Abstracts Archive - Page 2452 of 2607 - ACR Meeting Abstracts

Abstract Number: 2301 • 2012 ACR/ARHP Annual Meeting
The Interferon Type I Signature Is Increased in Monocytes From Systemic Sclerosis Patients
Zana Brkic¹, Lenny van Bon², Cornelia G. van Helden-Meeuwsen³, Madelon C. Vonk⁴, Hanneke Knaapen⁵, Wim van den Berg⁵, Paul L. Van Daele³, Virgil A. Dalm¹, Timothy Radstake² and Marjan A. Versnel¹, ¹Erasmus Medical Center, Immunology, Rotterdam, Netherlands, ²Rheumatology and Clinical Immunology, University Medical Center Utrecht/Radboud University Nijmegen Medical Center, Utrecht/Nijmegen, Netherlands, ³Immunology, Erasmus Medical Center, Rotterdam, Netherlands, ⁴Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, ⁵Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands
Background/Purpose: Systemic sclerosis (SSc) is a complex fibrosing disease of unknown etiology. The past decade clear indications for an aberrant immune system have been revealed.…
Abstract Number: 2302 • 2012 ACR/ARHP Annual Meeting
Secreted Frizzled-Related Protein 4 Induces a Profibrotic Phenotype in Systemic Sclerosis Fibroblasts by Activating a Non-Canonical WNT Signaling Pathway
Justin Gillespie¹, Paul Emery² and Francesco Del Galdo³, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Medicine, Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Background/Purpose: Systemic Sclerosis (SSc) is a chronic fibrotic disease involving autoimmune activation, fibroproliferative vasculopathy and tissue fibrosis of skin and multiple internal organs. Several studies…
Abstract Number: 2262 • 2012 ACR/ARHP Annual Meeting
Hypogammaglobulinemia in Pediatric Systemic Lupus Erythematosus
Emilina Lim¹ and Megan A. Cooper², ¹Pediatric Rheumatology, Washington University in Saint Louis- St. Louis Children's Hospital, St. Louis, MO, ²Pediatrics, Washington University School of Medicine, St. Louis, MO
Background/Purpose: : Systemic lupus erythematosus (SLE) is characterized by B cell activation, elevated serum IgG and prominent circulating immune complexes. However, hypogammaglobulinemia in SLE patients…
Abstract Number: 2263 • 2012 ACR/ARHP Annual Meeting
The Association Between Prior Pregnancy Morbidity and Cardiovascular Events in Women with Systemic Lupus Erythematosus
Megan E. B. Clowse¹, Eliza F. Chakarvarty², Jill P. Buyon³ and Gerald McGwin Jr.⁴, ¹Rheumatology, Duke University Medical Center, Durham, NC, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, CA, ³Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁴Epidemiology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Adverse pregnancy outcomes have been associated with increased cardiovascular disease in healthy women. We hypothesized that women with SLE and a history of adverse…
Abstract Number: 2265 • 2012 ACR/ARHP Annual Meeting
Clinical Manifestations of Systemic Lupus Erythematosus Vary Based On Age of Disease Onset
Flora Simmons¹, Natasha M. Ruth², Gary S. Gilkeson³ and Diane L. Kamen⁴, ¹Rheumatology, Medical University of South Carolina, Charleston, SC, ²Pediatric Rheumatology, Medical University of South Carolina, Charleston, SC, ³Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁴Department of Medicine, Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Charleston, SC
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease which disproportionately affects women of child-bearing age. However, onset during childhood and late adult onset can…
Abstract Number: 2266 • 2012 ACR/ARHP Annual Meeting
Outcome of Renal Transplantation in Lupus Patients with Positive and Negative Serology: Survival of the Graft and Patients After Transplant
Zahi Touma¹, Murray B. Urowitz², Dominique Ibanez² and D. D. Gladman³, ¹Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Division of Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada
Background/Purpose: Lupus nephritis (LN) occurs in 50-75% of adults with SLE and up to 20% of LN patients may advance to end stage renal disease…
Abstract Number: 2267 • 2012 ACR/ARHP Annual Meeting
Genome-Wide Pathway Analysis of Genome-Wide Association Studies On Systemic Lupus Erythematosus
Young Ho Lee¹, Sung Jae Choi², Jong Dae Ji² and Gwan Gyu Song³, ¹Internal Medicine, Rheumatology, Korea University Medical Center, Seoul, South Korea, ²Rheumatology, Korea University Medical Center, Seoul, South Korea, ³Div of Rheum, Dept of Int Med, Korea Univ College of Med, Seoul, South Korea
Background/Purpose: Genome-wide association studies (GWASs) have been successfully used to identify novel common genetic variants that contribute to susceptibility to complex diseases, but individual GWASs…
Abstract Number: 2268 • 2012 ACR/ARHP Annual Meeting
Hyperacetylation of Histone H4 in Systemic Lupus Erythematosus
Yiu Tak Leung¹, Lihua Shi², Kelly Maurer², Li Song², Zhe Zhang³, Michelle Petri⁴ and Kathleen E. Sullivan², ¹Medicine/Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Immunology ARC 1216, The Children's Hospital of Philadelphia, Philadelphia, PA, ³Bioinformatics, Bioinformatics, Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Systemic lupus erythematosus (SLE) is the prototypical autoimmune disease and is characterized by multi-systemic chronic inflammation. Epigenetic processes, such as posttranslational histone modifications, can…
Abstract Number: 2269 • 2012 ACR/ARHP Annual Meeting
The Differences of DNA Methylome and Transcriptome Among Diverse Clinical Manifestations of Systemic Lupus Erythematosus
Ming Zhao¹, Shuangyan Luo¹, Honglong Wu², Siyang Liu², Meini Tang¹, Wenjing Cheng¹, Qing Zhang¹, Xinhai Yu¹, Tak Mao Chan³, Yudong Xia², Na Yi², Fei Gao², Li Wang², Ning Li² and Qianjin Lu⁴, ¹Department of Dermatology, Second Xiangya Hospital, Central South University; Hunan Key Laboratory of Medical Epigenomics, Changsha, China, ²Beijing Genomics Institute at Shenzhen, Shenzhen, China, Shenzhen, China, ³Division of Nephrology, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China, ⁴Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China
Background/Purpose: Aberrant DNA methylation and gene expression have been observed in systemic lupus erythematosus (SLE). However, patterns of DNA methylation and gene expression associated with…
Abstract Number: 2270 • 2012 ACR/ARHP Annual Meeting
The DNA Methylome of Systemic Lupus Erythematosus (SLE) From Whole Peripheral Blood Mononuclear Cells (PBMCs)
Robert Shoemaker¹, Lou H. Bookbinder², David L. Boyle³, Gary S. Firestein⁴, Jonathan E. Lim⁵ and David W. Anderson⁶, ¹Bioinformatics, NexDx, Inc., San Diego, CA, ²Molecular Biology, NexDx, Inc., San Diego, ³Div of Rheum, UCSD School of Medicine, La Jolla, CA, ⁴Div of Rheumatology, UCSD School of Medicine, La Jolla, CA, ⁵Research and Development, NexDx, Inc., San Diego, ⁶Research and Development, NexDx, Inc., San Diego, CA
Background/Purpose: SLE is a disease where epigenetic mechanisms play a role. Methylation of DNA at CpG loci is known to influence the suppression or activation…
Abstract Number: 2271 • 2012 ACR/ARHP Annual Meeting
Variation of Interferon-Alpha Production in Healthy Individuals and Association with Autoimmune Susceptibility Genes
Olof Berggren¹, Andrei Alexsson², Gunnar V. Alm³, Ann-Christine Syvänen⁴, Lars Rönnblom² and Maija-Leena Eloranta², ¹Department of Medical Sciences, SciLife Lab, Rheumatology, Uppsala University, Uppsala, Sweden, Uppsala, Sweden, ²Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden, ³Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden, ⁴Department of Medical Sciences, Molecular Medicine, Uppsala University, Uppsala, Sweden
Background/Purpose: Many autoimmune diseases, e.g. systemic lupus erythematosus (SLE), have an activated type I interferon (IFN) system and about 40 SLE susceptibility loci, many within…
Abstract Number: 2272 • 2012 ACR/ARHP Annual Meeting
Gene Expression Signatures in Monocytes From Primary Antiphospholipd Syndrome, Systemic Lupus Erythematosus and Lupus with Antiphospholipid Syndrome Identify Specific Pathways Involved in the Pathogenesis of Atherosclerosis and Cardiovascular Disease
Chary Lopez-Pedrera¹, Sebastiano Messineo², Carlos Perez-Sanchez¹, Patricia Ruiz-Limon¹, Mª Angeles Aguirre³, Rosario M. Carretero-Prieto⁴, Antonio Rodriguez-Ariza¹, Nuria Barbarroja⁴, Francisco Velasco¹, Munther A. Khamashta⁵, Eduardo Collantes-Estevez¹ and Mª Jose Cuadrado⁶, ¹IMIBIC-Reina Sofia Hospital, Cordoba, Spain, ²Dipartimento di Scienze della Salute, Universitá Magna Graecia di Catanzaro, Dipartimento di Scienze della Salute, Universitá Magna Graecia di Catanzaro, Italy., Catanzaro, Italy, ³Rheumatology, IMIBIC-Reina Sofia Hospital, Cordoba, Spain, ⁴Rheumatology Unit, IMIBIC-Reina Sofia University Hospital, Cordoba, Spain, ⁵Lupus Research Unit, The Rayne Institute, St Thomas Hospital, Kings College London School of Medicine, London, United Kingdom, ⁶Lupus Research Unit, The Rayne Institute, Kings College London School of Medicine, London, United Kingdom
Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by immune-mediated inflammation in multiple organ systems. SLE, primary Antiphospholipid syndrome (APS) and secondary APS (SAPS) share several…
Abstract Number: 2273 • 2012 ACR/ARHP Annual Meeting
Functional Genetic Polymorphisms in Immunoglobulin-Like Transcript 3 Are Associated with Decreased Surface Expression On Dendritic Cells and Increased Serum Cytokines in Lupus Patients
Mark A. Jensen, Karen C. Patterson, Akaash A. Kumar, Marissa Kumabe, Beverly S. Franek and Timothy B. Niewold, Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL
Background/Purpose: Hyperactivity of the type I interferon (IFN) pathway is involved in the pathogenesis of systemic lupus erythematosus (SLE). Immunoglobulin like transcript (ILT3) is an…
Abstract Number: 2274 • 2012 ACR/ARHP Annual Meeting
Genes Associated with Systemic Lupus Erythematosus Show Evidence of Selection in the Gullah African American Population
Paula S. Ramos¹, Satria Sajuthi², Yiqi Huang³, Diane L. Kamen⁴, Jasmin Divers², Kenneth M. Kaufman⁵, John B. Harley⁶, Robert P. Kimberly⁷, Carl D. Langefeld², Michèle M. Sale³, W. Timothy Garvey⁸ and Gary S. Gilkeson⁹, ¹Department of Medicine, Medical University of South Carolina, Charleston, SC, ²Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ³Department of Medicine and Center for Public Health Genomics, University of Virginia, Charlottesville, VA, ⁴Department of Medicine, Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Charleston, SC, ⁵1Center for Autoimmune Genomics and Etiology and Rheumatology Division, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati, Cincinnati, OH, ⁶Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁷Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁸Department of Nutrition Sciences and Birmingham VA Medical Center, University of Alabama at Birmingham, Birmingham, AL, ⁹Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC
Background/Purpose: In spite of its higher prevalence and severity, little is known about the genetic etiology of systemic lupus erythematosus (SLE) in African Americans (AA).…
Abstract Number: 2275 • 2012 ACR/ARHP Annual Meeting
NR1H3 (LXR alpha) Gene Polymorphisms Are Associated with Systemic Lupus Erythematosus in Koreans
Ja-Young Jeon¹, Hyoun-Ah Kim¹ and Chang-Hee Suh², ¹Department of Rheumatology, Ajou University School of Medicine, Suwon, South Korea, ²Department of Rheumatology, Ajou University Hospital, Suwon, South Korea
Background/Purpose: Liver X receptorsare established sensors of lipid and cholesterol homeostasis. The recent studies have reported that LXRs are involved in regulation of inflammation and…

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