Abstracts Archive - Page 2532 of 2607 - ACR Meeting Abstracts

Abstract Number: 1094 • 2012 ACR/ARHP Annual Meeting
The Relationship Between Lumbar Spine Individual Radiographic Features and Low Back Symptoms with and without Associated Leg Symptoms: The Johnston County Osteoarthritis Project
Adam P. Goode¹, Janet K. Freburger², Timothy S. Carey³, Chad E. Cook⁴, Jordan Renner⁵, Sean D. Rundell⁶ and Joanne M. Jordan⁷, ¹Community and Family Medicine, Duke University, Durham, NC, ²Sheps Center for HSR & IOA, University of NC CB 7590, Chapel Hill, NC, ³UNC School of Medicine, Cecil G. Sheps Center for Health Services Research University of North Carolina, Chapel Hill, NC, ⁴Physical Therapy, Walsh University, OH, ⁵UNC School of Medicine, University of North Carolina, Chapel Hill, NC, ⁶Department of Radiology, University of Washington, Seatle, WA, ⁷Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC
Background/Purpose: Little is known of the relationships between low back symptoms (LBS) and associated leg symptoms and lumbar spine individual radiographic features (IRF). We examined…
Abstract Number: 1095 • 2012 ACR/ARHP Annual Meeting
Metal Concentrations in Patients with Failed Metal-On-Metal Hip Prostheses Determine the Inflammatory Phenotype in Peri-Implant Tissue
Erja-Leena Paukkeri¹, Riku Korhonen¹, Antti Eskelinen², Marko Pesu³, Kaija Vasama⁴, Teemu Moilanen² and Eeva Moilanen¹, ¹The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland, ²Coxa Hospital for Joint Replacement, Tampere, Finland, ³Immunoregulation, Institute of Biomedical Technology, University of Tampere, Tampere, Finland, ⁴Fimlab Laboratories, Tampere, Finland
Background/Purpose: Hip arthroplasty is the standard treatment of a painful hip destruction in rheumatoid arthritis and osteoarthritis. The use of metal-on-metal (MoM) bearing surfaces in…
Abstract Number: 1055 • 2012 ACR/ARHP Annual Meeting
Sec61 Is Indispensable for Antigen Cross-Presentation and the Development of Lupus Nephritis: A Novel ‘Self-Organized Criticality Theory’ Explaining the Cause of Systemic Lupus Erythematosus (SLE)
Ken Tsumiyama and Shunichi Shiozawa, Department of Medicine, Kyushu University Beppu Hospital, Beppu, Japan
Background/Purpose: We found that systemic lupus erythematosus (SLE) was induced experimentally by repeatedly immunizing the mice normally not prone to autoimmune diseases by any exogenous…
Abstract Number: 1056 • 2012 ACR/ARHP Annual Meeting
Fc Receptor Gamma-Dependent Autoimmune Endocarditis in K/BxN Mice
Patricia M. Hobday¹, Jennifer L. Auger², J. Sjef Verbeek³, Jeffrey V. Ravetch⁴ and Bryce A. Binstadt², ¹Department of Pediatrics, Division of Pediatric Rheumatology, University of Minnesota, Minneapolis, MN, ²Center for Immunology and Department of Pediatrics, University of Minnesota, Minneapolis, MN, ³Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands, ⁴The Rockefeller University, New York, NY
Background/Purpose: Arthritis and endocarditis co-exist in several human rheumatic diseases, including systemic lupus erythematosus, rheumatic fever, and rheumatoid arthritis. K/BxN TCR transgenic mice, well known…
Abstract Number: 1057 • 2012 ACR/ARHP Annual Meeting
A Specific Inhibitor of Spleen Tyrosine Kinase, PRT062607, Is a Potent Modulator of Innate Immune Cell Function
Lynn A. Kamen¹, Gillian Stephens¹, Anjali Pandey² and Uma Sinha¹, ¹Biology, Portola Pharmaceuticals, South San Francisco, CA, ²Chemistry, Portola Pharmaceuticals, South San Francisco, CA
Background/Purpose: Tumor Necrosis Factor-α (TNF-α) is an essential component of the inflammatory stimuli leading to rheumatoid arthritis (RA). Therapeutics targeting TNF-α are the standard of…
Abstract Number: 1058 • 2012 ACR/ARHP Annual Meeting
Fulminant Toll-Like Receptor 9-Induced Macrophage Activation Syndrome and Hemophagocytosis Occur Independently of Interferon Gamma
Scott W. Canna¹, Julia Wrobel², Portia A. Kreiger³, Michele E. Paessler⁴ and Edward M. Behrens⁵, ¹Pediatric Rheumatology, Childrens Hospital of Philadelphia, Philadelphia, PA, ²Pediatric Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA, ³Pathology, Nemours/A.I. DuPont Hospital for Children, Wilmington, DE, ⁴Hematopathology, Childrens Hospital of Philadelphia, Philadelphia, PA, ⁵Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: Macrophage Activation Syndrome (MAS) is a potentially lethal cytokine storm syndrome that complicates various rheumatic diseases. We have previously shown that Toll-like Receptor (TLR9)…
Abstract Number: 1059 • 2012 ACR/ARHP Annual Meeting
Endogenous Complement Factor H Plays an Important Role in Controlling Immune Complex-Induced Inflammatory Arthritis
Nirmal K. Banda¹, Gaurav Mehta², Viviana P. Ferreira³, Claudio Cortes³, Michael K. Pangburn⁴, William P. Arend² and V. Michael Holers², ¹University of Colorado School of Medicine, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ³Department of Medical Microbiology and Immunology, University of Toledo Health Science Campus, Toledo, OH, ⁴Department of Biochemistry, University of Texas Health Sciences Center, Tyler, TX
Background/Purpose: The complement system, a major component of innate immunity, likely plays an important role in the pathogenesis of rheumatoid arthritis (RA). Factor H (fH)…
Abstract Number: 1060 • 2012 ACR/ARHP Annual Meeting
Protein Kinase C Inhibitor Generates Human Tolerogenic Dendritic Cells That Induce Tr1 and Foxp3⁺ Regulatory T Cells
Takuya Matsumoto, Hitoshi Hasegawa, Jun Ishizaki, Koichiro Suemori, Sachiko Onishi and Masaki Yasukawa, Department of Bioregulatory Medicine, Ehime University Graduate School of Medicine, Toon, Japan
Background/Purpose: Tolerogenic dendritic cells (tDCs) play a critical role in immune tolerance and are involved in the pathogenesis of autoimmune diseases such as rheumatoid arthritis.…
Abstract Number: 1061 • 2012 ACR/ARHP Annual Meeting
Generation of Myeloid-Derived Suppressor Cells in Vitro From Murine Bone Marrow Precursors
Julia Kurko¹, Beata Tryniszewska¹, Tibor A. Rauch¹, Colt Egelston², Tibor T. Glant¹ and Katalin Mikecz¹, ¹Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Immunology, Rush University Medical Center, Chicago, IL
Background/Purpose: Myeloid-derived suppressor cells (MDSCs) are innate immune cells that expand under pathological conditions (such as cancer and autoimmune diseases) in response to local growth…
Abstract Number: 1062 • 2012 ACR/ARHP Annual Meeting
Identification of Highly Potent and Selective Interleukin-1 Receptor-Associated Kinase 4 Inhibitors for the Treatment of Rheumatic Diseases
Divya Chaudhary¹, Shaughnessy Robinson², Craig E. Masse¹, Matthew D. Wessel², Shawn Watts², Jeremy Greenwood², Mee Shelley², Mark Brewer², Geraldine Harriman¹, Leah L. Frye², Ronald T. Wester¹, Rosana Kapeller¹ and Donna Romero¹, ¹25 First Street Suite 404, Nimbus Discovery, Inc., Cambridge, MA, ²Schrödinger, Inc., New York, NY
Background/Purpose: Interleukin-1 receptor-associated kinase 4 (IRAK4) is a key mediator of the innate immune response orchestrated by interleukin-1 receptor (IL-1R), interleukin-18 receptor (IL-18R), IL-33…
Abstract Number: 1063 • 2012 ACR/ARHP Annual Meeting
Dysfunction of Natural Killer and Natural Killer T Cells in Patients with Adult Onset Still’s Disease
Young-Nan Cho¹, Sung-Ji Lee¹, Tae-Jong Kim², Hye-Mi Jin¹, Dong-Jin Park², Seung-Jung Kee³ and Yong-Wook Park¹, ¹Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, South Korea, ²Rheumatology, Chonnam National University Medical School, Gwangju, South Korea, ³Laboratory Medicine, Chonnam National University Medical School and Hospital, Gwangju, South Korea
Background/Purpose: Adult onset Still’s disease (AOSD) is an uncommon systemic inflammatory disorder of unknown etiology. Natural killer (NK) cell dysfunction is frequently observed in some…
Abstract Number: 1064 • 2012 ACR/ARHP Annual Meeting
CD1c-Expressing Myeloid Dendritic Cells From Joints of Rheumatoid Arthritis Patients Produce Increased Levels of T Cell-Attracting Chemokines and Strongly Activate Autologous T Cells
F.M. Moret¹, C.E. Hack², F.P.J.G. Lafeber¹, T.R.D.J. Radstake¹ and J.A.G. van Roon¹, ¹Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Immunology, UMC Utrecht, Utrecht, Netherlands
Background/Purpose: Myeloid dendritic cells (mDCs) are potent T cell-activating antigen-presenting cells that have been implicated to play a crucial role in the regulation of tolerance…
Abstract Number: 1065 • 2012 ACR/ARHP Annual Meeting
Hypoxia-Inducible Factor-1α: Trigger of Toll-Like Receptor Signalling-Engaged Inflammation in Rheumatoid Arthritis
Fanlei Hu¹, Rong Mu¹, Jiaxin Zhu¹, Wenwei Shao², Lianjie Shi¹, Philip L. Cohen³, Xiaoyan Qiu² and Zhanguo Li¹, ¹Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, ²Department of Immunology, School of Basic Medical Science, Peking University, Beijing, China, ³Rheumatology, Temple University, Philadelphia, PA
Background/Purpose: Hyperplasia of synovial fibroblasts, infiltration with lymphocytes, and tissue hypoxia are the major characteristics of rheumatoid arthritis (RA). Data has confirmed the central role…
Abstract Number: 1066 • 2012 ACR/ARHP Annual Meeting
Extrathymic Autoimmune Regulator (AIRE) Expression in Rheumatoid Arthritis
A.R. Noort¹, K.P.M. van Zoest², M.C. Lebre³, P. P. Tak⁴ and S.W. Tas³, ¹Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²Division of Clinical Immunology & Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ³Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ⁴Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam and GlaxoSmithKline, Amsterdam, Netherlands
Background/Purpose: The Autoimmune Regulator (AIRE) is a transcription factor that is involved in the negative selection of self-reactive thymocytes in the thymus and therefore is…
Abstract Number: 1067 • 2012 ACR/ARHP Annual Meeting
Spontaneous Aggregation of the Anti-Viral Mavs Protein in Certain Systemic Lupus Erythematosus Patients May Explain Excessive Type I Interferon Production
Philip L. Cohen¹ and Wen-Hai Shao², ¹Rheumatology, Temple University, Philadelphia, PA, ²Medicine, Temple University School of Medicine, Philadelphia, PA
Background/Purpose: Patients with systemic lupus (SLE) often have increased type I interferon levels (IFN-I) and activation of IFN-inducible genes (IFN signature). The mitochondrial adaptor protein…

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