Abstract Number: 1033 • 2012 ACR/ARHP Annual Meeting
Reliability and Responsiveness of Two Methods for Assessment of Magnetic Resonance Imaging Abnormalities in Hip Osteoarthritis in a Placebo-Controlled Trial of Intra-Articular Steroid Injection
Background/Purpose: Inflammation in osteoarthritis (OA) is the basis for the use of steroid injection therapy which has demonstrated efficacy for symptoms of hip OA in…Abstract Number: 1034 • 2012 ACR/ARHP Annual Meeting
Changing Osteoarthritis Treatment Assessment Paradigms: Subchondral Bone Is a More Responsive Measure of Progression Than the Current Radiographic Standard
Background/Purpose: Radiographic joint space width (JSW) assessment, a surrogate for cartilage assessment, is the standard for structure modification trials of osteoarthritis (OA). However the subchondral…Abstract Number: 995 • 2012 ACR/ARHP Annual Meeting
Genetic Effects of HLA-DRB1, IL4R, and FcγRIIb On Long-Term Treatment Responses in Patients with Early Rheumatoid Arthritis: 78-Week Results of a Phase 4 Study
Background/Purpose: Previous analyses suggested that the HLA-DRB1 shared epitope (SE), and the IL4R V50I and the FcγRIIb I232T single nucleotide polymorphisms (SNPs) affected response to…Abstract Number: 996 • 2012 ACR/ARHP Annual Meeting
Genetic Predictors of Methotrexate Efficacy and Toxicity in Early Rheumatoid Arthritis: Results From the Treatment of Early Aggressive Rheumatoid Arthritis Trial
Background/Purpose: Methotrexate (MTX) has emerged as first-line therapy for early moderate to severe rheumatoid arthritis (RA), but individual variation in treatment efficacy and toxicity remains…Abstract Number: 997 • 2012 ACR/ARHP Annual Meeting
Evidence of Novel Genetic Predictors of Methotrexate Efficacy in Rheumatoid Arthritis
Background/Purpose: Methotrexate (MTX), a disease-modifying anti-rheumatic drug used as first-line therapy in rheumatoid arthritis (RA), is characterized by considerable heterogeneity in individual treatment response. We…Abstract Number: 998 • 2012 ACR/ARHP Annual Meeting
Association Study of Genetic Risk Variants for Psoriasis in a Large Cohort of Psoriatic Arthritis, Psoriasis and Controls of the Spanish Population and Association with Relevant Clinical Subphenotypes
Background/Purpose: Psoriatic Arthritis (PsA) is a complex disease with a substantial genetic risk component (first-degree relative risk ~ 55). Recently, Genomewide Association Studies (GWAS) have…Abstract Number: 999 • 2012 ACR/ARHP Annual Meeting
Identification of New Epistatic Interactions with the HLA Region in the Genetic Etiology of Psoriasis and Psoriatic Arthritis
Background/Purpose: Psoriatic Arthritis (PsA) is a complex disease and is present in ~11% in patients with Psoriasis (Ps). Recently, Genomewide Association Studies (GWAS) have expanded…Abstract Number: 1000 • 2012 ACR/ARHP Annual Meeting
Epistatic Interaction Between BANK1 and BLK in Rheumatoid Arthritis: Results From a Large Trans-Ethnic Meta-Analysis
Background/Purpose: BANK1 and BLK belong to pleiotropic genes and recently a genetic and physical interaction between BANK1 and BLK has been detected in systemic lupus…Abstract Number: 1001 • 2012 ACR/ARHP Annual Meeting
CNstream2: Improved SNP and CNV Genotyping Reveals New Loci Associated with Rheumatic Diseases
Background/Purpose: In Genome-Wide Association Studies (GWAS), the performance of the genotyping algorithm is crucial to identify new SNPs associated to disease risk. Recently, new methods…Abstract Number: 1002 • 2012 ACR/ARHP Annual Meeting
Microrna Expression Profiles in Peripheral Blood Mononuclear Cells of Early Onset Psoriatic Arthritis
Background/Purpose: Micro-RNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression. It is known that an altered miRNA expression plays an important role in…Abstract Number: 1003 • 2012 ACR/ARHP Annual Meeting
Role of Particular Class I MHC Haplotypes in Determining Different Traits within the Psoriatic Arthritis Phenotypes
Background/Purpose: A rigorously ascertained psoriatic arthritis (PsA) cohort demonstrated considerable genetic heterogeneity and provided preliminary evidence that MHC genes determine quantitative traits within the PsA…Abstract Number: 1004 • 2012 ACR/ARHP Annual Meeting
A Unique Single Nucleotide Polymorphism in the 3’ UTR of the MED29 Gene On Chromosome 19 Is Associated with the Clinical Outcome of Different Biologic Response Modifiers
Background/Purpose: Due to the wide range of highly specific and effective biologic response modifiers that are available today for the treatment of RA it has…Abstract Number: 1005 • 2012 ACR/ARHP Annual Meeting
The Identification of Pathway Markers in Behcet’s Disease Using Genomewide Association Data From Two Different Populations
Background/Purpose: Behcet's disease (BD) is a multi-system inflammatory disease, characterized by recurrent exacerbations affecting several organs including orogenital mucosa, eyes and skin. Two recent genome-wide…Abstract Number: 1006 • 2012 ACR/ARHP Annual Meeting
Dynamic Gene Expression of Wnt Signaling Pathway During Osteogenic Stimulation in Vitro of Osteoarthritis Mesenchymal Stem Cells
Background/Purpose: The role of Wnt signalling in Mesenchymal Stem Cell (MSC) fate is still unclarified. Both, canonical and non-canonical pathways have been implicated in differentiation…Abstract Number: 1007 • 2012 ACR/ARHP Annual Meeting
High Resolution Peripheral Quantitative CT Detects Marked Differences in Metacarpal Head and Shaft and Ultra-Ultra-Distal Radius Bone Volumetric Density and Microstructure in Early Rheumatoid Arthritis
Background/Purpose: Despite improvements in clinical management of rheumatoid arthritis (RA), many with early disease are still at high risk for developing periarticular erosions and osteopenia,…
ACR Meeting Abstracts