Abstracts Archive - Page 2563 of 2607 - ACR Meeting Abstracts

Abstract Number: 594 • 2012 ACR/ARHP Annual Meeting
Evidence of Human Leucozyte Antigen-B27 in Healthy Individuals and Patients with Uveitis Is a Risk Factor for Alterations in Bone Metabolism
Sarah Schmidt¹, Stephanie Finzel¹, Jürgen Rech², Matthias Englbrecht¹, Silke Winkler¹, Isabel Schmidt¹, Roula Said-Nahal³, Maxime A. Breban³ and Georg A. Schett¹, ¹Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Medizinische Klinik 3, University of Erlangen-Nuremberg, Erlangen, Germany, ³Rheumatology Division, Ambroise Paré Hospital (AP-HP), and Versailles Saint Quentin en Yvelines University, Boulogne-Billancourt, France
Background/Purpose: To test whether positivity for HLA-B27 per se is associated with changes of biomarkers of the Wnt pathway. HLA-B27 is strongly associated with the…
Abstract Number: 595 • 2012 ACR/ARHP Annual Meeting
A Genomewide Association Study of Anterior Uveiti
Dorith Claushuis¹, Adrian Cortes², Linda A. Bradbury¹, Tammy M. Martin³, James T. Rosenbaum⁴, John D. Reveille⁵, Paul Wordsworth⁶, Jennifer Pointon⁶, Australo-Anglo-American Spondyloarthritis Consortium⁷, David Evans⁸, Paul Leo², Pamela Mukhopadhyay² and Matthew A. Brown², ¹Human Genetics Group, The University of Queensland Diamantina Institute, Brisbane, Australia, ²Human Genetics Group, The University of Queensland Diamantina Insititute, Brisbane, Australia, ³Ophthalmology/L467AD, Oregon Health & Science Univ, Portland, OR, ⁴Arthritis and Rheumatic diseases, Oregon Health and Science University, Portland, OR, ⁵Internal Medicine/Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX, ⁶Ndorms, Nuffield Orthopaedic Centre, Oxford, United Kingdom, ⁷Houston, TX, ⁸School of Social and Community Medicine, Bristol University, Bristol, United Kingdom
Background/Purpose: Anterior uveitis (AU) is the most common extra-articular manifestation of ankylosing spondylitis (AS), occurring in up to 30-40% of AS cases. The aim of…
Abstract Number: 596 • 2012 ACR/ARHP Annual Meeting
Evolution of Atherosclerosis in Psoriatic Arthritis: Is the Former an Independent Inflammatory Process?
Roberta Ramonda¹, Massimo Puato², Valentina Modesti³, Mariagrazia Lorenzin⁴, Paola Frallonardo⁴, Augusta Ortolan⁴, Carla Campana³, Alessandro Lo Nigro³ and Leonardo Punzi⁵, ¹Rheumatology Unit, University of Padova, Padova, Italy, ²Department of Internal Medicine, University of Padova, Padova, Italy, ³Unit of Rheumatology, University of Padova, Padova, Italy, ⁴Rheumatology Unit, Department of Medicine, University of Padova, Padova, Italy, ⁵Clinical and Experimental Medicine, Rheumatology Unit - University of Padova, Padova, Italy
Background/Purpose: A non-invasive study focusing on the structural and functional properties of the carotid arteries was carried out in psoriatic arthritis (PsA) patients. Increased cardiovascular…
Abstract Number: 597 • 2012 ACR/ARHP Annual Meeting
Investigating the Genetic Association Between ERAP1 and Spondyloarthritis
Amir Kadi¹, Brigitte Izac², Roula Said-Nahal³, Ariane Leboime⁴, Kurt L. de Vlam⁵, Dirk Elewaut⁶, Gilles Chiocchia² and Maxime A. Breban³, ¹Institut Cochin - Université Paris Descartes - INSERM U1016 - CNRS (UMR 8104), Paris, France, ²Immunology and Hematology Department, Institut Cochin - INSERM U1016 - CNRS (UMR 8104), Paris, France, ³Rheumatology Division, Ambroise Paré Hospital (AP-HP), and Versailles Saint Quentin en Yvelines University, Boulogne-Billancourt, France, ⁴Rheumatology Division, Ambroise-Paré Hospital AP-HP, Boulogne-Billancourt, France, ⁵Rheumatology, University Hospitals Leuven, Leuven, Belgium, ⁶Rheumatology, Department of Rheumatology Ghent University Hospital, Ghent, Belgium
Background/Purpose: A robust association was recently identified between polymorphisms in the non-major histocompatibility complex gene ERAP1 and ankylosing spondylitis (AS) in several populations. The aim…
Abstract Number: 598 • 2012 ACR/ARHP Annual Meeting
The Non-Synonymous Polymorphism IL23R Arg381Gln Is Associated with Ankylosis in Spondyloarthritis
Amir Kadi¹, Félicie Costantino², Brigitte Izac³, Ariane Leboime⁴, Roula Said-Nahal⁵, Gilles Chiocchia³ and Maxime A. Breban⁵, ¹Institut Cochin - Université Paris Descartes - INSERM U1016 - CNRS (UMR 8104), Paris, France, ²INSERM U987, Faculté des Sciences de la Santé Simone Veil, Montigny-le-Bretonneux, France, ³Immunology and Hematology Department, Institut Cochin - INSERM U1016 - CNRS (UMR 8104), Paris, France, ⁴Rheumatology Division, Ambroise-Paré Hospital AP-HP, Boulogne-Billancourt, France, ⁵Rheumatology Division, Ambroise Paré Hospital (AP-HP), and Versailles Saint Quentin en Yvelines University, Boulogne-Billancourt, France
Background/Purpose: Spondyloarthritis (SpA) is a group of articular disorders sharing genetic background. Single-nucleotide polymorphisms (SNP) of the interleukin 23 receptor (IL23R) gene have been reproducibly…
Abstract Number: 599 • 2012 ACR/ARHP Annual Meeting
LIGHT (TNFSF14), Cathepsin K, DKK-1 and Sclerostin in Ankylosing Spondylitis: Osteoclast/OSTEOBLAST Imbalance Unrelated to Disease Activity and Effect of ANTI-TNFα Treatment On the WNT/β Catenin Pathway
Alberto Cauli¹, Grazia Dessole¹, Giovanni Porru¹, Matteo Piga¹, Alessandra Vacca², Valentina Ibba¹, Pietro Garau¹ and Alessandro Mathieu¹, ¹Unit and Chair of Rheumatology, University Hospital of Cagliari, Cagliari, Italy, ²Rheumatology Unit - Medical Sciences, University of Cagliari, Cagliari, Italy
Background/Purpose: Ankylosing Spondylitis (AS) is an inflammatory arthritis characterized by erosions and new bone formation. These processes appear to be related by the fine balance…
Abstract Number: 600 • 2012 ACR/ARHP Annual Meeting
Regulatory T Cells in Spondyloarthritis (SpA) Animal Model and Modulatory Role of Inducible Costimulator (ICOS)
Luiza Krause¹, Ingrid Fert¹, Karine Labroquère², Muriel Andrieu², Gilles Chiocchia³ and Maxime A. Breban⁴, ¹Immunology and Hematology Department, Institut Cochin - INSERM U1016 - CNRS (UMR 8104)-Université Paris Descartes (UMR-S 1016), Paris, France, ²Cochin Immunobiology Facility, Paris, France, ³Versailles Saint Quentin en Yvelines University, INSERM U987, UFR des Sciences de la Santé, Montigny-le-Bretonneux, France, ⁴Rheumatology Division, Ambroise Paré Hospital (AP-HP), and Versailles Saint Quentin en Yvelines University, Boulogne-Billancourt, France
Background/Purpose: HLA-B27/human β2m transgenic rats (B27-rats), a model of SpA develop spontaneous colitis and arthritis. It was recently shown in this model that IL-17 producing…
Abstract Number: 601 • 2012 ACR/ARHP Annual Meeting
Bath Ankylosing Spondylitis Functional Index (BASFI) Is a Better Indicator of Poor Quality of Life Than Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) in Ankylosing Spondylitis: Results From SIRAS – the Scotland and Ireland Registry for Ankylosing Spondylitis
Gareth T. Jones¹, Linda E. Morton¹, Gary J. Macfarlane¹ and Scotland and Ireland Registry for Ankylosing Spondylitis², ¹Musculoskeletal Research Collaboration (Epidemiology Group), University of Aberdeen, Aberdeen, United Kingdom, ²Aberdeen
Background/Purpose: Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Functional Index (BASFI) are validated instruments used to determine disease activity and function amongst ankylosing spondylitis…
Abstract Number: 602 • 2012 ACR/ARHP Annual Meeting
Sexual and Reproductive Health Counseling Among Adolescents with Systemic Lupus Erythematosus
Xue Tian¹, Murray H. Passo², Janice D. Key³, Thomas C. Hulsey⁴ and Natasha M. Ruth¹, ¹Pediatric Rheumatology, The Medical University of South Carolina, Charleston, SC, ²Pediatric Rheumatology, Medical University of South Carolina, Charleston, SC, ³Adolescent Medicine, The Medical University of South Carolina, Charleston, SC, ⁴Pediatrics, The Medical University of South Carolina, Charleston, SC
Background/Purpose: Systemic Lupus Erythematosus (SLE) is an autoimmune disease that is known to target young adults, especially women of child-bearing age. Although it is well-accepted…
Abstract Number: 603 • 2012 ACR/ARHP Annual Meeting
Cell Bound Complement Activation Products Are Associated with Disease Activity in Systemic Lupus Erythematosus
Kenneth C. Kalunian¹, W. Winn Chatham², Elena M. Massarotti³, Joyce Reyes-Thomas⁴, Richard Furie⁵, Jill P. Buyon⁶, Emily C. Somers⁷, Chaim Putterman⁸, Rachel L. Gross⁹, Kyriakos A. Kirou¹⁰, Rosalind Ramsey-Goldman¹¹, Christine Hsieh¹², Thierry Dervieux¹³ and A. Weinstein¹⁴, ¹UCSD School of Medicine, La Jolla, CA, ²University of Alabama at Birmingham, Birmingham, AL, ³Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁴Rheum/Forchheimer Rm 701, Albert Einstein College of Med, Bronx, NY, ⁵North Shore-LIJ Health System, Lake Success, NY, ⁶Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁷IntMed, Environmental Health, and OB/GYN, University of Michigan, Ann Arbor, MI, ⁸Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ⁹Rheumatology, Albert Einstein College of Medicine, New York, NY, ¹⁰Hospital for Special Surgery, New York, NY, ¹¹Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ¹²Rheumatology, University of Chicago, Chicago, IL, ¹³Research and Development, Exagen Diagnostics, Albuquerque, NM, ¹⁴Washington Hospital Center, Washington, DC
Background/Purpose: Elevated cell-bound complement activation products (CBCAPs) and decreased erythrocyte complement receptor 1 (ECR1) expression may correlate with disease activity in systemic lupus erythematosus (SLE).…
Abstract Number: 604 • 2012 ACR/ARHP Annual Meeting
Comparing the ACR and the SLICC Criteria for the Classification of SLE Patients Using Data from an Existing Multi-Ethnic Cohort
Graciela S. Alarcon¹, Gerald McGwin Jr.², Larry Madger³ and Michelle Petri⁴, ¹Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²Epidemiology, University of Alabama at Birmingham, Birmingham, AL, ³Epidemiology, University of Maryland, Baltimore, MD, ⁴Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: The SLICC group has proposed a modification of the revised/updated SLE ACR classification criteria; it has comparable metric properties but is felt to be…
Abstract Number: 605 • 2012 ACR/ARHP Annual Meeting
Increased Incidence of Herpes Zoster Among Patients with Systemic Lupus Erythematosus
Eliza F. Chakarvarty¹, Kaleb Michaud², Robert S. Katz³ and Frederick Wolfe⁴, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, CA, ²Rheumatology, National Data Bank for Rheumatic Diseases & University of Nebraska Medical Center, Omaha, NE, ³Rush University Medical Center, Chicago, IL, ⁴National Data Bank for Rheumatic Diseases, Wichita, KS
Background/Purpose: Herpes zoster (HZ) is the painful reactivation of latent varicella zoster virus infection. The incidence of HZ may be increased in some autoimmune…
Abstract Number: 606 • 2012 ACR/ARHP Annual Meeting
Risk Factors Associated with Cervical Human Papillomavirus Infection in Women with Systemic Lupus Erythematosus: The Role of Rituximab
Mario Garcia-Carrasco¹, Claudia Mendoza Pinto¹, Alejandro Taboada-Cole¹, Verónica Vallejo-Ruiz², Julio Reyes-Leyva² and Aurelio Lopez-Colombo³, ¹Systemic Autoimmune Disease, HGR 36 CMN Manuel Ávila Camacho, Instituto Mexicano del Seguro Social, Puebla, Mexico, ²Laboratorio de Biología Molecular y Virología, Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Hospital General de Zona No. 5, Puebla, Mexico, ³Research Departament, Delegación Estatal, Instituto Mexicano del Seguro Social, Puebla, Mexico
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic, autoimmune, multisystemic disease that affects women of reproductive age. Women with SLE have an increased risk of…
Abstract Number: 607 • 2012 ACR/ARHP Annual Meeting
Activity Index After Renal Failure in a Cohort of 32 Patients with Lupus Nephritis
Cristina Gonzalez-Pulido¹, Sara Croca² and D.A. Isenberg³, ¹Internal Medicine, University Hospital Virgen del Rocio, Seville, Spain, ²Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom, ³Centre for Rheumatology Research, University College London, London, United Kingdom
Background/Purpose: Most published studies that have measured activity in patients with lupus nephritis suggest the disease is relatively quiescent after renal failure. Purpose: To analyze…
Abstract Number: 608 • 2012 ACR/ARHP Annual Meeting
Association of Discoid Lupus with Other Clinical Manifestations Among Patients with Systemic Lupus Erythematosus
Joseph F. Merola¹, Christina Iversen², Jose A. Gomez-Puerta², Tabatha Norton², Hsun Tsao², Peter H. Schur², Elena M. Massarotti², Bonnie L. Bermas³ and Karen H. Costenbader², ¹Rheumatology, Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Prior studies suggest that cutaneous discoid lupus (DLE) is a marker for less severe disease with a low frequency of nephritis and end-stage renal…

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