Abstracts Archive - Page 2491 of 2607 - ACR Meeting Abstracts

Abstract Number: 1680 • 2012 ACR/ARHP Annual Meeting
Diagnostic Value of the Assessment of Spondyloarthropathy International Society (ASAS) Criteria for Children with Enthesitis Related Arthritis (ERA): A Single Center Study of 124 Patients
Mehul Jariwala¹, Manjari Agarwal¹ and Sujata Sawhney², ¹Institute of Child Health, Sir Ganga Ram Hospital, New Delhi, India, ²Paediatric rheumatology, Sir Ganga Ram Hospital, New Delhi, India
Background/Purpose: Enthesitis Related Arthritis (ERA) is a common subtype (36%) of Juvenile Idiopathic Arthritis (JIA) seen in India 1. These criteria do not distinguish between…
Abstract Number: 1681 • 2012 ACR/ARHP Annual Meeting
Increased Arterial Stiffness in Juvenile Idiopathic Arthritis (JIA) Patients Compared with Matched Controls – a Pilot Study
Hanne Aulie¹, Mette-Elise Estensen², Anne Marit Selvaag¹, Patrick Segers³, Oyvind Molberg⁴, Vibke Lilleby¹, Svend Aakhus² and Berit Flatø⁴, ¹Department of Rheumatology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, ²Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, ³IBiTech-bioMMeda, Ghent University, Ghent, Belgium, ⁴Department of Rheumatology, Oslo University hospital, Rikshospitalet, Oslo, Norway
Background/Purpose: Systemic arterial properties in adult patients with JIA are not well described. The aim of this study was to evaluate arterial properties in young…
Abstract Number: 1682 • 2012 ACR/ARHP Annual Meeting
Sustained Clinical Remission (Disease Activity Score 28 <2.6) Protects for Cardiovascular Disease in Rheumatoid Arthritis Patients
Elke.E.A. Arts¹, Jaap Fransen², Alfons A. den Broeder³, Calin Popa¹ and Piet L.C.M. van Riel¹, ¹Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ³Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands
Background/Purpose: Chronic inflammation appears to be an independent risk factor for CVD in rheumatoid arthritis (RA), but there is no clear difference in CVD risk…
Abstract Number: 1683 • 2012 ACR/ARHP Annual Meeting
Associations Between Lipid and Rheumatoid Arthritis Genetic Factors, and Low Density Lipoprotein Levels in RA Patients
Katherine P. Liao¹, Dorothee Diogo², Tianxi Cai³, Jing Cui⁴, Raul N. Guzman P.⁵, Vivian Gainer⁵, Shawn N. Murphy⁵, Susanne Churchill⁶, Isaac Kohane⁷, Elizabeth W. Karlson¹ and Robert M. Plenge⁸, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ³Biostatistics, Harvard School of Public Health, Boston, MA, ⁴Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁵Research Computing, Partners Healthcare Systems, Boston, MA, ⁶Information Systems, Partners Healthcare Systems, Boston, MA, ⁷Medicine, Brigham and Women's Hospital, Boston, MA, ⁸Division of Rheumatology, Immunology and Allergy and Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
Associations between lipid and rheumatoid arthritis genetic factors, and low density lipoprotein levels in RA patientsBackground/Purpose: In epidemiologic studies, low density lipoprotein (LDL), a major…
Abstract Number: 1684 • 2012 ACR/ARHP Annual Meeting
Increased Risk of Major Cardiovascular Events in a Nationwide Cohort of Rheumatoid Arthritis Patients Treated with Biological Agents
Signe Abitz Winther¹, Peter Riis Hansen¹, Søren Lund Kristensen¹, Lene Dreyer², Ole Ahlehoff¹, Louise Linde³, Christian Torp-Pedersen¹ and Jesper Lindhardsen¹, ¹Department of Cardiology, Copenhagen University Hospital Gentofte, Hellerup, Denmark, ²Internal Medicine - Rheumatology Section, Copenhagen University Hospital at Gentofte, Copenhagen, Denmark, ³Internal Medicine - Rheumatology Section, Copenhagen University Hospital Gentofte, Hellerup, Denmark
Background/Purpose: Patients with rheumatoid arthritis (RA) are at increased risk of cardiovascular disease, but in contrast to the well-established risk of myocardial infarction (MI), the…
Abstract Number: 1685 • 2012 ACR/ARHP Annual Meeting
Differential Impact of Cardiac Risk Factors On Coronary Plaque Presence and Features in Asymptomatic Patients with Rheumatoid Arthritis Compared to Controls
George A. Karpouzas¹, Jennifer Malpeso², Tae-Young Choi², Silvia Munoz¹ and Matthew Budoff², ¹Rheumatology, Harbor-UCLA, Torrance, CA, ²Cardiology, Harbor-UCLA Medical Center, Torrance, CA
Background/Purpose: Traditional cardiac risk factors (CRFs) associate with myocardial infarction (MI) risk in both Rheumatoid arthritis (RA) and the general population. Subclinical atherogenesis has been…
Abstract Number: 1686 • 2012 ACR/ARHP Annual Meeting
Vertebral Fracture Assessment-Detected Abdominal Aortic Calcification Enhances Cardiovascular Disease Risk Stratification of Rheumatoid Arthritis Patients
Ausaf Mohammad¹, Derek Lohan², Diane Bergin², Sarah Mooney², John Newell³, Martin O'Donnell⁴, Robert J. Coughlan¹ and John J. Carey¹, ¹Rheumatology, Galway University Hospitals, Galway, Ireland, ²Radiology, Galway University Hospitals, Galway, Ireland, ³Clinical Research Facility, National University of Ireland, Galway, Ireland, ⁴Clinical Research Facility, Galway University Hospitals, Galway, Ireland
Vertebral Fracture Assessment-detected Abdominal Aortic Calcification Enhances Cardiovascular Disease Risk Stratification of Rheumatoid Arthritis Patients Background/Purpose: Osteoporosis and cardiovascular disease (CVD) are major comorbidities and CVD…
Abstract Number: 1687 • 2012 ACR/ARHP Annual Meeting
The Risk of Atrial Fibrillation in Patients with Rheumatoid Arthritis Compared to the General Population: A Large Cohort Study
Seoyoung C. Kim¹, Jun Liu² and Daniel H. Solomon³, ¹Div. of Pharmacoepidemiology and Pharmacoeconomics, Div. of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ²Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Harvard Medical School, Boston, Boston, MA, ³Division of Rheumatology, Brigham and Women's Hospital, Boston, MA
Background/Purpose: It is well-known that rheumatoid arthritis (RA) is associated with cardiovascular disease such as myocardial infarction. However, little evidence exists on the risk of…
Abstract Number: 1688 • 2012 ACR/ARHP Annual Meeting
Evolution of Preclinical Autoimmunity in Individuals At Risk for Development of Rheumatoid Arthritis
Hani S. El-Gabalawy¹, David B. Robinson¹, Irene Smolik¹, Donna M. Hart¹, Elizabeth D. Ferucci², Marianna M. Newkirk³, Marvin J. Fritzler⁴, Catriona Cramb⁵, Jeremy Sokolove⁶ and William H. Robinson⁷, ¹Arthritis Centre, University of Manitoba, Winnipeg, MB, Canada, ²Division of Community Health Services, Alaska Native Tribal Health Consortium, Anchorage, AK, ³Medicine, McGill University Health Centr, Montreal, QC, Canada, ⁴Medicine, University of Calgary, Calgary, AB, Canada, ⁵CCSR 4135 Immunology Rheumatol, Stanford University, Palo Alto, CA, ⁶Medicine, Stanford University, Palo Alto, CA, ⁷Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Rheumatoid arthritis (RA) is prevalent, severe, and predominantly seropositive in many North American Native (NAN) populations. We have shown a strong tendency towards familial…
Abstract Number: 1689 • 2012 ACR/ARHP Annual Meeting
Anti-Peptidylarginine Deiminase 3/4 Cross-Reactive Antibodies: A Novel Biomarker with Clinical and Mechanistic Implications in Rheumatoid Arthritis
Erika Darrah¹, Jon T. Giles², Herbert Bull³, Felipe Andrade⁴ and Antony Rosen¹, ¹Division of Rheumatology, Johns Hopkins University, Baltimore, MD, ²Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ³Consultant, Westfield, NJ, ⁴Division of Rheumatology, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Peptidylarginine deiminases (PADs) have emerged as key participants in the pathogenesis of rheumatoid arthritis (RA) due to their expression in inflamed RA synovium and…
Abstract Number: 1690 • 2012 ACR/ARHP Annual Meeting
Citrullination within the Atherosclerotic Plaque: A New Potential Target for Anti-Citrullinated Protein Antibodies
Jeremy Sokolove¹, Orr Share¹, Matthew Brennan¹, Lauren J. Lahey¹, Amy H. Kao², Eswar Krishnan³, Mary Chester M. Wasko⁴ and William H. Robinson⁵, ¹Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ²Lupus Center of Excellence, Allegheny Singer Research Institute, Pittsburgh, PA, ³Medicine, Standford University, Palo Alto, CA, ⁴West Penn Allegheny Health System, Temple University School of Medicine, Pittsburgh, PA, ⁵Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Patients with rheumatoid arthritis (RA) are at increased risk for cardiovascular disease due to accelerated atherosclerosis. This risk has mainly been limited to seropositive…
Abstract Number: 1691 • 2012 ACR/ARHP Annual Meeting
Early Signs of Subclinical Inflammation and Local Antibody Production in Early Rheumatoid Lungs
Gudrun Reynisdottir¹, Reza Karimi², Jimmy Ytterberg³, Vijay Joshua¹, Helga Olsen², Aase Haj Hensvold¹, Anders Harju⁴, Johan Grunewald², Sven Nyren⁵, Anders Eklund², Lars Klareskog⁶, Roman Zubarev⁷, Magnus Skold² and Anca Catrina¹, ¹Department of Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ²Department of Medicine, Division of Respiratory Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ³Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁴Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ⁵Radiology, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, Stockholm, Sweden, ⁶Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden, ⁷Karolinska Institutet, Stockholm, Sweden
Background/Purpose: The aims of the current study was to investigate if inflammatory lung changes are present in RA patients early in the disease process and…
Abstract Number: 1692 • 2012 ACR/ARHP Annual Meeting
Lung Microbiome Differs in Subjects with Rheumatoid Arthritis-Related Autoimmunity without Inflammatory Arthritis Compared to Healthy Seronegative Controls
M. Kristen Demoruelle¹, Jill M. Norris², V. Michael Holers³, Kevin D. Deane¹ and J. Kirk Harris⁴, ¹Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ²Epidemiology, Colorado School of Public Health, Aurora, CO, ³Rheumatology Division, University of Colorado School of Medicine, Aurora, CO, ⁴University of Colorado Anschutz Medical Campus, Aurora, CO
Background/Purpose: Emerging data suggest that microorganisms and mucosal inflammation may play a role in the etiology of rheumatoid arthritis (RA). Furthermore, our published findings…
Abstract Number: 1693 • 2012 ACR/ARHP Annual Meeting
Oncogenic Activation of MAPK in Rheumatoid Arthritis Synovial Fibroblasts
Niloofar L. Farmani¹, Keith K. Colburn², Grace Chan³, Erica Li³, Emil Heinze⁴, Antonia Rubell³, Robert Nishimura⁵ and Richard H. Weisbart³, ¹Medicine, Olive View-UCLA Medical Center, Sylmar, CA, ²Dept Med - Rheum Sect, Loma Linda Univ Medical Center, Loma Linda, CA, ³Research, VAGLAHS, Sepulveda, CA, ⁴Rheumatology, Olive View-UCLA Medical Center, Sylmar, CA, ⁵Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA
Background/Purpose: Transformed synovial fibroblasts (SF) mediate joint-specific damage in rheumatoid arthritis (RA) by expressing integrins and metalloproteinase that promote adhesion to and invasion of cartilage.…
Abstract Number: 1694 • 2012 ACR/ARHP Annual Meeting
Infection Risk in Patients with Low Immunoglobulins Following Rituximab Treatment in Rheumatoid Arthritis
Ronald F. van Vollenhoven¹, Gregg J. Silverman², Clifton O. Bingham III³, Patrick Durez⁴, Patrica B. Lehane⁵, Nicola Tyson⁵ and Elena Fisheleva⁵, ¹Karolinska University Hospital, Stockholm, Sweden, ²Medical and Pathology, NYU School of Medicine, New York, NY, ³Department of Medicine, Johns Hopkins University, Baltimore, MD, ⁴University Hospital St Luc, UCL, Brussels, Belgium, ⁵Roche Products Limited, Welwyn Garden City, United Kingdom
Background/Purpose: This study analyzed infection rates in patients (pts) with low immunoglobulin (Ig) serum concentrations following rituximab (RTX) treatment in RA clinical trials. Methods: Pooled…

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