ACR Meeting Abstracts

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  • Abstract Number: 2009 • ACR Convergence 2023

    Screening and Treatment of Low Bone Mineral Density in Allogeneic Hematopoietic Cell Transplant Patients

    Perry Fuchs, Christina Ferraro, Chao Zhang, Chad Deal, Betty Hamilton and Sarah Keller, Cleveland Clinic Foundation, Cleveland, OH

    Background/Purpose: Bone mineral density (BMD) loss and fracture are important causes of increased morbidity following allogeneic hematopoietic stem cell transplant (allo-HCT).Recent societal recommendations support screeningDual…
  • Abstract Number: 2082 • ACR Convergence 2023

    Delivery of Rheumatology Education to Internal Medicine Residents in Rwanda: Evaluation of a New Virtual Rheumatology Course Supplemented by On-site Clinical Teaching

    Carol Hitchon1, Becky Abdissa Adugna2, Richard Akintayo3, Paul Caldron4, Ines Colmegna5, Ida Dey6, Paul McGill7, Andres Ponce8, Rosie Scuccimarri9, Mohammed Tikly10, Girish Mody11 and Michele Meltzer12, 1University of Manitoba, Winnipeg, MB, Canada, 2Addis Ababa University, Addis Ababa, Ethiopia, 3Dumfries and Galloway Royal Infirmary, Edinburgh, United Kingdom, 4Arizona Arthritis & Rheumatology Associates, P.C. - Emeritus (no longer in patient care role), Depoe Bay, OR, 5The Research Institute of the McGill University Health Centre, Montréal, QC, Canada, 6University of Ghana Medical School, Accra, Ghana, 7Department of Rheumatology Stobhill Hospital, Glasgow, United Kingdom, 8Jefferson, Philadelphia, PA, 9McGill University/Montreal Children's Hospital, Montréal, QC, Canada, 10Wits University, Johannesburg, South Africa, 11University of KwaZulu-Natal, Durban, South Africa, 12Thomas Jefferson University/Rheumatology for All,Inc., Philadelphia, PA

    Background/Purpose: There exists a critical lack of rheumatology resources in many parts of the world including sub-Saharan African countries. As a result, in these countries,…
  • Abstract Number: 2114 • ACR Convergence 2023

    The Relationship Between Disease Activity of Rheumatoid Arthritis and Kidney Function

    Sho Fukui1, Wolfgang Winkelmayer2, Sara Tedeschi1, Javier Marrugo1, Hongshu Guan1, Leslie Harrold3, Heather Litman3, Tomohiro Shinozaki4 and Daniel Solomon5, 1Brigham and Women's Hospital, Boston, MA, 2Baylor College of Medicine, Houston, TX, 3CorEvitas, LLC, Waltham, MA, 4Tokyo University of Science, Tokyo, Japan, 5Brigham and Women's Hospital, Newton, MA

    Background/Purpose: Chronic kidney disease (CKD) is a common comorbidity of rheumatoid arthritis (RA) affecting 10-20% of patients. However, the influence of the longitudinal RA disease…
  • Abstract Number: 2130 • ACR Convergence 2023

    Prevalence and Risk Factors of Pneumocystis Jirovecii Colonization in Patients with Rheumatoid Arthritis Treated with Tumor Necrosis Factor Inhibitors and Tocilizumab

    Yi-Min Huang1, Chieh-An Chuang2, Jui-Hung Kao2, Yen-Chun Lin2, Jen-Hao Chen3, Chiao-Feng Cheng4, Cheng-Hsun Lu4, Yu-Min Kuo4, Chieh-Yu Shen4, Chin-Hsiu Liu5, Ko-Jen Li4, Song-Chou Hsieh4, Jung-Yien Chien4 and Po-Ren Hsueh4, 1National Taiwan University Cancer Center, Taipei City, Taiwan, 2National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan, 3National Taiwan University Cancer Center, Taipei, Taiwan, 4National Taiwan University Hospital, Taipei, Taiwan, 5National Taiwan University Hospital, Taipei, Taiwan

    Background/Purpose: Patients with rheumatoid arthritis (RA) are susceptible toPneumocystis jiroveciicolonization and prone to develop life-threateningPneumocystispneumonia (PCP). An increased risk ofP. jiroveciicolonization and PCP was found…
  • Abstract Number: 2133 • ACR Convergence 2023

    Cardiovascular Risk Factors Are Associated with Discontinuation of Advanced Therapies Due to Treatment Failure in Rheumatoid Arthritis: Results from the OBRI

    Samar Aboulenain1, Xiuying Li2, Mohammad Movahedi3, Claire Bombardier1 and Bindee Kuriya1, 1University of Toronto, Toronto, ON, Canada, 2Toronto General Hospital, Toronto, ON, Canada, 3Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada

    Background/Purpose: Cardiovascular (CVD) comorbidity can impact overall RA care. We demonstrated that CVD risk factors were associated with higher disease activity and disability. Here, we…
  • Abstract Number: 1950 • ACR Convergence 2023

    Thromboembolic Risk Associated with Intravenous Immune Globulin Use in Patients with Idiopathic Inflammatory Myopathy: A Large Database Study

    Rohan Mehta1, Mike Putman2 and Didem Saygin3, 1Medical College of Wisconsin, Milwaukee, WI, 2Division of Rheumatology, Medical College of Wisconsin, Milwaukee, WI, 3University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Intravenous immune globulin (IVIG) recently received regulatory approval for the treatment of dermatomyositis, one of the idiopathic inflammatory myopathies (IIM). The pivotal randomized trial…
  • Abstract Number: 1857 • ACR Convergence 2023

    More Than 50% of Rheumatoid Arthritis (RA) Patients with High or Moderate CDAI (clinical Disease Activity Index) Screen Positive on MDHAQ (multidimensional Health Assessment Questionnaire) Indices for FAST4 (fibromyalgia Assessment Screening Tool) And/or MDS2 (MDHAQ Depression Screen)

    Juan Schmukler and Theodore Pincus, Rush University Medical Center, Chicago, IL

    Background/Purpose: Treat to target in rheumatoid arthritis (RA) suggests escalation of therapy in patients whose scores are high or moderate on a disease activity index…
  • Abstract Number: 2139 • ACR Convergence 2023

    Associations of Adipocytokines with Cancer Incidence in a Prospective Rheumatoid Arthritis Cohort

    Namrata Singh1, Aaron Baraff2, K Wysham3, Punyasha Roul4, Grant Cannon5, Brian Sauer6, Geoffrey Thiele4, Bryant England4, Ted R Mikuls7 and Joshua Baker8, 1University of Washington, Bellevue, WA, 2VA Puget Sound Seattle, Seattle, WA, 3VA Puget Sound/University of Washington, Seattle, WA, 4University of Nebraska Medical Center, Omaha, NE, 5University of Utah and Salt Lake City VA, Salt Lake City, UT, 6Salt Lake City VA/University of Utah, Salt Lake City, UT, 7Division of Rheumatology and Immunology, University of Nebraska Medical Center, Omaha, NE, 8University of Pennsylvania, Philadelphia, PA

    Background/Purpose: A prior study suggested a higher risk of cancer mortality in patients with rheumatoid arthritis (RA) with higher levels of circulating leptin, an adipocytokine…
  • Abstract Number: 1946 • ACR Convergence 2023

    Zetomipzomib Demonstrates Favorable Long-term Safety and Tolerability Profile Without Signs of Immunosuppression: Results from the PRESIDIO Study and Its Open-label Extension Study in Patients with Dermatomyositis and Polymyositis

    Rohit Aggarwal1, Namita Goyal2, Diana Lam3, Allen Ng3, Richard Leff4, Kathryn Ray3, Eunmi Park3 and Noreen Henig3, 1University of Pittsburgh, Pittsburgh, PA, 2UCI Health, Orange, CA, 3Kezar Life Sciences, South San Francisco, CA, 4Kezar Life Sciences, Chadds Ford, PA

    Background/Purpose: Polymyositis (PM) and dermatomyositis (DM) are chronic autoimmune diseases characterized by muscle inflammation and weakness. In a collagen-induced myositis mouse model, immunoproteasome inhibition has…
  • Abstract Number: 1823 • ACR Convergence 2023

    Higher Body Mass Index and Older Age, Both of Which Are Linked to Immunothrombosis Are Associated with Improved Survival with Baricitinib Therapy in COVID-19 Pneumonia

    Paula David1, Niv Ben-Shabbat2, Or Hen1, Howard Amital3, Abdulla watad4 and Dennis McGonagle5, 1University of Leeds, Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), Leeds, United Kingdom, 2Department of Medicine 'B'. Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, 3Sheba Medical Center - Tel Hashomer, Ramat Gan, Israel, 4Sheba Medical Center, Ramat Gan, Israel, 5Leeds Biomedical Research Centre, University of Leeds, Leeds, United Kingdom

    Background/Purpose: Immunothrombosis is a critical pathological feature of fulminant COVID-19 pneumonia in which immunosuppression with common immunomodulatory agents such as corticosteroids, IL-6 receptor blockers, and…
  • Abstract Number: 2124 • ACR Convergence 2023

    Expansion of Atypical B Cells Accompanies Rheumatoid Arthritis-like Immune Dysregulation in ACPA+ At-risk Individuals

    Adam Savage1, Ziyuan He1, Marla Glass1, Julian Reading1, LauraKay Moss2, Marie Feser2, Vlad Tsaltskan3, Katherine Nguyen Nguyen3, Kristen Demoruelle2, kristine Kuhn4, David Boyle3, Cate Speake5, Xiao-Jun Li1, Peter Skene1, Troy Torgerson1, Tom Bumol1, V. Michael Holers6, Jane Buckner7, Gary Firestein8, kevin Deane2 and Mark Gillespie1, 1Allen Institute for Immunology, Seattle, WA, 2University of Colorado Anschutz Medical Campus, Aurora, CO, 3University of California San Diego, La Jolla, CA, 4University of Colorado School of Medicine, Aurora, CO, 5Benaroya Research Institute, Seattle, WA, 6University of Colorado, Denver, CO, 7Benaroya Research Institute at Virginia Mason, Seattle, WA, 8University of California San Diego, San Diego, CA

    Background/Purpose: Seropositive RA is preceded by an at-risk stage characterized by elevated circulating autoantibodies (AAb), including ACPA, in otherwise healthy individuals without clinically-apparent inflammatory arthritis.…
  • Abstract Number: 2094 • ACR Convergence 2023

    Increasing Collaboration, Education, and Awareness of Scleroderma Through an Interprofessional Education Program: Emphasizing the Importance of a Multidisciplinary Team and the Patient as the Primary Educator

    Corey Fellon1, Hannah Bowen2 and Lee Shapiro3, 1Albany Medical College, Albany, NY, 2Steffens Scleroderma Foundation, Batavia, NY, 3Albany Medical College, Stillwater, NY

    Background/Purpose: Scleroderma is a condition that can affect almost every organ system and thus requires an interprofessional team to optimally manage symptoms and improve patient…
  • Abstract Number: 2019 • ACR Convergence 2023

    2023 EULAR Recommendations for the Management of Fatigue in People with Inflammatory Rheumatic and Musculoskeletal Diseases

    Emma Dures1, Bayram Farisogullari2, Eduardo Santos3, Anna Molto4, Caroline Feldthusen5, Claire Harris6, Corinna Elling-Audersch7, Deirdre Conolly8, Elena Elefante9, Fernando Estévez-López10, Ilaria Bini11, Jette Primdahl12, Kirsten Hoeper13, Marie Urban14, Mart van de Laar15, Marta Redondo16, Peter Böhm17, Raj Amarnani18, Rhys Hayward6, Rinie Geenen19, Simona Rednic20, Susanne Pettersson21, Tanja Thomsen22, Till Uhlig23, Valentin Ritschl24 and Pedro Machado25, 1Academic Rheumatology, Bristol Royal Infirmary; and Faculty of Health and Applied Sciences, University of the West of England, Bristol, United Kingdom, 2Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey, 3Health Sciences Research Unit: Nursing (UICISA: E), Nursing School of Coimbra (ESEnfC), Coimbra, Portugal, 4HOPITAL COCHIN AP-HP, Service de Rhumatologie, Paris, France, 5Institute of Neuroscience and Physiology, University of Gothenburg, Department of Health and Rehabilitation, Unit of Physiotherapy, Sahlgrenska Academy, Gothenburg, Sweden, 6Northwick Park Hospital, London North West University Healthcare NHS Trust, Department of Rheumatology, London, United Kingdom, 7Deutsche Rheuma-Liga Bundesverband e.V., Patient Research Partner, Bonn, Germany, 8School of Medicine, Trinity College Dublin, Discipline of Occupational Therapy, Dublin, Ireland, 9Rheumatology Unit, Department of clinical and experimental medicine, University of Pisa, Pisa, Italy, 10Harvard T.H. Chan School of Public Health, Department of Social and Behavioral Sciences, Boston, MA, 11Anmar, Young, Rome, Italy, Rome, Italy, 12University Hospital of Southern Denmark, Danish Hospital for Rheumatic Diseases, Sønderborg, Denmark, 13Hannover Medical School, Department of Rheumatology and Immunology, Hannover, Germany, 14University Hospitals Bristol, Research Design Service, Bristol, United Kingdom, 15University of Twente, Department of Psychology, Health and Technology, Enschede, Netherlands, 16Camilo José Cela University, Faculty of Heath Sciences, Madrid, Spain, 17German League against rheumatism, Forschungspartner, Bonn, Germany, 18Barts Health NHS Trust, Barts Health Rheumatology Service, London, United Kingdom, 19Utrecht University, Vorstenbosch, Netherlands, 20Prof Dr Simona Rednic, Cluj, Romania, 21Karolinska Institute, Division of Rheumatology, Department of Medicine Solna, Stockholm, Sweden, 22University of Copenhagen, Copenhagen Centre for Arthritis Research, Centre for Rheumatology and Spine Diseases VRR, Rigshospitalet, Copenhagen, Denmark, 23Center for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway, 24Medical University of Vienna, Vienna, Austria, 25Centre for Rheumatology & Department of Neuromuscular Diseases, University College London, London, UK. Department of Rheumatology, Northwick Park Hospital, London North West University Healthcare NHS trust, London, UK., London, United Kingdom

    Background/Purpose: Fatigue is prevalent in people with inflammatory rheumatic and musculoskeletal diseases (I-RMDs) and recognized as one of the most challenging symptoms to manage (1).…
  • Abstract Number: 1578 • ACR Convergence 2023

    Impact of Anxiety or Depression Status and Fibromyalgia on Adherence to Treatment of Patients with Takayasu Arteritis

    Alejandra Espinosa-Orantes1, David Vera-Bustamante2, Jessica Roldan Ortega3, Maria Mejia-Avila4, Jose Raul Molina5, Evelyn Aranda Cano5, Adriana Miguel-Alvarez5, Ismael Valenzuela5, Viridiana Del Río-Guerrero6, Paloma Rodriguez5, Mauricio Mora-Ramirez5, Nilda Espinola-Zavaleta4, Luis H Silveira-torre6, Angélica Vargas Guerrero7 and Laura A Martínez-Martínez8, 1Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico, 2BENEMERITA UNIVERSIDAD AUTONOMA DE PUEBLA, Mexico City, Mexico, 3INSTITUTO NACIONAL DE CARDIOLOGIA, Ciudad de México, Mexico, 4Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico, 5Instituto Nacional de Cardiologia, Mexico City, Mexico, 6Instituto Nacional de Cardiología, Mexico City, Mexico, 7Instituto Nacional de Cardiología, Mexico City, Mexico, 8Universidad Nacional Autónoma de México - Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico

    Background/Purpose: Takayasu arteritis (TAK) is a chronic, granulomatous large-vessel vasculitis. As TAK has a chronic course, higher frequency rates of anxiety and depression are reported…
  • Abstract Number: 2125 • ACR Convergence 2023

    Comparing the ITIS Diet and the Mediterranean Diet in Rheumatoid Arthritis: Preliminary Findings on Clinical and Microbiome Outcomes

    Marta Sala Climent1, Martha Cedeno1, Roxana Coras2, Tiffany Holt1, Soo-In Choi3, Abha Singh4, Katherine Nguyen Nguyen5, Susan Lee1, Simone Zuffa Zuffa1, Meritxell Agustin-Perez1, Marta Fernandez-Bustamante1, Shahrokh Golshan1, Arthur Kavanaugh6 and Monica Guma5, 1University of California San Diego, San Diego, CA, 2Cedars-Sinai Medical Center, Los Angeles, CA, 3University of California San Diego, Alicante, CA, 4Department of Medicine, University of California San Diego, La Jolla, CA, 5University of California San Diego, La Jolla, CA, 6University of California San Diego, School of Medicine, Riverside, CA

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic condition characterized by persistent joint inflammation, functional impairment, and disability. Adhering to a Western diet has been associated…
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