Abstracts Archive - Page 2506 of 2605 - ACR Meeting Abstracts

Abstract Number: 1448 • 2012 ACR/ARHP Annual Meeting
Inhibition of Calcium/Calmodulin-Dependent Protein Kinase IV Suppresses the Autoimmunity in Lupus-Prone Mice
Kunihiro Ichinose¹, Atsushi Kawakami² and George C. Tsokos³, ¹Department of Immunology and Rheumatology, Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ²Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³Medicine/Rheumatology, BIDMC, Harvard Medical School, Boston, MA
Inhibition of Calcium/Calmodulin-Dependent Protein Kinase IV Suppresses the Autoimmunity in Lupus-Prone Mice. Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease associated with abnormal…
Abstract Number: 1449 • 2012 ACR/ARHP Annual Meeting
Numbers of Splenic Long-Lived Plasma Cells in Autoimmune and Pre-Autoimmune Lupus Mice Are Linked to a Hyper-Responsive Variant of the Thrombopoietin Receptor and Enhanced Megakaryopoiesis
Oliver Winter¹, Katrin Moser², Rudolf A. Manz³ and Falk Hiepe⁴, ¹Department of Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Berlin, Germany, ²German Arthritis Research Center (DRFZ Berlin), Berlin, Germany, ³Institute for Systemic Inflammation Research (ISEF), University of Lübeck, Lübeck, Germany, ⁴Med. Klinik m. Sp. Rheumatologie und klin. Immunologie, Charité University Hospital Berlin, Berlin, Germany
Background/Purpose: Autoantibodies contribute to the pathogenesis of the autoimmune disease Systemic Lupus Erythematosus (SLE) by stimulating the immune response. Further, deposits of immune complexes in…
Abstract Number: 1450 • 2012 ACR/ARHP Annual Meeting
MEDI-551 Depletes a Majority of Murine B Cells and Reduces Serum Titers of Autoantibodies in the SLE1-huCD19 TG Mice
Sandra Gallagher¹, Yue Wang¹, Isharat Yusuf¹, Thomas McCaughtry¹, Ronald Herbst² and Laura Carter¹, ¹Respiratory, Inflammation and Autoimmune, MedImmune, Gaithersburg, MD, ²Respiration, Inflammation and Autoimmunity, MedImmune, Gaithersburg, MD
Background/Purpose: Systemic Lupus Erythematosus (SLE) is characterized by chronic inflammation that can affect various organs. Hyperactive B cells appear to be key drivers in SLE…
Abstract Number: 1451 • 2012 ACR/ARHP Annual Meeting
Estrogen Receptor Alpha Deficiency Protects Against Cognitive Defects in Murine Lupus
Melissa A. Cunningham¹, Osama S. Naga², Heather A. Boger³, Ann-Charlotte E. Granholm-Bentley³ and Gary S. Gilkeson⁴, ¹Med/Rheumatology, MUSC, Charleston, SC, ²Medicine/Rheumatology, Medical University of South Carolina, Charleston, SC, ³Neuroscience, Medical University of SC, Charleston, SC, ⁴Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Up to 80% of SLE patients have cognitive defects or affective disorders. The mechanism of CNS injury responsible for cognitive impairment is unknown. Anti-dsDNA…
Abstract Number: 1452 • 2012 ACR/ARHP Annual Meeting
Inherent Strain-Based Differences in Qualitative CD4 T Cell Responses Determine Lupus Severity
Kateryna Soloviova¹, Maksym Puliaiev¹ and Charles S. Via², ¹Pathology Department, Uniformed Services University of Health Sciences, Bethesda, MD, ²Pathology Rm B3-100, Uniformed Services University of Health Sciences, Bethesda, MD
Background/Purpose: A lupus-like disease can be induced in B6D2F1 mice by the transfer of parental DBA/2 splenocytes (DBA->F1). Transfer of splenocytes from the other parent…
Abstract Number: 1453 • 2012 ACR/ARHP Annual Meeting
Estrogen Receptor Alpha Impacts Th17 Expansion in Murine Lupus
Melissa A. Cunningham¹, Osama S. Naga², Jackie G. Eudaly³ and Gary S. Gilkeson⁴, ¹Med/Rheumatology, MUSC, Charleston, SC, ²Medicine/Rheumatology, Medical University of South Carolina, Charleston, SC, ³Med/Rheumatology, Medical University of SC, Charleston, SC, ⁴Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Systemic lupus erythematosus is a disease that disproportionately affects females. The mechanisms underlying the female predominance in this disease are largely unknown. We previously…
Abstract Number: 1454 • 2012 ACR/ARHP Annual Meeting
Characterization of Renal Mononuclear Phagocyte Populations in Murine SLE Nephritis
Ranjit Sahu¹, Ramalingam Bethunaickan² and Anne Davidson¹, ¹Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY, ²Autoimmunity, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Macrophages and dendritic cells contribute to renal damage in chronic renal diseases including lupus nephritis. However owing to their multiple phenotypic and functional variations,…
Abstract Number: 1455 • 2012 ACR/ARHP Annual Meeting
Mitochondrial Dysfunction in the Liver of Lupus-Prone MRL/Lpr Mice Prior to Disease Onset
Zachary A. Oaks¹, Tiffany Telarico² and Andras Perl³, ¹SUNY, Syracuse, NY, ²Medicine, SUNY Upstate Medical University, Syracuse, NY, ³Dept of Medicine, SUNY Upstate Medical University, Syracuse, NY
Background/Purpose: Liver dysfunction, characterized by serum elevation of liver enzymes, is detectable in 20% of patients with systemic lupus erythematosus (SLE.) Males had a higher…
Abstract Number: 1416 • 2012 ACR/ARHP Annual Meeting
Tumor Necrosis Factor Alpha Is Associated with Mood Disorders in Patients with Systemic Lupus Erythematosus
Mariana Postal¹, Aline T. Lapa¹, Nailu A. Sinicato¹, Karina Peliçari¹, Lilian Costallat² and Simone Appenzeller³, ¹Medicine, State University of Campinas, Campinas, Brazil, ²Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Campinas, Brazil, ³Medicine, Faculty of Medical Science, State University of Campinas Unicamp, São Paulo, Brazil
Background/Purpose: Elevated serum levels of tumor necrosis factor alpha (TNF-α) have been reported in patients with major depressive disorder and in patients with depression in…
Abstract Number: 1417 • 2012 ACR/ARHP Annual Meeting
Favorable Response to Belimumab At Three Months
Katrina M. Shum¹, Jill P. Buyon², H. Michael Belmont¹, Andrew G. Franks Jr.³, Richard Furie⁴, Diane L. Kamen⁵, Susan Manzi⁶, Michelle Petri⁷, Rosalind Ramsey-Goldman⁸, Chung-E Tseng¹, Ronald F. van Vollenhoven⁹, Daniel Wallace¹⁰ and Anca Askanase¹, ¹NYU School of Medicine, New York, NY, ²Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, ³Dermatology & Medicine (Rheumatology), New York University, New York, NY, ⁴North Shore-LIJ Health System, Lake Success, NY, ⁵Department of Medicine, Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Charleston, SC, ⁶Division of Rheumatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁷Johns Hopkins University School of Medicine, Baltimore, MD, ⁸Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁹The Karolinska Institute, Stockholm, Sweden, ¹⁰Cedars-Sinai/UCLA, Los Angeles, CA
Background/Purpose: Belimumab (Benlysta) is a monoclonal antibody that inhibits soluble B-Lymphocyte Stimulator and improves SLE disease activity. This study was initiated to evaluate the use…
Abstract Number: 1418 • 2012 ACR/ARHP Annual Meeting
Directed Intuitive Assessment of Lupus (the DIAL system for real world clinics) Correlates Well with BILAG and SLEDAI
Anca D. Askanase¹, Katrina M. Shum¹, Stan Kamp², Fredonna C. Carthen², Teresa J. Aberle³ and J.T. Merrill², ¹NYU School of Medicine, New York, NY, ²Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Arthritis & Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Disease activity measures used in SLE clinical studies, including the SLEDAI (SLE Disease Activity Index) and BILAG (British Isles Lupus Assessment Group) index are…
Abstract Number: 1419 • 2012 ACR/ARHP Annual Meeting
Infections Increase Risk of Arterial and Venous Thromboses in Systemic Lupus Erythematosus Patients: 4925 Patient Years of Follow-up
Renata Baronaite Hansen¹ and Søren Jacobsen², ¹Department of Rheumatology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark, ²Department of Rheumatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
Background/Purpose: Patients with systemic lupus erythematosus (SLE) are at increased risk of developing coronary heart disease as well as infections. Acute infections have been recognized…
Abstract Number: 1420 • 2012 ACR/ARHP Annual Meeting
Ethnicity and B Cell Depletion Therapy in Systemic Lupus Erythematosus
A. Lois-Iglesias¹, J. Ishorari² and D.A. Isenberg², ¹Rheumatology, University Hospital Ramón y Cajal, Madrid, Spain. University College London, London, United Kingdom, ²Centre for Rheumatology, University College London, London, United Kingdom
Background/Purpose:The aim of this study was to determine if there is any relation between ethnicity and outcome in patients with SLE treated with B cell…
Abstract Number: 1421 • 2012 ACR/ARHP Annual Meeting
Antimalarials Protect Systemic Lupus Erythematosus Patients From Damage Accrual During the First Five Years of the Disease
Ioana Ruiz-Arruza¹, D. D. Gladman¹, Dominique Ibanez² and Murray B. Urowitz², ¹Division of Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ²Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Studies in the last 20 years have demonstrated that antimalarials (AM) prevent flares, protect from damage accrual, reduce the risk of thrombosis and increase…
Abstract Number: 1422 • 2012 ACR/ARHP Annual Meeting
Clinical Associations of Anti-Smith Antibodies in Profile: A Multiethnic Lupus Cohort
Yesenia C. Santiago-Casas¹, Luis M. Vila¹, Gerald McGwin Jr.², Ryan S. Cantor², Michelle Petri³, Rosalind Ramsey-Goldman⁴, John D. Reveille⁵, Robert P. Kimberly⁶, Graciela S. Alarcon⁷ and Elizabeth E. Brown⁸, ¹Department of Medicine, Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, PR, ²Epidemiology, University of Alabama at Birmingham, Birmingham, AL, ³Johns Hopkins University School of Medicine, Baltimore, MD, ⁴Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Internal Medicine/Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX, ⁶Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁷Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁸University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Anti-Smith (anti-Sm) antibodies are highly specific for systemic lupus erythematosus (SLE) and have an important value in the diagnosis of this disease. However, whether…

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