Abstracts Archive - Page 2537 of 2607 - ACR Meeting Abstracts

Abstract Number: 1008 • 2012 ACR/ARHP Annual Meeting
Segmentation and Quantification of Bone Erosions in the Hands of Patients with Rheumatoid Arthritis Using High Resolution Computed Tomography
Dominique Toepfer¹, Stephanie Finzel², Oleg Museyko¹, Klaus Engelke³ and Georg A. Schett², ¹Institute of Medical Physics, University of Erlangen-Nuremberg, Erlangen, Germany, ²Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ³Institute of Medical Physics, University of Erlangen, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Bone erosions are important for diagnosis and monitoring of disease activity in RA. However, semi-quantitative scoring schemes may be inadequate for a true 3D…
Abstract Number: 1009 • 2012 ACR/ARHP Annual Meeting
A New Approach for Detecting Progressive Joint Damage Using 3D Imaging From High-Resolution Peripheral Quantitative Computed Tomography: Measuring Reproducibility
Cheryl Barnabe¹, Helen R. Buie², Michelle Kan², Susan G. Barr³, Liam Martin³ and Steven K. Boyd², ¹Medicine, Community Health Sciences, University of Calgary, Calgary, AB, Canada, ²Mechanical Engineering, University of Calgary, Calgary, AB, Canada, ³Medicine, University of Calgary, Calgary, AB, Canada
A New Approach for Detecting Progressive Joint Damage using 3D Imaging from High-Resolution Peripheral Quantitative Computed Tomography: Measuring Reproducibility Background/Purpose: Joint space narrowing is an…
Abstract Number: 1010 • 2012 ACR/ARHP Annual Meeting
Bone Loss Before Clinical Onset of Rheumatoid Arthritis o Subjects with Anti-Citrullinated Protein Antibodies
Stephanie Finzel¹, Veronika Lang², Arnd Kleyer¹, Juergen Rech³, Bernhard Manger¹, Elizabeth Araujo¹, Axel J. Hueber⁴, Ulrike Harre⁵ and Georg Schett¹, ¹Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Dept. of Medicine, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Germany, ³Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁵Institute for Clinical Immunology, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) are a major risk factor for rapid disease progression in rheumatoid arthritis (RA). We have recently shown that ACPA directly…
Abstract Number: 1011 • 2012 ACR/ARHP Annual Meeting
Structural Damage Is Reduced by Early Achievement of Clinical Remission
Paul Emery¹, Vibeke Strand², Andrew S. Koenig³, Ronald Pedersen³ and Eustratios Bananis⁴, ¹Medicine, Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, ²Biopharmaceutical Consultant, Portola Valley, CA, ³Specialty Care, Pfizer Inc, Collegeville, PA, ⁴Specialty Care, Pfizer Inc., Collegeville, PA
Background/Purpose: The importance of early, intensive treatment of rheumatoid arthritis (RA) to decrease disease activity and prevent structural damage is established.1 The objective of this…
Abstract Number: 1012 • 2012 ACR/ARHP Annual Meeting
Radiographic Deformity of the Foot Is Starting From the Early Stage of Rheumatoid Arthritis
Kenji Mamoto¹, Tatsuya Koike², Tadashi Okano¹, Atsuko Kamiyama², Yuko Sugioka¹, Masahiro Tada¹ and Hiroaki Nakamura¹, ¹Orthopedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan, ²Rheumatosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan
Background/Purpose: Foot deformities frequently arise in patients with rheumatoid arthritis (RA). It might cause gait dysfunction and lead to disability. However, the precise mechanism of…
Abstract Number: 1013 • 2012 ACR/ARHP Annual Meeting
The Influence of Vertebral Fractures On the Functional Disability of Patients with Rheumatoid Arthritis
Soo-Kyung Cho¹, Joo-Hyun Lee², Min-Kyung Han³, Seunghun Lee⁴, Ji Young Kim⁵, Jeong Ah Ryu⁶, Yun Young Choi⁵, Sang-Cheol Bae⁷ and Yoon-Kyoung Sung⁸, ¹Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ²Department of Rheumatology, Ilsan Paik Hospital, Inje University, Goyang, South Korea, ³Department of Rheumatology, Hanyang University Hospital for Rheumatic Disease, Seoul, South Korea, ⁴Department of Radiology, Department of Radiology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ⁵Department of Nuclear Medicine, Hanyang University College of Medicine, Seoul, South Korea, ⁶Department of Radiology, Hanyang University College of Medicine, Seoul, South Korea, ⁷Hanyang University Hospital for Rheumatic Diseases, Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, ⁸Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea
Background/Purpose: Rheumatoid arthritis (RA) is a chronic, painful, and disabling disease associated with reduced health-related quality of life (HRQOL) compared to the general population. Higher…
Abstract Number: 1014 • 2012 ACR/ARHP Annual Meeting
Trimmed Analyses, a New Approach to the Analysis of Sharp Score Data in the Assessment of Progression in Patients with Rheumatoid Arthritis
Robert B. M. Landewé¹, Désirée van der Heijde², Carol Connell³, John Bradley⁴, David Gruben³ and Michael Brown³, ¹Academic Medical Center/University of Amsterdam & Atrium Medical Center, Amsterdam, Netherlands, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Pfizer Inc., Groton, CT, ⁴Pfizer Inc, Groton, CT
Background/Purpose: Tofacitinib is a novel oral Janus kinase inhibitor being investigated as a targeted immunomodulator and disease-modifying therapy for RA. In the Phase 3 ORAL…
Abstract Number: 975 • 2012 ACR/ARHP Annual Meeting
Dense Genotyping of Risk Loci in Black South Africans with Rheumatoid Arthritis: An Association Study
Nimmisha Govind¹, Ananyo Choudhury², Bridget Hodkinson¹, Claudia Ickinger¹, Jacqueline Frost³, Annette T. Lee⁴, Peter K. Gregersen⁵, Richard J. Reynolds⁶, S. Louis Bridges Jr.⁷, Scott Hazelhurst², Michèle Ramsay³ and Mohammed Tikly¹, ¹Rheumatology, Division of Rheumatology, University of the Witwatersrand, Johannesburg, South Africa, ²Wits Bioinformatics Department, Wits Bioinformatics Department, University of the Witwatersrand, Johannesburg, South Africa, ³Division of Human Genetics, National Health Laboratory Service, Division of Human Genetics, National Health Laboratory Service, University of the Witwatersrand, Johannesburg, South Africa, ⁴Genomics & Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ⁵Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ⁶Clinical Immunology and Rheumatology, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁷University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Genome wide association studies (GWAS) have identified numerous rheumatoid arthritis (RA) risk loci in patients of European and Asian ancestry but the causal variants…
Abstract Number: 976 • 2012 ACR/ARHP Annual Meeting
Effect of Interactions Between Validated Rheumatoid Arthritis Genetic Factors and Environmental Factors On Rheumatoid Arthritis Risk
Chia-Yen Chen¹, Linda T. Hiraki², Susan Malspeis³, Jing Cui⁴, Bing Lu⁴, Robert M. Plenge⁵, Karen H. Costenbader⁴ and Elizabeth W. Karlson⁶, ¹Department of Epidemiology, Harvard School of Public Health, Boston, MA, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard School of Public Health, Boston, MA, ³Rheumatology, Brigham and Women's Hospital, Boston, MA, ⁴Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁵Division of Rheumatology, Immunology and Allergy and Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ⁶Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Studies have shown associations between environmental factors and rheumatoid arthritis (RA) risk. Also, genome-wide association studies (GWAS) have identified genetic markers associated with RA…
Abstract Number: 977 • 2012 ACR/ARHP Annual Meeting
14-3-3 Eta Is a Novel Citrullination Target in Rheumatoid Arthritis That Enhances Diagnostic Utility in Anti-CCP Negative Patients
Walter P. Maksymowych¹, Vivian P. Bykerk², Désirée van der Heijde³, R. Landewe⁴ and Anthony Marotta⁵, ¹Department of Medicine, University of Alberta, Edmonton, AB, Canada, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ⁵Augurex Life Sciences Corp, North Vancouver, BC, Canada
Background/Purpose: 14-3-3 eta is normally an intracellular protein and only in the disease state is it released into the extracellular space. We have previously presented…
Abstract Number: 978 • 2012 ACR/ARHP Annual Meeting
A Genome-Wide Interaction Study with Smoking Suggests New Risk Loci for Two Different Subsets of Rheumatoid Arthritis; Results From Swedish Epidemiological Investigation of Rheumatoid Arthritis Study
Xia Jiang¹, Henrik Källberg¹, Leonid Padyukov², Lars Klareskog³ and Lars Alfredsson¹, ¹Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ²Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ³Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Rheumatoid arthritis (RA) is believed to have a multifactorial etiology, involving both genetic and environmental components, and can be divided into two major subsets…
Abstract Number: 979 • 2012 ACR/ARHP Annual Meeting
Cell-Type Specific Type I Interferon Signatures in Systemic Lupus Erythematosus and Viral Infection: What Makes the Difference?
Chieko Kyogoku¹, Joachim R. Grün¹, Tobias Alexander², Robert Biesen³, Falk Hiepe⁴, Thomas Häupl³, Andreas Radbruch¹ and Andreas Grützkau¹, ¹German Rheumatism Research Centre Berlin (DRFZ), an institute of the Leibniz Association, Berlin, Germany, ²Department of Rheumatology and Clinical Immunology, Charité – University Hospital, Berlin, Germany, ³department of Rheumatology and Clinical Immunology, Charité University Hospital Berlin, Berlin, Germany, ⁴Med. Klinik m. Sp. Rheumatologie und klin. Immunologie, Charité University Hospital Berlin, Berlin, Germany
Background/Purpose: Gene expression profiling experiments using peripheral blood mononuclear cells (PBMCs) revealed a crucial role of type I interferon (IFN) in the pathogenesis of systemic…
Abstract Number: 980 • 2012 ACR/ARHP Annual Meeting
Genomewide Association Study in Systemic Lupus Erythematosus: Known Loci
Antonio Fernandez-Nebro¹, Patricia E. Carreira², Ricardo Blanco³, Victor M. Martinez-Taboada⁴, Luis Carreño⁵, Alejandro Olive⁶, José Luis Andreu⁷, Mª Angeles Aguirre⁸, Paloma Vela⁹, Jose Javier Pérez Venegas¹⁰, Jose Luís Marenco¹¹, Joan Miquel Nolla¹², Antonio Zea¹³, José M. Pego-Reigosa¹⁴, Mercedes Freire González¹⁵, Gabriela Ávila¹⁶, María América López-Lasanta¹⁶, Raül Tortosa¹⁶, Antonio Julià¹⁶ and Sara Marsal¹⁶, ¹Rheumatology, Hospital Regional Universitario Carlos Haya, Málaga, Spain, ²Rheumatology, Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain, ³Rheumatology, Hospital Universitario Marques De Valdecilla, Santander, Spain, ⁴Rheumatology, Hospital Universitario Marques de Valdecilla. IFIMAV, Santander, Spain, ⁵Rheumatology, Gregorio Marañón Hospital, Madrid, Spain, ⁶Rheumatology Service, Germans Trias Pujol Hospital, Barcelona, Spain, ⁷Rheumatology, Puerta de Hierro Universitary Hospital, Madrid, Spain, ⁸Rheumatology, IMIBIC-Reina Sofia Hospital, Cordoba, Spain, ⁹Rheumatology, Hospital General Universitario de Alicante, Alicante, Spain, ¹⁰Rheumatology, Hospital del SAS de Jerez de la Frontera, Jerez De La Frontera, Spain, ¹¹Rheumatology, HU Puerta de Hierro Majadahonda, Madrid, Spain, ¹²Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, ¹³Rheumatology, Hospital Universitario Ramon y Cajal, Madrid, Spain, ¹⁴Rheumatology, Hospital do Meixoeiro, Vigo, Spain, ¹⁵Rheumatology, Complejo Hospitalario Universitario de La Coruña,, La Coruña, Spain, ¹⁶Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease with an estimated prevalence of 40:100,000 cases in European populations. SLE has a strong genetic…
Abstract Number: 981 • 2012 ACR/ARHP Annual Meeting
Aggregated Genetic Information Explains Variations On Hand Radiographic Scores in Rheumatoid Arthritis Patient
Jing Cui¹, Nancy A. Shadick², Katherine P. Liao³, Michael Weinblatt⁴, Robert M. Plenge⁵ and Elizabeth W. Karlson³, ¹Rheumatology, Brigham and Women's Hospital, Boston, MA, ²Rheumatology/Immunology, Brigham and Women's Hospital, Boston, MA, ³Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁴Rheumatology & Immunology, Brigham & Women's Hospital, Boston, MA, ⁵Division of Rheumatology, Immunology and Allergy and Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Rheumatoid arthritis (RA) has an estimated heritability of approximately 60%. Joint destruction as a severity measure of RA is influenced by genetic factors, however…
Abstract Number: 982 • 2012 ACR/ARHP Annual Meeting
Genetic Variants near Insulin-Like Growth Factor Binding Protein 3 (IGFBP3) Are Associated with Hip Osteoarthritis
Daniel S. Evans¹, Neeta Parimi¹, Ana M. Valdes², Hanneke J.M Kerkhof³, Frederic Cailotto⁴, Michael C. Nevitt⁵, Steven R. Cummings¹, Rik J. Lories⁶, Timothy D. Spector⁷, Nigel K. Arden⁸, Joyce B. van Meurs³ and Nancy E. Lane⁹, ¹California Pacific Medical Center Research Institute, San Francisco, CA, ²Department of Twin Research and Genetic Epidemiology, Dept of Twin Research and Genetic Epidemiology, St. Thomas' Hospital, King's College London, London, United Kingdom, ³Department of Internal Medicine, Erasmus Medical Center and The Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Healthy Aging, Rotterdam, Netherlands, ⁴Laboratory for Skeletal Development and Joint Disorders, Department of Development and Regeneration, KU Leuven, Leuven, Belgium, ⁵Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ⁶Dept of Development and Regeneration, Laboratory for Skeletal Development and Joint Disorders, KU Leuven, Leuven, Belgium, ⁷Dept of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom, ⁸NDORMS; MRC Lifecourse Epidemiology Unit, Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom, ⁹Internal Medicine, Center for Musculoskeletal Health, UC Davis School of Medicine, Sacramento, CA
Background/Purpose: Hip osteoarthritis (HOA) is one of the most common joint disorders and can result in pain and disability. HOA is heritable, but the particular…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].