ACR Convergence 2023

    Characterization of Crevicular Fluid Microbiota in Primary Sjögren’s Syndrome

    Gabriela Hernandez-Molina1, Alberto Lopez-Reyes2, Carlos Hernandez-Hernandez3, Vanessa Ruiz3, Amaya Llorente-Chavez4, Vanessa Saavedra-González4, Luis llorente4 and Gabriela Martínez-Nava2, 1Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 2Laboratorio de Gerociencias, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City, Mexico, 3Servicio Dental. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 4Departamento de Inmunología y Reumatología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

    Background/Purpose: To describe the taxonomic composition of the microbiota in the crevicular fluid of patients with primary Sjögren's syndrome (PSS), and to assess their association…
  • Abstract Number: 2229 • ACR Convergence 2023

    Individual Entheseal Points Have Differential Frequency of Involvement and Impact on Patient Reported Outcomes in Patients with Active Psoriatic Arthritis: Pooled Analysis of Two Phase 3, Randomized, Double-Blind, Placebo-Controlled Studies

    Laura Coates1, Iain McInnes2, Sibel Aydin3, Mitsumasa Kishimoto4, Philip J. Mease5, May Shawi6, Miriam Zimmermann7, Emmanouil Rampakakis8, Frederic Lavie9 and Dennis McGonagle10, 1University of Oxford, Oxford, United Kingdom, 2University of Glasgow, Glasgow, United Kingdom, 3Department of Medicine, Ottawa Hospital Riverside Campus, Ottawa, ON, Canada, 4Kyorin University School of Medicine, Yokohoma, Japan, 5Swedish Medical Center/Providence St. Joseph Health and University of Washington School of Medicine, Seattle, WA, 6Immunology, Janssen Research & Development, LLC, Titusville, NJ, 7Immunology, Janssen Medical Affairs, LLC, Zug, Switzerland, 8McGill University, Department of Pediatrics / JSS Medical Research, Scientific Affairs, Montreal, QC, Canada, 9The Janssen Pharmaceutical Companies of Johnson & Johnson, Paris, France, 10Leeds Biomedical Research Centre, University of Leeds, Leeds, United Kingdom

    Background/Purpose: In patients with mono/oligoarticular psoriatic arthritis (PsA), swelling or tenderness of specific joints can be associated with poorer patient-reported outcomes (PROs) and physician global…
  • Abstract Number: 2228 • ACR Convergence 2023

    Early Improvement in 3 Visual Analogue Scale (3VAS)/4VAS Predicts Reduced Rates of Radiographic Change in Bio-naive Active Psoriatic Arthritis Patients Receiving Guselkumab Treatment

    William R Tillett1, Laura Coates2, marijn vis3, Enrique Soriano4, Joseph F. Merola5, Miriam Zimmermann6, May Shawi7, Mohamed Sharaf8, Peter Nash9 and Philip Helliwell10, 1Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, 2University of Oxford, Oxford, United Kingdom, 3Erasmus Medical Center, Rotterdam, Netherlands, 4Rheumatology Section, Internal Medicine Services, Hospital Italiano de Buenos Aires, and University Institute Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 5Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 6Immunology, Janssen Medical Affairs, LLC, Zug, Switzerland, 7Immunology, Janssen Research & Development, LLC, Titusville, NJ, 8Immunology, Janssen MEA, Dubai, United Arab Emirates, 9School of Medicine, Griffith University, Brisbane, Australia, 10University of Leeds, Leeds, United Kingdom

    Background/Purpose: Guselkumab (GUS), a fully human IL-23p19 subunit inhibitor, was shown to reduce mean changes in radiographic progression vs placebo (PBO) by week (W)24 and…
  • Abstract Number: 2221 • ACR Convergence 2023

    Clinical and Molecular Patterns Associated with Persistence of Inflammation in Spondyloarthritis Patients: Unveiling Potential Biomarkers

    Lourdes Ladehesa Pineda1, Ivan Arias de la Rosa2, Laura Cuesta-López3, Clementina López Medina4, María Ángeles Puche Larrubia5, Miriam Ruiz-Ponce3, María del carmen Ábalos Aguilera3, Pedro Ortiz Buitrago3, Yasin Hanaee3, Carlos Perez-Sanchez6, Chary López-Pedrera3, Alejandro Escudero-Contreras7, Eduardo Collantes Estévez8 and Nuria Barbarroja9, 1Rheumatology Department Reina Sofia Universitary Hospital, Cordoba, Spain, 2IMIBIC/Reina Sofia Hospital/University of Cordoba. Rheumatology service. Cordoba. Spain, Cordoba, Spain, 3IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 4Rheumatology Department, Cochin Hospital; INSERM (U1153): Clinical Epidemiology and Biostatistics, University of Paris; Rheumatology Department, Reina Sofia Hospital, Cordoba / IMIBIC / University of Cordoba, Cordoba, Spain, 5Department of Rheumatology, Reina Sofia University Hospital, Cordoba, Spain, 6IMIBIC, Córdoba, Spain, 7Rheumatology Department, Reina Sofia University Hospital, Cordoba/Maimonides Biomedical Research Institute of Cordoba (IMIBIC)/University of Cordoba, Córdoba, Spain, 8Maimonides Biomedical Research Institute of Cordoba (IMIBIC)/University of Cordoba, Cordoba, Spain, 9University of Cordoba, Córdoba, Spain

    Background/Purpose: Chronic inflammation is closely associated with an increased risk of cardiovascular diseases (CVD) through the activation of the immune system and the release of…
  • Abstract Number: 2185 • ACR Convergence 2023

    35 Years Follow-up of Primary Sjögren’s Disease: A Single Center Study

    Lorena Montano-Tapia1, Resit Yildrim2, Ana Mafalda Abrantes3 and David Isenberg4, 1Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Spain, 2Eskişehir Osmangazi University I, Eskişehir, Turkey, 3Centro Hospitalar Universitario Lisboa Norte, Lisbon, Portugal, 4University College London, London, United Kingdom

    Background/Purpose: Primary Sjögren’s syndrome (pSS) is an autoimmune rheumatic disease characterized by lymphocytic infiltration of exocrine glands. Its clinical manifestations are heterogeneous. Currently, the evidence…
  • Abstract Number: 2193 • ACR Convergence 2023

    Anti-citrullinated Protein Antibodies in Sjögren’s Syndrome Define a Subset of Patients with Lower B Cell Activation Markers and Higher Risk of Lung Involvement

    Augusto Silva1, Filipa Costa2, Mariana Silva2, Giovanni Fulvio3, Matilde Bandeira2, Manuel Silvério-António4, Nikita Khmelinskii2, Chiara Baldini3 and Vasco Romão2, 1Santa Maria Hospital, Maceira, Portugal, 2Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal, 3University of Pisa, Pisa, Italy, 4Hospital Santa Maria, Lisboa, Portugal

    Background/Purpose: Extraglandular manifestations may occur in up to 40-50% of patients with SS, including inflammatory arthralgia and chronic polyarthritis (1-3). ACPA are prototypical markers of…
  • Abstract Number: 2188 • ACR Convergence 2023

    Lung Cysts in Primary SS: New Findings on an Allegedly Innocuous Iiagnosis

    Regis Sewa Marques, Maria Fernanda Zacarin, Pamela Bellini, Raissa Dudienas D Pereira, Aloma Guinami Scabora, Zoraida Sachetto, Manoel Bertolo and ALISSON PUGLIESI, Universidade Estadual de Campinas, Campinas, Brazil

    Background/Purpose: Lung cysts are a frequent finding in patients with SS, with previous data indicating a prevalence of approximately 30% on chest CT scans. In…
  • Abstract Number: 2192 • ACR Convergence 2023

    New Inducible Mouse Model of Sjögren’s Syndrome Represents a Valuable Tool to Assess the Impact of Gene Knockout on the Disease’s Physiopathology

    Dorian Parisis1, Nargis Bolaky2, Anissa Benchehida2, Christoph Küper3, jason Perret2, Muhammad Soyfoo1 and Christine Delporte2, 1Hôpital Universitaire de Bruxelles - Hôpital Erasme, Brussels, Belgium, 2Faculté de médecine - Université Libre de Bruxelles, Brussels, Belgium, 3Institute for Molecular Medicine, MSH Medical School Hamburg, Hamburg, Germany

    Background/Purpose: Primary Sjögren's syndrome (pSS) is a chronic rheumatic disease characterized by lymphocytic infiltration of exocrine glands, resulting in sicca syndrome with extra-glandular autoimmune features.…
  • Abstract Number: 2208 • ACR Convergence 2023

    Awareness and Attitudes Regarding Axial Spondyloarthritis Among Non-Rheumatology Physicians in the United States

    William Odell1, Swetha Ann Alexander2, Nicolas Page3, Narinder Maheshwari4 and Abhijeet Danve5, 1Yale University, Wethersfield, CT, 2University of Utah Health, Salt Lake City, UT, 3Yale University, New Haven, CT, 4UCONN Health, Farmington, CT, 5Yale University School of Medicine, Glastonbury, CT

    Background/Purpose: Average diagnostic delay for axial spondyloarthritis (axSpA) is 7 to 10 years. Lack of timely referral of inflammatory back pain (IBP) patients by non-rheumatology…
  • Abstract Number: 2215 • ACR Convergence 2023

    Can Axial Spondyloarthritis Unequivocally Be Diagnosed by Rheumatologists in Patients with Chronic Back Pain of Less Than Two Years Duration? The Primary Outcome of the Two-year SPondyloArthritis Caught Early (SPACE) Cohort

    Mary Lucy marques1, Sofia Ramiro2, Miranda Van Lunteren3, Rosalinde Stal3, Robert BM Landewé4, Marleen van de Sande5, Karen Minde Fagerli6, Inger Jorid Berg6, Maikel van oosterhout7, Sofia Exarchou8, Roberta Ramonda9, Désirée van der Heijde2 and Floris Van Gaalen3, 1Leiden University Medical Center; Centro Hospitalar e Universitário de Coimbra (Department of Rheumatology), Coimbra, Portugal, 2Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Leiden University Medical Center, Department of Rheumatology, Leiden, Netherlands, 4Amsterdam Rheumatology & Clinical Immunology Center, Amsterdam and Zuyderland MC, Herleen, Netherlands, 5Amsterdam UMC, University of Amsterdam, Department of Rheumatology & Clinical Immunology and Department of Experimental Immunology, Amsterdam Infection & Immunity Institute; Amsterdam Rheumatology & Immunology Center (ARC), Academic Medical Center, Amsterdam, Netherlands, 6Center for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway, 7Groene Hart Ziekenhuis, Gouda, Netherlands, 8Lund University, Åkarp, Sweden, 9University of Padova, Department of Rheumatology, Padova, Italy

    Background/Purpose: Unacceptable diagnostic delay in axial Spondyloarthritis (axSpA) remains an issue. In 2008, the longitudinal SPondyloArthritis Caught Early (SPACE)-cohort started to assess the prevalence of…
  • Abstract Number: 2236 • ACR Convergence 2023

    Guselkumab Provides Rapid Clinically Meaningful Improvements in Clinical and Patient Reported Outcomes and Sustained Disease Control of Psoriatic Arthritis

    Jeffrey R Curtis1, Atul Deodhar2, Enrique Soriano3, Emmanouil Rampakakis4, May Shawi5, Natalie shiff6, Marcie Strauss7, Chenglong Han8, William R Tillett9 and Dafna Gladman10, 1Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, AL, 2Division of Arthritis and Rheumatic Disease, Oregon Health & Science University, Portland, OR, 3Rheumatology Section, Internal Medicine Services, Hospital Italiano de Buenos Aires, and University Institute Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 4McGill University, Department of Pediatrics / JSS Medical Research, Scientific Affairs, Montreal, QC, Canada, 5Immunology, Janssen Research & Development, LLC, Titusville, NJ, 6Immunology, Janssen Scientific Affairs, LLC / Adjunct, Community Health and Epidemiology, University of Saskatchewan, Horsham, PA, 7MEDASOURCE, Medical Group, Indianapolis, IN, 8Immunology, Janssen Global Services, LLC, Malvern, PA, 9Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, 10Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Department of Medicine, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Guselkumab (GUS) has demonstrated robust efficacy across key PsA domains at Week (W) 24, with effects sustained or further enhanced through 2 years. Timing…
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