Abstracts Archive - Page 2502 of 2607 - ACR Meeting Abstracts

Abstract Number: 1525 • 2012 ACR/ARHP Annual Meeting
Determinants of Poor Quality of Life in ANCA Associated Vasculitis (AAV)
Neil Basu¹, Andrew McClean², Raashid A. Luqmani³, Lorraine Harper², Oliver Flossmann⁴, David Jayne⁵, Mark Little⁶, Esther N. Amft⁷, Neeraj Dhaun⁸, John McLaren⁹, Vinod Kumar¹⁰, Lars Erwig¹¹, Gareth T. Jones¹, David M. Reid¹² and Gary J. Macfarlane¹, ¹Musculoskeletal Research Collaboration (Epidemiology Group), University of Aberdeen, Aberdeen, United Kingdom, ²Nephrology, University of Birmingham, Birmingham, United Kingdom, ³Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, United Kingdom, ⁴Nephrology, Royal Berkshire Hospital, Reading, United Kingdom, ⁵Vasculitis and Lupus Clinic, Addenbrookes Hospital University of Cambridge, Cambridge, United Kingdom, ⁶Clinical Medicine, Trinity College Dublin, Dublin, Ireland, ⁷Rheumatic Diseases Unit, Western General Hospital, Edinburgh, United Kingdom, ⁸Nephrology, Edinburgh Royal Infirmary, Edinburgh, United Kingdom, ⁹Fife Rheumatic Diseases Unit, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, United Kingdom, ¹⁰Rheumatology, Ninewells Hospital, Dundee, United Kingdom, ¹¹Division of Applied Medicine, University of Aberdeen, Aberdeen, United Kingdom, ¹²Musculoskeletal Research Collaboration (Medicine & Therapeutics), University of Aberdeen, Aberdeen, United Kingdom
Determinants of Poor Quality of Life in ANCA Associated Vasculitis (AAV) Background/Purpose : Patients with ANCA associated vasculitis (AAV) report significantly reduced quality of life (QOL),…
Abstract Number: 1526 • 2012 ACR/ARHP Annual Meeting
Patient Reported Outcomes in ANCA-Associated Vasculitis. A Prospective Comparison Between Birmingham Vasculitis Activity Score and Routine Assessment of Patient Index Data 3
Osama ElSallabi¹, Joel A. Block¹ and Antoine Sreih², ¹Section of Rheumatology, Rush University Medical Center, Chicago, IL, ²Medicine/Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: ANCA-associated vasculitis (AAV) is a rare group of diseases comprising Granulomatosis with polyangiitis (Wegener’s; GPA), Microscopic Polyangiitis (MPA), and Churg-Strauss Syndrome (CSS). These diseases…
Abstract Number: 1527 • 2012 ACR/ARHP Annual Meeting
Patient Global Assessments for Disease Activity Are Predictive of Future Flare in Granulomatosis with Polyangiitis (Wegener’s)
Gunnar Tomasson¹, John C. Davis Jr.², Gary S. Hoffman³, W. Joseph McCune⁴, Ulrich Specks⁵, Robert F. Spiera⁶, E. William St. Clair⁷, John H. Stone⁸ and Peter A. Merkel⁹, ¹Department of Public Health Sciences, University of Iceland, Reykjavik, Iceland, ²Genentech, Inc, South San Francisco, CA, ³Rheumatic & Immunologic Dis, Cleveland Clinic, Cleveland, OH, ⁴Int Med/ Rheum, University of Michigan, Ann Arbor, MI, ⁵Mayo Clinic, Rochester, MN, ⁶Rheumatology, Hospital for Special Surgery, New York, NY, ⁷Medicine, Duke University Medical Center, Durham, NC, ⁸Rheumatology, Massachusetts General Hospital, Boston, MA, ⁹University of Pennsylvania, Philadelphia, PA
Background/Purpose: In granulomatosis with polyangiitis GPA), disease activity is assessed by physician-based measures. In some other rheumatic diseases, such as rheumatoid arthritis (RA) and ankylosing…
Abstract Number: 1528 • 2012 ACR/ARHP Annual Meeting
Assessing Fatigue in Systemic Vasculitis From the Patient’s Perspective
Peter C. Grayson¹, Naomi Amudala², Carol McAlear³, Renée Leduc⁴, Denise Shereff⁵, Rachel Richesson⁶, Liana Fraenkel⁷ and Peter A. Merkel⁸, ¹Section of Rheumatology & the Clinical Epidemiology Unit, Boston University School of Medicine, Vasculitis Center, Boston, MA, ²Rheumatology & Vasculitis, Boston University Medical Center, Boston, MA, ³Vasculitis Clinical Research Consortium, University of Pennsylvania, Philadelphia, PA, ⁴Pediatrics Epidemiology Center, University of South Florida, Tampa, FL, ⁵Division of Bioinformatics and Biostatistics, University of South Florida, Tampa, FL, ⁶Epidemiology & Biostatistics, University of South Florida, Tampa, FL, ⁷Medicine, Section of Rheumatology, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare System, New Haven, CT, ⁸University of Pennsylvania, Philadelphia, PA
Background/Purpose: Fatigue is considered an important disease burden by patients with vasculitis, yet mechanisms underlying fatigue are poorly understood. Physician-derived measures of vasculitis disease activity…
Abstract Number: 1529 • 2012 ACR/ARHP Annual Meeting
Upper Airway Gene Expression Profiling in Granulomatosis with Polyangiitis
Peter C. Grayson¹, Katrina Steiling², Paul A. Monach³, Ji Xiao⁴, Xiaohui Zhang², Yuriy Alekseyev², Stephano Monti⁴, Avrum Spira⁵ and Peter A. Merkel⁶, ¹Section of Rheumatology & the Clinical Epidemiology Unit, Boston University School of Medicine, Vasculitis Center, Boston, MA, ²Computational Biomedicine, Boston University Medical Center, Boston, MA, ³Rheumatology, Boston University, Boston, MA, ⁴Computational Biomedicine, Boston University Medial Center, Boston, MA, ⁵Computational Biomedicine, Boston University School of Medicine, Boston, MA, ⁶University of Pennsylvania, Philadelphia, PA
Background/Purpose: Nasal disease occurs in the majority of patients with granulomatosis with polyangiitis (Wegener's, GPA) and is often a presenting symptom of the disease. The…
Abstract Number: 1530 • 2012 ACR/ARHP Annual Meeting
Plasma Cell Analysis As a Biomarker for Disease Activity in Patients with Granulomatosis with Polyangiitis
Bimba F. Hoyer¹, Adriano Taddeo², Maika Rothkegel², Gerd Burmester³, Andreas H. Radbruch² and Falk Hiepe⁴, ¹Rheumatology/Immunology, Charite University Hospital, Berlin, Germany, ²Deutsches Rheumaforschungszentrum, Berlin, Germany, ³Department of Rheumatology and Clinical Immunology, Charité – University Medicine Berlin, Berlin, Germany, ⁴Med. Klinik m. Sp. Rheumatologie und klin. Immunologie, Charité University Hospital Berlin, Berlin, Germany
Background/Purpose: B cells are thought to play an important role in granulomatosis with polyangiitis (GPA) due to the presence of autoantibodies reacting with specific neutrophil…
Abstract Number: 1531 • 2012 ACR/ARHP Annual Meeting
Comparative Proteomic Analysis of Neutrophils Between Microscopic Polyangiitis and Granulomatosis with Polyangiitis
Teisuke Uchida¹, Kouhei Nagai², Toshiyuki Sato², Mitsumi Arito², Nobuko Iizuka², Manae Kurokawa², Naoya Suematsu², Kazuki Okamoto², Shoichi Ozaki³ and Tomohiro Kato⁴, ¹Clinical Proteomics and Molecular Medicine, St. Marianna University Graduate School of Medicine,, Kawasaki, Japan, ²Clinical Proteomics and Molecular Medicine, St. Marianna University Graduate School of Medicine, Kawasaki, Japan, ³Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ⁴Clinical Proteomics and Molecular Medicine, St. Mariannna University Graduate School of Medicine., Kawasaki, Japan
Background/Purpose: Both microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) belong to ANCA-associated vasculitis (AAV), in which dysfunction of polymorphonuclear cells (PMN) is thought to…
Abstract Number: 1532 • 2012 ACR/ARHP Annual Meeting
Serum Angiopoietin-2 Level Reflects the Disease Activity and Renal Function in Antineutrophilic Cytoplasmic Antibody-Associated Vasculitis
Yoko Wada¹, Hiroe Sato¹, Takeshi Nakatsue¹, Shuichi Murakami¹, Takeshi Kuroda², Masaaki Nakano³ and Ichiei Narita¹, ¹Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, ²Health Administration Center, Niigata University, Niigata, Japan, ³School of Health Sciences, Faculty of Medicine, Niigata University, Niigata, Japan
Background/Purpose: Angiopoietin-2 (Ang-2) has emerged as a key mediator of endothelial cell activation. Ang-1 and Ang-2 are antagonistic ligands which bind with similar affinity to…
Abstract Number: 1533 • 2012 ACR/ARHP Annual Meeting
Increased Circulating FoxP3⁺ T-Cells in Patients with Granulomatosis with Polyangiitis Are Attributed to an Increase in the Non-Suppressor FoxP3^Low CD45RO⁺ T_Reg Cell Subpopulation
Wayel H. Abdulahad¹, Coen A. Stegeman², Minke G. Huitema¹, Abraham Rutgers¹, Peter Heeringa³, Pieter C. Limburg⁴ and Cees G.M. Kallenberg¹, ¹Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ²Nephrology, University Medical Center Groningen, Groningen, Netherlands, ³Pathology and Medical Biology, University Medical Center Groningen, Groningen, Netherlands, ⁴Department of Laboratory Medicine, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Human FoxP3+T-cells are functionally heterogeneous, and can be classified into three phenotypically distinct subpopulations based on the expression levels of FoxP3 and the memory…
Abstract Number: 1534 • 2012 ACR/ARHP Annual Meeting
IgG4 Plasma Cell Infiltration in Granulomatosis with Polyangiitis (formerly Wegener’s) Lung Biopsies
Mollie Carruthers¹, Shweta Shinagare², Arezou Khosroshahi¹, Vikram Deshpande² and John H. Stone¹, ¹Rheumatology, Massachusetts General Hospital, Boston, MA, ²Pathology, Massachusetts General Hospital, Boston, MA
Background/Purpose: Granulomatosis with polyangiitis (GPA) and IgG4-related disease (IgG4-RD) are both immune-mediated conditions that can involve multiple organ systems. In GPA, IgG4-positive plasma cell infiltration…
Abstract Number: 1535 • 2012 ACR/ARHP Annual Meeting
Genetic Background of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in a Japanese Population: Association of STAT4 with Myeloperoxidase Antineutrophil Cytoplasmic Antibody-Positive Vasculitis
Aya Kawasaki¹, Naoya Inoue¹, Chihiro Ajimi¹, Ikue Ito¹, Ken-ei Sada², Shigeto Kobayashi³, Hidehiro Yamada⁴, Hiroshi Furukawa⁵, Makoto Tomita⁶, Takayuki Sumida⁷, Shigeto Tohma⁸, Nobuyuki Miyasaka⁹, Shoichi Ozaki⁴, Hiroshi Hashimoto¹⁰, Hiroshi Makino², Masayoshi Harigai¹¹ and Naoyuki Tsuchiya¹, ¹Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ²Department of Medicine and Clinical Science, Okayama University, Okayama, Japan, ³Department of Internal Medicine, Juntendo University Koshigaya Hospital, Tokyo, Japan, ⁴Internal Medicine, St. Marianna University, Kawasaki, Japan, ⁵Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan, ⁶Clinical Research Center, Tokyo Medical and Dental University, Tokyo, Japan, ⁷Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ⁸Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, National Hospital Organization, Sagamihara, Japan, ⁹Department of Medicine and Rheumatology and Global Center of Excellence Program, Tokyo Medical and Dental University, Tokyo, Japan, ¹⁰Juntendo University School of Medicine, Tokyo, Japan, ¹¹Dept of Pharmacovigilance, Tokyo Medical and Dental University, Tokyo, Japan
Background/Purpose: In antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), geographic difference in the type of vasculitis is well known. While granulomatosis with polyangiitis (GPA) is the…
Abstract Number: 1536 • 2012 ACR/ARHP Annual Meeting
Clinical Features of Patients with Anti-Neutrophil Cytoplasmic Autoantibodies Targeting Native Myeloperoxidase Antigen
Yuji Yamanishi¹, Toshiko Ito-Ihara², Shigeto Kobayashi³, Peter Y. Shane⁴, Gary S. Firestein⁵, Hiroshi Hashimoto⁶ and Kazuo Suzuki⁷, ¹Division of Rheumatology, Hiroshima Rheumatology Clinic, Hiroshima, Japan, ²Department of Clinical Innovative Medicine, Translational Research Center, Kyoto University Hospital, Kyoto, Japan, ³Department of Internal Medicine, Juntendo University Koshigaya Hospital, Tokyo, Japan, ⁴Tokyo Medical and Dental University, Tokyo, Japan, ⁵Div of Rheumatology, UCSD School of Medicine, La Jolla, CA, ⁶Juntendo Tokyo Koto Geriatric Center, Tokyo, Japan, ⁷National Institute of Infectious Diseases, Tokyo, Japan
Background/Purpose: ANCA is a useful diagnostic marker in systemic vasculitic disorders with small-vessel involvement, but depending on the particular test used the myeloperoxidase (MPO)-ANCA results…
Abstract Number: 1497 • 2012 ACR/ARHP Annual Meeting
Activation of Sirt1 Attenuates Bleomycin Induced Scleroderma Through Inhibiting Mammalian Target of Rapamycin Activation
Xiaoxia Zhu¹, Jianhua Qiu², Qiong Liu³, Minrui Liang⁴ and Hejian Zou⁵, ¹Rheumatology, Huashan Hospital, Fudan University, Shanghai, China, ²Neuroscience Center, Massachusetts General Hospital, Harvard Medical School, Massachusetts, USA, Boston, MA, ³Institute of Rheumatology, Immunology and Allergy,Shanghai Medical College, Fudan University, Shanghai, China, ⁴Department of Rheumatology, Huashan Hospital,Fudan University,Shanghai, Shanghai, China, ⁵Rheumatology, Huashan Hospital, Shanghai, China
Background/Purpose: Scleroderma is an autoimmune disease, characterized by progressive fibrosis of skin and internal organs. Inflammation is one of the main manifestations of scleroderma, especially…
Abstract Number: 1498 • 2012 ACR/ARHP Annual Meeting
Wisp-1 Neutralization Reduces Gvhd-Induced Skin Fibrosis by Altering TSLP-OX40L Axis-Dependent Th2 Responses
Raphael Lemaire, Tim Burwell, Rachel Griffin, Julie Bakken, Joseph Madary, Lynne Murray, Ronald Herbst and Jane Connor, Research, MedImmune LLC, Gaithersburg, MD
Background/Purpose: There is accumulating evidence for a role of Wnt-signaling pathway activation in connective tissue disorders, including dermal and lung fibrosis. In particular, expression of…
Abstract Number: 1499 • 2012 ACR/ARHP Annual Meeting
The Soluble Guanylate Cyclase Mediates Its Anti-Fibrotic Effects by Inhibiting TGF-β Signaling
Christian Beyer¹, Sonia C. Schindler², Alfiya Distler³, Clara Dees⁴, Helena Reichert², Hümeyra Akan², Peter Sandner⁵, Oliver Distler⁶, Georg Schett⁷ and Joerg HW Distler³, ¹Department of Internal Medicine 3, Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ³Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁵Bayer Health Care, Global Drug Discovery – Common Mechanism Research, Bayer Health Care, Global Drug Discovery – Common Mechanism Research, Wuppertal, Germany, ⁶Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁷Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: We have recently demonstrated that stimulation of the soluble guanylate cyclase (sGC) has potent anti-fibrotic activity in different models of fibrosis. sGC stimulation increases…

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