Abstracts Archive - Page 2528 of 2605 - ACR Meeting Abstracts

Abstract Number: 1098 • 2012 ACR/ARHP Annual Meeting
Knee Osteoarthritis and Frailty in Older Adults: Findings From the Multicenter Osteoarthritis Study and Osteoarthritis Initiative
Devyani Misra¹, Michael C. Nevitt², Cora E. Lewis³, James Torner⁴, David T. Felson⁵ and Tuhina Neogi⁶, ¹Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ²Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ³Preventive Medicine, University of Alabama, Birmingham, Birmingham, AL, ⁴Epidemiology, University of Iowa, Iowa City, Iowa City, IA, ⁵Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ⁶Clinical Epidemiology, Boston University School of Medicine, Boston, MA
Background/Purpose: Both knee osteoarthritis (OA) and the frailty syndrome affect older adults and both are associated with functional limitation and disability. Frailty in elders is…
Abstract Number: 1099 • 2012 ACR/ARHP Annual Meeting
Whole Blood Lead Is Associated with Symptoms, but Not Radiographic Osteoarthritis, in Multiple Joint Sites: The Johnston County Osteoarthritis Project
Amanda E. Nelson¹, Xiaoyan A. Shi², Todd A. Schwartz³, Jordan B. Renner⁴, Kathleen L. Caldwell⁵, Charles G. Helmick⁶ and Joanne M. Jordan⁷, ¹University of North Carolina Thurston Arthritis Research Center, Chapel Hill, NC, ²SAS Institute, Inc, Cary, NC, ³University of North Carolina Gillings School of Global Public Health, Dept of Biostatistics, Chapel Hill, NC, ⁴University of North Carolina School of Medicine, Dept of Radiology, Chapel Hill, NC, ⁵Centers for Disease Control and Prevention, Atlanta, GA, ⁶National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, ⁷Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC
Background/Purpose: We have previously identified associations between whole blood lead (Pb) and knee osteoarthritis (OA) and with biomarkers of joint metabolism. We hypothesized that Pb…
Abstract Number: 1100 • 2012 ACR/ARHP Annual Meeting
A Functional Growth Hormone Receptor Polymorphism, Exon 3 Deleted Ghr, Is Associated with Radiographic Knee Osteoarthritis in Females with Familial Osteoarthritis At Multiple Sites: The Garp Study
Kim M.J.A. Claessen¹, Margreet Kloppenburg², H.M. Kroon³, Jessica Bijsterbosch⁴, Alberto M. Pereira¹, Hans A. Romijn¹, Tahar Straaten van der⁵, Marian Beekman⁶, P.E. Slagboom⁶, Nienke R. Biermasz¹ and Ingrid Meulenbelt⁷, ¹Endocrinology, Leiden University Medical Center, Leiden, Netherlands, ²Department Rheumatology and Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands, Leiden, Netherlands, ³Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁴Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, Netherlands, ⁶Molecular Epidemiology, Leiden University Medical Center, Leiden, Netherlands, ⁷The Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Healthy Aging, Rotterdam, Netherlands
Background/Purpose: Genetic influences contribute considerably to the development of osteoarthritis (OA), and are most likely of a polygenic nature. Until now, genetic studies have identified…
Abstract Number: 1101 • 2012 ACR/ARHP Annual Meeting
Condroitin Sulfate Decreases Chemokine Levels and Synovitis in knee osteoarthritis Patients
Jordi Monfort¹, Paula Escudero², Cristobal Orellana³, Laura Piqueras⁴, Laura Tio⁵, Francisco Montañés⁶, Natalia García⁷, Chantal Company², Pere Benito⁸ and Maria Jesús Sanz², ¹Reumatologia, Hospital del Mar, Barcelona, Spain, ²Pharmacology, Universitary Clinic Hospital Research Foundation-INCLIVA, University of Valencia, Valencia, Spain, ³Rheumatology, Corporació Sanitaria Parc Taulí, Sabadell, Spain, ⁴University Clinic Hospital Research Foundation-INCLIVA, University of Valencia, Valencia, Spain, ⁵U.R. Inflamació cel·lular i cartílag, GRICIC. FIMIM, Barcelona, Spain, ⁶Rhaumatology, Hospital del Mar, Barcelona, Spain, ⁷GRICIC. FIMIM, Barcelona, Spain, ⁸Hospital del Mar, Barcelona, Spain
Background/Purpose: Synovitis is one of the major signs of structure damage in osteoarthritis (OA) progression. Chondroitin sulfate (CS) is an effective drug in the treatment…
Abstract Number: 1102 • 2012 ACR/ARHP Annual Meeting
Immunoreactive Collagen Type II Cleavage Products and Their Nitrated Forms in Rheumatoid Arthritis and Osteoarthritis: An Outpatient Cross-Sectional Study
Ruediger Mueller¹, Axel Finckh², Guy Heynen³ and Johannes von Kempis⁴, ¹Division of Rheumatology, Cantonal Hospital, St. Gallen, Switzerland, ²Rheumatology, Geneva University Hospitals, Geneva 14, Switzerland, ³Consulting, CH-6300 Zug, Switzerland, ⁴Rheumatology, Kantonsspital St. Gallen, St. Gallen, Switzerland
Background/Purpose: Catabolism of type II collagen (COLII) involves multiple metalloproteinases, aggrecanases and cathepsin, releasing heterogeneous triple helix cleavage products. The complex regulation of these enzymes and of inducible…
Abstract Number: 1103 • 2012 ACR/ARHP Annual Meeting
Cumulative Occupational Physical Load As Risk Factor for Knee Osteoarthritis
Allison M. Ezzat¹, Jolanda Cibere², Mieke Koehoorn³, Eric C. Sayre⁴ and Linda C. Li⁵, ¹School of Rehabilitation Science, University of British Columbia, Vancouver, BC, Canada, ²Division of Rheumatology, Arthritis Research Centre of Canada, Richmond, BC, Canada, ³University of British Columbia, Vancouver, BC, Canada, ⁴Arthritis Research Centre of Canada, Vancouver, BC, Canada, ⁵Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Knee osteoarthritis (OA) results from the interaction of multiple risk factors, one of which may be physically demanding occupations. The purpose of this study…
Abstract Number: 1104 • 2012 ACR/ARHP Annual Meeting
The Association of Demographic, Modifiable, Structural and Biomechanical Risk Factors with Medial and Lateral Patellofemoral Joint Structural Damage On MRI: The Multicenter Osteoarthritis Study
Joshua J. Stefanik¹, Ke Wang², K. Douglas Gross³, Frank Roemer⁴, John A. Lynch⁵, Neil Segal⁶, Cora E. Lewis⁷, Michael C. Nevitt⁸, Ali Guermazi⁹ and David T. Felson¹⁰, ¹Clinical Epidemiology, Boston University, Boston, MA, ²Biostatistics, Boston University, Boston, MA, ³Physical Therapy, MGH Institute of Health Professions, Boston, MA, ⁴Klinikum Augsburg, Augsburg, Germany, ⁵Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, ⁶Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA, ⁷Preventive Medicine, University of Alabama, Birmingham City, Birmingham, AL, ⁸Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ⁹Radiology, Boston University, Boston, MA, ¹⁰Boston University, Boston, MA
Background/Purpose: Past investigations into risk factors for patellofemoral joint (PFJ) osteoarthritis (OA) have been limited by the use of radiography, which is insensitive to identify…
Abstract Number: 1105 • 2012 ACR/ARHP Annual Meeting
Lateral Tibio-Femoral Shift Related to Medial Knee Osteoarthritis
Roy H. Lidtke¹, Berna Goker², Abdurrahman Tufan³, Laura E. Thorp⁴ and Joel A. Block¹, ¹Section of Rheumatology, Rush University Medical Center, Chicago, IL, ²Internal Medicine-Rheumatology, Gazi University Medical School, Ankara, Turkey, ³Internal Medicine-Rheumatology, Gazi University School of Medicine, Ankara, Turkey, ⁴Anatomy and Cell Biology, Rush University Medical Center, Chicago, IL
Background/Purpose: Medial knee osteoarthritis (MKOA) has been shown to be related to malalignment of the knee joint with several radiographs used to quantify the abnormality.…
Abstract Number: 1106 • 2012 ACR/ARHP Annual Meeting
Evaluation of Foot Posture and Plantar Pressure Changes in Knee Osteoarthritis: Preliminary Report
Necati Balci and Lale Cerrahoglu, PMR Department, Celal Bayar University Medical School, Manisa, Turkey
Background/Purpose: Disturbances of weight bearing and walking pattern occur in patients with knee osteoarthritis (OA) due to impairments in knee joint. These impairments may lead…
Abstract Number: 1107 • 2012 ACR/ARHP Annual Meeting
Baseline Knee Flexion Pain, Age and Joint Line Tenderness Predict the Progression of Asymptomatic, Radiographic Knee Osteoarthritis to Symptomatic Knee Osteoarthritis Over 5 Years
Abhiram Gande¹ and James J. Irrgang², ¹Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, ²Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Knee Osteoarthritis (OA) is the most prevalent form of OA. Historically, not all people who have tell-tale signs of radiographic knee osteoarthritis progress to…
Abstract Number: 1108 • 2012 ACR/ARHP Annual Meeting
A Randomized Controlled Trial of Hylan G-F 20 for the Treatment of Carpometacarpal Osteoarthritis
Lisa A. Mandl¹, Scott Wolfe², Aaron Daluiski², Robert N. Hotchkiss³, Stephen L. Lyman⁴ and Jeffrey N. Katz⁵, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Department of Orthopedics, Hospital For Special Surgery, New York, NY, ³Department of Orthopedics, Hospital for Special Surgery, New York, NY, ⁴Research, Hospital Special Surgery, New York, NY, ⁵Rheumatology and Orthopedics, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Painful carpometacarpal osteoarthritis (CMC OA) is associated with substantial impairment, and is often unresponsive to medical treatment. Hylan G-F 20 has been shown…
Abstract Number: 1109 • 2012 ACR/ARHP Annual Meeting
Effects of Strontium Ranelate On Hand Osteoarthritis – Analysis of Data From the Sekoia Trial
E. Maheu¹, C. Cadet² and F. Berenbaum³, ¹AP-HP, Saint-Antoine Hospital, Rheumatology Department and DHU i2B, Paris, France, ²Rheumatology, Paris, France, ³Rheumatology, AP-HP St Antoine Hospital, Paris, France
Background/Purpose: Strontium ranelate (SrRan) has shown the ability to reduce radiological progression of knee osteoarthritis (OA) over 3 years. Patients with knee OA are also…
Abstract Number: 1110 • 2012 ACR/ARHP Annual Meeting
Radiologic Progression in Hand Osteoarthritis (OA) Over 2.6 Years – Data From the Sekoia Trial
Emmanuel Maheu¹, Christian Cadet² and Francis Berenbaum¹, ¹Rheumatology, AP-HP, St Antoine Hospital, Paris, France, ²Rheumatology, Paris, France
Background/Purpose: Hand OA is a frequent polyarticular disease. Few is known with respect to its radiological progression over time, which in addition is difficult to…
Abstract Number: 1111 • 2012 ACR/ARHP Annual Meeting
Erosive Evolution in Hand Osteoarthritis Is Associated with Incident Joint Tenderness Independent of MRI-Defined Bone Marrow Lesions and Synovitis
Ida K. Haugen¹, Barbara Slatkowsky-Christensen¹, Pernille Boyesen¹, Sølve Sesseng², Désirée van der Heijde³ and Tore K. Kvien⁴, ¹Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Radiology, Diakonhjemmet Hospital, Oslo, Norway, ³Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: Previous studies have shown no association between increased amount of radiographic hand osteoarthritis (OA) resulting in more hand pain/disabilities. In this longitudinal study, our…
Abstract Number: 1112 • 2012 ACR/ARHP Annual Meeting
Patients with Erosive Osteoarthritis Have Less Extensive Synovitis Than Patients with Rheumatoid Arthritis On Histopathology
Allen P. Anandarajah¹, Stephen Kates², Kate Burns³ and Ellen Giampoli⁴, ¹Dept of Rheumatology, Univ of Rochester Medical Ctr, Rochester, NY, ²Orthopedic Surgery, University of Rochester Medical Center, Rochester, NY, ³Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ⁴Pathology, University of Rochester Medical Ctr, Rochester, NY
Background/Purpose: Patients with erosive osteoarthritis (EOA) often develop disfiguring deformities and associated decline in hand function. We have previously demonstrated that synovitis was a common…

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