Abstracts Archive - Page 2576 of 2607 - ACR Meeting Abstracts

Abstract Number: 428 • 2012 ACR/ARHP Annual Meeting
TNFα Modulates the Expression of Circadian Clock Gene, Per2, Via D-Box Motif in the Promoter Region in Rheumatoid Synovial Cells
Kohsuke Yoshida¹, Akira Hashiramoto², Takaichi Okano³, Nao Shibanuma⁴ and Shunichi Shiozawa⁵, ¹Hyogo Prefectural Rehabilitation Center at Nishi-harima, Tatsuno, Japan, ²Department of Internal Medicine, Kobe University Graduate School of Medicine / The Center for Rheumatic Diseases, Kobe University Hospital, Kobe, Japan, ³The Center for Rheumatic Diseases,, Kobe University Hospital, Kobe, Japan, ⁴The Center for Rheumatic Diseases, Kobe University Hospital / Departmant of Orthopaedic Surgery, Kobe Kaisei Hospital, Kobe, Japan, ⁵Department of Medicine, Kyushu University Beppu Hospital, Beppu, Japan
Background/Purpose: The mammalian clock genes including Clock (circadian locomotor output cycles kaput), Bmal1 (brain and muscle Arnt-like protein 1), Per (Period) and Cry (Cryptochrome) regulate…
Abstract Number: 429 • 2012 ACR/ARHP Annual Meeting
The Significance of the Apoptosis Level and the Apoptosis Related Signal Proteins of CD4⁺t�ACD4⁺Foxp3⁺t Cell in Patients with Rheumatoid Arthritis
Ning Li¹, Tianrui Ma², Jie Han¹, Jieru Zhou¹ and Songguo Zheng³, ¹Rheumatology, Shanghai East Hospital, Shanghai, China, ²Rheumatology, Ningbo Pediatric Hospital, Ningbo, China, ³Division of Rheumatology and Immunology, Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA
Background/Purpose: To investigate the apoptosis of CD4+T cell and Tregs in the pathogenesis and disease activity of rheumatoid arthritis patients. Methods: Isolated lymphocytes from human…
Abstract Number: 390 • 2012 ACR/ARHP Annual Meeting
Performance of Criteria for Remission in a Long-Term Observational Study of Patients with Early Rheumatoid Arthritis
Bjorn Svensson¹, Maria LE Andersson², Sidona-Valentina Bala³, Kristina Forslind⁴ and Ingiäld Hafström⁵, ¹Section of Rheumatology, Institution of Clinical Science, Lund University, Lund, Sweden, ²R&D Center, Spenshult Hospital, Oskarström, Sweden, ³Department of Health Sciences,, Lund University, Lund, Sweden, ⁴Department of Medicine, Karolinska Institute, Stockholm, Department of Medicine, Karolinska Institute,, Stockholm, Sweden, ⁵Unit of Rheumatology, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: Remission is widely accepted as the goal of treatment in RA and has to be sustained to keep joint damage at a minimum (Smolen…
Abstract Number: 391 • 2012 ACR/ARHP Annual Meeting
DAS28 Is Not a Sufficient Disease Activity Measure for Obese Rheumatoid Arthritis Patients – Don’t Leave the Feet Behind
Vikram Garg¹, Paul Maranian², Mihaela B. Taylor³, Harold E. Paulus⁴, David Elashoff⁵ and Veena K. Ranganath⁶, ¹Division of Rheumatology, UCLA David Geffen School of Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, CA, ²Division of Rheumatology, UCLA Medical School, Los Angeles, CA, ³Rheumatology, University of California Los Angeles, Los Angeles, CA, ⁴Medicine-Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ⁵Departments of Biostatistics and Medicine, University of California, Los Angeles, Los Angeles, CA, ⁶Medicine/Rheumatology, University of California, Los Angeles, Western Consortium of Practicing Rheumatologists, Los Angeles, CA
Background/Purpose: Current literature suggests that obesity impacts disease activity in rheumatoid arthritis (RA) and the incidence of obesity is on the rise. The objective of…
Abstract Number: 392 • 2012 ACR/ARHP Annual Meeting
Analysis of Factors Impact On Patient Global Assessment in Daily Practice Based On Observational Cohort IORRA (Institute of Rheumatology, Rheumatoid Arthritis)
Yasushi Inoue¹, Eiichi Tanaka², Ayako Nakajima³, Eisuke Inoue⁴, Akiko Kobayashi⁴, Daisuke Hoshi¹, Naoki Sugimoto⁴, Kumi Shidara⁴, Yohei Seto⁴, Atsuo Taniguchi⁴, Shigeki Momohara¹ and Hisashi Yamanaka¹, ¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Tokyo Women's Medical University, Tokyo, Japan, ³Rheumatology, Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan, ⁴Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan
Background/Purpose: Patient global assessment (PtGA) is an element of the new ACR/EULAR remission criteria for rheumatoid arthritis (RA). This definition has been reported to better…
Abstract Number: 393 • 2012 ACR/ARHP Annual Meeting
Defining Criteria for Rheumatoid Arthritis Patient-Derived Disease Activity Score That Corrresponds to Disease Activity Score 28 and Clnical Disease Activity Index Based Statuses and Response Criteria
Alexander MH Leung¹, Daniel Farewell², Chak S. Lau³ and Ernest Choy⁴, ¹Department of Rheumatology, Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom, ²Institute of Primary Care and Public Health, Cardiff, ENGLAND, United Kingdom, ³Univ Dept of Medicine, Queen Mary Hospital, Hong Kong, Hong Kong, ⁴Section of Rheumatology, Cardiff University School of Medicine, Cardiff, United Kingdom
Background/Purpose: Patient-based disease activity score (PDAS1 [with ESR] & PDAS2 [without ESR]) in rheumatoid arthritis (RA) are validated patient reported outcome measures of disease activity.…
Abstract Number: 394 • 2012 ACR/ARHP Annual Meeting
Remission After One Year in ACPA Positive and ACPA Negative Patients with Early Arthritis
K.V.C. Wevers-de Boer¹, L. Heimans¹, K. Visser¹, A.A. Schouffoer², T.H.E. Molenaar³, J.B. Harbers⁴, C. Bijkerk⁵, I. Speyer⁶, M. de Buck⁷, P.B. de Sonnaville⁸, B.A. Grillet⁹, Tom Huizinga¹ and C.F. Allaart¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Haga Hospital, The Hague, Netherlands, ³Dept of Rheumatology, Groene Hart Hospital, Gouda, Netherlands, ⁴Franciscus Hospital, Roosendaal, ⁵Rheumatology, Reinier de Graaf Gasthuis, Delft, Netherlands, ⁶Rheumatology, Bronovo Hospital, Den Haag, Netherlands, ⁷MCH, The Hague, ⁸Department of Rheumatology, Admiraal de Ruyter hospital, Goes, Netherlands, ⁹Department of Rheumatology, Zorgsaam Hospital, Terneuzen, Netherlands
Background/Purpose: To evaluate possible differences in clinical response after one year of remission steered treatment in Anti Citrullinated Protein Antibody (ACPA) positive and negative RA…
Abstract Number: 395 • 2012 ACR/ARHP Annual Meeting
Trends in Disease Activity, Response and Remission Rates in Rheumatoid Arthritis During the Last Decade: Results From the NOR-DMARD Register
Anna-Birgitte Aga¹, Elisabeth Lie², Karen M. Fagerli², Till Uhlig², Tore K. Kvien² and Espen A. Haavardsholm³, ¹Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ³Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: During the past decade there has been an increasing focus on early, aggressive treatment of patients with rheumatoid arthritis (RA), and combined with the…
Abstract Number: 396 • 2012 ACR/ARHP Annual Meeting
Prevalence, Concordance and Predictors of Early and Sustained Remission Assessed by Various Indices in the French Early Arthritis Espoir Cohort
Cédric Lukas¹, Ihsane Hmamouchi², Xavier Le Loet³, Bruno Fautrel⁴ and Bernard Combe⁵, ¹Immuno-Rhumatologie, Hopital Lapeyronie, Montpellier, France, ²El Ayachi Hospital, Rabat, Morocco, ³Rheumatology Department, CHU de ROUEN, Rouen, France, ⁴Rheumatology / GRC08-EEMOIS, APHP-Pitie Salpetriere Hospital / UPMC, Paris, France, ⁵Rheumatology, Hopital Lapeyronie, Montpellier, France
Background/Purpose: Clinical remission is the best achievable state in patients with rheumatoid arthritis (RA). The definition of remission, however, is still under debate. The aim…
Abstract Number: 397 • 2012 ACR/ARHP Annual Meeting
Assessment of Global Disease Activity in Rheumatoid Arthritis Patients Monitored in the Measurement of Efficacy of Treatment in the Era of Rheumatology Database: The patient’s Versus the rheumatologist’s Opinion
E. Gvozdenovic¹, R. Koevoets¹, R. Wolterbeek², Désirée van der Heijde³, T.W.J. Huizinga¹, C.F. Allaart¹ and Robert B. M. Landewé⁴, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Biostatistics, Leiden University Medical Center, Leiden, Netherlands, ³Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Academic Medical Center/University of Amsterdam & Atrium Medical Center, Amsterdam, Netherlands
Background/Purpose: Disagreement on disease activity between rheumatoid arthritis (RA) patients and rheumatologists may influence treatment decisions and compliance. The aim is to compare the physician's…
Abstract Number: 398 • 2012 ACR/ARHP Annual Meeting
Basal Metabolic Rate As an Indicator of Rheumatoid Arthritis Disease Activity and Predictor of Remission
Heather Jones¹, Annette Szumski² and Andrew S. Koenig³, ¹Pfizer Inc., Collegeville, PA, ²Specialty Care, Pfizer Inc., Collegeville, PA, ³Specialty Care Business Unit, Pfizer Inc., Collegeville, PA
Background/Purpose: The role of body mass index (BMI) in rheumatoid arthritis (RA) disease activity and response to treatment has been difficult to determine.1 As a…
Abstract Number: 399 • 2012 ACR/ARHP Annual Meeting
Can Sustained Remission of Rheumatoid Arthritis Be Predicted? an Analysis From the Japanese National Database of Rheumatic Disease (NinJa)
Yoichiro Haji¹, Mitsumasa Kishimoto¹, Ryo Rokutanda¹, Sachiko Ohde², Gautam A. Deshpande³, Yuri Ohara¹, Chisun Min¹, Yasuhiro Suyama¹, Hisanori Shimizu¹, Ken-ichi Yamaguchi¹, Akira Takeda⁴, Yukio Matsui¹, Masato Okada¹ and Shigeto Tohma⁵, ¹Division of Allergy & Rheumatology, St. Luke's International Hospital, Tokyo, Japan, ²Center for Clinical Epidemiology, St.Luke's Life of Science Institute, Tokyo, Japan, ³Center for Clinical Epidemiology, St. Luke's Life Science Instutute, Tokyo, Japan, ⁴Division of Clinical Immunology & Rheumatology, International University of Health and Welfare Hospital, Nasu-shiobara, Japan, ⁵Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan
Background/Purpose: Achievement of clinical remission in rheumatoid arthritis (RA) is now the goal of therapy to reduce joint damage and disability, and maintain or improve…
Abstract Number: 400 • 2012 ACR/ARHP Annual Meeting
High Patient Global Assessment Scores Associate with the Residual Disease Activity Unidentified by a 28-Joint Examination in Rheumatoid Arthritis Patients Approaching Clinical Remission
Yasushi Inoue¹, Eiichi Tanaka², Ayako Nakajima³, Eisuke Inoue⁴, Akiko Kobayashi⁴, Daisuke Hoshi¹, Naoki Sugimoto⁴, Kumi Shidara⁴, Yohei Seto⁴, Atsuo Taniguchi⁴, Shigeki Momohara¹ and Hisashi Yamanaka¹, ¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Tokyo Women's Medical University, Tokyo, Japan, ³Rheumatology, Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan, ⁴Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan
Background/Purpose: Patient global assessment (PtGA) is a component of the new ACR/EULAR remission criteria for rheumatoid arthritis (RA). It has been reported that >50% of…
Abstract Number: 401 • 2012 ACR/ARHP Annual Meeting
Can We Improve Outcomes in Early Rheumatoid Arthritis by Determining Best Practices? An Analysis of the Canadian Early Rheumatoid Arthritis Cohort (CATCH)
Jamie Harris¹, Vivian P. Bykerk², Carol A. Hitchon³, Edward Keystone⁴, J. Carter Thorne⁵, Gilles Boire⁶, Boulos Haraoui⁷, Glen S. Hazlewood⁸, Ashley Bonner⁹, Janet E. Pope¹⁰ and CATCH Investigators¹¹, ¹Western University, London, ON, Canada, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³University of Manitoba, Winnipeg, MB, Canada, ⁴University of Toronto, Toronto, ON, Canada, ⁵Southlake Regional Health Centre, Newmarket, ON, Canada, ⁶Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁷Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ⁸Medicine, University of Toronto, Toronto, ON, Canada, ⁹McMaster University, Hamilton, ON, Canada, ¹⁰Medicine/Rheumatology, St. Joseph Health Care London, University of Western Ontario, London, ON, Canada, ¹¹Toronto, ON, Canada
Background/Purpose: The goal of ERA treatment is remission but many patients do not achieve this state due to patient factors and perhaps differences in treating…
Abstract Number: 402 • 2012 ACR/ARHP Annual Meeting
Discordant Inflammatory Markers in Veterans with Rheumatoid Arthritis: Baseline Characteristics and Relationship with Disease Activity
Rebecca Belsom¹, Archana Jain¹, Jeffrey R. Curtis², Shuo Yang³, Ted R. Mikuls⁴, Lang Chen⁵ and Angelo L. Gaffo⁶, ¹Rheumatology, University of Alabama, Birmingham, AL, ²Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Clinical Immunology/Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁴Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁵Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁶Medicine, Birmingham VA Medical Center and University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Discrepancies between erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) elevations with clinical disease activity frequently occur in rheumatoid arthritis (RA) patients and may…

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