Abstract Number: 549 • 2012 ACR/ARHP Annual Meeting
A Randomized, Open-Label Study of Maintenance of Partial Remission with Naproxen Vs No Treatment: Results of the Infliximab As First Line Therapy in Patients with Early Active Axial Spondyloarthritis Trial, Part II
Background/Purpose: In patients with axial SpA who have achieved partial remission, it is unclear whether continuous treatment with NSAIDs is superior to stopping treatment. Objectives:…Abstract Number: 550 • 2012 ACR/ARHP Annual Meeting
Differences in the Prevalence of Inflammatory Articular Disease in Psoriatic Patients, Applying Clinical, Ultrasound and/or Radiological Data. Implications in the Classification of Psoriatic Arthritis according to Caspar Criteria
Background/Purpose: a) To determine differences in the prevalence of inflammatory articular disease (IAD) in patients with cutaneous psoriasis when applying clinical, ultrasound (PDUS) or radiological…Abstract Number: 510 • 2012 ACR/ARHP Annual Meeting
IL-7 and IL-7 Receptor Blockade to Selectively Inhibit TLR7-Induced B Cell Activation in Primary Sjögren’s Syndrome
Background/Purpose: Toll-like receptors (TLRs) are involved in the recognition of nucleic acids (viral, bacterial, and possibly self) and have been implicated in several auto-immune diseases.…Abstract Number: 511 • 2012 ACR/ARHP Annual Meeting
A New Pathogenic Role of Salivary Gland Epithelial Cells in the Costimulation of T Lymphocytes in Primary Sjögren’s Syndrome: 0X40 Ligand Expression, T-Cell Induction of OX40 and Promotion of T-Cell Survival, Proliferation and Activation
Background/Purpose: OX40/OX40L interaction is a pivotal costimulatory pathway involved in multiple autoimmune diseases. It provides a key signal for T-cell proliferation and differentiation in effector…Abstract Number: 512 • 2012 ACR/ARHP Annual Meeting
Memory B Cell Phenotypic and Gene Expression Profiling in Primary Sjogren’s Syndrome: Implications for Disease Diagnosis
Background/Purpose: A paucity of known causative mechanisms in primary Sjögren’s Syndrome (pSS) contributes to inadequate classification criteria. However, known memory-phenotype B cell aberrations could enrich…Abstract Number: 513 • 2012 ACR/ARHP Annual Meeting
Regulatory B Cells in Primary Sjögren’s Syndrome
Background/Purpose: B cells have traditionally been considered as positive regulators of humoral immune response, however their negative regulatory role has recently being recognized. Objective. To…Abstract Number: 514 • 2012 ACR/ARHP Annual Meeting
Frequencies and Numbers of Circulating IL-10 Producing Regulatory B Cells Are Not Disturbed in Pss-Patients but Correlate Negatively with the EULAR Sjögren Syndrome Disease Activity Score (ESSDAI)
Background/Purpose: Recently, a specific and functionally important subset of regulatory B cells (Breg) that negatively regulate autoimmunity and inflammation has been described. Breg cells exert…Abstract Number: 515 • 2012 ACR/ARHP Annual Meeting
Stages of Sjogren’s Syndrome Defined by Immune Mediators
Background/Purpose: Sjogren’s syndrome (SS) is characterized by destruction of the salivary and lachrymal glands but also systemic manifestations such as lung disease, kidney disease and…Abstract Number: 516 • 2012 ACR/ARHP Annual Meeting
Characterization of Dominant B- and Plasma Cell Clones in Patients with Primary Sjögren’s Syndrome and Patients with Sicca Syndrome
Background/Purpose: Primary Sjögren's syndrome (pSS) is an autoimmune exocrinopathy characterized by chronic inflammation and destruction of the salivary and lacrimal glands. Infiltration of B and…Abstract Number: 517 • 2012 ACR/ARHP Annual Meeting
Overexpression of BMP6 Is Associated with Loss of Salivary Gland Activity in Sjögren’s Syndrome Patients and Mice
Background/Purpose: A hallmark of Sjögren’s syndrome (SS) is the loss of activity in secretory epithelia, specifically the larcrimal and salivary glands. The mechanism(s) driving this…Abstract Number: 518 • 2012 ACR/ARHP Annual Meeting
Spontaneous Sialadenitis Like Sjögren’s Syndrome in Orphan Nuclear Receptor γt (RORγt) Transgenic Mice
Background/Purpose: The nuclear receptors retinoic-acid-receptor-related orphan receptors gt (RORγt) is required for the generation of Th17 cells expressing the proinflammatory cytokine IL-17. Th17 cells expressing…Abstract Number: 519 • 2012 ACR/ARHP Annual Meeting
Sex-Specific Regulatory T Cell Dysfunction in a Mouse Model of Sjögren Syndrome
Background/Purpose: CD4+Foxp3+ regulatory T cells (Tregs) are a specialized population of lymphocytes which prevent autoimmunity in normal hosts. Treg dysfunction has been implicated in autoimmunity; however results…Abstract Number: 520 • 2012 ACR/ARHP Annual Meeting
Genetic Associations to Germinal Centre Formation in Primary Sjögren’s Syndrome
Background/Purpose: Primary Sjögren’s syndrome (pSS) is an autoimmune rheumatic disease mainly affecting the salivary and lacrimal glands causing xerostomia and keratoconjunctivitis sicca. Focal mononuclear cell…Abstract Number: 521 • 2012 ACR/ARHP Annual Meeting
Differences in Genome-Wide DNA Methylation Profiles Across Multiple Cell and Tissue Types in Sjögren’s Syndrome (SS)
Background/Purpose: Increasing evidence supports a role for epigenetic factors, including DNA methylation status, in autoimmune disease risk and severity. Our goal is to characterize DNA…Abstract Number: 522 • 2012 ACR/ARHP Annual Meeting
Genetic Variation in the NCR3 Locus Is Associated with Anti-SSA⁄SSB Positive Primary Sjögren′s Syndrome in Scandinavian Samples
Background/Purpose: Candidate gene studies in primary Sjögren’s syndrome (pSS) have identified polymorphisms in genes involved in the type I interferon (IFN) system and the type…
ACR Meeting Abstracts