Abstracts Archive - Page 2473 of 2607 - ACR Meeting Abstracts

Abstract Number: 1972 • 2012 ACR/ARHP Annual Meeting
Assessment of Fracture Risk in Postmenopausal Women with Rheumatoid Arthritis
Sina Esmaeilzadeh, Nurten Eskiyurt, Ekin Sen and Merih Akpinar, Physical Medicine and Rehabilitation, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
Background/Purpose: The aim of this study is to determine the risk of osteoporotic fracture in postmenopausal women with rheumatoid arthritis (RA) and to examine the…
Abstract Number: 1973 • 2012 ACR/ARHP Annual Meeting
Effect of Adalimumab On the Serum Level of Undercarboxylated Osteocalcin (ucOC), Bone Biochemical Markers and Bone Mineral Density
Yoshitada Sakai¹, Akira Hashiramoto², Takaichi Okano², Yoshiko Kawasaki³, Nao Shibanuma⁴ and Masahiro Kurosaka⁵, ¹The Center of Rheumatic Diseases/ Division of Rehabilitation Medicine, Kobe University Hospital, Kobe, Japan, ²The Center for Rheumatic Diseases,, Kobe University Hospital, Kobe, Japan, ³The Center of Rheumatic Diseases, Kobe University Hospital, Kobe, Japan, ⁴The Center for Rheumatic Diseases, Kobe University Hospital / Departmant of Orthopaedic Surgery, Kobe Kaisei Hospital, Kobe, Japan, ⁵Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
Background/Purpose: The osteoporotic fracture in patients with rheumatiod arthritis (RA) is caused by systemic osteoporosis as well as periarticular osteoporosis, On the other hand, the…
Abstract Number: 1974 • 2012 ACR/ARHP Annual Meeting
Incidence of Atypical Femur Fractures Associated with Bisphosphonate Use for Osteoporosis: A Systematic Review of the Literature
John N. Mecchella¹, John A. Batsis², Robin J. Larson³ and Gautham Suresh⁴, ¹Rheumatology, Dartmouth Hitchcock Medical Center, Lebanon, NH, ²General Internal Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, ³The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, NH, ⁴Neonatology, Pediatrics, Dartmouth Hitchcock Medical Center, Lebanon, NH
Background/Purpose: Reports of a link between bisphosphonate use in patients with osteoporosis and atypical femoral fractures--those occurring in subtrochanteric or diaphyseal locations--have generated significant concern…
Abstract Number: 1975 • 2012 ACR/ARHP Annual Meeting
Mortality After Fragility Hip Fracture in Middle Aged and Elderly Men and Women in Southern Norway
Andreas P. Diamantopoulos¹, Mari Hoff², Marc C. Hochberg³ and Glenn Haugeberg¹, ¹Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway, ²Rheumatology, St Olavs Hospital, Trondheim, Norway, ³Department of Medicine, University of Maryland, Baltimore, MD
Background/Purpose: The mortality of the fragility hip fracture patients has been reported to be higher compared to the general population for both men and women,…
Abstract Number: 1976 • 2012 ACR/ARHP Annual Meeting
Treatment Satisfaction in Postmenopausal Women Previously Treated with Bisphosphonates Who Transitioned to Denosumab Vs Ibandronate Therapy in an Open-Label Study
Santiago Palacios¹, Giovanni Iolascon², Irene Agodoa³, Hema Viswanathan³, Prayashi Ghelani⁴, Irene Ferreira⁵, Cynthia O'Malley⁶, Rachel B. Wagman⁷ and Sydney Bonnick⁸, ¹Instituto Palacios, Madrid, Spain, ²Seconda Universita di Napoli, Naples, Italy, ³Amgen Inc, Thousand Oaks, CA, ⁴Ovatech Solutions, London, United Kingdom, ⁵Amgen Inc., Cambridge, United Kingdom, ⁶Center for Observational Research, Amgen, Inc., Thousand Oaks, CA, ⁷Amgen Inc., Thousand Oaks, CA, ⁸Clinical Research Center of North Texas, Denton, TX
Background/Purpose: Higher treatment satisfaction is associated with greater persistence with osteoporosis therapy in postmenopausal women (Barrett-Connor OI 2012). Greater satisfaction has been reported with subcutaneous…
Abstract Number: 1977 • 2012 ACR/ARHP Annual Meeting
Relationship Between Baseline Bone Turnover Marker Levels and Bone Mineral Density Changes in Men with Low Bone Mineral Density Receiving Denosumab or Placebo
Eric Orwoll¹, Ugis Gruntmanis², Steven Boonen³, Yu-Ching Yang⁴, Rachel B. Wagman⁴, Jesse W. Hall⁴ and Paul D. Miller⁵, ¹Oregon Health and Science University, Portland, OR, ²Dallas Veterans Affairs Medical Center and University of Texas Southwestern Medical Center, Dallas, TX, ³Leuven University, Leuven, Belgium, ⁴Amgen Inc., Thousand Oaks, CA, ⁵Colorado Center for Bone Research, Lakewood, CO
Background/Purpose: Denosumab, a fully human monoclonal antibody to RANKL, has been shown to increase bone mineral density (BMD) in postmenopausal women with high or low…
Abstract Number: 1978 • 2012 ACR/ARHP Annual Meeting
A Web-Based Intervention Aimed to Improve Bone Health Among Individuals On Chronic Glucocorticoids
Amy H. Warriner¹, Ryan C. Outman², Nathan Markward³, Ronald Aubert³, Jeffrey R. Curtis⁴, Robert Epstein³, Felix Freuh³, Julia McEachern³, David T. Redden⁵, Monika M. Safford², Eric Stanek³, Amy Steinkellner³ and Kenneth G. Saag⁶, ¹Endocrinology, Diabetes, and Metabolism, The University of Alabama at Birmingham, Birmingham, AL, ²Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, ³Medco, Bethesda, MD, ⁴Rheumatology & Immunology, Univ of Alabama-Birmingham, Birmingham, AL, ⁵Biostatistics, University of Alabama at Birmingham, Birmingham, AL, ⁶Div Clinical Immun & Rheum, Univ of Alabama-Birmingham, Birmingham, AL
Background/Purpose: Despite a significant associated fracture risk, previous population-based studies document low osteoporosis treatment rates for individuals treated with chronic glucocorticoids (GCs) at risk for…
Abstract Number: 1939 • 2012 ACR/ARHP Annual Meeting
Overexpression of Ankyrin Repeat Domain Containing Protein 1 Gene (ANKRD1) in Dermatomyositis Muscle Biopsies Is Correlated to Hypoxia and Perifascicular Atrophy
Samuel K. Shinjo¹, Sueli M. Oba-Shinjo², Miyuki Uno³ and Suely K. N. Marie³, ¹Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ³Neurology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: ANKRD1 codes for ankyrin repeat domain containing protein 1, which belongs to the muscle ankyrin repeat protein family involved in a mechano-signaling pathway that…
Abstract Number: 1940 • 2012 ACR/ARHP Annual Meeting
A Comprehensive Study of Novel Serum Markers of ILD Associated with Inflammatory Myopathies
Fang Chen¹, Xiaoming Shu¹, Xin Lu² and Guochun Wang³, ¹China-Japan Friendship Hospital, Beijing, China, ²Rheumatology, China-Japan Friendship Hospital, Beijing, China, ³Department of Rheumatology, China-Japan Friendship Hospital, Beijing, China
Background/Purpose: To investigate and compare the association between serum markers and Interstitial Lung Disease (ILD) in patients with inflammatory myopathies(IIM). Methods: Serum levels of KL-6,…
Abstract Number: 1941 • 2012 ACR/ARHP Annual Meeting
Clinical Evaluation of Anti-Aminoacyl tRNA Synthetase Antibodies in Japanese Patients with Connective Tissue Diseases
Masakazu Matsushita, Toshio Kawamoto, Ken Yamaji, Naoto Tamura and Yoshinari Takasaki, Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Anti-Jo-1 antibody is an autoantibody specifically detected in sera of patients with polymyositis/dermatomyositis (PM/DM). The antigen corresponding to this autoantibody is histidyl-tRNA synthase, being…
Abstract Number: 1942 • 2012 ACR/ARHP Annual Meeting
Increased Levels of Eotaxin and MCP-1 in Juvenile Dermatomyositis Median 17 Years After Diagnosis; Associations with Disease Activity, Duration and Organ Damage
Helga Sanner¹, Thomas Schwartz², Berit Flatø¹, Maria Vistnes², Geir Christensen² and Ivar Sjaastad³, ¹Department of Rheumatology, Oslo University Hospital, Oslo, Norway, ²Institute for Experimental Medical Research, University of Oslo, Oslo, Norway, ³Institute for Experimental Medical Research, Oslo University Hospital, Oslo, Norway
Background/Purpose: Juvenile dermatomyositis (JDM) is a systemic vasculopathic disease of childhood affecting skeletal muscle, skin and other organs. Increased abundance of pro-inflammatory cytokines has been…
Abstract Number: 1943 • 2012 ACR/ARHP Annual Meeting
Autophagy Expressions Were Decreased in Circulating T Cells in Inflammatory Myopathies Patients
Fang Chen¹, Xiaoming Shu², Xin Lu³ and Guochun Wang¹, ¹Department of Rheumatology, China-Japan Friendship Hospital, Beijing, China, ²China-Japan Friendship Hospital, Beijing, China, ³Rheumatology, China-Japan Friendship Hospital, Beijing, China
Background/Purpose: The autophagy in circulating lymphocytes in IIM patients has not been clarified yet. Our research is aimed to study the autophagy in circulating T…
Abstract Number: 1944 • 2012 ACR/ARHP Annual Meeting
Expression of Human Leukocyte Antigen-G in Polymyositis or Dermatomyositis
Xiaolan Tian¹, Xiaoming Shu², Xin Lu¹, Qinglin Peng³ and Guochun Wang⁴, ¹Department of rheumatology, China-Japan Friendship Hospital, Beijing, China, ²Rheumatology, China-Japan Friendship Hospital, Beijing, China, ³Department of Rheumatology,, China-Japan Friendship Hospital, Beijing, China, ⁴Department of Rheumatology, China-Japan Friendship Hospital, Beijing, China
Background/Purpose: Human leukocyte antigen-G is a non-classical MHC--I molecule that may be involved in the pathogenesis of autoimmune diseases, but the significance of HLA-G in…
Abstract Number: 1945 • 2012 ACR/ARHP Annual Meeting
Anti-Transcription Intermediary Factor 1-Gamma (TIF1-Υ) Autoantibody Detection by ELISA and Immunoprecipitation in a Prospective Myositis Cohort: Predictive Value for Cancer Associated Myositis
Rohit Aggarwal¹, Noreen Fertig², Danielle Goudeau³, Chad Stephans⁴, Qi Zengbiao⁵, Diane Koontz⁵, Mary Lucas⁶, Marc C. Levesque³ and Chester V. Oddis⁷, ¹Rheumtology, University of Pittsburgh, Pittsburgh, PA, ²University of Pittsburgh, Pittsburgh, PA, ³Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁴Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁵Department of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁶Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁷Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Myositis [particularly dermatomyositis (DM)] is associated with cancer and anti-transcription intermediary factor-1 gamma (TIF1γ) is a serologic risk factor for cancer associated myositis (CAM).…
Abstract Number: 1946 • 2012 ACR/ARHP Annual Meeting
Effect of Immunosuppressive Treatment On Gene Expression in Patients with Polymyositis and Dermatomyositis
Ingela M. Loell¹, Yi-Wen Chen², Marina Korotkova³, Kanneboyina Nagaraju² and Ingrid E. Lundberg⁴, ¹Rheumatology Unit, Department of Medicine, Karolinska University Hospital in Solna, Karolinska Institutet, Stockholm, Sweden, ²Center for Genetic Medicine Research, Children's National Medical Center, Washington, DC, ³Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ⁴Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Polymyositis (PM) and dermatomyositis (DM) muscle tissue is characterized by infiltrating T cells, macrophages and dendritic cells, as well as cytokines and chemokines. In…

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