Abstracts Archive - Page 2460 of 2607 - ACR Meeting Abstracts

Abstract Number: 2180 • 2012 ACR/ARHP Annual Meeting
Coronary Flow Reserve and Asymmetric Dimethylarginine Levels: New Measurements for Identifying Subclinical Atherosclerosis in Patients with Primary Sjögren’s Syndrome
F. Atzeni¹, L. Boccassini¹, M.C. Signorello², MA Carrideo², L. Gianturco², V. De Gennaro Colonna³, L. Drago⁴, M. Turiel² and P. Sarzi-Puttini¹, ¹Rheumatology Unit, L. Sacco University Hospital of Milan, Milan, Italy, ²IRCCS Galeazzi Orthopedic Institute, University of Milan, Department of Health Technologies, Cardiology Unit,, Milan, Italy, ³Pharmacology Department, University of Milan, Milan, Italy, ⁴Laboratory Unit, IRCCS Galeazzi Orthopedic Institute, Department of Health Technologies, University of Milan, Milan, Italy
Background/Purpose: Clinical and biochemical data suggest that autoimmune diseases are associated with endothelial dysfunction and increased atherosclerosis. We have previously shown that asymmetric dimethylarginine (ADMA)…
Abstract Number: 2181 • 2012 ACR/ARHP Annual Meeting
Concomitant Atheosclerosis and Impaired Bone Health in Patients with Primary Sjogren’s Syndrome
Clio P. Mavragani¹, Fotini Gravani², Andrianos Nezos¹, Eleni Antypa³, Kiki Maselou⁴, Dimitrios Ioakeimidis⁵, Michael Koutsilieris¹ and Haralampos M. Moutsopoulos⁶, ¹Department of Experimental Physiology, School of Medicine, University of Athens, Athens, Greece, Athens, Greece, ²Department of Rheumatology, General Hospital of Athens "G.Gennimatas", Athens, Greece, ³Department of Radiology, General Hospital of Athens, Greece, ⁴Department of Immunolgy, General Hospital of Athens, Greece, ⁵Department of Rheumatology, General Hospital of Athens "G.Gennimatas", Greece, Greece, ⁶Department of Pathophysiology, School of Medicine, University of Athens, Athens, Greece
Background/Purpose: To determine the prevalence of subclinical atherosclerosis and impaired bone health in primary Sjogren’s syndrome (pSS) patients and to explore whether they associate with…
Abstract Number: 2141 • 2012 ACR/ARHP Annual Meeting
Effects of Cigarette Smoking On EARLY Arthritis (CONAART)
Maria Haye Salinas¹, Ana C. Alvarez¹, Rafael Chaparro del Moral², Mariana Benegas², Christian A. Waimann³, Rodolfo Perez Alamino⁴, Rodrigo Garcia Salinas⁵, Ana Lucía Barbaglia⁶, Veronica Bellomio⁷, Josefina Marcos⁸, Adrian Salas⁹, Cristian Quiroz¹⁰, Federico Ceccato¹¹, Sergio Paira¹¹, Dora Lia Vazquez¹², Gabriela Salvatierra¹³, M. Crespo¹⁴, Edson Javier Velozo¹⁵, Oscar L. Rillo¹⁶, Enrique Soriano¹⁷, Antonio Catalan Pellet⁵, Alberto Berman Sr.¹⁸, Juan Carlos Marcos¹⁹, Gustavo Citera²⁰ and Francisco Caeiro²¹, ¹Rheumatology, Hospital Privado, Córdoba, Argentina, ²Rheumatology, Hospital Tornu, Buenos Aires, Argentina, ³Rheumatology section, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ⁴Rheumatology, Louisiana State University, New Orleans, LA, ⁵Rheumatology, Hospital Rivadavia, Buenos Aires, Argentina, ⁶Rheumatology, Hospital Padilla, Tucuman, Argentina, ⁷Centro Medico Privado de Reumatologia, Tucuman, Argentina, ⁸Rheumatology Unit, HIGA San Martín La Plata, La Plata, Argentina, ⁹Hospital San Martin, La Plata, Argentina, ¹⁰Internal Medicine, Rheumatology Unit, Internal Medical Services, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ¹¹Rheumatology, Hospital Jose Maria Cullen, Santa Fe, Argentina, ¹²Rheumatology, Centro Integral de Reumatologia, Santiago del Estero, Argentina, ¹³Rheumatology, Centro de enfermedades Reumaticas, Santiago Del Estero, Argentina, ¹⁴Rheumatology, Hospital Señor del Milagro, Salta, Argentina, ¹⁵Rheumatology, Sanatorio Adventista del Plata, Entre Rios, Argentina, ¹⁶Rheumatology, Hospital General de Agudos "Dr. E. Tornú", Buenos Aires, Argentina, ¹⁷Rheumatology Section, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ¹⁸Internal Medicine, Hospital Padilla, Tucuman, Argentina, ¹⁹Rheumatology, Hospital San Martin, La Plata, Argentina, ²⁰Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ²¹Rheumatology, Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina
Background/Purpose: According to recent reports the cigarette smoking persons have 2-4 times greater risk of developing rheumatoid arthritis (RA). The cigarette smoking is associated with…
Abstract Number: 2142 • 2012 ACR/ARHP Annual Meeting
Magnetic Resonance Imaging-Proven Osteitis At Baseline Predicts the Early Rheumatoid Arthritis Patients Who Will Develop Rapid Radiographic Progression: MRI Is Beneficial to Find the Window of Opportunity in Early RA
Mami Tamai¹, Yoshikazu Nakashima², Takahisa Suzuki³, Yoshiro Horai², Akitomo Okada⁴, Junko Kita⁴, Shin-ya Kawashiri², Naoki Iwamoto⁴, Kunihiro Ichinose⁵, Kazuhiko Arima⁴, Hideki Nakamura¹, Tomoki Origuchi⁶, Masataka Uetani⁷, Kiyoshi Aoyagi⁸, Katsumi Eguchi⁹ and Atsushi Kawakami², ¹Department of Immunology and Rheumatology, Nagasaki University, Nagasaki, Japan, ²Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁴Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁵Department of Immunology and Rheumatology, Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁶Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁷Department of Radiology and Radiation Research, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁸Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁹Sasebo City General Hospital, Sasebo, Nagasaki, Japan
Background/Purpose: Window of opportunity exists in the earlier phase of rheumatoid arthritis (RA), thus, early recognition of the RA patients who will develop rapid radiographic…
Abstract Number: 2143 • 2012 ACR/ARHP Annual Meeting
Analysis of Factors Associated with the Health Assessment Questionnaire Score Change in Five Years
Shinji Yoshida¹, Katsunori Ikari², Kensuke Ochi³, Yoshiaki Toyama⁴, Atsuo Taniguchi⁵, Hisashi Yamanaka¹ and Shigeki Momohara¹, ¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Department of Orthopaedic Surgery, Institute of Rheumatology, Tokyo Women's Medical University, Shinjuku-ku, Japan, ³Department of Orthopaedic Surgery, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ⁴Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan, ⁵Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan
Background/Purpose: The Health Assessment Questionnaire (HAQ) score is thought to be a disease specific tool for the assessment of inflammatory joint disorders including rheumatoid arthritis…
Abstract Number: 2144 • 2012 ACR/ARHP Annual Meeting
Early RA Patients Fulfilling the New 2010 ACR/EULAR Criteria, Display Better Clinical Responses to DMARD Therapy but Have Higher Radiographic Damage Progression Than Patients with Early RA Not Fulfilling the 2010 ACR/EULAR Criteria
Ruediger Mueller¹, Toni Kaegi¹, Axel Finckh² and Johannes von Kempis¹, ¹Rheumatology, Kantonsspital St. Gallen, St. Gallen, Switzerland, ²Rheumatology, Geneva University Hospitals, Geneva 14, Switzerland
Background/Purpose: New ACR/EULAR criteria for the classification of rheumatoid arthritis (RA) were recently proposed. The aim of this analysis was to examine the impact of…
Abstract Number: 2145 • 2012 ACR/ARHP Annual Meeting
Age At Onset Determines Severity and choice of Treatment in Early Rheumatoid Arthritis
Lena Innala¹, Bozena Möller², Lotta Ljung³, Torgny Smedby⁴, Anna Södergren⁵, Staffan Magnusson⁶, Ewa H. Berglin⁵, Solbritt M. Rantapää-Dahlqvist⁷ and Solveig Wållberg-Jonsson⁵, ¹Rheumatology, Institution of Public health and clinical medicine/ Rheumatology, University of Umeå, Rheumatology, Sweden, Umeå, Sweden, ²Department of Rheumatology, Sunderby Hospital, Luleå, Sweden, ³Clinical epidemiology unit, Karolinska Institutet, Stockholm, Sweden, ⁴Department of Rheumatology, Östersund hospital, Östersund, Sweden, ⁵Rheumatology, Institution of Public health and clinical medicine/ Rheumatology, University of Umeå, Umeå, Sweden, ⁶Department of Internal Medicine, Sundsvall Hospital, Sundsvall, Sweden, ⁷Department for Public Health and Clinical Medicine/ Rheumatology, Umeå University, Umeå, Sweden
Background/Purpose: Mortality is increased in rheumatoid arthritis (RA). Contributing factors are disease activity/severity and comorbidity. A relationship between age at onset and pharmacological treatment has…
Abstract Number: 2146 • 2012 ACR/ARHP Annual Meeting
Impact of Severity Index for Rheumatoid Arthritis On Healthcare Costs and Utilizations in Patients with Rheumatoid Arthritis
Onur Baser¹, Li Wang², Juan Du³, Hai Wang³ and Lin Xie⁴, ¹President/Adjunct Professor of Internal Medicine, STATinMED Research/The University of Michigan, Ann Arbor, MI, ²Director, Analytic Research, STATinMED Research, Dallas, TX, ³STATinMED Research, Ann Arbor, MI, ⁴Director, Health Economics & Outcomes Research, STATinMED Research, Ann Arbor, MI
Background/Purpose: Examine the impact of a claims-based severity index for rheumatoid arthritis (RA) on healthcare costs and utilizations of RA patients using large U.S. claims…
Abstract Number: 2147 • 2012 ACR/ARHP Annual Meeting
Risks to Visit Emergency Room in Patients with Rheumatoid Arthritis: A Two-Year Retrospective Study
Yoshiki Nagai, Naoto Yokogawa, Kota Shimada and Shoji Sugii, Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan
Background/Purpose: Patients with rheumatoid arthritis (RA) suffer from both physical disabilities and medical comorbidities and tend to use emergency room for many reasons. However, the…
Abstract Number: 2148 • 2012 ACR/ARHP Annual Meeting
Peer to Peer Mentoring for Individuals with Early Inflammatory Arthritis: Feasibility Pilot
Mary J. Bell¹, Paula Veinot², Gayathri Embuldeniya², Joyce Nyhof-Young³, Joanna Sale⁴, Joan Sargeant⁵, Peter Tugwell⁶, Sydney Brooks⁷, Susan Ross⁷, Ruth Tonon⁷, Sharron Sandhu², Dawn Richards⁸, Jennifer Boyle⁷, Kerry Knickle⁹, Nicky Britten¹⁰, Emma Bell², Fiona Webster¹¹ and Mary Cox-Dublanski¹², ¹Division of Rheumatology, Sunnybrook Health Sciences Centre and University of Toronto, Toronto, ON, Canada, ²Rheumatology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ³University Health Network, University of Toronto, Toronto, ON, Canada, ⁴Healthy Policy, Management, and Evaluation, University of Toronto, St. Michael's Hospital, Toronto, ON, Canada, ⁵Dalhousie University, Halifax, NS, Canada, ⁶Institute of Population Health, Center For Global Health, University of Ottawa, Ottawa General Hospital, Ottawa, ON, Canada, ⁷The Arthritis Society, Ontario Division, Toronto, ON, Canada, ⁸Canadian Arthritis Network Consumer Advisory Council, Toronto, ON, Canada, ⁹University of Toronto, Toronto, ON, Canada, ¹⁰University of Exeter, Exeter, United Kingdom, ¹¹Department of Family and Community Medicine, University of Toronto, Toronto, ON, Canada, ¹²St. Mary's General Hospital, Kitchener, ON, Canada
Background/Purpose: The goal of this research is to examine the potential benefit of early peer support to improve the health and quality of life of…
Abstract Number: 2149 • 2012 ACR/ARHP Annual Meeting
Atsttrin-â, an Engineered Protein Derived From Progranulin Growth Factor, Binds to TNF Receptors and Exhibits Potent Anti-Inflammatory Activity in Mice
Yunpeng Zhao, Qingyun Tian, Haicheng Song, Fanhua Wei and Chuanju Liu, Orthopaedic Surgery, NYU Hospital for Joint Diseases, New York, NY
Background/Purpose: Progranulin (PGRN) is a multifunctional growth factor. Recently, we reported that PGRN and its derived protein Atsttrin-α (referred to as “Atsttrin” in our previous…
Abstract Number: 2150 • 2012 ACR/ARHP Annual Meeting
Action of Tofacitinib Via Human Dendritic Cells
Satoshi Kubo¹, Kunihiro Yamaoka², Shigeru Iwata¹ and Yoshiya Tanaka¹, ¹First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
Background/Purpose: Tofacitinib, an oral Janus Kinase (JAK) inhibitor, has gathered attention in treatment of Rheumatoid arthritis (RA). Although JAKs are well known for its importance…
Abstract Number: 2152 • 2012 ACR/ARHP Annual Meeting
Inhibition of Fucose Incorporation Abrogates the Development of Arthritis by Suppressing the Inflammatory Macrophage Development and TNF-α Production
Jun Li¹, Hui-Chen Hsu², PingAr Yang¹, Qi Wu¹, David M. Spalding³, W. Winn Chatham⁴, Robert P. Kimberly⁵, S. Louis Bridges Jr.⁶ and John D. Mountz⁷, ¹Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Clinical Immunology and Rheum, University of Alabama at Birmingham, Birmingham, AL, ⁴University of Alabama at Birmingham, Birmingham, AL, ⁵Clinical Immun & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁶Clinical Immunology & Rheum, University of Alabama at Birmingham, Birmingham, AL, ⁷Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham and Birmingham VA Medical center, Birmingham, AL
Background/Purpose: Fucosylation, catalyzed by fucosyltransferases (Futs), is an important glycosylation process involved in inflammation, cell death, and differentiation. We have observed an extremely high positive correlation…
Abstract Number: 2153 • 2012 ACR/ARHP Annual Meeting
Target-Directed Development of a Proposed Biosimilar Rituximab (GP2013): Comparability of Antibody-Dependent Cellular Cytotoxicity Activity and Pre-Clinical Pharmacokinetics and Pharmacodynamics with Originator Rituximab
Antonio da Silva¹, Ulrich Kronthaler¹, Ines Meyer¹, Anastassia Papandrikopoulou², Thomas Stangler¹ and Jan Marinus Visser¹, ¹Preclinical Development, Sandoz Biopharmaceuticals / HEXAL AG, Holzkirchen, Germany, ²Medical Communications, Sandoz Biopharmaceuticals / HEXAL AG, Holzkirchen, Germany
Background/Purpose: Biosimilars are biologics approved by highly-regulated markets as similar to existing agents, with the aim of offering more affordable treatment and thereby increasing patient…
Abstract Number: 2154 • 2012 ACR/ARHP Annual Meeting
Regulation of Folate Pathway Related Genes in Methotrexate naïve and Methotrexate Treated Patients with Rheumatoid Arthritis
Marjolein Blits¹, Gerrit Jansen², Saskia Vosslamber¹, Yehuda G. Assaraf³ and Cornelis L. Verweij¹, ¹Pathology, VU University Medical Center, Amsterdam, Netherlands, ²Department of Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ³Haifa, Israel
Background/Purpose: Rheumatoid arthritis (RA) is one of the most prevalent systemic autoimmune disorders. The folate antagonist methotrexate (MTX) is an anchor drug in the treatment…

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