Abstracts Archive - Page 2540 of 2607 - ACR Meeting Abstracts

Abstract Number: 973 • 2012 ACR/ARHP Annual Meeting
New Genetic Risk Loci for the Radiographic Severity of Rheumatoid Arthritis
Diederik P.C. de Rooy¹, Sacha Zhernakova¹, Roula Tsonaka², Fina Kurreeman³, René E.M. Toes¹, Tom W. J. Huizinga⁴, Jeanine Houwing-Duistermaat⁵, Peter K. Gregersen⁶ and Annette H.M. van der Helm-van Mil¹, ¹Rheumatology, Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Medical Statistics, Leiden University Medical Center, Leiden, Netherlands, ³Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Department of Rheumatology, Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵Statistics, Statistics, Leiden University Medical Center, Leiden, Netherlands, ⁶Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: The severity of joint destruction is highly variable between Rheumatoid Arthritis (RA) patients; approximately 54% of this variance is explained by genetic factors. Many…
Abstract Number: 974 • 2012 ACR/ARHP Annual Meeting
Identification of Susceptibility Loci for Inflammatory Arthritis
K. J. A. Steel¹, Anne Hinks², John Bowes³, Joanna Cobb², Edward Flynn⁴, Carl D. Langefeld⁵, Sampath Prahalad⁶, Johannes Peter Haas⁷, John F. Bohnsack⁸, Stephen Guthery⁸, Anne Barton¹, Susan D. Thompson⁹ and Wendy Thomson¹, ¹Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom, ²Arthritis Research UK Epidemiology Unit, Manchester Academic Health Sciences Centre, Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, ³Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom, ⁴Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester Academy of Health Sciences, Manchester, United Kingdom, ⁵Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ⁶Pediatrics, Emory Children's Center, Atlanta, GA, ⁷Childrens Hospital, Erlangen, Germany, ⁸Department of Pediatrics,, University of Utah, Salt Lake City, ⁹Department of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: One of the principal findings of genome wide association studies in autoimmune diseases has been the substantial overlap of genetic susceptibility loci identified. This…
Abstract Number: 934 • 2012 ACR/ARHP Annual Meeting
Direct Medical Cost Associated with Organ System Involvement in a Commercially Insured Population with Systemic Lupus Erythematosus in the United States
Alan Oglesby¹, Emily Durden², Siva Narayanan³, Paul Juneau⁴ and Kathleen L. Wilson⁵, ¹GlaxoSmithKline, Research Triangle Park, NC, ²Thomson Reuters, Austin, TX, ³Global Health Economics and Outcomes Research and Epidemiology, Human Genome Sciences, Inc., Rockville, MD, ⁴Truven Health Analytics, Washington, DC, ⁵Thomson Reuters Healthcare, Cambridge, MA
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs including the heart, lungs, kidneys, as well as the joints and…
Abstract Number: 935 • 2012 ACR/ARHP Annual Meeting
Primary Care Preventive Services in Patients with Systemic Lupus Erythematosus Compared to Others in Their Community
Cristina Drenkard¹, Kimberley Rask², Gaobin Bao³, Gnanesh Patel⁴, Suparna Bagchi⁵ and S. Sam Lim⁶, ¹Medicine, Div Rheumatology, Emory University, Atlanta, GA, ²Health Policy and Management, Emory University, Atlanta, GA, ³Medicine, Emory University, Atlanta, GA, ⁴Emory University, Atlanta, GA, ⁵Georgia Department of Public Health, Atlanta, GA, ⁶Emory University School of Medicine, Division of Rheumatology, Atlanta, GA
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic illness frequently complicated by infections, cardiovascular disease (CVD) and cancer. Primary care preventive services (PCS) are recommended…
Abstract Number: 936 • 2012 ACR/ARHP Annual Meeting
Autoimmune Diseases: Declining Mortality Between 1999 and 2008 However Continuing to be a Leading Cause of Death in Children-A 10-Year Retrospective Review
Eric Y. Yen¹ and Deborah K. McCurdy², ¹Pediatrics/Rheumatology, UCLA Division of Pediatric Rheumatology, Los Angeles, CA, ²Pediatric Rheumatology, UCLA Division of Pediatric Rheumatology, Los Angeles, CA
Background/Purpose: Autoimmune diseases are chronic illnesses that cause significant and chronic disability in children and may lead to death. Using mortality data from 1995, Walsh…
Abstract Number: 937 • 2012 ACR/ARHP Annual Meeting
Changes in Ten Year Survival Among SLE Patients At an Academic Center in North America (1970-2011)
Joseph F. Merola¹, Bonnie L. Bermas², Bing Lu¹, Peter Hsun Tsao¹, Tabatha Norton¹, Christina Iversen¹, Elizabeth W. Karlson², Peter H. Schur¹ and Karen H. Costenbader¹, ¹Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Data from other large SLE cohorts have suggested improving survival among SLE patients in recent years with protective effects from antimalarial use and less…
Abstract Number: 938 • 2012 ACR/ARHP Annual Meeting
Hospitalizations in Systemic Lupus Erythematosus: A Longitudinal Study
Hong Fang¹, Jie Xu² and Michelle Petri¹, ¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Hospitalizations are one of the major direct costs in SLE. A review of studies looking at the contributions of different medical components to the…
Abstract Number: 939 • 2012 ACR/ARHP Annual Meeting
Shared High Risk of Intensive Care Unit Admission in Three Autoimmune Inflammatory Diseases
Christine Peschken¹, Carol A. Hitchon², Allan Garland³, Charles N. Bernstein³, Randy Fransoo⁴ and Ruth Ann Marrie³, ¹Medicine & Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada, ²University of Manitoba, Winnipeg, MB, Canada, ³Internal Medicine, University of Manitoba, Winnipeg, MB, Canada, ⁴Manitoba Centre for Health Policy, University of Manitoba, Winnipeg, MB, Canada
Background/Purpose: Little is known about the influence of autoimmune inflammatory diseases on the risk of critical illness, as defined by Intensive care unit admissions (ICU).…
Abstract Number: 940 • 2012 ACR/ARHP Annual Meeting
Incidence of Systemic Lupus Erythematosus in England, 1998-2010
Herve Caspard¹, Amy Steffey², Jie Li² and Trung N. Tran², ¹Epidemiology, Clinical Development, MedImmune LLC, Gaithersburg, MD, ²Epidemiology, Clinical Development, MedImmune, Gaithersburg, MD
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic auto-immune disease associated with a wide spectrum of clinical manifestations and increased mortality. The most recent data…
Abstract Number: 941 • 2012 ACR/ARHP Annual Meeting
Validity and Reliability of the Systemic Lupus Activity Questionnaire (SLAQ): A Prospective Study
Yuko Okamoto, Yasuhiro Katsumata, Yasushi Kawaguchi, Sayumi Baba, Kae Takagi, Hisae Ichida, Takahisa Gono, Masanori Hanaoka, Yuko Ota and Hisashi Yamanaka, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: Traditional assessments of systemic lupus erythematosus (SLE) disease activity, such as the SLE Disease Activity Index 2000 (SLEDAI-2K) and the Systemic Lupus Activity Measure…
Abstract Number: 942 • 2012 ACR/ARHP Annual Meeting
Validity and Reliability of the Lupus Damage Index Questionnaire (LDIQ): A Prospective Study
Yuko Okamoto, Yasuhiro Katsumata, Yasushi Kawaguchi, Sayumi Baba, Kae Takagi, Hisae Ichida, Takahisa Gono, Masanori Hanaoka, Yuko Ota and Hisashi Yamanaka, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: The Systemic Lupus International Collaborating Clinics/American College of Rheumatology (ACR) Damage Index (SDI) is a validated instrument for assessing organ damage in systemic lupus…
Abstract Number: 943 • 2012 ACR/ARHP Annual Meeting
Impact of Systemic Lupus Erythematosus On Work Productivity and Income in the United States
Alan Oglesby¹, Ellen Sulcs², Siva Narayanan³, Mechele Lee² and Cindy Garris⁴, ¹GlaxoSmithKline, Research Triangle Park, NC, ²Healthcare Research, Harris Interactive Inc., Rochester, NY, ³Global Health Economics and Outcomes Research and Epidemiology, Human Genome Sciences, Inc., Rockville, MD, ⁴US Health Outcomes, GlaxoSmithKline, Research Triangle Park, NC
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex, chronic autoimmune disorder characterized by fluctuating periods of disease activity affecting multiple organ systems. This study was…
Abstract Number: 944 • 2012 ACR/ARHP Annual Meeting
Job-Related Burden and Effort-Reward Imbalance in Patients with Systemic Lupus Erythematosus
Jutta G. Richter¹, Thomas Muth², Ralph Brinks¹, Tobias Koch³, Johannes Siegrist⁴, Nicole Hoffmann¹, Peter Angerer² and Matthias Schneider¹, ¹Department of Endocrinology, Diabetes and Rheumatology, Heinrich-Heine-University, Duesseldorf, Germany, ²Institute for Occupational and Social Medicine, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany, ³Department of Rheumatology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany, ⁴Department of Medical Sociology, Heinrich-Heine-University, Duesseldorf, Germany
Background/Purpose: Working life factors influence patients’ (life) satisfaction and well being. Effort at work is part of a social contract that reciprocates effort by adequate…
Abstract Number: 945 • 2012 ACR/ARHP Annual Meeting
Work Loss in Systemic Lupus Erythematosus, the General Public, and Other Chronic Conditions
S. Sam Lim¹, Greg Dennis², Hong Kan³, Priti M. Jhingran³, Charles T. Molta⁴, Gaobin Bao⁵ and Cristina Drenkard⁶, ¹Emory University School of Medicine, Division of Rheumatology, Atlanta, GA, ²Human Genome Sciences, Inc., Rockville, MD, ³GlaxoSmithKline, Research Triangle Park, NC, ⁴GlaxoSmithKline, Philadelphia, PA, ⁵Medicine, Emory University, Atlanta, GA, ⁶Medicine, Div Rheumatology, Emory University, Atlanta, GA
Background/Purpose: Systemic lupus erythematosus (SLE) predominantly develops in young groups, when many are establishing themselves in the workforce and can have a devastating impact on…
Abstract Number: 946 • 2012 ACR/ARHP Annual Meeting
Self-Reported Disease Activity and Health-Related Quality of Life in a Longitudinal Cohort of Patients with Systemic Lupus Erythematosus
Siva Narayanan¹, Ellen Sulcs², Alan Oglesby³, Cindy Garris⁴ and Mechele Lee², ¹Global Health Economics and Outcomes Research and Epidemiology, Human Genome Sciences, Inc., Rockville, MD, ²Healthcare Research, Harris Interactive Inc., Rochester, NY, ³GlaxoSmithKline, Research Triangle Park, NC, ⁴US Health Outcomes, GlaxoSmithKline R&D, Research Triangle Park, NC
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex, multisystem autoimmune disease with variable clinical manifestations and an unpredictable waxing and waning disease course impacting patient…

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