ACR Meeting Abstracts

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  • Abstract Number: 1868 • ACR Convergence 2023

    Long-term Efficacy of a 2-year MRI Treat-to-target Strategy on Radiographic Joint Damage Progression in Rheumatoid Arthritis Patients in Clinical Remission – Five Year Follow-up of the IMAGINE-RA Randomized Clinical Trial

    Signe Møller-Bisgaard1, Kim Hørslev-Petersen2, Lykke Ørnbjerg1, Bo Ejbjerg3, Merete L Hetland1, Jakob Moeller4, Robin Christensen5, Sabrina Mai Nielsen6, Daniel Glinatsi7, Mikael Boesen8, Kristian Stengaard-Pedersen9, Ole Rintek Madsen10, Bente Jensen11, Jan Alexander Villadsen2, Ellen-Margrethe Hauge9, Oliver Hendricks2, Hanne Merete Lindegaard12, Niels Steen Krogh13, Anne Grethe Jurik9, Henrik Thomsen4 and Mikkel Østergaard14, 1Copenhagen Center for Arthritis Research, Rigshospitalet, Copenhagen, Denmark, 2Danish Hospital for Rheumatic Diseases, Sønderborg, Denmark, 3Slagelse Hospital, Slagelse, Denmark, 4Herlev-Gentofte Hospital, Herlev, Denmark, 5Musculoskeletal Statistics Unit, The Parker Institute, Copenhagen, Denmark, 6The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark, 7Copenhagen Center for Arthritis Research, Rigshospitalet, Copenhagen, Sweden, 8Copenhagen University Hospital, Bispebjerg and Frederiksberg Hospital, Naerum, Denmark, 9Aarhus University Hospital, Aarhus, Denmark, 10Herlev-Gentofte Hospital, Gentofte, Denmark, 11Bispebjerg-Frederiksberg Hospital, Frederiksberg, Denmark, 12Odense Hospital, Odense, Denmark, 13ZiteLab ApS, Frederiksberg, Denmark, 14Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet; University of Copenhagen, Copenhagen, Denmark

    Background/Purpose: Radiographic joint damage progresses in 20-30% of rheumatoid arthritis (RA) patients despite fulfilling clinical remission criteria (1). Osteitis assessed on MRI is a well…
  • Abstract Number: 1933 • ACR Convergence 2023

    Analysis of IgG4-Related Disease in a Diverse Long Island Population: Insights from the Rheumatology Clinic

    Young Min Cho1, Galina Marder2, Koushik Sangaraju3, Lara El Khoury2, Kourosh Shargani4 and Jevon Fragoso5, 1Northwell, Glen Cove, NY, 2Northwell, Great Neck, NY, 3Staten Island University Hospital - Northwell Health, Staten Island, NY, 4Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY, 5Northwell, Queens, NY

    Background/Purpose: IgG4-related disease (IgG4RD) is an immune-mediated disease characterized by dense lymphoid-lymphoplasmacytic infiltrates with high IgG4-positive plasma cells with heterogeneous clinical manifestations. The data on…
  • Abstract Number: 1963 • ACR Convergence 2023

    Effect of JAK-STAT Inhibition by Baricitinib and Tofacitinib on Disease Phenotype in a Mouse Model of Myositis

    Rita Spathis, Sabrina Narvesen, Deeva Robles Kuriplach, Karen Huang, Teja Sundar, Daniel Shulman, Elizabeth Bagley, Kanneboyina Nagaraju and Melissa Morales, Binghamton University, Johnson City, NY

    Background/Purpose: Dysregulation of the interferon (IFN) pathway plays a major role in the pathophysiology of autoimmune myositis. Upregulation of type 1 IFN stimulated genes (an…
  • Abstract Number: 1861 • ACR Convergence 2023

    Efficacy of Non-pharmacological Interventions: A Systematic Review Informing the 2023 EULAR Recommendations for the Management of Fatigue in People with Inflammatory Rheumatic and Musculoskeletal Diseases

    Eduardo Santos1, Bayram Farisogullari2, Emma Dures3, Rinie Geenen4 and Pedro Machado5, 1Health Sciences Research Unit: Nursing (UICISA: E), Nursing School of Coimbra (ESEnfC), Coimbra, Portugal, 2Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey, 3Academic Rheumatology, Bristol Royal Infirmary; and Faculty of Health and Applied Sciences, University of the West of England, Bristol, United Kingdom, 4Utrecht University, Vorstenbosch, Netherlands, 5Centre for Rheumatology & Department of Neuromuscular Diseases, University College London, London, UK. Department of Rheumatology, Northwick Park Hospital, London North West University Healthcare NHS trust, London, UK., London, United Kingdom

    Background/Purpose: To identify the best evidence on the efficacy of non-pharmacological interventions in reducing fatigue in people with I-RMDs and to summarise their safety in…
  • Abstract Number: 1935 • ACR Convergence 2023

    Pre-exposure Prophylaxis with Tixegvimab/cilgavimab Is Effective in Limiting the Risk and Severity of COVID-19 in Patients with Auto Immune or Inflammatory Diseases at Increased Risk of Severe COVID-19

    Marion THOMAS1, Maeva MASSON2, Raphaele Seror3, Samuel Bitoun4, Henry DUPUY5, Lazato ESTIBALIZ5, Christophe Richez6, Yannick ALLANORE7 and Jerome AVOUAC8, 1HOPITAL COCHIN AP-HP, Service de Rhumatologie, Paris, France, 2CHU Toulouse, Toulouse, France, 3University Hospital Paris Saclay, Le Kremlin-Bicêtre, France, 4CHU Bicêtre APHP, Le Kremlin-Bicêtre, France, 5CHU Bordeaux, Bordeaux, France, 6Université de Bordeaux, Bordeaux, France, 7Université Paris Cité, Paris, France, 8Rheumatology A Department, Hôpital Cochin, AP-HP Centre - Université Paris Cité, Paris, France

    Background/Purpose: Patients with autoimmune or inflammatory diseases treated with immunosuppressants such as anti-CD20 are at increased risk for severe COVID-19 and have a high probability…
  • Abstract Number: 1877 • ACR Convergence 2023

    Diagnostic Yield of 18F-FDG PET-CT for Large Vessel Involvement in Patients with Suspected Giant Cell Arteritis and Negative Temporal Artery Biopsy

    Javier Narvaez1, Paula V. Estrada-Alarcón2, Paola Vidal-Montal3, Iván Sánchez-Rodriguez4, Aida Sabate-Llobera4, Montserrat Cortes-Romera4 and Joan Miquel Nolla5, 1Hospital Universitario de Bellvitge, Barcelona, Spain, 2Hospital de San Juan Despí Moisès Broggi, Barcelona, Spain, 3Department of Rheumatology. Hospital Universitario de Bellvitge, Barcelona, Spain, 4Department of Nuclear Medicine – PET IDI. Hospital Universitario de Bellvitge, Barcelona, Spain, 5Department of Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain

    Background/Purpose: Every effort should be made to confirm a suspected diagnosis of giant cell arteritis (GCA). According to the 2018 update of the EULAR recommendations…
  • Abstract Number: 1859 • ACR Convergence 2023

    Examining Hydroxychloroquine Prescribing and SLE Damage in a Statewide Lupus Cohort

    Jenna Cormier1, Bryn Sutherland1, Yiran Jiang2, David Gazeley3, Jonathan Katz4, Shalvi Parikh4, Carlos Torres5, Eden Charles5, Ang Yu6, Felix Elwert6 and Christie M. Bartels7, 1Medical College of Wisconsin, Milwaukee, WI, 2Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, 3Medical College of Wisconsin, Wauwatosa, WI, 4Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, 5University of Wisconsin School of Medicine and Public Health, Madison, WI, 6Department of Sociology, University of Wisconsin, Madison, WI, 7University of Wisconsin, School of Medicine and Public Health, Madison, WI

    Background/Purpose: Systemic lupus erythematosus (SLE) is a heterogeneous disease that disproportionately affects women, racially and ethnically minoritized populations, and people of lower socioeconomic status (SES).…
  • Abstract Number: 1125 • ACR Convergence 2023

    A Rheumatologic Clinical Profile of the VEXAS Syndrome: Results from a Survey Conducted Among Rheumatologic Units of 126 Hospitals Across Spain

    Marta López I Gómez1, Paula García Escudero2, Marta López3, Berta Magallanes López4, Meritxell Salles Lizarzaburu5, Beatriz Frade Sosa6, Elena Riera7, Ernesto Trallero Araguás8, MARIA ELVIRA DIEZ ALVAREZ9, Francisco Javier Toyos Sáenz de Miera10, Alicia Garcia Dorta11, José Ángel Hernández Beriain12, Marta Ibáñez Martínez13, carolina Merino14, PALOMA VELA15, Ana Victoria Orenes Vera16, Diego Dios Santos17, Jose Alberto Miranda Filloy18, Clara García Belando19, María Rodríguez Laguna20, Ignacio Vázquez21, Joaquin Belzunegui22, Judit Font23, Carlos de Miguel Sánchez24, Zuriñe Ortiz de Zárate Caballero25 and Jaime Calvo Alén26, 1Hospital Universitario de Araba, Pamplona, Spain, 2Hospital Universitario Araba, Bilbao, Spain, 3Hospital Universitario Arava, Pamplona, Spain, 4Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, 5C. H. de Manresa - Fundació Althaia, Barcelona, Spain, 6Hospital Clínic de Barcelona, Barcelona, Spain, 7H. U. Mútua Terrasa, Barcelona, Spain, 8Department of Rheumatology, Hospital Universitario Vall d'Hebron, Barcelona, Spain, 9Rheumatology, Hospital Universitario de León, León, Spain, 10Hospital Virgen Macarena, Sevilla, Spain, 11Rheumatology Unit, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, 12Rheumatology, Hospital Insular de Gran Canaria, Las Palmas de Gran Canaria, Spain, 13C. A. U. de Salamanca, Salamanca, Spain, 14Rheumatology Department Hospital Universitario Puerta de Hierro, Majadahonda (Madrid), Spain, 15Rheumatology, Hospital General Universitario Alicante, Alicante, Spain, 16H. Arnau de Vilanova, Valencia, Spain, 17Rheumatology department, Complexo Hospitalario Universitario A Coruña (CHUAC). Instituto de Investigación Biomédica A Coruña (INIBIC), A Coruña, Spain, 18C. H. U. Lucus Augusti, Lugo, Spain, 19Hospital Los Arcos del Mar Menor, Murcia, Spain, 20H. Clínico San Carlos, Madrid, Spain, 21H. U. Dr. Peset, Valencia, Spain, 22H. C. Alto Deba, Donostia, Spain, 23Hospital Universitario Germans Trias i Pujol, Badalona, Spain, 24Hospital Universitario de Araba, Hematology, VItoria, Spain, 25Hospital Universitario de Araba, Internal Medicine, Vitoria, Spain, 26Hospital Universitario Araba, Vitoria, Spain

    Background/Purpose: The newly described VEXAS syndrome is a very heterogenous disease with rheumatologic and hematologic manifestations, caused by somatic mutations affecting UBA1 gene, that still…
  • Abstract Number: 1604 • ACR Convergence 2023

    First and Recurrent Thrombosis Risk After 4,454 Patient-Years of Follow-Up: Prospective Results from the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository (“Registry”)

    Jonathan Thaler1, Yasaman Ahmadzadeh2, Danieli Andrade3, leslie skeith4, Maria Tektonidou5, Savino Sciascia6, Vittorio Pengo7, Jose Pardos-Gea8, Guillermo Ruiz-Irastorza9, Chary Lopez-Pedrera10, H Michael Belmont11, Kello Nina12, Paul R. Fortin13, Denis WAHL14, Maria Gerosa15, Guilherme De Jesús16, Zhuoli Zhang17, Tatsuya Atsuma18, Maria Efthymiou19, D. Ware Branch20, Laura Andreoli21, Esther Rodriguez almaraz22, Michelle Petri23, Giulia Pazzola24, Ricard Cervera25, Bahar Artim Esen26, Hui Shi27, Jason Knight27, Guillermo Pons-Estel28, Rohan Willis29, Ali Duarte-Garcia30, Maria Laura Bertolaccini31, Hannah Cohen32, Doruk Erkan1 and On Behalf Of APS ACTION33, 1Hospital for Special Surgery, New York, NY, 2Roger Williams Medical Center, Providence, RI, 3University of São Paulo, São Paulo, Brazil, 4University of Calgary, Calgary, AB, Canada, 5Joint Academic Rheumatology Program, First Department of Propedeutic and Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece, 6University of Turin, Torino, Italy, 7Department of Cardiac-Thoracic-Vascular Sciences and Public Health University of Padova, Padova, Italy, 8Vall d'Hebron University Hospital, Barcelona, Spain, 9Hospital Universitario Cruces, Barakaldo, Spain, 10IMIBIC - Reina Sofia Hospital, Córdoba, Spain, 11NYU School of Medicine, New York, NY, 12Northwell Health, Brooklyn, NY, 13Centre ARThrite - CHU de Québec - Université Laval, Quebec City, QC, Canada, 14University of Lorraine, Nancy, France, 15University of Milan, Milano, Italy, 16Universidade do Estado do Rio de Janeiro, Rio De Janeiro, Brazil, 17Peking University First Hospital, Rheumatology and Immunology Department, Beijing, China, 18Hokkaido University, Department of Rheumatology, Endocrinology and Nephrology, Sapporo, Japan, 19University College London, London, United Kingdom, 20University of Utah, Salt Lake City, UT, 21University of Brescia, Brescia, Italy, 22Hospital Universitario 12 de Octubre, Madrid, Spain, 23Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Timonium, MD, 24Azienda Ospedaliera Santa Maria Nuova di Reggio Emilia, Reggio Emilia, Italy, 25Hospital Clínic de Barcelona, Barcelona, Spain, 26Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 27University of Michigan, Ann Arbor, MI, 28CREAR, Rosario, Argentina, 29University of Texas Medical Branch, Galveston, TX, 30Mayo Clinic, Rochester, MN, 31King's College London, London, United Kingdom, 32University College London Hospitals NHS Foundation Trust, London, United Kingdom, 33on behalf of APS ACTION, New York, NY

    Background/Purpose: The APS ACTION Registry was created to study the natural course of disease over 10 years in persistently antiphospholipid antibody (aPL)-positive patients with or…
  • Abstract Number: 1147 • ACR Convergence 2023

    Blood-Based Biomarkers of Inflammation and Tissue Remodeling Can Discriminate Between Rheumatoid Arthritis, Psoriasis, and Psoriatic Arthritis and Are Associated with Hand Function

    Helena Port I Linares1, Birte Coppers2, Sara Bayat2, Godonou Elie-Tino2, Larissa Valor-Mendez2, David Simon2, Filippo Fagni2, Giulia Corte2, Anne-Christine Bay-Jensen3, Koray Tascilar2, Axel Hueber4, Verena Schoenau2, Michael Sticherling5, Simon Heinrich6, Daniela Bohr2, Georg Schett7, Arnd Kleyer8, Sigrid Leyendecker6, Signe Holm Nielsen3 and Anna-Maria Liphardt9, 1Nordic Bioscience A/S / University of Copenhagen, Copenhagen, Denmark, 2Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg & Universitätsklinikum Erlangen, Department of Internal Medicine 3 - Rheumatology and Immunology / Deutsches Zentrum Immuntherapie, Erlangen, Germany, 3Nordic Bioscience, Herlev, Denmark, 4Division of Rheumatology, Klinikum Nürnberg, Paracelsus Medical University / Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg & Universitätsklinikum Erlangen, Department of Internal Medicine 3 - Rheumatology and Immunology, Nürnberg, Germany, 5Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg & Universitätsklinikum Erlangen, Department of Dermatology, Erlangen, Germany, 6Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Institute of Applied Dynamics, Erlangen, Germany, 7Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, 8University Hospital Erlangen, Erlangen, Germany, 9Friedrich-Alexander-University Erlangen-Nuremberg, Internal Medicine 3 - Rheumatology and Immunology, University Hospital Erlangen, Erlangen, Germany

    Background/Purpose: Inflammatory musculoskeletal diseases including rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are characterized by physical function impairment due to progressive inflammatory and structural changes.…
  • Abstract Number: 1870 • ACR Convergence 2023

    Assessing the Appropriateness of Imaging Modalities in Primary Care for Low Back Pain and Their Impact on Outcomes: A Retrospective Observational Study in a Single Center in Trenton

    Damira Sereda1, Cristine Arcilla2, Kudret Arslan3 and Daniel Goldsmith4, 1Capital Health Medical Canter, Trenton, NJ, 2Capital Health Regional Medical Center, Ewing Township, NJ, 3Capital Health Medical Center, Trenton, NJ, 4Capital Health Regional Medical Center, Trenton, NJ

    Background/Purpose: Low back pain (LBP) is a leading cause of doctor visits and disability. The annual direct expenditures for LBP management exceed $80 billion, not…
  • Abstract Number: 1136 • ACR Convergence 2023

    Challenges in Diagnosing VEXAS Syndrome: Delayed Diagnosis, Misdiagnosis, and Associations with Specific Gene Mutations

    Paula García Escudero1, Marta López i Gómez2, Marta López Maraver3, PALOMA VELA4, María Rodríguez Laguna5, carolina Merino6, Ana Victoria Orenes Vera7, Clara García Belando8, Diego Dios Santos9, Jose Alberto Miranda Filloy10, Francisco Javier Toyos Sáenz de Miera11, Alicia Garcia Dorta12, Ignacio Vázquez13, José Ángel Hernández Beriain14, MARIA ELVIRA DIEZ ALVAREZ15, Marta Ibáñez Martínez16, Beatriz Frade Sosa17, Judit Font Urgelles18, Meritxell Salles Lizarzaburu19, Elena Riera Alonso20, Ernesto Trallero Araguás21, Berta Magallanes López22, Joaquín Belzunegui Otano23, Carlos de Miguel Sánchez24, Zuriñe Ortiz de Zárate Caballero25 and Jaime Calvo Alén26, 1Hospital Universitario Araba, Bilbao, Spain, 2Hospital Universitario de Araba, Pamplona, Spain, 3Hospital Universitario de Araba, Vitoria, Spain, 4Rheumatology, Hospital General Universitario Alicante, Alicante, Spain, 5H. Clínico San Carlos, Madrid, Spain, 6Rheumatology Department Hospital Universitario Puerta de Hierro, Majadahonda (Madrid), Spain, 7H. Arnau de Vilanova, Valencia, Spain, 8Hospital Los Arcos del Mar Menor, Murcia, Spain, 9Rheumatology department, Complexo Hospitalario Universitario A Coruña (CHUAC). Instituto de Investigación Biomédica A Coruña (INIBIC), A Coruña, Spain, 10C. H. U. Lucus Augusti, Lugo, Spain, 11Hospital Virgen Macarena, Sevilla, Spain, 12Rheumatology Unit, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, 13H. U. Dr. Peset, Valencia, Spain, 14Rheumatology, Hospital Insular de Gran Canaria, Las Palmas de Gran Canaria, Spain, 15Rheumatology, Hospital Universitario de León, León, Spain, 16C. A. U. de Salamanca, Salamanca, Spain, 17Hospital Clínic de Barcelona, Barcelona, Spain, 18Hospital Universitario Germans Trías i Pujol, Barcelona, Spain, 19C. H. de Manresa - Fundació Althaia, Barcelona, Spain, 20Hospital Universitario Mútua Terrassa, Barcelona, Spain, 21Department of Rheumatology, Hospital Universitario Vall d'Hebron, Barcelona, Spain, 22Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, 23Hospital Universitario Donosti, Donosti, Spain, 24Hospital Universitario de Araba, Hematology, VItoria, Spain, 25Hospital Universitario de Araba, Internal Medicine, Vitoria, Spain, 26Hospital Universitario Araba, Vitoria, Spain

    Background/Purpose: The newly described VEXAS syndrome is a very heterogenous disease with rheumatologic and hematologic manifestations, caused by somatic mutations affecting UBA1 gene, that still…
  • Abstract Number: 1156 • ACR Convergence 2023

    Presentations and Outcomes of Idiopathic Inflammatory Myopathies in Hong Kong

    Iris Tang1, Ho So2, Teresa li3, Vivian Tang4, Chi Ho5 and Roy Ho6, 1Department of Medicine, University of Hong Kong, Hong Kong, Hong Kong, 2Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, 3Queen Mary Hospital, Hong Kong, Hong Kong, 4North District Hospital, Hong Kong, Hong Kong, 5Alice Ho Miu Ling Nethersole Hospital, Hong Kong, Hong Kong, 6Queen Elizabeth Hospital, Hong Kong, Hong Kong

    Background/Purpose: Idiopathic inflammatory myopathies (IIM) are a group of heterogeneous autoimmune diseases with cutaneous, musculoskeletal, and systemic involvements. The Hong Kong Myositis Registry (MyoHK) was…
  • Abstract Number: 1613 • ACR Convergence 2023

    Tetrodotoxin Sensitive Nav1.7 Sodium Channel SCN9A Gene Polymorphism rs6754031(T >G) Is Associated with Fibromyalgia

    Koshy Nithin Thomas, Shivika Guleria, Amita Aggarwal and Able Lawrence, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, India

    Background/Purpose: SCN9A gene encodes a tetrodotoxin sensitive Nav1.7 Sodium channel expressed in dorsal root ganglia, peripheral nerves, olfactory nerves and inner ear. Rare Mutations in…
  • Abstract Number: 1872 • ACR Convergence 2023

    Performance Analysis of a Deep Learning Algorithm to Detect Positive SIJ MRI According to the ASAS Definition in axSpA Patients

    Joeri Nicolaes1, Evi Tselenti2, Theodore Aouad3, Clementina López Medina4, Antoine Feydy5, Hugues Talbot3, Bengt Hoepken6, Natasha De Peyrecave7 and Maxime Dougados8, 1KU Leuven, Department of Electrical Engineering (ESAT), Center for Processing Speech and Images; UCB Pharma, Anderlecht, Belgium, 2Veramed, London, United Kingdom, 3CentraleSupélec, Universite Paris-Saclay, Inria, Gif-sur-Yvette, France, 4Rheumatology Department, Cochin Hospital; INSERM (U1153): Clinical Epidemiology and Biostatistics, University of Paris; Rheumatology Department, Reina Sofia Hospital, Cordoba / IMIBIC / University of Cordoba, Cordoba, Spain, 5INSERM (U1153): Clinical Epidemiology and Biostatistics, University of Paris; Radiology Department, Cochin Hospital, Paris, France, 6UCB Pharma, Monheim, Germany, 7UCB Pharma, Brussels, Belgium, 8Rheumatology Department, Cochin Hospital; INSERM (U1153): Clinical Epidemiology and Biostatistics, University of Paris, Paris, France

    Background/Purpose: Magnetic resonance imaging (MRI) of the sacroiliac joints (SIJ) is an essential tool in the evaluation of patients with axial spondyloarthritis (axSpA). In-depth knowledge…
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