Abstracts Archive - Page 2593 of 2607 - ACR Meeting Abstracts

Abstract Number: 160 • 2012 ACR/ARHP Annual Meeting
Pegloticase Long-Term Safety: Data From the Open-Label Extension Trial
Michael A. Becker¹, Herbert S. B. Baraf², Robert A. Yood³, Aileen M. Dillon⁴, Janitzia Vazquez-Mellado⁵, Faith D. Ottery⁶, Dinesh Khanna⁷ and John S. Sundy⁸, ¹Medicine, University of Chicago, Chicago, IL, ²Arthritis & Rheumatism Associates, Wheaton, MD, ³Reliant Medical Group, Worcester, MA, ⁴Rheumatology Section, Kaiser Foundation Hospital, San Francisco, CA, ⁵Rheumatology, Hospital General de Mexico, Mexico city, Mexico, ⁶Medical Affairs, Savient Pharmaceuticals, Inc., East Brunswick, NJ, ⁷Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁸Duke Clinical Research Institute, Duke University Medical Center, Durham, NC
Background/Purpose: Pegloticase is a recombinant modified mammalian uricase conjugated to mPEG and approved for treatment of refractory chronic gout. Pegloticase safety was evaluated during 2…
Abstract Number: 161 • 2012 ACR/ARHP Annual Meeting
Increased Serum Uric Acid: Consequence or Cause of Increased Cardiovascular Risk
Inger L. Meek¹, Harald E. Vonkeman² and Mart A.F.J. van de Laar³, ¹Rheumatology & Clinical Immunology, Rheumatology Center Twente, Medisch Spectrum Twente & Twente University, Enschede, Netherlands, ²Rheumatology Center Twente, Medisch Spectrum Twente & Twente University, Enschede, Netherlands, ³Rheumatology, Medisch Spectrum Twente & University of Twente, Enschede, Netherlands
Background/Purpose: Reports on cardiovascular (CV) disease in hyperuricemia and gout show conflicting results. Some studies show hyperuricemia to be an independent risk factor for CV…
Abstract Number: 162 • 2012 ACR/ARHP Annual Meeting
Metabolic Syndrome: The Genesis of Nephrolithiasis in Gout Patients
Filipi M. Mello¹, Rafael B. Tomita², Ricardo Fuller³, Marco Antonio G. P. Filho², Thiago B. M. Barros⁴, Leandro L. do Prado², Kristopherson L. Augusto² and Claudia Goldenstein-Schainberg⁵, ¹Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Rheumatology Division, Rheumatology Division - University of São Paulo, São Paulo, Brazil, ³Reumatologia, Reumatologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, ⁴Rheumatology, Reumatologia Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁵Reumatologia, Rheumatology Division - University of São Paulo, São Paulo, Brazil
Background/Purpose: Gout patients have a high frequency of metabolic syndrome (MS), a disorder known to be associated with hyperinsulinemia. The latter condition augments proximal tubular…
Abstract Number: 163 • 2012 ACR/ARHP Annual Meeting
Evaluating Allopurinol Therapy and Serum Uric Acid Levels in Medicare Beneficiaries with Gout
Melea Ward¹, Anthony M. Louder², Keith A. Szymanski³ and Leonardo Tamariz⁴, ¹Competitive Health Analytics, Louisville, KY, ²Competitive Health Analytics, Inc., Louisville, KY, ³Takeda Pharmaceuticals America, Inc., Deerfield, IL, ⁴University of Miami, Miami, FL
Background/Purpose: Higher serum uric acid levels in gout patients have been associated with an increased frequency and risk of gout flares and greater subsequent healthcare…
Abstract Number: 164 • 2012 ACR/ARHP Annual Meeting
The Prevalence of Gout in a Large Tertiary Hospital and the Impact of in-Hospital Attacks of Acute Gout On Patient Outcomes and Health Resource Utilisation – a Nested Case-Control Study
John HY Moi¹, Mark Tacey², Carol Roberts³, Caroline Brand², Alexandra Gorelik³ and Sharon Van Doornum², ¹Department of Rheumatology, Department of Medicine (RMH), The Royal Melbourne Hospital, The University of Melbourne, Melbourne, Australia, ²Melbourne EpiCentre, The University of Melbourne, Melbourne, Australia, ³Melbourne EpiCentre, The Royal Melbourne Hospital, Melbourne, Australia
Background/Purpose: Acute gout can develop in hospitalised patients either as a new event or as a recurrence of established disease. To date there have been…
Abstract Number: 165 • 2012 ACR/ARHP Annual Meeting
Colchicine Is Associated with a Decreased Rate of Myocardial Infarction in Gout Patients: Interim Results From a Retrospective Cohort Study
Daria B. Crittenden¹, Cilian J. White¹, Michael DeBerardine¹, Grace Kim², Binita Shah³, Jessica C. Kimmel¹, Rima D. Patel¹, Steven P. Sedlis³, Jeffrey D. Greenberg⁴, Craig T. Tenner⁵, Bruce N. Cronstein¹ and Michael H. Pillinger¹, ¹Internal Medicine, NYU School of Medicine, Division of Rheumatology, New York, NY, ²NYU School of Medicine, Division of Rheumatology, New York, NY, ³NYU School of Medicine, Division of Cardiology, New York, NY, ⁴Division of Rheumatology, Department of Medicine, NYU Hospital for Joint Diseases, New York, NY, ⁵Internal Medicine, NYU School of Medicine, Department of Internal Medicine, New York, NY
Background/Purpose: Atherosclerosis is an inflammatory process, but to date no anti-inflammatory agent has definitively been shown to alter cardiovascular (CV) risk. Colchicine is an anti-inflammatory…
Abstract Number: 166 • 2012 ACR/ARHP Annual Meeting
Low-Dose Allopurinol Promotes Greater Serum Urate Lowering in Gout Patients with Chronic Kidney Disease Vs Normal Renal Function
Michael DeBerardine¹, Mark C. Fisher², Robert T. Keenan³, Michael H. Pillinger⁴ and Daria B. Crittenden⁴, ¹NYU School of Medicine, Division of Rheumatology, New York, NY, ²Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Boston, MA, ³Rheumatology, Duke University, Durham, NC, ⁴Internal Medicine, NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: Patients with chronic kidney disease (CKD) may be at increased risk for allopurinol (ALLO) hypersensitivity, possibly because impaired renal excretion causes accumulation of the…
Abstract Number: 127 • 2012 ACR/ARHP Annual Meeting
Ultrasonographic Evaluation of the Hands of Patients with Primary and Secondary Sjögren´s Syndrome
Cristina Hernández-Díaz¹, Luis M. Amezcua-Guerra², Angélica Vargas², Alberto Lopez-Reyes³ and Carlos Pineda⁴, ¹Musculoskeletal Ultrasound, Instituto Nacional de Rehabilitación, Mexico City, Mexico, ²Rheumatology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico, ³Synovial fluid and molecular analysis laboratory, Instituto Nacional de Rehabilitacion, Mexico City, Mexico, ⁴Biomedical Research, Instituto Nacional de Rehabilitacion, Mexico City, Mexico
Background/Purpose: Primary Sjögren’s syndrome (pSS) is an autoimmune disease characterized by lymphocyte infiltration of various exocrine glands, often associated with joint involvement traditionally described as…
Abstract Number: 128 • 2012 ACR/ARHP Annual Meeting
Quantitative Assessment of Synovitis in Patients with Rheumatoid Arthritis Using Fluorescence Optical Imaging
Valentin S. Schäfer¹, Wolfgang Hartung², Patrick Hoffstetter³, Jörn Berger⁴, Martina Müller⁵, Martin Fleck² and Boris P. Ehrenstein², ¹Rheumatology & Clinical Immunology, Asklepios Klinikum Bad Abbach, Bad Abbach, Germany, ²Rheumatology & Clinical Immunology, Asklepios Clinic Bad Abbach, Bad Abbach, Germany, ³Radiology, Asklepios Klinikum Bad Abbach, Bad Abbach, Germany, ⁴mivenion GmbH, Berlin, Germany, ⁵Clinic for Internal Medicine I, University Clinic Regensburg, Regensburg
Background/Purpose: To prospectively evaluate quantitative assessment of indocyanine green (ICG)-enhanced fluorescence optical imaging (FOI) for differentiation of synovitic from non-synovitic joints in patients suffering from…
Abstract Number: 129 • 2012 ACR/ARHP Annual Meeting
Comparison of Automated, Computer-Based Assessment and Visually Assessed Disease Activity Scores in ICG-Enhanced Fluorescence Optical Imaging in Patients with Rheumatic Disorders: A Feasibility Study
Stephanie G. Werner¹, Michael Schirner², Hans-Eckhard Langer³, Mathias Cziumplik², Jörn Berger², Marina Backhaus¹ and Malte Bahner², ¹Rheumatology/Immunology, Charite University Hospital, Berlin, Germany, ²mivenion GmbH, Berlin, Germany, ³RHIO (Rheumatology, Immunology, Osteology) Duesseldorf, Duesseldorf, Germany
Background/Purpose: Modern diagnostic imaging technologies including US and MRI become increasingly important in the management of rheumatic joint disorders. Semiquantitative scores, like the RAMRIS or…
Abstract Number: 130 • 2012 ACR/ARHP Annual Meeting
Is Bone Scintigraphy Still Useful to Diagnose Rheumatoid Arthritis After the Appearance of 2010 ACR/EULAR Classification Criteria?
Ji Young Kim¹, Soo-Kyung Cho², Min-Kyung Han², Yun Young Choi¹ and Yoon-Kyoung Sung², ¹Department of Nuclear Medicine, Hanyang University College of Medicine, Seoul, South Korea, ²Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea
Background/Purpose: For many years, the importance of bone scintigraphy to measure inflammation in the joints of patients with RA has been emphasized. Moreover, increased blood…
Abstract Number: 131 • 2012 ACR/ARHP Annual Meeting
Subclinical Arthritis Visualised by Positron Emission Tomography and Macrophage Targeting Precedes Clinical Flare in Rheumatoid Arthritis Patients in DAS28 Remission
Y.Y.J. Gent¹, A.E. Voskuyl¹, N. Ahmadi², N. Hoetjes³ and C.J. van der Laken¹, ¹Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ²Radiology, VU University Medical Center, Amsterdam, Netherlands, ³Nuclear Medicine & PET research, VU University Medical Center, Amsterdam, Netherlands
Background/Purpose: Macrophages play an important role in the pathophysiology of Rheumatoid Arthritis (RA). Targeting of macrophages by (R)-[11C]PK11195 positron emission tomography (PET) has previously been successfully…
Abstract Number: 132 • 2012 ACR/ARHP Annual Meeting
FDG-PET Evaluation of Axillary Lymph Nodes and Large Joints of Patients with Rheumatoid Arthritis Treated with Anti-TNF Drugs
Koichi Okamura¹, Yukio Yonemoto², Tetsuya Kaneko³, Kimihiko Takeuchi⁴, Tsutomu Kobayashi¹ and Kenji Takagishi¹, ¹Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan, ²Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan, ³Department of Orthopaedic Surgery, Inoue Hospital, Takasaki, Gunma, Japan, ⁴Department of Rheumatology, Isesaki Fukushima Hospital, Isesaki, Gunma, Japan
Background/Purpose: F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) can be used to image synovial inflammation in patients with rheumatoid arthritis (RA). The development of molecular…
Abstract Number: 133 • 2012 ACR/ARHP Annual Meeting
Utility of PET-CT Imaging in IgG4-Related Disease
Arezou Khosroshahi¹, Leslie Lee², Mollie Carruthers¹, Rusen Acu², Pietro Bonaffini², Vikram Deshpande³, Dushyant Sahani² and John H. Stone¹, ¹Rheumatology, Massachusetts General Hospital, Boston, MA, ²Radiology, Massachusetts General Hospital, Boston, MA, ³Pathology, Massachusetts General Hospital, Boston, MA
Background/Purpose: IgG4-related disease (IgG4-RD) is a systemic fibro-inflammatory condition characterized by unique pathological features that affect a wide variety of organs. The disease process may…
Abstract Number: 134 • 2012 ACR/ARHP Annual Meeting
Co-Existence of Gout in Rheumatoid Arthritis: It Does Happen! A Population Based Study
Adlene Jebakumar¹, Cynthia S. Crowson², P. Deepak Udayakumar¹ and Eric L. Matteson¹, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Department of Health Sciences Research, Mayo Clinic, Rochester, MN
Background/Purpose: Even though there are a few cases in the literature reporting co-existence of gout and rheumatoid arthritis (RA), it has been a long time…

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