Abstracts Archive - Page 2589 of 2607 - ACR Meeting Abstracts

Abstract Number: 220 • 2012 ACR/ARHP Annual Meeting
Efficacy of Rituximab for the Treatment of Refractory Inflammatory Myopathies Associated with Anti-Histidyl-tRNA Synthetase Antibodies (the FORCE Jo1 Study)
Yves Allenbach¹, Aude Rigolet², Marguerite Guiguet³, Isabelle Marie⁴, Eric Hachulla⁵, Dominique Farge⁶, Kuberaka Mariampillai⁷, Serge Jacquot⁸, Fabienne Jouen⁹, Olivier Boyer¹⁰, Lucile Musset¹¹, Serge Herson⁷ and Olivier Benveniste¹², ¹Internal Medicine Dpt 1, Pitié-Salpêtrière Hospital, APHP, Paris, France, ²Department: inflammation, immunopathology and biotherapy (DHU i2B), Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University Hospital, Paris, France, ³Biostatistique, Pitie-Salpetriere Hospital, Paris, France, ⁴Service de médecine interne, CHU de Rouen, Rouen, France., Rouen, France, ⁵Department of Internal Medicine, Claude Huriez University Hospital, Lille, France, ⁶Medicine, EBMT, Paris, France, ⁷Department: inflammation, immunopathology and biotherapy (DHU i2B), Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University, Paris, France, ⁸INSERM U905, University of Rouen, Rouen, France, ⁹Immunology, Rouen University Hospital, Rouen Cedex, France, ¹⁰Immunology, INSERM U905, University of Rouen, Rouen, France, ¹¹Laboratoire d'Immunochimie, CHU Pitié-Salpêtrière, Paris, France, ¹²Internal Medecine Dpt 1, Pitié-Salpêtrière Hospital, APHP, Paris, France
Background/Purpose: anti-histidyl-tRNA synthetase (anti-Jo1) antibodies are found in approximately 25–30% of patients with idiopathic inflammatory myopathies, frequently in the frame of an anti-synthetase syndrome characterized…
Abstract Number: 221 • 2012 ACR/ARHP Annual Meeting
Expanding the Clinical and Serological Spectrum of MDA5-Associated Dermatomyositis
John C. Hall¹, Livia Casciola Rosen¹, Sonye K. Danoff², Lesly-Anne Samedy³ and Lisa Christopher-Stine⁴, ¹Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Medicine/Pulmonary, Johns Hopkins University, Baltimore, MD, ³Division of Rheumatology, Johns Hopkins University, Baltimore, MD, ⁴Medicine and Neurology, Johns Hopkins University, Baltimore, MD
Background/Purpose: Dermatomyositis (DM) is a heterogeneous systemic disease with specific autoantibodies (Abs) which correlate with unique clinical phenotypes. Melanoma differentiation-associated gene 5 (MDA5) Abs have…
Abstract Number: 222 • 2012 ACR/ARHP Annual Meeting
Lung Nodules in Patients with Idiopathic Inflammatory Myopathies
Laura C. Cappelli¹, Andrew L. Mammen², Sonye K. Danoff³, Grant H. Louie⁴, Thomas E. Lloyd⁵ and Lisa Christopher-Stine⁶, ¹Ste 4500, Johns Hopkins University, Baltimore, MD, ²NIAMS, NIH, Bethesda, MD, ³Medicine/Pulmonary, Johns Hopkins School of Medicine, Baltimore, MD, ⁴Rheumatology, Johns Hopkins University, Baltimore, MD, ⁵Neurology, Johns Hopkins, Baltimore, MD, ⁶Medicine and Neurology, Johns Hopkins University, Baltimore, MD
Background/Purpose: The idiopathic inflammatory myopathies are associated with an increased incidence of malignancy, and interstitial lung disease (ILD) has been reported in as many as…
Abstract Number: 223 • 2012 ACR/ARHP Annual Meeting
High Prevalence and Clustering Over Time of Anti-PL-7 Autoantibody-Positive Idiopathic Inflammatory Myopathies
Yoshioki Yamasaki¹, Minoru Satoh², Hidehiro Yamada¹, Machiko Mizushima¹, Takahiro Okazaki¹, Hiroko Nagafuchi¹, Seido Ooka³, Tomohiko Shibata¹, Hiromasa Nakano⁴, Hitoshi Ogawa¹, Kohei Azuma¹, Akihiko Maeda¹, Hirofumi Mitomi¹, Tomofumi Kiyokawa¹, Kosei Tsuchida¹, Hidenori Mikage¹, Jason Y.F. Chan² and Shoichi Ozaki¹, ¹Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ²Medicine, University of Florida, Gainesville, FL, ³St. Marianna University School of Medicine, Kawasaki, Japan, ⁴Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan
Background/Purpose: Unusually high prevalence of autoantibodies to threonyl tRNA (PL-7) [17% in polymyositis/dermatomyositis (PM/DM) associated with lower levels of serum creatine kinase (CK) and milder…
Abstract Number: 224 • 2012 ACR/ARHP Annual Meeting
Standardized Incidence Ratios and Predictors of Malignancies in 215 Southern Chinese Patients with Inflammatory Myopathies
Chi Chiu Mok¹, Chi Hung To¹, ML Yip² and King Yee Ying³, ¹Medicine, Tuen Mun Hospital, Hong Kong, Hong Kong, ²Division of Rheumatology, Department of Medicine, Kwong Wah Hospital, Kowloon, Hong Kong, ³Department of Medicine, Princess Margaret Hospital, Hong Kong, Hong Kong
Background/Purpose: To examine the standardized incidence ratios (SIRs) and predictive factors for malignancy in a cohort of southern Chinese patients with inflammatory myopathies (IM). Methods:…
Abstract Number: 225 • 2012 ACR/ARHP Annual Meeting
Polymyositis in HIV+ Patients Is Associated to Uncontrolled Viral Load
Yves Allenbach¹, Odile Dubourg², Thierry Maisonobe², Anthony Behin³, Charles Duyckaerts², Guillaume Breton⁴, Olivier Fain⁵, Marie-Caroline Meyhoas⁶, Catherine Leport⁷, Marc-Antoine Valentin⁸, Daniel Vittecoq⁹, Jean-François Bergmann¹⁰, Thomas Anslik¹¹, Marie-Paule Chauveheid¹², Zahir Amoura¹³, Thomas de Broucker¹⁴, Pierre Bourgeois¹⁵, Bruno Eymard³, Serge Herson¹⁶ and Olivier Benveniste¹⁷, ¹Internal Medicine Dpt 1, Pitié-Salpêtrière Hospital, APHP, Paris, France, ²Neuropathology, Pitie-Salpetriere Hospital, Paris, France, ³Institute of Myology, Pitie-Salpetriere Hospital, Paris, France, ⁴Internal Medecine, Pitie-Salpetriere Hospital, Paris, France, ⁵Internal Medicine, Jean Verdier Hospital, Bondy, France, ⁶Department of Infectious Diseases, Saint Antoine Hospital, Paris, France, ⁷Epidemic and biological risk coordination unit, AP-HP, Paris, France, ⁸Department of Infectious Diseases, Pitié-Salpetriere Hospital, Paris, France, ⁹Department of Infectious Diseases, K Bicetre Hospital, Kremlin-Bicetre, France, ¹⁰Internal Medicine, Lariboisiere Hospital, Paris, France, ¹¹Internal Medicine, Ambroise Pare Hospital, Boulogne Billancourt, France, ¹²Internal Medicine,, University Paris-7, APHP, Bichat Hospital, Paris, France, ¹³Department of Internal Medicine 2. Referal center for SLE/APS, CHU Pitié-Salpêtrière, Paris, France, ¹⁴Department of Neurology, Delafontaine Hospital, Saint Denis, France, ¹⁵Rheumatology, APHP,Pitie-Salpetriere Hospital, Paris 6, Paris, France, ¹⁶Department: inflammation, immunopathology and biotherapy (DHU i2B), Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University, Paris, France, ¹⁷Internal Medecine Dpt 1, Pitié-Salpêtrière Hospital, APHP, Paris, France
Background/Purpose: Different myopathies can be observed in HIV-infected patients, such as idiopathic inflammatory myopathies (inclusion-body myositis or polymyositis) or toxic mitochondrial myopathies secondary to antiretroviral…
Abstract Number: 226 • 2012 ACR/ARHP Annual Meeting
Autoantibodies to Small Ubiquitin-Like Modifier Activating Enzymes in Japanese Patients with Dermatomyositis
Manabu Fujimoto¹, Takashi Matsushita², Yasuhito Hamaguchi³, Kenzo Kaji³, Minoru Hasegawa¹ and Kazuhiko Takehara⁴, ¹Dermatology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan, ²Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan, ³Department of Dermatology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan, ⁴Dermatology, Kanazawa University, Kanazawa, Japan
Background/Purpose: Myositis-specific autoantibodies (MSAs) are closely associated with distinct clinical subsets within idiopathic inflammatory myopaties, and thus serve as useful diagnostic tools. Recently, anti-small ubiquitin-like modifier…
Abstract Number: 187 • 2012 ACR/ARHP Annual Meeting
Effect of Colchicine On Cholesterol Levels in Patients with Familial Mediterranean Fever and Behçet’s Syndrome
SerdaL Ugurlu¹, Emire Seyahi², Idil Hanci³, Huri Ozdogan⁴, Seval Masatlioglu-Pehlivan⁵ and Hasan Yazici⁶, ¹Division of Rheumatology,Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, ²Rheumatology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey, ³Department of Neurology, Krankrenhaus Nordwest, Frankfurt am Main, Frankfurt, Germany, ⁴Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, ⁵Haydarpasa Numune Research and Education Hospital, MD,Rheumatology, Istanbul, Turkey, ⁶Istanbul University, Cerrahpasa Medical School, Istanbul University, Cerrahpasa Medical School, Rheumatology, Istanbul, Turkey
Background/Purpose: We and others have previously shown that patients with Familial Mediterranean Fever (FMF) had low cholesterol levels when compared to healthy controls (1-2). The…
Abstract Number: 188 • 2012 ACR/ARHP Annual Meeting
Etiology of Uveitis: A Hospital-Based Study in a Referral Centre
Claudia Ferrari¹, Rosaria Talarico¹, Michele Figus², Chiara Stagnaro³, Anna d'Ascanio⁴ and Stefano Bombardieri⁵, ¹University of Pisa, Rheumatology Unit, Pisa, Italy, ²Neurosciences Department, Ophthalmology Unit, University of Pisa, Pisa, Italy, ³Rheumatology Unit, University of Pisa, Pisa, Italy, ⁴Department of Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ⁵Department of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy
Background/Purpose: Defined as an intraocular inflammation, uveitis may be associated to a systemic disease or represent an isolated entity. It affects people from all parts…
Abstract Number: 189 • 2012 ACR/ARHP Annual Meeting
Pedal Swelling As a Characteristic Phenotype of the New Category of Autoinflammatory Disease Associated with NOD2 Gene Mutations
Qingping Yao, Rheumatic and Immunologic Dis, Cleveland Clinic, Cleveland, OH
Background/Purpose: Autoinflammatory diseases are characterized by seemingly unprovoked episodes of inflammation, without high titer autoantibodies or antigen specific T cells, and derive from genetic variants…
Abstract Number: 190 • 2012 ACR/ARHP Annual Meeting
NLRP3 Gene Analysis for Patients with Schnitzler’s Syndrome
Cong-Qiu Chu¹, Carrie R. Austin², Trudy M. Doyle², Kelley A. Goodwin², Noha El Torgomen², Regina Treudler³ and Tammy M. Martin⁴, ¹Rheumatology, Oregon Health & Science Univ and Portland VA Medical Center, Portland, OR, ²Casey Eye Institute, Oregon Health & Science University, Portland, OR, ³Department of Dermatology, Venereology and Allergology, Universitätsklinikum Leipzig AöR, Leipzig, Germany, ⁴Ophthalmology/L467AD, Oregon Health & Science Univ, Portland, OR
Background/Purpose: Schnitzler's syndrome is characterized by chronic urticaria, intermittent fever, arthralgia, bone pain, gammopathy and marked systemic inflammation. The striking response to IL-1 blockade suggests…
Abstract Number: 191 • 2012 ACR/ARHP Annual Meeting
Analysis of Genes Involved in Autoinflammatory Diseases in Adult Onset Still’s Disease
Emma Garcia-Melchor¹, Dolors Grados², Eva Gonzalez-Roca¹, Elena Riera³, Manel Juan¹, Jordi Yagüe¹, Juan Ignacio Aróstegui¹, Javier Narváez⁴ and Alejandro Olivé⁵, ¹Immunology Department, Hospital Clinic Barcelona, Barcelona, Spain, ²Rheumatology Department, Hospital Universitario Germans Trias i Pujol, Badalona, Spain, ³Rheumatology Department, Hospital Mutua de Terrassa, Terrassa, Spain, ⁴Rheumatology Department, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain, ⁵Rheumatology, Hospital Universitario Germans Trias i Pujol, Badalona, Spain
Background/Purpose: Adult Onset Still’s Disease (AOSD) is a systemic inflammatory disease characterized by fever, skin rash, articular involvement, lymphadenopathy, hepatosplenomegaly and serositis. Due to the…
Abstract Number: 192 • 2012 ACR/ARHP Annual Meeting
Clinical and Laboratory Findings in A Cohort of Italian Patients with Adult Onset Still’S Disease: The Role of IL-18 As A Disease Biomarker
Roberta Priori¹, Serena Colafrancesco², Carlo Perricone², Antonina Minniti², Cristiano Alessandri², Giancarlo Iaiani³ and Guido Valesini², ¹Department of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy, ²Rheumatology Unit, Sapienza University of Rome, Rome, Italy, ³Department of Infectious Diseases and Tropical Medicine, Sapienza University of Rome, Rome, Italy
Background/Purpose: Adult Onset Still's Disease (AOSD) is a systemic inflammatory syndrome driven by interleukin (IL)-18. Since differential diagnosis between AOSD, sepsis and other inflammatory conditions…
Abstract Number: 193 • 2012 ACR/ARHP Annual Meeting
Tocilizumab in Adult Still’s Disease : The Israeli Experience
Ori Elkayam¹, Nizar Jiries², Zvi Dranitzki³, Shaye Kivity⁴, Merav Lidar⁵, Ofer Levy⁶, Mahmoud Abu-Shakra⁷, Hagit Sarvagil-Maman⁸, Hagit Padova⁸, Dan Caspi⁹ and Itzhak Rosner¹⁰, ¹Rheumatology, Tel-Aviv Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel- Aviv, Israel, ²Rheumatology, Bnai Zion Medical Center, Israel, ³Medicine, Hadassah hebrew university, Jerusalem, Israel, ⁴Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, affliated to Sackler Faculty of Medicine, Tel-Aviv University Israel, Tel-Aviv, Israel, ⁵Medicine F, Sheba Medical Center, Ramat Gan, Israel, ⁶Rheumatology, Asaf Harofe Medical Center, ⁷Medicine and Rheumatology, Soroka Medical Centre and Ben Gurion University, Beer-Sheva, Israel, ⁸Rheumatology, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, ⁹Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ¹⁰Rheumatology, Bnai Zion Medical Center / Technion Faculty of Medicine, Haifa, Israel
Background/Purpose: The objective of this study was to review the clinical and laboratory characteristics of patients with adult's Still disease treated with tocilizumab (TCZ) in…
Abstract Number: 194 • 2012 ACR/ARHP Annual Meeting
LONG-TERM Efficacy of Tocilizumab in A Patient with Amyloidosis and Interstitial Pneumonia Secondary to Multicentric Castleman’s Disease (MCD)
Michihito Katayama¹, Soichiro Tsuji¹, Satoshi Teshigawara¹, Eriko Kudo-Tanaka¹, Maiko Yoshimura¹, Akane Watanabe¹, Akiko Yura², Yoshinori Harada³, Yoshinori Katada³, Jun Hashimoto¹, Masato Matsushita⁴, Yukihiko Saeki⁵ and Shiro Ohshima⁵, ¹Dept of Rheumatology, Osaka-Minami Medical Center, Kawachinagano City, Japan, ²Dept of Allergology, Allergology,Osaka-Minami Medical Center, Kawachinagano City, Japan, ³Dept of Allergology, Kawachinagano City, Japan, ⁴Rheumatology, Osaka Minami Medical Center, Osaka, Japan, ⁵Dept of Clinical Research, Osaka-Minami Medical Center, Kawachinagano City, Japan
Background/Purpose: Castleman’s disease is a benign lymphoproliferative disorder characterized histologically by follicular hyperplasia and capillary proliferation with endothelial hyperplasia. In addition, overproduction of Interleukin-6 (IL-6)…

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