Abstracts Archive - Page 2474 of 2607 - ACR Meeting Abstracts

Abstract Number: 1947 • 2012 ACR/ARHP Annual Meeting
Muscle Wasting in HTNFtg Mice, an Animal Model for Rheumatoid Arthritis, Due to Increased Cathepsin L and LC3B Expression
Martin Willburger¹, Birgit Niederreiter¹, Ewald Unger², Josef S. Smolen³, Kurt Redlich¹ and Silvia Hayer¹, ¹Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Center for Medical Physics and Biomedicla Engineering, Medical University of Vienna, Vienna, Austria, ³Division of Rheumatology, Department of Internal Medicine III,, Medical University of Vienna and Hietzing Hospital, Vienna, Austria
Background/Purpose: To investigate the impact of systemic inflammation on skeletal muscles in human tumor necrosis factor transgenic (hTNFtg) animals. Methods: We isolated triceps surae, quadriceps,…
Abstract Number: 1948 • 2012 ACR/ARHP Annual Meeting
Decreased C4A Gene Copy Numbers in Children with Juvenile Dermatomyositis: Association with Decreased C4 Protein and Lower Absolute Number of CD3 Negative CD16/56+ Natural Killer Cells
Lauren M. Pachman¹, Katherine E. Lintner², Yee Ling Wu², Lori J. Ferguson³, Gabrielle A. Morgan⁴, Chiang-Ching Huang⁵ and C. Yung Yu⁶, ¹Division of Pediatric Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH, ³Children's Hospital of Chicago Research Center, Cure JM Myositis Center, Chicago, IL, ⁴Cure JM Myositis Center, Ann & Robert H. Lurie Children's Hospital of Chicago Research Center, Chicago, IL, ⁵Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH
Background/Purpose: Juvenile Dermatomyositis (JDM), a systemic vasculopathy, is member of the family of autoimmune diseases. In 56% of untreated JDM, a decrease in the absolute…
Abstract Number: 1949 • 2012 ACR/ARHP Annual Meeting
Anti-Transcription Intermediary Factor 1-Gamma (TIF1-Υ) Autoantibody ELISA Development and Validation
Rohit Aggarwal¹, Chester V. Oddis², Noreen Fertig³, Danielle Goudeau⁴, Diane Koontz⁵, Chad Stephans⁶, Zengbiao Qi⁷ and Marc C. Levesque⁴, ¹Medicine / Rheumatology, University of Pittsburgh, Pittsburgh, PA, ²Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ³University of Pittsburgh, Pittsburgh, PA, ⁴Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁵Department of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁶Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁷Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Anti-transcription intermediary factor 1-gamma (TIF1-g) autoantibody is disease-specific for myositis and identifies a subset of dermatomyositis patients at risk of cancer. Currently non-quantitative immunoprecipitation…
Abstract Number: 1950 • 2012 ACR/ARHP Annual Meeting
Anti-Signal Recognition Particle Autoantibody ELISA Development and Validation: Utility in Patients with Necrotizing Myopathy
Rohit Aggarwal¹, Chester V. Oddis², Danielle Goudeau³, Chad Stephans⁴, Noreen Fertig⁵, Qi Zengbiao⁶, Diane Koontz⁶ and Marc C. Levesque³, ¹Rheumtology, University of Pittsburgh, Pittsburgh, PA, ²Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ³Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁴Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁵University of Pittsburgh, Pittsburgh, PA, ⁶Department of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Anti-signal recognition particle (SRP) autoAb identifies a myositis subset with a necrotizing myopathy and poor prognosis. Currently, immunoprecipitation (IP) is used to identify anti-SRP.…
Abstract Number: 1951 • 2012 ACR/ARHP Annual Meeting
Elevated Level of Tumor Necrosis Factor-Like Weak Inducer of Apoptosis in Patients with Polymyositis or Dermatomyositis
Qinglin Peng, Xin Lu, Ning Zu, Lu Zhang and Guochun Wang, Department of Rheumatology, China-Japan Friendship Hospital, Beijing, China
Background/Purpose: TNF-like weak inducer of apoptosis (TWEAK), a member of the tumor necrosis factor (TNF) family, has emerged as a cytokine that regulates multiple cellular…
Abstract Number: 1952 • 2012 ACR/ARHP Annual Meeting
The Effect of CXCL10 Blockade in C Protein-Induced Myositis
Jinhyun Kim¹, Jiyong Choi², Sung Hae Chang³, Ki Chul Shin⁴, Sung-Hye Park⁵, Hye Won Kim⁶, Hye Jin Oh⁴, Myeong Jae Yoon⁷, Bong Seung Ku⁸, Eun Young Lee⁶, Eun Bong Lee³, Hiroshi Kawachi⁹, Hitoshi Kohsaka¹⁰ and Yeong Wook Song¹¹, ¹Department of Internal medicine, Chungnam National University School of Medicine, Daejeon, South Korea, ²Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, ⁴Rheumatology, Seoul National University College of Medicine, Seoul, South Korea, ⁵Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea, ⁶Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, ⁷Department of Internal Medicine, School of Medicine, Seoul National University, Seoul, South Korea, ⁸Rheumatology, Department of Internal Medicine, School of Medicine, Seoul National University Hospital, Seoul, Korea, Seoul, South Korea, ⁹Department of Cell Biology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, ¹⁰Department of Medicine and Rheumatology, Tokyo Medical and Dental University, Tokyo, Japan, ¹¹Division of Rheumatology, Department of Internal Medicine, Seoul National University, Seoul, South Korea
Background/Purpose: CXCL10 (also called interferon-γ-inducible protein 10 [IP-10]) is a chemokine that plays a critical role in the infiltration of T cell in autoimmune disease…
Abstract Number: 1953 • 2012 ACR/ARHP Annual Meeting
Antibodies to NXP-2 and Transcriptional Intermediary Factor-Gamma Identify Patients with Cancer-Associated Dermatomyositis
David Fiorentino¹, Lisa Christopher-Stine², Lorinda Chung³, Bharathi Lingala⁴, Andrew L. Mammen⁵, Antony Rosen⁶ and Livia Casciola-Rosen⁶, ¹Dermatology, Stanford University School of Medicine, Redwood City, CA, ²Medicine and Neurology, Johns Hopkins University, Baltimore, MD, ³Rheumatology, Stanford Univ Medical Center, Palo Alto, CA, ⁴Dermatology, Stanford University, Redwood City, CA, ⁵NIAMS, NIH, Bethesda, MD, ⁶Division of Rheumatology, Johns Hopkins University, Baltimore, MD
Background/Purpose: Dermatomyositis (DM) is known to be associated with internal malignancy, and identifying patients at high risk is a high priority. Recently, several groups have…
Abstract Number: 1954 • 2012 ACR/ARHP Annual Meeting
Immune Responses to NXP-2 and TIF-g Are Associated with Distinct Clinical Phenotypes and Prognosis for Skin Disease in Dermatomyositis Patients
David Fiorentino¹, Lorinda Chung², Lisa Zaba¹, Bharathi Lingala³, Antony Rosen⁴ and Livia Casciola-Rosen⁴, ¹Dermatology, Stanford University School of Medicine, Redwood City, CA, ²Rheumatology, Stanford Univ Medical Center, Palo Alto, CA, ³Dermatology, Stanford University, Redwood City, CA, ⁴Division of Rheumatology, Johns Hopkins University, Baltimore, MD
Background/Purpose: Myositis-specific antibodies have been proposed as tools for disease classification as they are correlated with certain clinical and genetic features. Recently, two new DM-specific…
Abstract Number: 1955 • 2012 ACR/ARHP Annual Meeting
Is the Pattern of Capillary Deposition of Complement Membrane Attack COPMLEX Useful in the Differential Diagnosis of Inflammatory?
Patrick Gordon¹, Nuria Villagra², Istvan Bodi², Andrew King², Stefan Buk², Tibor Hortobagyi² and Safa Al-Sarraj², ¹Department of Rheumatology, King's College London, London, United Kingdom, ²Department of Clinical Neuropathology, King's College Hospital, London, United Kingdom
Background/Purpose: Inflammatory myopathies are a heterogeneous group of diseases. We investigated if the location and pattern of deposition of complement membrane attack complex (MAC) can…
Abstract Number: 1956 • 2012 ACR/ARHP Annual Meeting
A New Linked Set of Autoantibodies in Dermatomyositis: Anti-Mi-2 and Anti-Transcription Intermediary Factor (TIF) 1alpha
Minoru Satoh¹, Jason YF Chan¹, Yi Li¹, Monica Vázquez-Del Mercado², Marcelo Petri³, Luis J. Jara⁴, Miguel A. Saavedra⁵, Claudia Cruz-Reyes⁶, Eric S. Sobel⁷, Westley H. Reeves⁸, Angela Ceribelli⁹ and Edward K.L. Chan⁹, ¹Medicine, University of Florida, Gainesville, FL, ²Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Hospital Civil JIM, Universidad de Guadalajara, Guadalajara, Jalisco, México, Mexico, ³Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Universidad de Guadalajara, Guadalajara, Mexico, ⁴Research and Education, Hospital de Especialidades Centro Medico La Raza, México City, Mexico, ⁵Centro Medico La Raza Instituto Mexicano del Seguro Social Mexico D.F., México D.F., Mexico, ⁶Centro Medico La Raza Instituto Mexicano del Seguro Social Mexico D.F., Mexico D. F., Mexico, ⁷Medicine/Div of Rheumatology, University of Florida, Gainesville, FL, ⁸Rheumatology & Clinical Imm, University of Florida, Gainesville, FL, ⁹Oral Biology, University of Florida, Gainesville, FL
Background/Purpose: Myositis specific autoantibodies (MSA) produced in patients with polymyositis/dermatomyositis (PM/DM) are clinically useful biomarkers in diagnosis and management. Anti-Mi-2 antibodies that recognize nucleosome remodeling…
Abstract Number: 1957 • 2012 ACR/ARHP Annual Meeting
Prevalence and Associated Factors of Vitamin D Insufficiency and Deficiency in 4,793 Japanese Patients with Rheumatoid Arthritis
Takefumi Furuya¹, Takayuki Hosoi², Eiichi Tanaka³, Ayako Nakajima⁴, Atsuo Taniguchi⁵, Shigeki Momohara¹ and Hisashi Yamanaka¹, ¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Department of Clinical Research and Development, National Center for Geriatrics and Gerontology, Aichi, Japan, ³Tokyo Women's Medical University, Tokyo, Japan, ⁴Rheumatology, Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan, ⁵Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan
Background/Purpose: Vitamin D (25[OH]D) insufficiency and deficiency is reported to be common in patients with rheumatoid arthritis (RA) and is associated with increased disease activity…
Abstract Number: 1958 • 2012 ACR/ARHP Annual Meeting
Bone Mineral Density in Lupus Erythematosus Women One Year After Rituximab Therapy
Claudia Mendoza-Pinto¹, Mario Garcia-Carrasco¹, Mario Jiménez-Hernández¹, Alma Rodríguez-Gallegos², Socorro Méndez-Martínez¹ and Aurelio Lopez-Colombo³, ¹Systemic Autoimmune Disease, HGR 36 CMN Manuel Ávila Camacho, Instituto Mexicano del Seguro Social, Puebla, Mexico, ²Laboratorios Clínicos de Puebla, Puebla, Mexico, ³Research Departament, Delegación Estatal, Instituto Mexicano del Seguro Social, Puebla, Mexico
Background/Purpose: Low bone mineral density (BMD) and osteoporosis may be significant complications in patients with systemic lupus erythematosus (SLE). Recent studies have shown that biologic therapy could…
Abstract Number: 1919 • 2012 ACR/ARHP Annual Meeting
Regulatory T Cells in IgG4-Related Disease Patients Presenting with Sclerosing Sialadenitis and Dacryoadenitis
Winnie K. Pang¹, Ya Liu², Julie Wang², Song Guo Zheng², Kiran Qidwai³, Russell K. Brynes³ and Francisco P. Quismorio Jr.¹, ¹Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA, ²Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, ³Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA
Background/Purpose: IgG4-Related Disease (IgG4-RD) is characterized by inflammation and fibrosis of various organ systems. Its diverse clinical presentations include autoimmune pancreatitis, retroperitoneal fibrosis, sialadenitis, and…
Abstract Number: 1920 • 2012 ACR/ARHP Annual Meeting
Spectrum of IgG4-Related Disease and Diagnostic Value of Serum IgG4 Determinations
Emma Kotisalmi¹, Tom Pettersson², Aaro Miettinen³, Johanna Arola⁴ and Martti Färkkilä⁵, ¹Department of Medicine, University of Helsinki, Helsinki, Finland, ²Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland, ³Department of Immunology, Huslab, Helsinki, Finland, ⁴Department of Pathology, University of Helsinki and Huslab, Helsinki, Finland, ⁵Department of Gastroenterology, Helsinki University Central Hospital, Helsinki, Finland
Background/Purpose: IgG4-related disease is a recently described systemic inflammatory and fibrosing condition that may mimic various other systemic rheumatic diseases. We studied the occurrence of…
Abstract Number: 1921 • 2012 ACR/ARHP Annual Meeting
Diagnostic Utility of Serum IgG4 in IgG4-Related Disease
Mollie Carruthers¹, Tamara Augustin², John H. Stone¹ and Arezou Khosroshahi¹, ¹Rheumatology, Massachusetts General Hospital, Boston, MA, ²Internal Medicine, Internal Medicine, Northshore Medical Center, Salem, MA
Background/Purpose: IgG4-related disease (IgG4-RD) is a recently recognized fibro-inflammatory disease with multi-organ system involvement, often but not always characterized by elevated serum IgG4 concentrations. The…

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