Abstracts Archive - Page 2462 of 2607 - ACR Meeting Abstracts

Abstract Number: 2129 • 2012 ACR/ARHP Annual Meeting
Dickkopf-1 Is Increased in Rheumatoid Arthritis of Recent Onset and Might Be a New Biomarker of Structural Progression. Data From the Espoir Cohort
Raphaèle Seror¹, Stephan Pavy², Thierry Schaeverbeke³, Alain Saraux⁴, Xavier Mariette⁵ and Corinne Miceli-Richard¹, ¹Rheumatology, Université Paris Sud, Le Kremlin Bicêtre, France, ²Hopital Bicetre, Paris, France, ³Service de Rhumatologie, Groupe Hospitalier Pellegrin, Bordeaux, France, ⁴Rhumatologie, CHU de la Cavale Blanche, Brest Cedex, France, ⁵Rheumatology, Université Paris-Sud, Le Kremlin Bicetre, France
Background/Purpose: Dickkopf-1 (DKK-1) is an inhibitory protein of the Wnt signalling pathway that could be involved in subchondral bone erosions occurring in rheumatoid arthritis (RA).…
Abstract Number: 2130 • 2012 ACR/ARHP Annual Meeting
Studies of Disease and Therapy-Response Biomarkers in Early Rheumatoid Arthritis Treated with Methotrexate
Aase Haj Hensvold¹, Saedis Saevarsdottir*², Wanyiang Li*³, Vivianne Malmström⁴, Guy Cavet⁵, Lars Klareskog⁶ and Anca Catrina¹, ¹Department of Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ²Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ³Crescendo Bioscience Inc. 341 Oyster Point Blvd South San Francisco, CA 94080, San Francisco, CA, ⁴Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ⁵Crescendo Bioscience Inc., South San Francisco, CA, ⁶Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden
*equally contributed Background/Purpose: To identify disease and therapy response serum biomarkers in early untreated RA patients started on methotrexate as the only DMARD. Methods: 186…
Abstract Number: 2131 • 2012 ACR/ARHP Annual Meeting
An Evaluation of Prognostic Factors for Orthopaedic Joint Surgery in Rheumatoid Arthritis. Results From Two Multicentre UK Inception Cohorts (1986-2011)
Elena Nikiphorou¹, Lewis Carpenter², Sam Norton³, David James⁴, Patrick D. Kiely⁵, David Walsh⁶, Richard Williams⁷ and Adam Young³, ¹Research Department of Epidemiology & Public Health, UCL and Rheumatology Department, St Albans City Hospital, ERAS, St Albans City Hospital & University College London (UCL), London, United Kingdom, ²Centre for Lifespan & Chronic Illness Research, University of Hertfordshire, Hatfield, United Kingdom, ³Rheumatology, ERAS, St Albans City Hospital, St Albans, United Kingdom, ⁴Rheumatology, Diana Princess of Wales Hospital, Grimsby, United Kingdom, ⁵Rheumatology Dept, St. Georges Hospital, London, United Kingdom, ⁶Academic Rheum/Clin Sci Bldg, City Hospital, Nottingham, United Kingdom, ⁷Rheumatology, County Hospital, Hereford, United Kingdom
Background/Purpose: The need for orthopaedic surgery in Rheumatoid Arthritis (RA) is the result of failed medical treatment and a surrogate marker for joint destruction. Reliable…
Abstract Number: 2132 • 2012 ACR/ARHP Annual Meeting
Disease Activity and Anti-CCP Status, but Not Sociodemographic Factors or Patient Comorbidities, Affect Time to Diagnosis in Early Rheumatoid Arthritis
Cheryl Barnabe¹, Juan Xiong², Gilles Boire³, Carol A. Hitchon⁴, Boulos Haraoui⁵, Janet E. Pope⁶, J. Carter Thorne⁷, Edward Keystone⁸, Diane Tin⁹, Vivian P. Bykerk¹⁰ and Canadian ArThritis CoHort¹¹, ¹Medicine, Community Health Sciences, University of Calgary, Calgary, AB, Canada, ²University of Toronto, Toronto, Canada, ³Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁴University of Manitoba, Winnipeg, MB, Canada, ⁵Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ⁶Medicine/Rheumatology, St. Joseph Health Care London, University of Western Ontario, London, ON, Canada, ⁷Southlake Regional Health Centre, Newmarket, ON, Canada, ⁸University of Toronto, Toronto, ON, Canada, ⁹The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, ¹⁰Rheumatology, Hospital for Special Surgery, New York, NY, ¹¹Toronto
Background/Purpose: Delays in patient presentation to primary care providers, subsequent referral for rheumatology assessment, and recognition of rheumatoid arthritis (RA) by the rheumatologist increase time…
Abstract Number: 2133 • 2012 ACR/ARHP Annual Meeting
Relationship Between Clinical Response and Radiographic Outcomes in Patients with Moderate Rheumatoid Arthritis
Josef S. Smolen¹, Ronald F. van Vollenhoven², Andrew S. Koenig³, Ronald Pedersen³, Annette Szumski⁴ and Eustratios Bananis⁴, ¹Department of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria, ²Unit for Clinical Trial Therapy research, The Karolinska Institute, Stockholm, Sweden, ³Specialty Care, Pfizer Inc, Collegeville, PA, ⁴Specialty Care, Pfizer Inc., Collegeville, PA
Background/Purpose: Clinical evidence has established the importance of early, intensive treatment of rheumatoid arthritis (RA) to decrease disease activity and prevent joint damage.1 The objective…
Abstract Number: 2134 • 2012 ACR/ARHP Annual Meeting
The Changed Prognosis of Patients with Early Rheumatoid Arthritis
Karin Britsemmer¹ and Dirkjan van Schaardenburg², ¹Rheumatology, Jan van Breemen Research Institute / Reade, Amsterdam, Netherlands, ²Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands
The Changed Prognosis of Patients with Early Rheumatoid Arthritis Background/Purpose: The treatment of rheumatoid arthritis (RA) has changed greatly during the past fifteen to twenty…
Abstract Number: 2135 • 2012 ACR/ARHP Annual Meeting
Trabecular Bone Texture parameters are Correlated with Magnetic Resonance Imaging (MRI) bone Edema At Hand and Wrist in Active Rheumatoid Arthritis (RA)
Thao Pham¹, Sophie Trijau¹, Roland Chapurlat², Damien Loeuille³, Thierry Schaeverbeke⁴, Christian Roux⁵, Claude-Laurent Benhamou⁶, Olivier Vittecoq⁷, Jean Sibilia⁸, Frederic Mistretta⁹ and Cécile Hacquard-Bouder¹⁰, ¹Rheumatology Department, Sainte Marguerite Hospital, Marseille, France, ²Hôpital Edouard Herriot, Lyon, France, ³Rheumatology, CHU Brabois, Vandoeuvre les Nancy, France, ⁴Service de Rhumatologie, Groupe Hospitalier Pellegrin, Bordeaux, France, ⁵Rheumatology, Paris Descartes University, Paris, France, ⁶Centre Hospitalier Régional d'Orléans, Orleans, France, ⁷Rheumatology, Rouen University Hospital & Inserm905, University of Rouen, Rouen Cedex, France, ⁸Rheumatology, CHU Hautepierre, Strasbourg, France, ⁹Lyon, France, ¹⁰Abbott France, Rungis, France
Background/Purpose: In RA, bone marrow edema (BME) is predictive of erosive progression. Bone erosions are assumed to appear through activation of local bone resorption mechanisms,…
Abstract Number: 2136 • 2012 ACR/ARHP Annual Meeting
Alcohol Use and Radiographic Disease Progression in African Americans with Recent Onset Rheumatoid Arthritis
Marshall Davis¹, Kaleb Michaud¹, Harlan Sayles¹, Doyt L. Conn², Larry W. Moreland³, S. Louis Bridges Jr.⁴ and Ted R. Mikuls¹, ¹Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ²Rheumatology, Emory Univ School of Medicine, Atlanta, GA, ³Division of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁴Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Previous studies have shown that alcoholic beverage consumption can modify levels of circulating inflammatory cytokines and alter expression of innate immune system receptors. Recognizing…
Abstract Number: 2137 • 2012 ACR/ARHP Annual Meeting
Contribution of Disease Activity, Joint Damage and Comorbidity to Impairment (SOFI) and Disability (HAQ) in Rheumatoid Arthritis Patients Over 20 Years
Meliha C. Kapetanovic¹, Elisabet Lindqvist², Jan-Åke Nilsson³, Pierre Geborek⁴, Tore Saxne⁵ and Kerstin Eberhardt⁶, ¹Dept of Clinical Sciences Lund, Section of Rheumatology, Lund University, Lund, Sweden, ²Department of Clinical Sciences Lund, Section of Rheumatology and Skåne University Hospital, Lund University, Lund, Sweden, ³Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ⁴Section of Rheumatology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden, ⁵Section of Rheumatology, Deparment of Clinical Sciences, Lund, Lund University, Lund, Sweden, ⁶Department of Clinical Sciences Lund, Section of Rheumatology, Skåne University Hospital, Lund University, Lund, Sweden, Lund, Sweden
Background/Purpose: To study the contribution of disease activity, joint damage and co-morbidity on development of impairment measured by signals of functional impairment (SOFI) and disability…
Abstract Number: 2138 • 2012 ACR/ARHP Annual Meeting
Racial and Ethnic Disparities in Rheumatoid Arthritis Outcomes in Community-Based U.S. Rheumatology Practices: Results From the Consortium of Rheumatology Researchers of North America Registry
Jeffrey D. Greenberg¹, Tanya Spruill², Gbenga Ogedebe³, Joel M. Kremer⁴, Ying Shan⁵, Katherine C. Saunders⁶, Yusuf Yazici⁷ and Leslie R. Harrold⁵, ¹NYU Hospital for Joint Diseases, New York, NY, ²Center for Healthful Behavior Change, Department of Population Health, NYU School of Medicine, New York, NY, ³New York University School of Medicine, New York, NY, ⁴Albany Medical College and The Center for Rheumatology, Albany, NY, ⁵Dept of Medicine, UMass Medical School, Worcester, MA, ⁶Corrona, LLC., Southborough, MA, ⁷New York University, New York, NY
Background/Purpose: Disparities in medication use and clinical outcomes have been reported in patients with rheumatoid arthritis (RA) and other chronic diseases. However, there is little…
Abstract Number: 2139 • 2012 ACR/ARHP Annual Meeting
Smoking Is Associated with Worsening Functional Status Over Time in a Diverse Cohort of Patients with Rheumatoid Arthritis
Matthew Reimert¹, Laura Trupin², Patricia P. Katz³, Edward H. Yelin⁴, Jennifer Barton² and John B. Imboden⁵, ¹Rheumatology, University of CA San Francisco, San Francisco, CA, ²Medicine, University of California, San Francisco, San Francisco, CA, ³Medicine, University of California San Francisco, San Francisco, CA, ⁴Medicine, UC San Francisco, San Francisco, CA, ⁵Department of Medicine, Division of Rheumatology, UCSF, San Francisco, CA
Background/Purpose: Although the effects of tobacco use on disease onset, severity, and response to therapy have been well studied in rheumatoid arthritis (RA), there is…
Abstract Number: 2140 • 2012 ACR/ARHP Annual Meeting
A Longitudinal Study of Prognostic Factors in Patients with Early RA Providing Direction for Future Clinical Treatment- Predict Study
Paul Bird¹, David Nicholls², Julien P. de Jager³, Hedley Griffiths⁴, Lynden Roberts⁵, Kathleen Tymms⁶, Jane Zochling⁷, Mark H. Arnold⁸, Geoffrey O. Littlejohn⁹ and OPAL Consortium¹⁰, ¹Combined Rheumatology Practice, Sydney, Australia, ²Coast Joint Care, Maroochydore, Australia, ³Suite 2, Osler House, Southport, Australia, ⁴Barwon Rheumatology Service, Geelong, Australia, ⁵School of Medicine, James Cook University, Townsville, Australia, ⁶Canberra Rheumatology, Canberra, ACT, Australia, ⁷Menzies Research Institute Tasmania, Hobart, Australia, ⁸Orthopaedic Arthritis Spec Ctr, Level 2 The Gallery, Chatswood, Australia, ⁹Rheumatology, Monash Medical Center, Melbourne, Australia, ¹⁰Melbourne, Australia
Background/Purpose: Despite the conspicuous increase in available treatment for rheumatoid arthritis [RA], and the shift to early, more aggressive management, there is a paucity of…
Abstract Number: 2101 • 2012 ACR/ARHP Annual Meeting
How Much Can Patient Reported Outcomes Improve Among Rheumatoid Arthritis Patients Who Have a Clinical Response to Biologic Therapy but Have Not Attained Low Disease Activity?
Jeffrey R. Curtis¹, Ying Shan, Jie Zhang¹, Jeffrey D. Greenberg³ and George W. Reed⁴, ¹Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²New York Hospital for Joint Disease, New York, NY, ³University of Massachusetts Medical School, Worcester, MA
Background/Purpose: Current treat-to-target (T2T) recommendations suggest that rheumatoid arthritis (RA) patients should strive for remission or low disease activity (LDA) as a goal. Treatment changes…
Abstract Number: 2102 • 2012 ACR/ARHP Annual Meeting
Patient Versus Physician Global Assessments in Ethnic Patients Wtih Rheumatoid Arthritis
Gail S. Kerr¹, Yusuf Yazici², Christopher J. Swearingen³, Luis R. Espinoza⁴, Edward L. Treadwell⁵, Yvonne R. S. Sherrer⁶, Angelia D. Mosley-Williams⁷, Akgun Ince⁸, Raj G. Nair⁹, Theresa Lawrence Ford¹⁰, Jeffrey Huang¹¹ and Carl A. Nunziato¹², ¹Rheumatology, Washington DC VAMC, Georgetown and Howard University, Washington, DC, ²New York University, New York, NY, ³Pediatric Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, ⁴Medicine-Section of Rheum, Louisiana State University, New Orleans, LA, ⁵Dept Medicine Div of Rheum, East Carolina University, Greenville, NC, ⁶Rheum/Immunology, Centre Rheum Immunol Arthritis, Fort Lauderdale, FL, ⁷John Dingell VAMC, Detroit, MI, ⁸Arthitis Consultants Inc, Saint Louis University, St. Louis, MO, ⁹Rheumatology, Washington Hospital Center, Washington DC, DC, ¹⁰North Georgia Rheumatology, Lawrenceville, GA, ¹¹Rheumatology, Howard University Hospital, Washington, DC, ¹²Rheumatology, Washington DC VA and Howard University, Howard University Hospital, Washington, DC
Background/Purpose: Patient reported outcomes in rheumatoid arthritis (RA) are validated tools that assess disease status, are easily administered and used as components of RA composite…
Abstract Number: 2103 • 2012 ACR/ARHP Annual Meeting
Reliability of DAS28 in Rheumatoid Arthritis When Based On Patient Self-Assessment of Tender and Swollen Joints
Ole Rintek Madsen and Cecilie Heegaard, Department of Rheumatology/C, Copenhagen University Hospital Gentofte, Hellerup, Denmark
Background/Purpose: Clinical assessment of disease activity is a routine procedure when evaluating individual rheumatoid arthritis (RA) patients in daily practice. Swollen joint count (SJC) and…

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