Abstracts Archive - Page 2543 of 2607 - ACR Meeting Abstracts

Abstract Number: 897 • 2012 ACR/ARHP Annual Meeting
IL-33 Promotes Mast Cell Survivial Via Inhibition of Apoptosis Associated with Enhanced Expression of Bcl-X_L
Shinjiro Kaieda¹, Jun-Xia Wang² and Peter A. Nigrovic³, ¹Department of Medicine, *Division of Respirology, Neurology and Rheumatology, Kurume University School of Medicine, kurume, Japan, ²Department of Medicine, *Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Mast cells (MCs) are potent innate immune cells that frequently accumulate in chronically inflamed tissues, including the arthritic synovium. The factors that regulate MC…
Abstract Number: 898 • 2012 ACR/ARHP Annual Meeting
Nuclear Receptor Related 1 Induces Synovial Hyperplasia Via Transcriptional Regulation of Novel Target Genes
Kimberlee S. Mix, Biological Sciences, Loyola University New Orleans, New Orleans, LA
Background/Purpose: Nuclear receptor related 1 (NURR1 / NR4A2) is an orphan member of the nuclear receptor super-family that functions as a constitutively active transcription factor.…
Abstract Number: 899 • 2012 ACR/ARHP Annual Meeting
A Role for Soluble Interleukin-6 Receptor As an Antagonist of Interleukin-27 Signaling
Misato Hashizume¹, Keiko Esaki² and Yoshihiro Matsumoto¹, ¹Product Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan, ²Discovery Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan
Background/Purpose: Recently, it has been reported that interleukin (IL)-27 treatment reduces inflammation and ameliorates arthritis in collagen-induced arthritis mice. IL-27 is a heterodimeric cytokine composed…
Abstract Number: 900 • 2012 ACR/ARHP Annual Meeting
Deletion of RBP-J in a Murine Model of Inflammatory Arthritis Reveals Differential Pro-Inflammatory Cytokine and FoxP3 Gene Expression
Soumya D. Chakravarty¹, Karmen Au², Xiaoyu Hu³ and Lionel B. Ivashkiv⁴, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, New York, NY, ³Arthritis Tissue Degeneration Program, Hospital for Special Surgery, New York, NY, ⁴Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY
Background/Purpose: The DNA-binding protein RBP-J serves as the central transcriptional regulator of the Notch signaling pathway. Prior work done using a knockdown approach of RBP-J…
Abstract Number: 901 • 2012 ACR/ARHP Annual Meeting
Colony-Stimulating Factor (CSF) Receptor 1 Blockade Overcomes Overlapping Effects of M-CSF and Interleukin-34 On Myeloid Differentiation and Gene Expression to Reduce Inflammation in Human and Murine Models of Rheumatoid Arthritis
Samuel Garcia¹, Linda M. Hartkamp², Inge E. van Es², Haishan Lin³, Li Long³, Emma L. Masteller³, Brian R. Wong³, Paul P. Tak⁴ and Kris A. Reedquist², ¹Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ²Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Five Prime Therapeutics, Inc., South San Francisco, CA, ⁴Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam and GlaxoSmithKline, Amsterdam, Netherlands
Background/Purpose: Disease activity and response to therapy in RA correlates with changes in synovial macrophage numbers and their products. M-CSF or IL-34 stimulation of their…
Abstract Number: 902 • 2012 ACR/ARHP Annual Meeting
Activation of NF-Kb Via Poly(I:C)-Induced Monocyte-Derived Microparticles Decreases TRAIL-Induced Apoptosis of Rheumatoid Arthritis Synovial Fibroblasts
Mojca Frank Bertoncelj¹, Blaz Rozman², Beat A. Michel³, Renate E. Gay¹, David S. Pisetsky⁴, Oliver Distler⁵, Steffen Gay⁶ and Astrid Juengel⁷, ¹Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland, ²Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, ³Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Department of Medicine, Duke University Medical Center, Durham, NC, ⁵Department of Rheumatology and Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁶Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, CH-8091, Switzerland, ⁷Center of Experimental Rheumatology, University Hospital Zurich, Zurich Schlieren, Switzerland
Background/Purpose: Decreased sensitivity of rheumatoid arthritis (RA) synovial fibroblasts (SF) to apoptosis leads to synovial hyperplasia and destruction of joints in RA. Activation of NF-kB…
Abstract Number: 903 • 2012 ACR/ARHP Annual Meeting
NR4A1 Mediates Anti-Inflammatory Effects of Apoptotic Cells
Natacha Ipseiz¹, Stefan Uderhardt¹, Georg A. Schett² and Gerhard Kronke¹, ¹Internal Medicine 3, University of Erlangen, Erlangen, Germany, ²Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: The nuclear receptor NR4A1 has been implicated as negative feedback regulator of NF kappa B signalling and as key regulator during the differentiation of…
Abstract Number: 904 • 2012 ACR/ARHP Annual Meeting
Perinatal Characteristics, Maternal Reproductive History and Juvenile Idiopathic Arthritis: A Case-Control Study
Samantha W. Bell¹, Beth A. Mueller¹, J. Lee Nelson², Parveen Bhatti¹ and Susan Shenoi³, ¹Epidemiology and Public Health, University of Washington, Seattle, WA, ²Immunogenetics D2-100, Fred Hutchinson Cancer Rsch, Seattle, WA, ³Pediatric Rheumatology, Seattle Children's Hospital, University of Washington, Seattle, WA
Background/Purpose: Juvenile Idiopathic Arthritis (JIA) is a heterogeneous group of chronic inflammatory arthritis conditions in children with onset before 16 years of age, and is the…
Abstract Number: 905 • 2012 ACR/ARHP Annual Meeting
The Association Between Lower Body Mass Index and Increased Risk of Giant Cell Arteritis Is Not Explained by Differences in Physical Activity
Karin Jakobsson¹, Lennart T.H. Jacobsson¹, Kenneth J. Warrington², Eric L. Matteson³, Kimberly P. Liang⁴, Olle Melander⁵ and Carl Turesson¹, ¹Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ²Division of Rheumatology, Mayo Clinic, Rochester, MN, ³Rheumatology, Mayo Clinic, Rochester, MN, ⁴Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁵Unit of Hypertension and Cardiovascular Disease, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden
Background/Purpose: There is limited data on predictors of giant cell arteritis (GCA). Low body mass index (BMI), a history of smoking and several hormonal factors…
Abstract Number: 906 • 2012 ACR/ARHP Annual Meeting
Patient-Rheumatologist Communication Concerning Medication and Disease Risks
Susan J. Blalock, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Medications play an important role in the management of rheumatoid arthritis. Principles of informed consent, informed and shared decision-making, and professional ethics highlight the importance…
Abstract Number: 907 • 2012 ACR/ARHP Annual Meeting
Use of Patient Preferences to Inform the Development of Disease Modifying Drugs for Osteoarthritis
Liana Fraenkel¹, Charles Cunningham², Gillian A. Hawker³ and Lisa Suter⁴, ¹Medicine, Section of Rheumatology, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare System, New Haven, CT, ²McMaster University, Hamilton, ON, Canada, ³Women's College Research Institute, University of Toronto, Toronto, ON, Canada, ⁴Medicine, Rheumatol, TAC S541, Yale University, New Haven, CT
Background/Purpose: Considerable efforts are currently being directed at developing robust and efficient trial designs to study the efficacy of disease modifying drugs (DMOADs) for osteoarthritis…
Abstract Number: 908 • 2012 ACR/ARHP Annual Meeting
Race, Gender and Total Knee Replacement Consideration: The Role of Social Support
Ernest R. Vina¹, Yona Cloonan², Said Ibrahim³, Michael J. Hannon⁴, Robert M. Boudreau⁵ and C. Kent Kwoh⁶, ¹Division of Rheumatology and Clinical Immunology, University of Pittsburgh and VA Healthcare System, Pittsburgh, PA, ²Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, ³Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ⁴Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁵Epidemiology, University of Pittsburgh, Pittsburgh, PA, ⁶School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: There is marked variation in patient preference (i.e. willingness) regarding total knee replacement (TKR), an effective treatment option for end-stage osteoarthritis (OA). Studies have…
Abstract Number: 909 • 2012 ACR/ARHP Annual Meeting
Determinants of Patient Preferences for Total Knee Replacement: A Comparison of Whites and African-Americans
C. Kent Kwoh¹, Robert M. Boudreau², Yona Cloonan³, Michael J. Hannon⁴, Ernest R. Vina⁵ and Said Ibrahim⁶, ¹School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ²Epidemiology, University of Pittsburgh, Pittsburgh, PA, ³Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, ⁴Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁵Division of Rheumatology and Clinical Immunology, University of Pittsburgh and VA Pittsburgh Healthcare System, Pittsburgh, PA, ⁶Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
Background/Purpose: TKR is a cost-effective treatment option for end-stage knee osteoarthritis (OA). Although it is one of the fastest growing elective surgeries, there are marked…
Abstract Number: 910 • 2012 ACR/ARHP Annual Meeting
The Cost-Effectiveness of Total Joint Arthroplasty: A Systematic Review of Published Literature
Meghan E. Daigle¹, Alexander M. Weinstein¹, Jeffrey N. Katz² and Elena Losina¹, ¹Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ²Rheumatology and Orthopedics, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Utilization of total hip arthroplasty (THA) and total knee arthroplasty (TKA) has nearly doubled in the last decade. These procedures are increasingly performed in…
Abstract Number: 911 • 2012 ACR/ARHP Annual Meeting
Race- and Sex-Specific Estimates of 10-, 20-, 30-Year, and Lifetime Risk of Diagnosed Symptomatic Knee Osteoarthritis and the Need for TKR in the US
Elena Losina¹, Meghan E. Daigle¹, Sara A. Burbine¹ and Jeffrey N. Katz², ¹Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ²Rheumatology and Orthopedics, Brigham and Women's Hospital, Boston, MA
Background/Purpose: A growing body of evidence suggests that females are more likely to be diagnosed with knee osteoarthritis (OA) and that obesity increases the risk…

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