Abstracts Archive - Page 2564 of 2607 - ACR Meeting Abstracts

Abstract Number: 609 • 2012 ACR/ARHP Annual Meeting
Peripheral Neuropathy in Systemic Lupus Erythematosus
Amin Oomatia¹, Hong Fang², Michelle Petri² and Julius Birnbaum³, ¹School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom, ²Johns Hopkins University School of Medicine, Baltimore, MD, ³Rheumatology, Johns Hopkins University, Baltimore, MD
Background/Purpose: Whilst Neurological disorders are a common manifestation of systemic lupus erythematosus (SLE), peripheral neuropathies have received little attention. The literature consists mostly of small…
Abstract Number: 610 • 2012 ACR/ARHP Annual Meeting
B Lymphocyte Stimulator Levels Are Higher in Caucasian SLE Patients Earlier in Disease Course and Predict Damage Accumulation
Eoghan M. McCarthy¹, Ruth Lee¹, Joan Ni Gabhann², Siobhan Smith², Michele Doran³, Gaye Cunnane³, Donough G. Howard¹, Paul G. O'Connell⁴, Grainne M. Kearns⁵ and Caroline Jefferies², ¹Rheumatology, Beaumont Hospital, Dublin 9, Ireland, ²Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland, ³Dept of Rheumatology, St. James Hospital, Dublin, Ireland, ⁴Department of Rheumatology, Beaumont Hospital, Dublin 9, Ireland, ⁵Rheumatology Department, Beaumont Hospital, Dublin, Ireland
Background/Purpose: B Lymphocyte Stimulator(BLyS) plays an important role in the pathogenesis of Systemic Lupus Erythematosus(SLE). Whilst trials of anti BLyS-targeted therapy have shown promise, the optimal…
Abstract Number: 571 • 2012 ACR/ARHP Annual Meeting
Description of Distribution of Active Inflammatory Lesions On Magnetic Resonance Imaging of the Sacroiliac Joints and the Spine in Patients with Early Axial Spondyloarthritis – Analysis of the Esther Trial Baseline Data
In-Ho Song¹, Christian Althoff², Hildrun Haibel¹, Joachim Listing³, Anja Weiß⁴, Bruce Freundlich⁵, Martin Rudwaleit⁶ and Joachim Sieper⁷, ¹Medical Department I, Rheumatology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany, ²Radiology, Charite Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany, ³German Rheumatism Research Center, Berlin, Germany, ⁴German Rheumatism Research Centre, Berlin, Germany, ⁵University of Pennsylvania, Philadelphia, PA, ⁶Endokrinologikum Berlin, Berlin, Germany, ⁷Medical Department I, Rheumatology, Charité Universitätesmedizin Berlin, Berlin, Germany
Background/Purpose: To address the question whether active inflammation starts at specific sites of the sacroiliac joints (SI-joints) and/ or the spine. Methods: Wb-MRIs of…
Abstract Number: 572 • 2012 ACR/ARHP Annual Meeting
Radiographic Damage in Ankylosing Spondylitis Over 12 Years of Follow-up: A Longitudinal Analysis
Sofia Ramiro¹, Carmen Stolwijk², A.M. Van Tubergen³, Désirée van der Heijde⁴ and Robert Landewé⁵, ¹Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, The Netherlands and Hospital Garcia de Orta, Almada, Portugal, ²Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ³Department of Medicine, Maastricht University Medical Center, Maastricht, Netherlands, ⁴Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam and Atrium Medical Center, Heerlen, Netherlands
Background/Purpose: Radiographic damage is one of the core outcomes recommended by the Assessment in Spondyloarthritis international Society (ASAS) for follow-up of patients with axial SpA.…
Abstract Number: 573 • 2012 ACR/ARHP Annual Meeting
Differential Association Between Human Leukocyte Antigen (HLA) Alleles and Joint Subluxation and Ankylosis in Patients with Psoriatic Arthritis
Vinod Chandran¹, Arane Thavaneswaran², Amir Haddad², Fawnda Pellett³ and Dafna D. Gladman⁴, ¹Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ²Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ³Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴Division of Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada
Background/Purpose: We have previously reported the association between HLA and KIR gene variants with the development of Arthritis Mutilans (AM) in psoriatic arthritis (PsA). However,…
Abstract Number: 574 • 2012 ACR/ARHP Annual Meeting
Long Term Inhibition of Interleukin (IL)-17A with Secukinumab Improves Clinical Symptoms and Reduces Spinal Inflammation As Assessed by Magnetic Resonance Imaging in Patients with Ankylosing Spondylitis
Xenofon Baraliakos¹, Jürgen Braun², D. D. Laurent³, Dominique L. Baeten⁴, D. van der Heijde⁵, Joachim Sieper⁶, Paul Emery⁷, Iain B. McInnes⁸, Jacob M. van Laar⁹, R. Landewe¹⁰, Paul Wordsworth¹¹, Jurgen Wollenhaupt¹², Herbert Kellner¹³, Andrew Wright³, Francois Vandenhende¹⁴, Kath Radford¹⁵, Babul Borah¹⁵ and Hueber Wolfgang¹⁵, ¹Rheumatology, Rheumazentrum Ruhrgebiet, Herne, Germany, ²Rheumazentrum Ruhrgebiet, Herne, Germany, ³Novartis Pharma AG, Basel, Switzerland, ⁴Department of Clinical Immunology and Rheumatology Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ⁵Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁶Charitè Berlin, Campus Benjamin Franklin, Berlin, Germany, ⁷Division of Rheumatic and Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom, ⁸Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, ⁹Newcastle University, Newcastle upon Tyne, United Kingdom, ¹⁰Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ¹¹Nuffield Orthopaedic Centre, Oxford, United Kingdom, ¹²Division of Reheumatology, Schoen-Klinik Hamburg-Eilbek Teaching Hospital of the University of Hamburg, Hamburg, Germany, ¹³Centre for Inflammatory Joint Diseases, Munich, Germany, Munich, Germany, ¹⁴Clinbay, Genappe, Belgium, Genappe, Belgium, ¹⁵Novartis Institutes for BioMedical Research, Basel, Switzerland
Background/Purpose: In a recent proof-of-concept (PoC) trial it was shown that secukinumab, a fully human IgG1k anti-IL17A monoclonal antibody, significantly improved clinical signs and symptoms…
Abstract Number: 575 • 2012 ACR/ARHP Annual Meeting
Profiling of Response to Anti-TNFα Therapy by Serum Markers of Tissue Degradation End Products in Ankylosing Spondylitis Patients
Anne Sofie Siebuhr¹, Anne C. Bay-Jensen², Morten Asser Karsdal³, Efstathios Vassiliadis⁴, Stephanie Wichuk⁵, Claus Christiansen⁶ and Walter P. Maksymowych⁷, ¹Rheumatology, Nordic Bioscience, Herlev, Denmark, ²Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ³Nordic Bioscience A/S, Herlev, Denmark, ⁴Nordic Bioscience, Herlev, Denmark, ⁵Medicine, University of Alberta, Edmonton, AB, Canada, ⁶CCBR, Ballerup, Denmark, ⁷Department of Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Chronic inflammatory diseases such as Ankylosing Spondylitis (AS) are diverse and therefore hard to clearly diagnose and treat. Conventional biomarkers for AS, as CRP…
Abstract Number: 576 • 2012 ACR/ARHP Annual Meeting
Reference Intervals of Spinal Mobility Measures in Normal Individuals – the Mobility Study
Sofia Ramiro¹, Carmen Stolwijk², A.M. Van Tubergen³, Patrick Royston⁴, Désirée van der Heijde⁵ and Robert Landewé⁶, ¹Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, The Netherlands and Hospital Garcia de Orta, Almada, Portugal, ²Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ³Department of Medicine, Maastricht University Medical Center, Maastricht, Netherlands, ⁴MRC Clinical Trials Unit, University College of London, London, United Kingdom, ⁵Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁶Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam and Atrium Medical Center, Heerlen, Netherlands
Background/Purpose: Spinal mobility is frequently assessed in the follow-up of patients with axial SpA, which is also in accordance with the recommendations by the Assessment…
Abstract Number: 577 • 2012 ACR/ARHP Annual Meeting
MRI of the Spine for Detection of Bone Spurs and Ankylosis in Patients with Ankylosing Spondylitis: Does MRI Offer Any Advantages Over Radiography?
Susanne Juhl Pedersen¹, Mikkel Østergaard², Robert GW Lambert³ and Walter P. Maksymowych⁴, ¹Dept. of Rheumatology, Copenhagen Center for Arthritis Research, Copenhagen, Denmark, ²Department of Rheumatology, Glostrup Hospital, Copenhagen, Denmark, ³Radiology, University of Alberta, Edmonton, AB, Canada, ⁴Department of Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: The current gold standard for detection of disease progression in ankylosing spondylitis (AS) is conventional radiography. The most reliable method mSASSS includes the anterior…
Abstract Number: 578 • 2012 ACR/ARHP Annual Meeting
Assessment of the Link Between Inflammation and Fat Metaplasia in Patients with Spondyloarthritis On Non-Biological Therapy: A Long Term Magnetic Resonance Imaging Study
Zheng Zhao¹, Susanne Juhl Pedersen², Robert GW Lambert³, Stephanie Wichuk⁴, Mikkel Ostergaard⁵ and Walter P. Maksymowych⁶, ¹Department of Rheumatology, University of Alberta and PLA General Hospital, Beijing, PR China, Beijing, AB, China, ²Dept. of Rheumatology, Copenhagen Center for Arthritis Research, Copenhagen, Denmark, ³Radiology, University of Alberta, Edmonton, AB, Canada, ⁴Medicine, University of Alberta, Edmonton, AB, Canada, ⁵Copenhagen Center for Arthritis Research, Copenhagen University Hospital at Glostrup, Glostrup, Denmark, ⁶Department of Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: There is growing awareness of the importance of fat metaplasia in the pathogenesis of SpA and its potential link with inflammation and new bone…
Abstract Number: 579 • 2012 ACR/ARHP Annual Meeting
Prevalence of Psoriatic Arthritis in Psoriasis Patients According to Newer Classification Criteria
Hernan Maldonado-Ficco¹, Gustavo Citera¹, Ana Alba Porrini² and Jose A. Maldonado-Cocco¹, ¹Rheumatology, Instituto de Rehabilitacion Psicofisica - Fundacion Reumatologica Argentina Dr. Osvaldo Garcia-Morteo, Buenos Aires, Argentina, ²Rheumatology, Hospital Argerich, Buenos Aires, Argentina
Background/Purpose: To determine the prevalence of Psoriatic Arthritis (PsA) in a cohort of psoriasis patients according to CASPAR criteria, and compare it with that resulting from…
Abstract Number: 580 • 2012 ACR/ARHP Annual Meeting
Changes in Sclerostin, Dickkopf-1 and Serum Markers of Inflammation, Cartilage and Bone Turnover in Patients with Axial Spondyloarthritis Treated with Adalimumab
Susanne Juhl Pedersen¹, Inge Juul Sørensen², Julia S. Johansen³, Patrick Garnero⁴, Anne Gitte Loft⁵, Jens Skoedt⁶, Gorm Thamsborg⁷, Karsten Asmussen⁸, Elka Kluger⁹, Jesper Nørregaard¹⁰, Torben Grube Christensen¹¹ and Mikkel Østergaard¹², ¹Copenhagen Center for Arthritis Research, Copenhagen University Hospital at Glostrup, Copenhagen, Denmark, ²Department of Rheumatology, Hvidovre Hospital, Copenhagen, Denmark, ³Department of Internal Medicine and Oncology, Herlev Hospital, Herlev, Denmark, ⁴INSERM, UMR 1033, Lyon and Cisbio Bioassays, Bagnols/Cèze, France, ⁵Department of Rheumatology, Sygehus Lillebaelt, Vejle, Denmark, ⁶Department of Rheumatology, Gentofte Hospital, Copenhagen, Denmark, ⁷Dep. of Rheumatology, Glostrup Hospital, Copenhagen, Denmark, ⁸Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark, ⁹King Christian 10th Rheumatism Hospital at Gråsten, Graasten, Denmark, ¹⁰Dep of Rheumatology, Hørsholm Hospital, Hørsholm, Denmark, ¹¹Department of Rheumatology, Slagelse Hospital, Slagelse, Denmark, ¹²Copenhagen University Hospital Glostrup, Copenhagen, Denmark
Background/Purpose: Few studies have investigated changes in plasma sclerostin and Dickkopf1 (DKK-1) in relation to other biomarkers of inflammation, cartilage and bone turnover during treatment…
Abstract Number: 581 • 2012 ACR/ARHP Annual Meeting
Examining a Role for Th17 Regulation and Toll-Like Receptor Signaling in Psoriatic Arthritis
Fatima Abji¹, Remy Pollock², Fawnda Pellett³, Vinod Chandran⁴ and Dafna D. Gladman², ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ³Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada
Background/Purpose: Psoriatic arthritis (PsA) is a seronegative inflammatory arthritis that develops in 30% of patients with cutaneous psoriasis (PsC). Joint inflammation in PsA is mediated…
Abstract Number: 582 • 2012 ACR/ARHP Annual Meeting
Proteomic Analysis of Synovial Tissue: A Unique Tool to Predict Response to Anti-TNF Alpha Therapy in Patients with Inflammatory Arthritis
Opeyemi S. Ademowo¹, Emily S. Collins¹, Cathy Rooney¹, A. W van Kuijk², Danielle M. Gerlag³, Paul P. Tak², Oliver FitzGerald⁴ and Stephen R. Pennington¹, ¹UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland, ²Clinical Immunology / Rheumatology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ³Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁴Department of Rheumatology, St. Vincent's University Hospital, Dublin, Ireland
Background/Purpose: Inflammatory arthritis, which includes rheumatoid arthritis (RA) and psoriatic arthritis (PsA), is a leading cause of joint deformity, disability and reduced quality of life…
Abstract Number: 583 • 2012 ACR/ARHP Annual Meeting
Familial Aggregation and Heritability of Ankylosing Spondylitis in Taiwan: A Nationwide Population Study
Chang-Fu Kuo¹, Matthew J. Grainge², Lai-Chu See³, Kuang-Hui Yu⁴, Shue-Fen Luo⁴, Ana M. Valdes⁵, I-Jun Chou⁶, Weiya Zhang¹ and Michael Doherty⁷, ¹Academic Rheumatology, School of Clinical Sciences, University of Nottingham, Nottingham, United Kingdom, ²Division of Epidemiology and Public Health, School of Community Health Sciences, University of Nottingham, Nottingham, United Kingdom, ³Department of Public Health, College of Medicine, Chang Gung University, Taoyuan, Taiwan, ⁴Division of Rheumatology, Immunology and Allergy, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ⁵Dept of Twin Research and Genetic Epidemiology, St. Thomas' Hospital, King's College London, London, United Kingdom, ⁶Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ⁷Academic Rheumatology, University of Nottingham, Nottingham, United Kingdom
Background/Purpose: To estimate the risk of ankylosing spondylitis (AS) among individuals with affected first-degree relatives and to assess the magnitude of genetic contribution to the…

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