Abstracts Archive - Page 2502 of 2605 - ACR Meeting Abstracts

Abstract Number: 1509 • 2012 ACR/ARHP Annual Meeting
Correlates of Skin Gene Expression Profile in Systemic Sclerosis
Shervin Assassi¹, Jeffrey T. Chang², Filemon K. Tan¹, Minghua Wu³, Gloria A. Salazar Cintora¹, Irum Zaheer⁴, Dinesh Khanna⁵, Daniel Furst⁶ and Maureen D. Mayes⁷, ¹Rheumatology, Univ of Texas Health Science at Houston, Houston, TX, ²Univ of Texas Health Science at Houston, Houston, TX, ³Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ⁴Methodist Hospital, Houston, TX, ⁵Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁶Div of Rheumatology, UCLA Medical School, Los Angeles, CA, ⁷Internal Medicine/Rheumatology, Univ of Texas Health Science at Houston, Houston, TX
Background/Purpose: Skin global gene expression profiling indicates presence of distinct gene expression signatures in patients with systemic sclerosis (SSc). We examine the correlation of the…
Abstract Number: 1510 • 2012 ACR/ARHP Annual Meeting
Critical Role of the Adhesion Receptor Dnax Accessory Molecule-1 (DNAM-1) in the Development of Inflammation-Driven Dermal Fibrosis in Mouse Model of Systemic Sclerosis
Jerome Avouac¹, Muriel Elhai², Michal Tomcik³, Manuel Friese⁴, Marco Colonna⁵, Günter Bernhardt⁶, Andre Kahan⁷, Gilles Chiocchia⁸, Joerg HW Distler⁹ and Yannick Allanore¹⁰, ¹Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ²Paris Descartes University, INSERM U1016, Institut Cochin, Sorbonne Paris Cité, Paris, France, ³Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague 2, Czech Republic, ⁴Zentrum für Molekulare Neurobiologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany, ⁵Washington University, Department of Immunology, St. Louis, MO, ⁶Institute of Immunology, Hannover Medical School, Hannover, Germany, ⁷Rheumatology A Department, Cochin Hospital, APHP, Paris Descartes University, Paris, France, ⁸Immunology and Hematology Department, Institut Cochin - INSERM U1016 - CNRS (UMR 8104), Paris, France, ⁹Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ¹⁰Rheumatology, Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France
Background/Purpose: DNAX accessory molecule 1 (DNAM-1) is an adhesion factor involved in the adhesion and co-stimulation of T cells. DNAM-1 has been recently identified as…
Abstract Number: 1511 • 2012 ACR/ARHP Annual Meeting
Low Circulating Endothelial Progenitor Cell Levels and High VEGF Serum Levels Are Associated with the Late Nailfold Capillaroscopic Pattern in Systemic Sclerosis
Jerome Avouac¹, Maeva Vallucci², Vanessa Smith³, Barbara Ruiz², Alberto Sulli⁴, Carmen Pizzorni⁵, Gilles Chiocchia⁶, Maurizio Cutolo⁷ and Yannick Allanore⁸, ¹Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ²Paris Descartes University, INSERM U1016, Institut Cochin, Sorbonne Paris Cité, Paris, France, ³Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ⁴Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, ⁵Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, ⁶Immunology and Hematology Department, Institut Cochin - INSERM U1016 - CNRS (UMR 8104), Paris, France, ⁷Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy, ⁸Rheumatology, Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France
Background/Purpose: To assess whether nailfold videocapillaroscopy (NVC) changes are associated with peripheral blood or serum levels of angiogenic biomarkers in systemic sclerosis (SSc). Methods: Endothelial…
Abstract Number: 1512 • 2012 ACR/ARHP Annual Meeting
Bleomycin Delivery by Osmotic Pump: A Superior Model for Human ILD
Rebecca Lee¹, Michael Bonner², Charles Reese², Elena Tourkina³, Zoltan Hajdu², Jing Zhang², Richard Visconti² and Stanley Hoffman², ¹Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ²Medical University of South Carolina, Charleston, SC, ³Rheumatology, Medical University of SC, Charleston, SC
Background/Purpose: Interstitial lung disease (ILD) represents a group of chronic, progressive, irreversible diseases associated with pulmonary fibrosis, including systemic sclerosis and idiopathic pulmonary fibrosis. In…
Abstract Number: 1513 • 2012 ACR/ARHP Annual Meeting
TSLP Receptor Deficiency Reduces IL-13 Expression and Prevents Fibrosis in Experimental Scleroderma
Alicia Usategui¹, Vanessa Miranda¹, Gabriel Criado², Manuel J. Del Rey¹, Elena Izquierdo¹, Warren J. Leonard³ and Jose L. Pablos¹, ¹Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ²Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ³Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by progressive fibrosis of the skin and internal organs. Although SSc shares pathogenetic features with other…
Abstract Number: 1514 • 2012 ACR/ARHP Annual Meeting
Differences in the Activation Levels and Expression Patterns of the Molecular Targets of Tyrosine Kinase Inhibitors May Account for the Heterogeneous Treatment Responses
Britta Maurer¹, Alfiya Akhmetshina², Renate E. Gay³, Beat A. Michel³, Steffen Gay⁴, Joerg H. W. Distler² and Oliver Distler³, ¹Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ³Department of Rheumatology and Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Switzerland, Zurich, Switzerland
Background/Purpose: In SSc, treatment responses to tyrosine kinase inhibitors (TKI) are less distinct compared to animal models. Therefore, we assessed whether the heterogeneous therapeutic effects…
Abstract Number: 1515 • 2012 ACR/ARHP Annual Meeting
Pharmacological Blockade of Adenosine A2A Receptors (A_2AR) Prevents Radiation-Induced Dermal Injury
Miguel Perez Aso¹, Yee C. Low², Obinna Ezeamuzie², Jamie Levine² and Bruce N. Cronstein³, ¹NYU School of Medicine, New York, NY, ²Department of Plastic Surgery, New York Univ Medical Center, New York, NY, ³Internal Medicine, NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: Ionizing radiation is a commonly used therapeutic modality and following irradiation dermal changes, including fibrosis and atrophy, may lead to such problems as contractures.…
Abstract Number: 1516 • 2012 ACR/ARHP Annual Meeting
TSLP Upregulation in Human SSc Skin and Induction of Overlapping Profibrotic Genes and Intracellular Signaling with IL-13 and TGFb
Romy Christmann¹, Allison Mathes², Giuseppina Stifano², Alsya J. Affandi³, Andreea Bujor³, Cristina Padilla³ and Robert Lafyatis³, ¹Rheumatology, Boston University School of Medicine, Boston, MA, ²Rheumatology, Boston University Medical Center, Boston, MA, ³Rheumatology, Boston University, Boston, MA
Background/Purpose: to investigate the expression of Thymic Stromal Lymphopoietin (TSLP) in diffuse cutaneous systemic sclerosis (dcSSc) patients and explore its effects in vivo and in vitro…
Abstract Number: 1477 • 2012 ACR/ARHP Annual Meeting
Skin Autofluorescence As a Measure of Oxidative Stress in Systemic Sclerosis Is Not Affected by Skin Thickness, Erythema or Melanin
Andrea Murray¹, T. Moore¹, J. Manning², Christopher E.M Griffiths³ and Ariane Herrick⁴, ¹School of Translational Medicine, University of Manchester, Manchester Academic Health Science Centre, Salford Royal NHS Foundation Trust, Manchester, United Kingdom, ²Department of Clinical Rheumatology, Salford Royal NHS Foundation Trust, Salford, United Kingdom, ³Dermatology Centre, University of Manchester, Manchester, United Kingdom, ⁴Musculoskeletal Research Group, University of Manchester, Salford, United Kingdom
Background/Purpose: Skin autofluorescence (AF) has been suggested as a non-invasive measure of oxidative stress in patients with diabetes and other diseases. We have previously shown…
Abstract Number: 1478 • 2012 ACR/ARHP Annual Meeting
Gender-Associated Differences in Disease Characteristics and Outcome in Systemic Sclerosis
Svetlana I. Nihtyanova¹, Voon H. Ong² and Christopher P. Denton³, ¹Department of Rheumatology, Royal Free and University College Medical School, London, United Kingdom, ²Department of Rheumatology, The Royal Free and University College Medical School, London, United Kingdom, ³Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom
Background/Purpose: Although significant female gender predominance is seen in majority of large systemic sclerosis (SSc) cohorts, multiple studies have suggested that male gender generally associates…
Abstract Number: 1479 • 2012 ACR/ARHP Annual Meeting
Early Versus Late Onset Systemic Sclerosis: Analysis of 1037 Patients From Rescle Registry
Marco A. Alba¹, Juan Carlos Mejia², Gerard Espinosa³, María-Victoria Egurbide⁴, Carles Tolosa⁵, Luis Trapiella⁶, Carmen Pilar Simeon⁷, Vicent Fonollosa⁸ and And RESCLE investigators⁹, ¹Systemic Autoimmune Diseases, Vasculitis Research Unit. Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, ²Department of Systemic Autoimmune Diseases, Hospital Clinic University Barcelona, Barcelona, Spain, ³Department of Autoimmune Diseases, Hospital Clínic, Barcelona, Barcelona, Spain, ⁴Autoimmune Disease Research Unit, Service of Internal Medicine,, Hospital de Cruces, UPV/EHU, Barakaldo, Spain, Barakaldo, Spain, ⁵Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí, Barcelona, Spain, ⁶Department of Internal Medicine,, Hospital Universitario Central de Asturias, Asturias, Spain, ⁷Servicio de Medicina Interna, Hospital Valle de Hebron, Barcelona, Spain, ⁸Department of Internal Medicine, Hospital Vall dxHebron, Barcelona, Spain, ⁹RESCLE, Barcelona, Spain
Background/Purpose: Systemic sclerosis (SSc) is characterized by extensive fibrosis, vascular dysfunction and the presence of several auto-antibodies. As in other autoimmune diseases, age at disease…
Abstract Number: 1480 • 2012 ACR/ARHP Annual Meeting
The 15% Rule in Scleroderma: A Systematic Review of the Frequency of Organ Complications in Systemic Sclerosis
Chayawee Muangchan¹, Murray Baron², Janet E. Pope³ and Canadian Scleroderma Research Group⁴, ¹Division of Rheumatology, Department of Medicine, Faculty of Medicine, Mahidol University, Siriraj Hospital, Bangkok, Thailand, ²Pavillion A, Rm 216, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, ³Medicine/Rheumatology, St. Joseph Health Care London, University of Western Ontario, London, ON, Canada, ⁴Division of Rheumatology, SMBD Jewish General Hospital, Montreal, QC, Canada
Background/Purpose : The prevalence of each organ complication in scleroderma (SSc) varies by definition used. However, it is important to be aware of several complications…
Abstract Number: 1481 • 2012 ACR/ARHP Annual Meeting
A Double-Blind Placebo-Controlled Crossover Trial of the Alpha-_2C Adrenoceptor Antagonist Orm-12741 for Prevention of Cold-Induced Vasospasm in Patients with Systemic Sclerosis
Ariane Herrick¹, Andrea Murray², Angela Ruck³, Juha Rouru⁴, Tonia Moore², John Whiteside³, Pasi Hakulinen⁴, Fredrick M. Wigley⁵ and Amir Snapir⁴, ¹Musculoskeletal Research Group, University of Manchester, Salford, United Kingdom, ²School of Translational Medicine, University of Manchester, Manchester Academic Health Science Centre, Salford Royal NHS Foundation Trust, Manchester, United Kingdom, ³Orion Pharma UK, Research & Development, Nottingham, United Kingdom, ⁴Orion Corporation Orion Pharma, Turku, Finland, ⁵Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: The alpha-2C adrenoceptor is thought to play a key role in mediating cold-induced vasospasm in the digits. A previous study suggested that in patients…
Abstract Number: 1482 • 2012 ACR/ARHP Annual Meeting
Laser Speckle Contrast Imaging May Help in the Differential Diagnosis of Raynaud’s Phenomenon
Alessandra Della Rossa¹, Massimiliano Cazzato¹, Walter Bencivelli¹, Anna d'Ascanio², Marta Mosca¹ and Stefano Bombardieri³, ¹Internal Medicine, Rheumatology Unit, Pisa, Italy, ²Department of Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ³Department of Internal Medicine, University of Pisa, Rheumatology Unit, Pisa, Italy
Background/Purpose: to investigate blood flow and microvascular reactivity by laser speckle perfusion imager (Perimed, Jarfalla) in consecutive patients affected by Raynaud’s phenomenon at baseline and…
Abstract Number: 1483 • 2012 ACR/ARHP Annual Meeting
Predictors of Digital Ulcers in Systemic Sclerosis: Correlation Between Clinical and Hemodynamic Features, Capillaroscopy, Endothelium Dysfunction and Angiogenesis Biomarkers
Ivone Silva¹, Isabel Almeida¹, António Marinho² and Carlos Vasconcelos³, ¹Raynaud Clinics, Porto, Portugal, ²Unidade de Imunologia Clínica, Porto, Portugal, ³Imunologia Clinica - M Interna, Hospital Geral Santo Antonio, Porto, Portugal
Background/Purpose: Digital Ulcers (DU) are a major disabling complication of Systemic Sclerosis (SSc) interfering with personal and professional life of our patients. The aim of…

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