Abstracts Archive - Page 2503 of 2607 - ACR Meeting Abstracts

Abstract Number: 1500 • 2012 ACR/ARHP Annual Meeting
Activation of Pregnane X Receptor Induces Regression of Experimental Dermal Fibrosis
Christian Beyer¹, Alla Skapenko², Alfiya Distler³, Clara Dees⁴, Helena Reichert⁵, Louis E. Munoz³, Jan Leipe⁶, Hendrik Schulze-Koops⁷, Oliver Distler⁸, Georg Schett⁹ and Joerg HW Distler³, ¹Department of Internal Medicine 3, Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Division of Rheumatology and Clinical Immunology, Med. Poliklinik,, University of Munich, Munich, Germany, ³Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁵Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ⁶Med. Poliklinik, University of Munich, Division of Rheumatology and Clinical Immunology, Munich, Germany, ⁷University of Munich, Munich, Germany, ⁸Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁹Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Pregnane-X-receptor (PXR) belongs to a superfamily of nuclear receptors that function as ligand-activated transcriptional factors. Although endogenous ligands have not yet been identified, PXR…
Abstract Number: 1501 • 2012 ACR/ARHP Annual Meeting
Increased Periostin Levels in Patients with Systemic Sclerosis
Yukie Yamaguchi¹, Junya Ono², Miho Masuoka³, Shoichiro Ohta⁴, Kenji Izuhara³, Zenro Ikezawa⁵, Michiko Aihara⁶ and Kazuo Takahashi⁶, ¹Department of Environmental-immuno Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ²Shino-Test Corporation, Sagamihara, Japan, ³Department of Biomolecular Sciences, Saga Medical School, Saga, Japan, ⁴Department of Laboratory Medicine, Saga medical School, Saga, Japan, ⁵Dermatology, International University of Health and Welfare Atami Hospital, Atami, Japan, ⁶Environmental-immuno Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
Background/Purpose: Systemic sclerosis (SSc) results in significant morbidity and mortality due to organ fibrosis characterized by increased deposition of extracellular matrix (ECM). Periostin is one…
Abstract Number: 1502 • 2012 ACR/ARHP Annual Meeting
Hedgehog Signaling in Murine Chronic Sclerodermatous Graft-Versus-Host Disease
Pawel Zerr¹, Katrin Palumbo-Zerr¹, Alfiya Distler², Michal Tomcik³, Stefan Vollath², Louis E. Munoz², Christian Beyer⁴, Clara Dees⁵, Friederike Egberts⁶, Ilaria Tinazzi⁷, Francesco Del Galdo⁸, Oliver Distler⁹, Georg Schett¹⁰, Bernd M. Spriewald¹¹ and Joerg HW Distler², ¹Department of Internal Medicine 3 and Institute for Clinical Immunology, Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ³Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague 2, Czech Republic, ⁴Department of Internal Medicine 3, Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁵Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁶Department of Dermatology, Department of Dermatology, Schleswig-Holstein University Hospital, Campus Kiel, Kiel, Germany, ⁷Unit of Rheumatology, Scleroderma Research Program, Leeds Institute of Molecular Medicine, Division of Musculoskeletal Diseases, University of Leeds, Leeds, United Kingdom, ⁸Musculoskeletal Diseases, Scleroderma Research Program, Leeds Institute of Molecular Medicine, Division of Musculoskeletal Diseases, University of Leeds, Leeds, United Kingdom, ⁹Department of Rheumatology, Center of Experimental Rheumatology and Zurich Center of Integrative Human Physiology, University Hospital Zurich, Zurich, Switzerland, ¹⁰Institute for Clinical Immunology, Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ¹¹Department of Internal Medicine V, Department of Internal Medicine V, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Sclerodermatous chronic graft-versus-host disease (cGvHD) is a prognosis limiting complication of allogeneic bone marrow transplantation. cGvHD can manifest on virtually every organ system. However,…
Abstract Number: 1503 • 2012 ACR/ARHP Annual Meeting
Effect of Thiol Antioxidants On the Profibrotic Phenotype of Scleroderma Dermal Fibroblasts
Pei-Suen Tsou¹, Beatrix Balogh², Adam J. Pinney², Elena Schiopu³, Dinesh Khanna⁴ and Alisa E. Koch⁵, ¹Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²University of Michigan Medical School, Ann Arbor, MI, ³Rheumatology/Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ⁴Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁵Internal Medicine - Rheumatology, University of Michigan Medical School, Ann Arbor, MI
Background/Purpose: Systemic sclerosis (Scleroderma, SSc) is a connective tissue disease characterized by vasculopathy and fibrosis of the skin and organs. Increase in superoxide production and…
Abstract Number: 1504 • 2012 ACR/ARHP Annual Meeting
A Possible Contribution of Visfatin to the Resolution of Skin Sclerosis in Patients with Diffuse Cutaneous Systemic Sclerosis Via a Direct Anti-Fibrotic Effect On Dermal Fibroblasts and Th1 Polarization of the Immune Response
Tetsuo Toyama¹, Yoshihide Asano², Yuri Masui³, Sayaka Shibata², Kaname Akamata¹, Shinji Noda², Naohiko Aozasa¹, Takashi Taniguchi², Takehiro Takahashi², Yohei Ichimura², Hayakazu Sumida², Koichi Yanaba², Takafumi Kadono² and Shinichi Sato¹, ¹Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ²Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ³Department of Dermatology, University of Tokyo, Tokyo, Japan
Background/Purpose: Our latest studies have demonstrated that adipocytokines, including adiponectin, apelin, and retinol-binding protein-4, are potentially involved in the development of complicated clinical symptoms associated…
Abstract Number: 1505 • 2012 ACR/ARHP Annual Meeting
Inactivation of Tankyrases Ameliorates Canonical Wnt Signaling and Prevents Experimental Fibrosis
Alfiya Distler¹, Lisa Deloch², Jingang Huang², Clara Dees², Neng Yu Lin², Christian Beyer³, Oliver Distler⁴, Georg A. Schett⁵ and Joerg HW Distler¹, ¹Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ³Department of Internal Medicine 3, Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁵Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Systemic sclerosis (SSc) is characterized by aberrant activation of fibroblasts with increased release of extracellular matrix components. Canonical Wnt signaling has recently emerged as…
Abstract Number: 1506 • 2012 ACR/ARHP Annual Meeting
Primary Human Scleroderma Dermal Endothelial Cells Exhibit Defective Angiogenesis
Pei-Suen Tsou¹, Bradley J. Rabquer², Beatrix Balogh², Ann Kendzicky², Bashar Kahaleh³, Elena Schiopu⁴, Dinesh Khanna⁵ and Alisa E. Koch⁶, ¹Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²University of Michigan Medical School, Ann Arbor, MI, ³Medicine/Rheumatology, University of Toledo, Toledo, OH, ⁴Rheumatology/Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ⁵Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁶Internal Medicine - Rheumatology, University of Michigan Medical School, Ann Arbor, MI
Background/Purpose: Angiogenesis, the formation of new blood vessels, plays a critical role in a number of pathological processes including systemic sclerosis (scleroderma, SSc). SSc is…
Abstract Number: 1507 • 2012 ACR/ARHP Annual Meeting
Propylthiouracil Reduces Fibrosis in Chronic Oxidant Stress Mouse Model of Scleroderma
Gianluca Bagnato¹, Alessandra Bitto², Natasha Irrera², Gabriele Pizzino², Neal Roberts³, Maurizio Cinquegrani⁴, Donatella Sangari¹, Francesco Squadrito², Gianfilippo Bagnato¹ and Antonino Saitta⁴, ¹Rheumatology, University of Messina, Messina, Italy, ²Pharmacology, University of Messina, Messina, Italy, ³Medical College of Virginia, Richmond, VA, ⁴Internal Medicine, University of Messina, Messina, Italy
Background/Purpose: Systemic sclerosis (SSc) is characterized by fibrosis of skin and visceral organs; vascular damage and resultant ischemia; and immunological dysregulation manifested by autoantibodies. Hypothyroidism,…
Abstract Number: 1508 • 2012 ACR/ARHP Annual Meeting
Simvastatin Attenuates Pulmonary Fibrosis in a Murine Model of Systemic Sclerosis
Gianluca Bagnato¹, Alessandra Bitto², Natasha Irrera², Gabriele Pizzino², Donatella Sangari¹, Maurizio Cinquegrani³, Neal Roberts⁴, Gianfilippo Bagnato¹, Francesco Squadrito² and Antonino Saitta³, ¹Rheumatology, University of Messina, Messina, Italy, ²Pharmacology, University of Messina, Messina, Italy, ³Internal Medicine, University of Messina, Messina, Italy, ⁴Medical College of Virginia, Richmond, VA
Background/Purpose: Simvastatin is best known for its antilipidemic action due to its inhibition of 3-hydroxy-3-methylglutaryl CoenzymeA (HMG CoA) reductase. Inhibition of biological precursors in this pathway also…
Abstract Number: 1509 • 2012 ACR/ARHP Annual Meeting
Correlates of Skin Gene Expression Profile in Systemic Sclerosis
Shervin Assassi¹, Jeffrey T. Chang², Filemon K. Tan¹, Minghua Wu³, Gloria A. Salazar Cintora¹, Irum Zaheer⁴, Dinesh Khanna⁵, Daniel Furst⁶ and Maureen D. Mayes⁷, ¹Rheumatology, Univ of Texas Health Science at Houston, Houston, TX, ²Univ of Texas Health Science at Houston, Houston, TX, ³Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ⁴Methodist Hospital, Houston, TX, ⁵Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁶Div of Rheumatology, UCLA Medical School, Los Angeles, CA, ⁷Internal Medicine/Rheumatology, Univ of Texas Health Science at Houston, Houston, TX
Background/Purpose: Skin global gene expression profiling indicates presence of distinct gene expression signatures in patients with systemic sclerosis (SSc). We examine the correlation of the…
Abstract Number: 1510 • 2012 ACR/ARHP Annual Meeting
Critical Role of the Adhesion Receptor Dnax Accessory Molecule-1 (DNAM-1) in the Development of Inflammation-Driven Dermal Fibrosis in Mouse Model of Systemic Sclerosis
Jerome Avouac¹, Muriel Elhai², Michal Tomcik³, Manuel Friese⁴, Marco Colonna⁵, Günter Bernhardt⁶, Andre Kahan⁷, Gilles Chiocchia⁸, Joerg HW Distler⁹ and Yannick Allanore¹⁰, ¹Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ²Paris Descartes University, INSERM U1016, Institut Cochin, Sorbonne Paris Cité, Paris, France, ³Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague 2, Czech Republic, ⁴Zentrum für Molekulare Neurobiologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany, ⁵Washington University, Department of Immunology, St. Louis, MO, ⁶Institute of Immunology, Hannover Medical School, Hannover, Germany, ⁷Rheumatology A Department, Cochin Hospital, APHP, Paris Descartes University, Paris, France, ⁸Immunology and Hematology Department, Institut Cochin - INSERM U1016 - CNRS (UMR 8104), Paris, France, ⁹Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ¹⁰Rheumatology, Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France
Background/Purpose: DNAX accessory molecule 1 (DNAM-1) is an adhesion factor involved in the adhesion and co-stimulation of T cells. DNAM-1 has been recently identified as…
Abstract Number: 1511 • 2012 ACR/ARHP Annual Meeting
Low Circulating Endothelial Progenitor Cell Levels and High VEGF Serum Levels Are Associated with the Late Nailfold Capillaroscopic Pattern in Systemic Sclerosis
Jerome Avouac¹, Maeva Vallucci², Vanessa Smith³, Barbara Ruiz², Alberto Sulli⁴, Carmen Pizzorni⁵, Gilles Chiocchia⁶, Maurizio Cutolo⁷ and Yannick Allanore⁸, ¹Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ²Paris Descartes University, INSERM U1016, Institut Cochin, Sorbonne Paris Cité, Paris, France, ³Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ⁴Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, ⁵Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, ⁶Immunology and Hematology Department, Institut Cochin - INSERM U1016 - CNRS (UMR 8104), Paris, France, ⁷Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy, ⁸Rheumatology, Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France
Background/Purpose: To assess whether nailfold videocapillaroscopy (NVC) changes are associated with peripheral blood or serum levels of angiogenic biomarkers in systemic sclerosis (SSc). Methods: Endothelial…
Abstract Number: 1512 • 2012 ACR/ARHP Annual Meeting
Bleomycin Delivery by Osmotic Pump: A Superior Model for Human ILD
Rebecca Lee¹, Michael Bonner², Charles Reese², Elena Tourkina³, Zoltan Hajdu², Jing Zhang², Richard Visconti² and Stanley Hoffman², ¹Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ²Medical University of South Carolina, Charleston, SC, ³Rheumatology, Medical University of SC, Charleston, SC
Background/Purpose: Interstitial lung disease (ILD) represents a group of chronic, progressive, irreversible diseases associated with pulmonary fibrosis, including systemic sclerosis and idiopathic pulmonary fibrosis. In…
Abstract Number: 1513 • 2012 ACR/ARHP Annual Meeting
TSLP Receptor Deficiency Reduces IL-13 Expression and Prevents Fibrosis in Experimental Scleroderma
Alicia Usategui¹, Vanessa Miranda¹, Gabriel Criado², Manuel J. Del Rey¹, Elena Izquierdo¹, Warren J. Leonard³ and Jose L. Pablos¹, ¹Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ²Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ³Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by progressive fibrosis of the skin and internal organs. Although SSc shares pathogenetic features with other…
Abstract Number: 1514 • 2012 ACR/ARHP Annual Meeting
Differences in the Activation Levels and Expression Patterns of the Molecular Targets of Tyrosine Kinase Inhibitors May Account for the Heterogeneous Treatment Responses
Britta Maurer¹, Alfiya Akhmetshina², Renate E. Gay³, Beat A. Michel³, Steffen Gay⁴, Joerg H. W. Distler² and Oliver Distler³, ¹Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ³Department of Rheumatology and Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Switzerland, Zurich, Switzerland
Background/Purpose: In SSc, treatment responses to tyrosine kinase inhibitors (TKI) are less distinct compared to animal models. Therefore, we assessed whether the heterogeneous therapeutic effects…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].