Abstracts Archive - Page 2605 of 2605 - ACR Meeting Abstracts

Abstract Number: 2655 • 2012 ACR/ARHP Annual Meeting
Rapid and Effective Response to Immunosuppression in Treating Macrophage Activation Syndrome Associated with a Heterozygous Dominant Negative Mutation in RAB27a Leading to Decreased Cytolytic Activity
Randy Q. Cron¹, Mingce Zhang², Christina J. Bemrich-Stolz² and Timothy Beukelman¹, ¹Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²Pediatrics, Univ of Alabama-Birmingham, Birmingham, AL
Background/Purpose: Hemophagocytic lymphohistiocytosis (HLH) is an often fatal disorder of infancy resulting from homozygous mutations in proteins involved in cytolysis (e.g. MUNC13-4, RAB27a, Perforin 1,…
Abstract Number: 2656 • 2012 ACR/ARHP Annual Meeting
Elevated Serum Follistatin-Like Protein 1 Suggests an Interleukin-1 Independent Pathway for Inflammation in Patients with Cryopyrin Associated Periodic Syndromes
Mark Gorelik¹, Daniel Bushnell², Raphaela T. Goldbach-Mansky³, Hal M. Hoffman⁴ and Raphael Hirsch⁵, ¹Pediatric Rheumatology/Floor 3, Univ of Pittsburgh Med Ctr Children's Hospital, Pittsburgh, PA, ²Division of Pediatric Rheumatology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ³Translational Autoinflammatory Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, ⁴Division of Allergy, Immunology and Rheumatology, University of California at San Diego, La Jolla, CA, ⁵Department of Pediatrics,, University of Iowa Carver College of Medicine, Iowa City, IA
Background/Purpose: Cryopyrin associated periodic syndromes (CAPS) are a group of IL-1β mediated autoinflammatory diseases characterized by fever, urticaria and conjunctivitis, and in severe cases, CNS…
Abstract Number: 2657 • 2012 ACR/ARHP Annual Meeting
Genome-Wide Association Meta-Analysis of Eight Independent Systemic Juvenile Idiopathic Arthritis Collections Reveals Regional Association Spanning the Major Histocompatibility Complex Class II and III Gene Cluster
Michael J. Ombrello¹, Elaine Remmers², Alexei A. Grom³, Wendy Thomson⁴, Alberto Martini⁵, Marco Gattorno⁶, Seza Ozen⁷, Sampath Prahalad⁸, John F. Bohnsack⁹, Andrew Zeft¹⁰, Norman T. Ilowite¹¹, Elizabeth D. Mellins¹², Ricardo A. G. Russo¹³, Claudio Len¹⁴, Sheila K. Oliveira¹⁵, Rae SM Yeung¹⁶, Lucy R. Wedderburn¹⁷, Jordi Anton Lopez¹⁸, Colleen Satorius¹⁹, Ioanna Tachmazidou²⁰, Carl D. Langefeld²¹, Eleftheria Zeggini²⁰, Susan D. Thompson²², Patricia Woo²³ and Daniel L. Kastner², ¹Translational Genetics and Genomics Unit, National Institute of Arthritis Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ³PRCSG, Cincinnati, OH, ⁴Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit, Manchester, United Kingdom, ⁵Pediatric Rheumatology Collaborative Study Group [PRSCG], Cincinnati, OH, ⁶Second Division of Paediatrics, Istituto Giannina Gaslini, Genova, Italy, ⁷Hacettepe University, Ankara, Turkey, ⁸Pediatrics, Emory Children's Center, Atlanta, GA, ⁹Dept of Pediatriacs, University of Utah, Salt Lake City, UT, ¹⁰Pediatric Rheumatology, The Cleveland Clinic, Cleveland, OH, ¹¹Pediatrics, The Children's Hospital at Montefiore, Bronx, NY, ¹²Dept of Pediatrics CCSR, Stanford University Medical Center, Stanford, CA, ¹³Immunology & Rheumatology, Hospital de Pediatria Garrahan, Buenos Aires, Argentina, ¹⁴Pediatrics, Universidade Federal de São Paulo / UNIFESP, Sao Paulo, Brazil, ¹⁵Pediatric Rheumatology, Instituto de Pediatria e Puericultura Martagão Gesteira (IPPMG) da Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil, ¹⁶Rheumatology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, ¹⁷Rheumatology Unit , Institute of Child Health, University College London (UCL), London, United Kingdom, ¹⁸pediatric Rheumatology, University Childrenxs Hospital, Barcelona, Spain, ¹⁹Inflammatory Disease Section, National Human Genome Research Institute, Nationsl Institutes of Health, Bethesda, MD, ²⁰The Wellcome Trust Sanger Institute, Cambridge, United Kingdom, ²¹Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ²²Department of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²³Division of Infection and Immunity, University College London, London, United Kingdom
Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) is a rare inflammatory disease that is inherited as a complex genetic trait. While the pathophysiology of sJIA is…
Abstract Number: 2662 • 2012 ACR/ARHP Annual Meeting
Tightening up: Musculoskeletal Ultrasound Could Further Individualise Treatment Decisions in Early Rheumatoid Arthritis Patients Treated by a Step-up DMARD Escalation Regimen
James Dale¹, David Purves², Alex McConnachie², Duncan Porter³ and Iain B. McInnes⁴, ¹Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, ²Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom, ³Rheumatology, Gartnavel General Hospital, Glasgow, United Kingdom, ⁴Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: Treat-to-target (T2T) strategies have significantly improved outcomes in early rheumatoid arthritis (RA). Treatment escalation is usually guided by a disease activity score; however, modern…
Abstract Number: 2663 • 2012 ACR/ARHP Annual Meeting
A Variant in the Osteoprotegerin Gene Is Associated with Coronary Atherosclerosis in Patients with Rheumatoid Arthritis: Results From a Candidate Gene Study
Cecilia P. Chung¹, Joseph F. Solus², Annette M. Oeser³, Chun Li⁴, Paolo Raggi⁵, Jeffrey R. Smith³ and C. Michael Stein³, ¹Medicine, Vanderbilt University, Nashville, TN, ²Medicine, Vanderbilt Medical Center, Nashville, TN, ³Vanderbilt University, Nashville, TN, ⁴Biostatistics, Vanderbilt University, Nashville, TN, ⁵Emory University, Atlanta, GA
Background/Purpose: Patients with rheumatoid arthritis (RA) have accelerated atherosclerosis. However, this association is not fully explained by traditional cardiovascular risk factors or markers of inflammation. Little is…
Abstract Number: 2664 • 2012 ACR/ARHP Annual Meeting
A Multi-Biomarker Disease Activity (VECTRA™ DA Algorithm) Score Reflects Clinical Disease Activity and Tracks Responses in Patients with Rheumatoid Arthritis Treated with Either Adalimumab, Etanercept, and Infliximab
Shintaro Hirata¹, Douglas J. Haney², Guy Cavet², Rebecca Bolce², Wanying Li², Nadine Defranoux², David Chernoff², Kunihiro Yamaoka¹, Kazuyoshi Saito¹ and Yoshiya Tanaka¹, ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²Crescendo Bioscience Inc., South San Francisco, CA
Background/Purpose : Anti-TNF therapy has become a standard therapeutic strategy for treatment of patients with rheumatoid arthritis (RA). A validated multi-biomarker disease activity algorithm (MBDA) blood…
Abstract Number: 2665 • 2012 ACR/ARHP Annual Meeting
Metabolic Reprogramming of Autoimmune T Cells in Rheumatoid Arthritis
Zhen Yang¹, Hiroshi Fujii², Shalini Mohan¹, Jorg J. Goronzy¹ and Cornelia M. Weyand³, ¹Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ²Department of Hematology and Rheumatology, Tohoku University, Sendai, Japan, ³Medicine, Stanford University School of Medicine, Stanford, CA
Background/Purpose: In RA, autoimmunity precedes clinical symptoms by a decade and persists unabated even when downstream inflammation is well controlled; exposing lymphocytes to chronic stimulation…
Abstract Number: 2626 • 2012 ACR/ARHP Annual Meeting
The Utility of the Patient Health Questionnaire-9 to Assess Suicide Risk in Patients with Systemic Sclerosis
Ilya Razykov¹, Marie Hudson², Murray Baron³ and Brett D. Thombs¹, ¹Psychiatry, McGill University, Montreal, QC, Canada, ²Jewish General Hospital, McGill University, Montreal, QC, Canada, ³Pavillion A, Rm 216, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada
Background/Purpose: Depression is common in rheumatic diseases, including systemic sclerosis (SSc). In the general population, depression is associated with suicidal ideation, attempts and completion. The…
Abstract Number: 2627 • 2012 ACR/ARHP Annual Meeting
Gender Differences of Concepts Important to People Living with Crohn’s Disease and Their Coverage by Commonly Used Patient-Reported Outcome Instruments: Patient’s Perspective Elevated by a Qualitative Study
Mona Dür¹, Michaela Coenen², Josef S. Smolen³, Clemens Dejaco⁴ and Tanja A. Stamm⁵, ¹Internal Medicine III Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Department of Medical lnformatics, Biometry and Epidemiology, Research Unit for Biopsychosocial Health, Ludwig-Maximilians-University, Munich, Germany, ³Division of Rheumatology, Department of Internal Medicine III,, Medical University of Vienna and Hietzing Hospital, Vienna, Austria, ⁴Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria, ⁵Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose: Crohn's disease (CD) has a major impact on functioning, health and well-being and patient-reported outcome (PRO) instruments have not been analysed from the perspective…
Abstract Number: 2628 • 2012 ACR/ARHP Annual Meeting
The Lumbo-Pelvic Muscles and Axial Spondyloarthritis: A Pilot Observational Study
Janet Millner¹, Julie A. Hides², Patricia Lewis³ and Jane Zochling³, ¹Physiotherapy, Royal Hobart Hospital, Hobart, Australia, ²School of Physiotherapy, Australian Catholic University, Brisbane, Australia, ³Menzies Research Institute Tasmania, Hobart, Australia
Background/Purpose: The importance of a physical approach in the management of axial spondyloarthritis (SpA) has been recognised for many years. It is supported by level…
Abstract Number: 2629 • 2012 ACR/ARHP Annual Meeting
Associations of Current and Early-Life Socioeconomic Positions with Risk of Self-Reported Doctor-Diagnosed Arthritis in a Family-Medicine Cohort of North-Carolinians
Antoine A. Baldassari¹, Rebecca J. Cleveland¹ and Leigh F. Callahan², ¹Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²Thurston Arthritis Res Ctr, University of North Carolina, Chapel Hill, NC
Background/Purpose: Socioeconomic position (SEP) across the lifecourse has been convincingly identified as a determinant of health. In particular, mounting evidence suggests that low current and…
Abstract Number: 2630 • 2012 ACR/ARHP Annual Meeting
Rheumatoid Arthritis and Osteoarthritis in the Population: How Different Is the Impact?
Christina H. Chan¹, Mayilee Canizares² and E.M. Badley³, ¹Division of Healthcare Outcomes and Research, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada, ²Division of Healthcare Outcomes and Research, Toronto Western Research Institute, Toronto, ON, Canada, ³Division of Health Care and Outcomes Research, Toronto Western Research Institute; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
Background/Purpose: It is a common perception that rheumatoid arthritis (RA) is a more severe and debilitating disease than osteoarthritis (OA); however, there have been many…
Abstract Number: 2631 • 2012 ACR/ARHP Annual Meeting
Radiographic Osteoarthritis Severity Is Associated with an Increased Risk of Developing Knee Pain: Findings From the Osteoarthritis Initiative
Jingbo Niu¹, David T. Felson², Tuhina Neogi³ and Yuqing Zhang⁴, ¹Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ²Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ³Clinical Epidemiology, Boston Univ School of Medicine, Boston, MA, ⁴School of Medicine, Boston Univ School of Medicine, Boston, MA
Background/Purpose : While knee pain is a major complaint from subjects with knee osteoarthritis (OA), most epidemiologic studies have found only weak to moderate associations…
Abstract Number: 2632 • 2012 ACR/ARHP Annual Meeting
Doing Is Believing: Health Beliefs Before and After an Exercised-Based Rehabilitation Programme for Chronic Knee Pain
Mike Hurley¹ and Dr Nicola E. Walsh², ¹School of Rehabilitation Sciences, St George's University of London, London, United Kingdom, ²Allied Health Professions, University of the West of England Bristol, Bristol, United Kingdom
Background/Purpose: An integrated exercise-based rehabilitation programme, Enabling Self-management and Coping with Arthritis knee Pain through Exercise (ESCAPE-knee pain), improves pain and physical disability of people…

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