ACR Meeting Abstracts

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  • Abstract Number: 1303 • ACR Convergence 2023

    Patient’s and Physician’s Evaluation of Global Assessment of Disease Activity over Follow up and Across Disease Activity Levels in Recent-Onset Rheumatoid Arthritis

    Audrey-Anne Couture1, Nathalie Carrier2, Hugues Allard-Chamard3, Sophie ROUX3, Patrick Liang3 and Gilles Boire3, 1University of Montréal, Montréal, QC, Canada, 2CIUSSS de l'Estrie - CHUS, Sherbrooke, QC, Canada, 3Université de Sherbrooke, Sherbrooke, QC, Canada

    Background/Purpose: Composite measures (e.g. SDAI) to assess Rheumatoid Arthritis (RA) disease activity incorporate patient (PGA) and evaluator (EGA) global assessments. EGA and PGA are often…
  • Abstract Number: 1168 • ACR Convergence 2023

    Evaluation of Agreement Between Functional and Radiological Changes in Idiopathic Inflammatory Myositis (IIM) Associated Interstitial Lung Disease (ILD)

    Sonali Narain1, Can Hu2, Michael Liu1, Himanshu Vashistha1, Kourosh Shargani3 and Galina Marder1, 1Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY, 2Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Fort Lee, NJ, 3Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY

    Background/Purpose: ILD is a major cause of morbidity and mortality in IIM. The diagnosis and progression of ILD often relies on high resolution computed tomography…
  • Abstract Number: 1252 • ACR Convergence 2023

    Physician Global Assessment of Disease Activity in Childhood-Onset Systemic Lupus Erythematosus – Does the Approach Matter?

    Ekemini Ogbu1, Hermine Brunner2, Jennifer Huggins3, Angela Merritt3, Megan Quilan-Waters3, Catherine Robben3, Chen Chen3, Daniel J Lovell4 and Bin Huang3, 1Cincinnati Children's Hospital Medical Center, University of Cincinnati School of Medicine, Johns Hopkins University, Cincinnati, OH, 2Cincinnati Children's Hospital Medical Center, Division of Rheumatology, Cincinnati, OH, 3Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 4UC Department of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati, Cincinnati, OH

    Background/Purpose: Physician Global Assessment of Disease Activity (PhGA) are commonly used outcome measures in pediatric rheumatology. For childhood-onset systemic lupus erythematosus (cSLE), the traditional visual…
  • Abstract Number: 1296 • ACR Convergence 2023

    Decline in Incidence of Extraarticular Manifestations of Rheumatoid Arthritis: A Population-Based Cohort Study

    Bradly Kimbrough1, Cynthia Crowson1, John Davis1, Eric Matteson2 and Elena Myasoedova1, 1Mayo Clinic, Rochester, MN, 2Mayo Clinic College of Medicine and Science, Rochester, MN, USA, Rochester, MN

    Background/Purpose: Extraarticular manifestations of rheumatoid arthritis (ExRA) are associated with increased disease burden and mortality. They are also common, affecting about half of patients with…
  • Abstract Number: 1316 • ACR Convergence 2023

    Influence of Rheumatoid Factor on Serum Drug Levels of TNF Inhibitors with Different Structures in Rheumatoid Arthritis

    Ana Martinez Feito1, Chamaida Plasencia-Rodríguez2, Marta Novella-Navarro2, Johanna E. Gehin3, Borja Hernandez-Breijo4, Claudia M.Brenis5, Alejandro Villalba6, Elisa Fernandez-Fernandez4, Irene Monjo7, Dora Pascual-Salcedo8, Pilar Nozal9 and Alejandro Balsa2, 1Immuno-Rheumatology research group , Institute for Health Research (IdiPAZ), Madrid, Spain, 2Hospital Universitario La Paz, Madrid, Spain, 3Dept. of Medical Biochemistry, Oslo University Hospital, Oslo, Norway, 4La Paz University Hospital, Madrid, Spain, 5VIB-UGent Inflammation Research Center Gent, Belgium, Gent, Belgium, 6Rheumatology Department, La Paz University Hospital, Madrid, Spain, 7University Hospital La Paz, Madrid, Spain, 8Immuno-Rheumatology Research Group, La Paz University Hospital, Madrid, Spain, 9Immunology Unit in La Paz University Hospital-Idipaz, Madrid, Spain

    Background/Purpose: Elevated rheumatoid factor (RF) in patients with rheumatoid arthritis (RA) is associated with higher disease activity. A significantly lower efficacy of TNF inhibitors (TNFi)…
  • Abstract Number: 1311 • ACR Convergence 2023

    T Cell Subset Signatures Predicted Clinical Response to Etanercept-biosimilar Yisaipu in Patients with Rheumatoid Arthritis

    Huaqun Zhu1, Sumei Tang1, Gong Cheng1, Yingni Li1, Yun Li1, Feng Sun1, Xiaolin Sun1, Jiahui Cheng1, Ru Li1 and Zhanguo Li2, 1Peking University People’s Hospital, Beijing, China, 2Peking University Health Science Center, Department of Rheumatology and Immunology, People's Hospital, Beijing, China

    Background/Purpose: Our study aimed to use machine-learning approaches to characterize the immune cell profiles of patients who were inadequate responders to Etanercept-Biosimilar Yisaipu (Yisaipu-IRs) and…
  • Abstract Number: 1306 • ACR Convergence 2023

    Statin Use Attenuates the Impact of Systemic Inflammation on Ischemic Cardiovascular Risk in Patients with Rheumatoid Arthritis

    George Karpouzas1, Sarah Ormseth2, Piet Van Riel3, Elena Myasoedova4, Miguel A Gonzalez-Gay5, Alfonso Corrales6, Solbritt Rantapaa-Dahlqvist7, Petros Sfikakis8, Patrick Dessein9, Linda Tsang9, Carol Hitchon10, Hani El Gabalawi11, Virginia Pascual Ramos12, Irazú Contreras Yañez13, Iris Colunga14, Dionicio A. Galarza-Delgado14, José Ramón Azpiri-López14, Silvia Rolefstad15, Anne Grete Semb16, Durga P Misra17, George Kitas18 and Ellen-Margrethe Hauge19, 1Harbor-UCLA Medical Center, Torrance, CA, 2The Lundquist Institute, Torrance, CA, 3Radboud University Medical Center, Drunen, Netherlands, 4Mayo Clinic, Rochester, MN, 5IDIVAL and School of Medicine, UC, Santander; Department of Rheumatology, IIS-Fundación Jiménez Díaz, Madrid, Santander, Spain, 6Rheumatology Department, Immunopathology Group, Hospital Universitario Marqués de Valdecilla-IDIVAL, Santander, Spain, 7Umeå University, Umeå, Umea, Sweden, 8National Kapodistrian University of Athens Medical School, Athens, Greece, 9University of Witwatersrand, Johannesburg, South Africa, 10University of Manitoba, Manitoba, MB, Canada, 11University of Manitoba, Winnipeg, MB, Canada, 12Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, 13Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 14Hospital Universitario UANL, Monterrey, Mexico, 15Diakonhjemmet Hospital, Oslo, Norway,, Oslo, Norway, 16Diakonhjemmet Hospital, Oslo, Norway, 17Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, India, 18The Dudley Group NHS Foundation Trust, Birmingham, United Kingdom, 19Aarhus University Hospital, Aarhus, Denmark

    Background/Purpose: Baseline and cumulative inflammation have both been associated with increased cardiovascular event (CVE) risk in patients with rheumatoid arthritis (RA). Statin therapy reduced systemic…
  • Abstract Number: 1180 • ACR Convergence 2023

    Machine Learning Approach for the Prediction of anti-MDA5 Positive Dermatomyositis Mortality

    Xinlei Liu1, Fumin Qi2, Wei Wei1 and Yin Zhao1, 1Tianjin Medical University General Hospital, Tianjin, China, 2Tianjin Medical University, Tianjin, China

    Background/Purpose: We describe a single-center clinical cohort of MDA5 positive dermatomyositis(DM) in China and apply a machine learning approach to predict the risk of mortality…
  • Abstract Number: 1273 • ACR Convergence 2023

    Long-term Follow-up of Treated-to-target RA and UA: Results of the BeSt and IMPROVED Studies

    Sascha Heckert1, Johanna Maria Maassen1, Isabell Nevins2, F. Fodili3, Margreet Steup-Beekman4, Thomas Huizinga1, Sytske Anne Bergstra1 and CF Allaart1, 1Leiden University Medical Center, Leiden, Netherlands, 2Leiden University Medical Center, Amsterdam, Netherlands, 3Stichting ReumaZorg ZWN, Roosendaal, Netherlands, 4Leiden University Medical Center, Den Haag, Netherlands

    Background/Purpose: In 2 trials with an original follow-up of 5-10 years, patients with early arthritis were treated to target, resulting in low disease activity or…
  • Abstract Number: 1261 • ACR Convergence 2023

    Network Analysis of Depression and Anxiety Symptoms in Chinese Rheumatoid Arthritis Patients

    Zhang Lijuan and Wu Beiwen, Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Background/Purpose: Rheumatoid arthritis (RA) patients are susceptible to comorbid anxiety and depression. From the network model perspective, comorbidity is due to direct interactions between depression…
  • Abstract Number: 1327 • ACR Convergence 2023

    Effects of Long-Term Low Dose Glucocorticoid Treatment for Rheumatoid Arthritis on Body Weight and Blood Pressure: A Pooled Analysis of Individual Patient Data from Five Randomised Trials

    Andriko Palmowski1, Sabrina Mai Nielsen2, Zhivana Boyadzhieva3, Linda Hartman4, Judith Oldenkott5, Björn Svensson6, Ingiäld Hafström7, Siegfried Wassenberg8, Ernest Choy9, John Kirwan10, Robin Christensen11, Maarten Boers12 and Frank Buttgereit13, 1Charité - Universitätsmedizin Berlin, Berlin, Germany, 2The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark, 3Charité Universitatsmedizine - Berlin, Berlin, Germany, 4Amsterdam University Medical Centers, Amsterdam, Netherlands, 5Charite - University Medicine Berlin, Berlin, Germany, 6Lund University, Lund, Sweden, 7Karolinska Institutet, Stockholm, Sweden, 8Rheumazentrum Ratingen, Ratingen, Germany, 9Section of Rheumatology, Cardiff University, Cardiff, United Kingdom, 10University of Bristol, Bristol, United Kingdom, 11Musculoskeletal Statistics Unit, The Parker Institute, Copenhagen, Denmark, 12Amsterdam UMC, Vrije Universiteit, Amersfoort, Netherlands, 13Charité Universitätsmedizin, Dept. Rheumatology, Berlin, Germany

    Background/Purpose: High-dose glucocorticoids (GCs) can cause weight gain and hypertension. It is unclear whether GCs at ≤7.5mg/day prednisone equivalent ("low dose"), administered for rheumatoid arthritis…
  • Abstract Number: 1319 • ACR Convergence 2023

    Real World Data on Antifibrotics in Rheumatoid Arthritis-Interstitial Lung Disease. National Multicenter Study of 73 Patients

    Belén Atienza-Mateo1, Ana Serrano-Combarro2, Maria Martin-Lopez3, Santos Castañeda4, Rafael Benito Melero-Gonzalez5, Jesus Loarce-Martos6, Natalia Mena Vazquez7, Carmen carrasco-Cubero8, Carolina Diez-Morrondo9, David Castro-Corredor10, Tomás Vazquez-Rodriguez11, andrea Garcia-Valle12, Gema Bonilla13, Marina Rodriguez-lopez14, Ignacio Brana Abascal15, SARA MARIA ROJAS HERRERA16, Juan Camilo Sarmiento-Monroy17, Pablo Andujar-Brazal18, Juan Ramon De Dios19, Carmen Gonzalez-Montagut Gomez20, Sergio Ordonez-Palau21, Anahy Maria Brandy-Garcia22, Fernando Lozano23, Maria Lopez-Lasanta24, Cristina Campos Fernández25, Marta Garijo Bufort26, Ivette Casafont-Sole27, Calderon Goercke28, Carlota Laura Iñiguez29, Francisco Ortiz-Sanjuán30, Emilio Giner-Serret31, Bryan Josue Flores Robles32, Mireia Moreno33, Evelin Cecilia Cervantes-Perez34, Diego Ferrer35, Ricardo Blanco36 and On behalf of the Collaborative Group Members37, 1Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 2Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain, 3Hospital 12 de Octubre, Madrid, Spain, 4Hospital Universitario de la Princesa, Madrid, Spain, 5CHU Vigo, O Carballino, Spain, 6Ramón y Cajal University Hospital, Madrid, Spain, 7IBIMA, Málaga, Spain, 8Department of Rheumatology, Hospital Universitario de Badajoz, Badajoz, Spain, 9Division of Rheumatology, Hospital de León, León, Spain, 10General University Hospital of Ciudad Real, Santa Cruz de Mudela (Ciudad Real), Spain, 11Rheumatology, Complejo Hospitalario Universitario de Ferrol, A Coruña, Spain, 12Division of Rheumatology, Complejo Asistencial Universitario de Palencia, Palencia, Spain, 13Department of Rheumatology, Hospital Clínico Universitario La Paz, Madrid, Spain, 14Division of Rheumatology, Hospital Clínico Universitario de Santiago, La Coruna, Spain, 15Division of Rheumatology, Hospital Universitario Central de Asturias, Oviedo, Spain, 16Division of Rheumatology, Hospital de Mérida, Mérida, Spain, 17Hospital Clínic, Barcelona, Spain, 18Division of Rheumatology, Hospital Universitario Doctor Peset, Valencia, Spain, 19Hospital Universitario Araba, Vitoria, Spain, 20H. Clínico Universitario de Valladolid, Valladolid, Spain, 21H. Arnau de Vilanova, Lleida, Spain, 22Hospital Germans Trias i Pujol, Badalona, Spain, 23Hospital Universitario 12 de Octubre, Madrid, Spain, 24Hospital Universitari Vall d'Hebron, Rheumatology, Barcelona, Spain, 25Hospital General Universitario Valencia, Valencia, Spain, 26H. de Sagunto, Valencia, Italy, 27Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 28Hospital Universitario Marqués de Valdecilla, Santander, Spain, 29Hospital Universitario Lucus Augusti, Lugo, Spain, 30Hospital Universitario y Politécnico La Fe, Valencia, Spain, 31Hospital Royo Villanova, Teruel, Spain, 32Hospital Universitario San Pedro, Logroño, Spain, 33Parc Tauli Hospital Universitari, I3PT(UAB), Barcelona, Spain, 34Complexo Hospitalario Universitario de Pontevedra, Pontevedra, Spain, 35Division of Pneumology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 36Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 37Spanish Collaborative Group of Interstitial Lung Disease Associated with Rheumatoid Arthritis, Spain, Spain

    Background/Purpose: Interstitial lung disease (ILD) is a critical complication of rheumatoid arthritis (RA). Abatacept and rituximab are the preferred disease-modifying antirheumatic drugs (DMARDs) for RA-ILD.…
  • Abstract Number: 1288 • ACR Convergence 2023

    Frailty Is Associated with Higher Risk of Readmission in Patients with Rheumatoid Arthritis

    Waqas Tahir1, Yenny Rosli2, Christopher Leung3, K Wysham4, Jiha Lee5, Radjiv Goulabchand6, Una Makris7, Siddharth Singh8 and Namrata Singh9, 1Mayo Clinic, Jacksonville, FL, 2University of Washington, Seattle, WA, 3Georgetown University School of Medicine, Washington, DC, 4VA Puget Sound/University of Washington, Seattle, WA, 5University of Michigan, Ann Arbor, MI, 6University of California San Diego, La Jolla, CA, 7UT Southwestern Medical Center and Dallas VA, Dallas, TX, 8University of California San Diego, San Diego, CA, 9University of Washington, Bellevue, WA

    Background/Purpose: With the advent of new therapies and increasing life expectancy, there is a rising number of older adults living with rheumatoid arthritis (RA). Patients…
  • Abstract Number: 1304 • ACR Convergence 2023

    Window of Opportunity to Achieve Better Functional Outcomes in Patients with RA: Effectiveness of an Early Treatment Strategy

    Vivian Bykerk1, Isabel Castrejon2, Vibeke Strand3, Stephanie Dahan4, Raul Castellanos-Moreira5, Leo Chen6 and Wayne Little4, 1Department of Rheumatology, Hospital for Special Surgery, New York, NY, 2Hospital Universitario Gregorio Marañón, Madrid, Spain, 3Stanford University, Palo Alto, CA, 4Bristol Myers Squibb, Princeton, NJ, 5Bristol Myers Squibb, Madrid, Spain, 6Syneos Health, Vancouver, BC, Canada

    Background/Purpose: RA is a chronic disease that can lead to irreversible damage and functional decline with delayed or inadequate treatment.1 Abatacept + MTX is effective…
  • Abstract Number: 1326 • ACR Convergence 2023

    Safety and Efficacy of Upadacitinib in Patients with Rheumatoid Arthritis Refractory to Biologic DMARDs: Results Through Week 204 from the SELECT-CHOICE Study

    Andrea Rubbert-Roth1, Koji Kato2, Boulos Haraoui3, Maureen Rischmueller4, Yanxi Liu2, Nasser Khan5, Heidi Camp2 and Ricardo Xavier6, 1Cantonal Hospital St. Gallen, St. Gallen, Switzerland, 2AbbVie, Inc., North Chicago, IL, 3Institut de Rhumatologie de Montréal, Montreal, QC, Canada, 4The Queen Elizabeth Hospital and Basil Hetzel Institute; Adelaide Medical School, University of Adelaide, Adelaide, Australia, 5Pharmacovigilance and Patient Safety, AbbVie, Inc., North Chicago, IL, 6Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

    Background/Purpose: To evaluate the long-term safety and efficacy of upadacitinib (UPA), an oral JAK inhibitor, through week 204 in patients with RA from the long-term…
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