Abstract Number: 1766 • 2012 ACR/ARHP Annual Meeting
Synovial Gene Expression and Response to Rituximab: Preliminary Data
Background/Purpose: Quality and duration of response to rituximab in rheumatoid arthritis have not been completely explained. In the synovium, three studies have indicated a relationship…Abstract Number: 1767 • 2012 ACR/ARHP Annual Meeting
Circulating Plasmablasts As a Source of Anti-Citrullinated Protein Antibodies in Patients with Rheumatoid Arthritis
Background/Purpose: Anti citrullinated protein antibodies (ACPA) are highly specific for rheumatoid arthritis (RA) and predict disease onset and severity. Accumulating evidence indicates that ACPA could…Abstract Number: 1768 • 2012 ACR/ARHP Annual Meeting
The Absolute Concentration of Anti Citrullinated Protein Antibodies in Serum and Synovial Fluid in Relation to Total Immunoglobulin-Concentrations
Background/Purpose: The presence of anti-citrullinated protein antibodies (ACPA) is one of the most predictive factors for the development of rheumatoid arthritis (RA). Nonetheless, relatively little…Abstract Number: 1769 • 2012 ACR/ARHP Annual Meeting
Affinity Purification and Characterisation of Anti-CCP Antibodies From Plasma and Synovial Fluids of Patients with Rheumatoid Arthritis
Background/Purpose: Autoimmunity in rheumatoid arthritis (RA) is characterized by autoantibodies to citrullinated proteins/peptides (ACPA). These antibodies (present in 60-70% of patients) antedate clinical onset and…Abstract Number: 1770 • 2012 ACR/ARHP Annual Meeting
Recognition of Citrullinated and Carbamylated Proteins by Human Antibodies: Specificity, Cross-Reactivity and the “AMC-Senshu” Method
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) play an important role in the diagnosis and prognosis of Rheumatoid Arthritis (RA). The Anti-Modified Citrulline (AMC) (‘Senshu’) method is…Abstract Number: 1771 • 2012 ACR/ARHP Annual Meeting
Anti Carbamylated Protein Antibodies (Anti-CarP) Are Present in Arthralgia Patients and Predict the Development of Rheumatoid Arthritis
Background/Purpose: Recently, we discovered a new autoantibody system in rheumatoid arthritis (RA): anti carbamylated protein antibodies (anti-CarP). These antibodies have additional prognostic value in predicting…Abstract Number: 1772 • 2012 ACR/ARHP Annual Meeting
Expansion of Autoreactive Unresponsive CD21-/Low B Cells in Sjögren’s Syndrome Associated Lymphoproliferation
Background/Purpose: Primary Sjögren's syndrome (pSS) is the autoimmune disease associated with the higher risk of developing non-Hodgkin lymphoma. Objective: To determine the nature of B…Abstract Number: 1773 • 2012 ACR/ARHP Annual Meeting
Hyperammaglobulinemia in Primary Sjögren’s Syndrome Is Induced by Triggering of TLR7 and 9
Background/Purpose: Multiple B cell aberrances have been linked to primary Sjögren’s syndrome (pSS), including autoantibody production and a skewed B cell differentiation. Further, approximately 50%…Abstract Number: 1774 • 2012 ACR/ARHP Annual Meeting
Identification of Target Antigens of Anti-Endothelial Cell Antibodies in Patients with ANCA-Associated Systemic Vasculitis: A Proteomic Approach
Background/Purpose: Anti-endothelial cell antibodies (AECA) are frequently detected in anti-neutrophil cytoplasm antibodies (ANCA)-associated systemic vasculitis (AAV) and are considered to play pathological roles but their…Abstract Number: 1775 • 2012 ACR/ARHP Annual Meeting
The Phosphoinositide 3-Kinase Pathway Regulates Fibroblast-Like Synoviocyte Invasion
Background/Purpose: Cartilage destruction mediated by invasive fibroblast-like synoviocytes (FLS) plays a central role in pathogenesis of RA. Increased cell migration and degradation of extracellular matrix…Abstract Number: 1776 • 2012 ACR/ARHP Annual Meeting
Anti-SSA/Ro Mediated Injury to the Endothelium Via Urokinase Plasminogen Activator Receptor/Tgfbeta Activation: Implications in the Pathogenesis of Congenital Heart Block
Background/Purpose: One mechanism by which anti-Ro antibodies are linked to the pathogenesis of (cardiac-NL) neonatal lupus is the increased urokinase plasminogen activator (uPA)/urokinase-type plasminogen activator receptor…Abstract Number: 1777 • 2012 ACR/ARHP Annual Meeting
The Bioenergetic Role of HIF-1 and HIF-2 During Angiogenesis of Human Microvascular Endothelial Cells
Background/Purpose: Hypoxia and angiogenesis are features of inflamed and injured tissues. The transcription factors Hypoxia inducible factor (HIF)-1 and (HIF)-2 control cellular metabolic response to…Abstract Number: 1737 • 2012 ACR/ARHP Annual Meeting
Diffuse Alveolar Hemorrhage Caused by Primary Antiphospholipid Syndrome
Background/Purpose: Diffuse alveolar hemorrhage (DAH) is an uncommon but severe complication of primary antiphospholipid syndrome (APS). The available literature is limited to very few case…Abstract Number: 1738 • 2012 ACR/ARHP Annual Meeting
Myocardial Dysfunction and Valvulopathy Worsens with Time in Patients with Antiphospholipid Syndrome: A 10-Year Follow-up Study
Background/Purpose: Valvular disease represents the most common cardiac manifestation among patients with antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) positive for antiphospholipid antibodies (aPL).…Abstract Number: 1740 • 2012 ACR/ARHP Annual Meeting
Impairment of Quality of Life in Patients with Antiphospholipid Syndrome
Background/Purpose : Quality of life (QoL) is an important outcome in clinical care especially in patients with chronic disease such as systemic lupus erythematosus (SLE).…
ACR Meeting Abstracts