Abstracts Archive - Page 2454 of 2607 - ACR Meeting Abstracts

Abstract Number: 2250 • 2012 ACR/ARHP Annual Meeting
A Clinical Analysis of Adult Patients with Autoimmune- and Infection-Associated Hemophagocytic Lymphohistiocytosis
Min W. So¹, Bon S. Koo¹, You J. Kim¹, Yong-G Kim¹, Wook J. Seo², Chang-K Lee¹ and Bin Yoo¹, ¹Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, ²Internal Medicine, Seoul Veterans Hospital, Seoul, South Korea
Background/Purpose: Hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially life-threatening disease. Secondary HLH is associated with various clinical conditions, including infections, malignancies, and autoimmune diseases.…
Abstract Number: 2251 • 2012 ACR/ARHP Annual Meeting
High Sensitivity C-Reactive Protein, Disease Activity and Cardiovascular Risk Factors in Systemic Lupus Erythematosus
Chi Chiu Mok¹, Daniel Birmingham², Ling Yin Ho¹ and Brad H. Rovin³, ¹Medicine, Tuen Mun Hospital, Hong Kong, Hong Kong, ²Medicine, Ohio State University Medical Center, Columbus, OH, ³Division of Nephrology, Ohio State University Medical Center, Columbus, OH

Background/Purpose: To study the level of high-sensitivity C-reactive protein (hsCRP) and its relationship with disease activity, damage and cardiovascular risk factors in patients with systemic…
Abstract Number: 2252 • 2012 ACR/ARHP Annual Meeting
Epratuzumab-Treated Systemic Lupus Erythematosus Patients Report Improvements in Health-Related Quality of Life: Final Results from an Open-Label Extension Study (SL0006)
V. Strand¹, K. Hobbs², D.J. Wallace³, K. Kalunian⁴, B. Kilgallen⁵, E. Nikaï⁶, W.A. Wegener⁷ and D.M. Goldenberg⁸, ¹Adjunct, Division of Immunology / Rheumatology, Stanford University, Palo Alto, CA, ²Denver Arthritis Clinic, Denver, CO, ³Cedars-Sinai Medical Center, Los Angeles, CA, ⁴UCSD School of Medicine, La Jolla, CA, ⁵UCB Pharma, Smyrna, GA, ⁶UCB Pharma, Brussels, Belgium, ⁷Immunomedics Inc, Morris Plains, NJ, ⁸Centre for Molecular Medicine and Immunology, Morris Plains, NJ
Background/Purpose: Epratuzumab, a monoclonal antibody targeting CD22, is in development for the treatment of systemic lupus erythematosus (SLE). Two randomized controlled trials (RCTs): ALLEVIATE 1…
Abstract Number: 2253 • 2012 ACR/ARHP Annual Meeting
Metabolic Syndrome Is Not Only a Risk Factor for Cardiovascular Events in Systemic Lupus Erythematosus but Also Associated with Cumulative Organ Damage: A Cross-Sectional Analysis of 311 Patients
Semra Ertan-Demir¹, Bahar Artim-Esen², Yasemin Sahinkaya², Özlem Pehlivan², Nilüfer Alpay-Kanitez², Ahmet Omma², Burak Erer², Sevil Kamali², Ahmet Gul², Orhan Aral², Lale Ocal² and Murat Inanc², ¹Internal Medicine, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ²Department of Internal Medicine, Rheumatology Division, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
Background/Purpose: Patients with systemic lupus erythematosus (SLE) have increased rates of cardiovascular (CV) events that are one of the major causes of mortality. In addition…
Abstract Number: 2254 • 2012 ACR/ARHP Annual Meeting
Discoid Lupus in Patients with Systemic Lupus Erythematosus
Ghassan AlJohani¹, Dominique Ibanez², D. D. Gladman¹ and Murray B. Urowitz², ¹Division of Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ²Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Discoid lupus lesions occur in 20% of patients with SLE at some point in their disease course, and are often resistant to therapy.…
Abstract Number: 2255 • 2012 ACR/ARHP Annual Meeting
Apolipoprotein B Containing Lipoprotein Subclasses and Subclinical Atherosclerosis in Patients with Systemic Lupus Erythematosus (SLE)
Adnan Kiani¹, Hong Fang¹, Ehtisham Akhter², Carmen Quiroga³, Nancy Simpson³, Petar Alaupovic³ and Michelle Petri¹, ¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Div of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Oklahoma Medical Research Foundation, Oklahoma, OK
Background/Purpose: Traditional classification in lipid biology using HDL, LDL and VLDL does not provide information on lipoprotein function. Apolipoproteins, (which are protein components of plasma…
Abstract Number: 2256 • 2012 ACR/ARHP Annual Meeting
A Population of IL-21 Producing CD4⁺ T Cells Correlates with Disease Damage in Systemic Lupus Erythematosus (SLE) Patients
Babak Noamani¹, Stacey Morrison², Dafna D. Gladman³, Jorge Sanchez-Guerrero⁴, Murray B. Urowitz⁵, Joan E. Wither⁶ and Carolina Landolt-Marticorena⁷, ¹Genetics and developmental biology, Toronto Western Research Institute, Toronto, ON, Canada, ²Div Rheumatology Rm MP-10-304, The Toronto Western Hospital, Toronto, ON, Canada, ³Division of Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ⁴UHN Toronto Western Hospital, Toronto, ON, Canada, ⁵Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁶1E420/Div of Rheumatology, Toronto Western Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ⁷Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: SLE mice models implicate IL-21, a T cell-derived cytokine, in disease pathogenesis with cytokine over-expression promoting the development of auto-antibodies and lupus-like clinical syndromes.…
Abstract Number: 2257 • 2012 ACR/ARHP Annual Meeting
Association of Low Vitamin D with High Disease Activity in an Australian Systemic Lupus Erythematosus Cohort
Kristy S. Yap¹, Alberta Y. Hoi² and Eric F. Morand², ¹Rheumatology, Monash Medical Centre, Clayton, Australia, ²Centre for Inflammatory Diseases, Monash University, Melbourne, Australia
Background/Purpose: Previous cross-sectional studies suggest that low vitamin D may be associated with higher disease activity in SLE. Vitamin D status varies with geographic location…
Abstract Number: 2258 • 2012 ACR/ARHP Annual Meeting
Risk Factors for Total Joint Replacement in Systemic Lupus Erythematosus Patients with Avascular Necrosis
Jennifer Lee¹, Dae-Jun Kim¹, Jae Ho Lee¹, Seung Min Jung¹, Seung-Ki Kwok¹, Ji Hyeon Ju², Kyung-Su Park¹, Sung-Hwan Park¹ and Ho-Youn Kim¹, ¹Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, South Korea, ²Rheumatology, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea
Background/Purpose: Avascular necrosis (AVN) is a common manifestation in patients with systemic lupus erythematosus (SLE) and is associated with significant morbidity. A number of studies…
Abstract Number: 2259 • 2012 ACR/ARHP Annual Meeting
Limitations of Current Treatment for Systemic Lupus Erythematosus: A Patient and Physician Survey
V. Strand¹, C. Galateanu², S. Lobosco³, D.S. Pushparajah², J. Sayers⁴ and R.F. van Vollenhoven⁵, ¹Stanford University, Portola Valley, CA, ²UCB Pharma, Brussels, Belgium, ³Adelphi Real World Ltd., Macclesfield, United Kingdom, ⁴Adelph Real World Ltd., Macclesfield, United Kingdom, ⁵Clinical Trials Unit Department of Rheumatology, The Karolinska Institute, Stockholm, Sweden
Background/Purpose: Current SLE treatment regimens follow an ‘add-on' paradigm: typically, therapies are added as the activity of a patient's disease increases. Most current treatments, particularly…
Abstract Number: 2260 • 2012 ACR/ARHP Annual Meeting
Serum DNAse I Anti DNAse I Antibodies , CRP and Antibodies to CRP Relation to Disease Activity in Systemic Lupus Eryhtematous: Longitudinal Studies
Ramnath Misra¹, Avadesh Pratap², Amit Singh¹ and Amita Aggarwal¹, ¹Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²Clinical Immunlogy, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Technician, Lucknow, India
Background/Purpose: Defective clearance of both nuclesomes and immune complexes has been suggested to intiate and perpetuate the disease. Defects in DNAse I gene in mice have shown SLE like symptoms,…
Abstract Number: 2261 • 2012 ACR/ARHP Annual Meeting
Ovarian Reserve Markers in Reproductive Age Women with Systemic Lupus Erythematosus
Olívio B. Malheiro¹, Carolina P. Rezende¹, Gilda A. Ferreira² and Fernando M. Reis¹, ¹Obstetrics and Gynecology, Federal University of Minas Gerais, Belo Horizonte, Brazil, ²Locomotor System Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil
Background/Purpose: Systemic lupus erythematosus (SLE) is a multisystem disease, which affects mostly women at reproductive age, and can promote premature ovarian dysfunction related to factors…
Abstract Number: 2222 • 2012 ACR/ARHP Annual Meeting
Spinal Mobility Measures in Normal Individuals – the Mobility Study
Sofia Ramiro¹, Carmen Stolwijk², A.M. Van Tubergen³, Désirée van der Heijde⁴ and Robert Landewé⁵, ¹Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, The Netherlands and Hospital Garcia de Orta, Almada, Portugal, ²Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ³Department of Medicine, Maastricht University Medical Center, Maastricht, Netherlands, ⁴Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam and Atrium Medical Center, Heerlen, Netherlands
Background/Purpose: Spinal mobility is one of the core outcomes recommended by the Assessment of Spondyloarthritis international Society (ASAS) for following patients with axial SpA. It…
Abstract Number: 2223 • 2012 ACR/ARHP Annual Meeting
Dysregulation of Chromatin Modification Enzymes in Psoriatic Arthritis
Remy Pollock¹, Fawnda Pellett², Vinod Chandran³ and Dafna D. Gladman⁴, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ⁴Division of Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada
Background/Purpose: Chromatin modification enzymes regulate gene expression by altering the accessibility of promoters to transcription factors. Several of these enzymes are dysregulated in rheumatoid arthritis,…
Abstract Number: 2224 • 2012 ACR/ARHP Annual Meeting
Oral Contraceptive Pill Use in Women with Ankylosing Spondylitis Is Associated with a Younger Age At Diagnosis
Dharini Mahendira¹, Arane Thavaneswaran², Adele Carty³, Nigil Haroon⁴, Ammepa Anton⁵, Laura A. Passalent⁶, Khalid A. Alnaqbi³, Laurie M. Savage⁷, Elin Aslanyan⁷ and Robert D. Inman⁸, ¹Rheumatology, St Michael's Hospital, Toronto, ON, Canada, ²Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ³Rheumatology, Toronto Western Hospital, Toronto, ON, Canada, ⁴Medicine/Rheumatology, University Health Network, Toronto Western Research Institute, University of Toronto, Toronto, ON, Canada, ⁵Rheumatology, University Health Network, Toronto, ON, Canada, ⁶Allied Health, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ⁷Spondylitis Association of America, Van Nuys, CA, ⁸Dept of Medicine/Rheumatology, Toronto Western Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada
Background/Purpose: While AS is traditionally recognized as a predominantly male disease, the impact of gender differences on AS pathogenesis has not been clearly established. Specifically,…

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