Abstracts Archive - Page 2450 of 2607 - ACR Meeting Abstracts

Abstract Number: 2312 • 2012 ACR/ARHP Annual Meeting
Senescent T Cells Promote Bone Loss in Rheumatoid Arthritis
Johannes Fessler¹, Rusmir Husic², Elisabeth Lerchbaum³, Verena Schwetz³, Claudia Stiegler³, Barbara Obermayer-Pietsch³, Winfried B. Graninger⁴ and Christian Dejaco⁵, ¹Rheumatology and Immunology, Medical University Graz, Graz, Austria, ²Rheumatology, Medical University Graz, Graz, Austria, ³Division of Endocrinology and Metabolism, Medical University Graz, Graz, Austria, ⁴Internal medicine/Rheumatology and Immunology, Medical University Graz, Graz, Austria, ⁵Rheumatology, Southend University Hospital, Westcliff-on-Sea, United Kingdom
Background/Purpose: To study the influence of aged CD28-T cells on systemic osteoporosis in rheumatoid arthritis (RA) patients. Methods: Prospective, cross-sectional study on 100 patients with…
Abstract Number: 2313 • 2012 ACR/ARHP Annual Meeting
The Autoantibody-Inducing CD4 T Cell (aiCD4 T cell) Belongs to CCR4⁺CD45RB^lo122^lo CD4 Subpopulation: A Novel ‘Self-Organized Criticality Theory’ Explains the Cause of Systemic Lupus Erythematosus (SLE)
Yumi Miyazaki¹, Ken Tsumiyama² and Shunichi Shiozawa², ¹Kyushu University Beppu Hospital/ Kobe University Graduate School of Health Sciences, Beppu/ Kobe, Japan, ²Kyushu University Beppu Hospital, Beppu, Japan
Background/Purpose: We found that systemic lupus erythematosus (SLE) was induced experimentally by repeatedly immunizing the mice normally not prone to autoimmune diseases by any exogenous…
Abstract Number: 2314 • 2012 ACR/ARHP Annual Meeting
Correlation Between Abatacept and Rheumatoid Factor – Can Rheumatoid Factor Be a Predictive Factor for Abatacept?
Tomonori Kobayakawa¹, Masatoshi Hayashi², Toshihisa Kanamono², Atsushi Kaneko³, Toshihisa Kojima⁴ and Naoki Ishiguro⁵, ¹Orthopedic Surgery, Nagoya university, Nagoya, Japan, ²Departments of Orthopedic surgery and Rheumatology, Nagano Red Cross Hospital, Nagano, Japan, ³Orthopedic Surgery, Nagoya Medical Center, Nagoya, Japan, ⁴Orthopedic Surgery and Rheumatology, Nagoya Univeristy, School of Medicine, Nagoya, Japan, ⁵Department of Orthopedic Surgery, Nagoya University, Graduate School & Faculty of Medicine, Nagoya, Aichi, Japan
Background/Purpose: Abatacept (ABT), a T-cell selective costimulatory regulator, went on the market in Japan in September 2010, with a number of reports issued on its…
Abstract Number: 2315 • 2012 ACR/ARHP Annual Meeting
Foxp3⁺ Treg Cells Decreased in Overexpression of T-Bet in PD-1 Deficient Mice
Masahiro Tahara¹, Yuya Kondo¹, Hiroto Tsuboi², Satoru Takahashi³, Isao Matsumoto¹ and Takayuki Sumida¹, ¹Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan, ²Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ³Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba city, Ibaraki, Japan
Background/Purpose: Programmed cell Death-1 (PD-1) plays an important role in peripheral T cell tolerance, therefore PD-1 deficient (PD-1 KO) mice develop strain-specific autoimmune phenotypes. C57BL/6…
Abstract Number: 2316 • 2012 ACR/ARHP Annual Meeting
Generation of CD4⁺ Follicular Helper Tcells by Complement and Immune Complexes
Anil K. Chauhan¹, Richard DiPaolo² and Terry L. Moore³, ¹Rheumatology, Saint Louis University, St. Louis, MO, ²Molecular Microbiology and Immunology, Saint Louis, MO, ³Internal Medicine/Rheumatology, Saint Louis University, Saint Louis, MO
Background/Purpose: Complement opsonized immune complexes (ICs) are key players of disease pathology. We showed in systemic lupus erythematosus (SLE), ICs and complement (C’) drive activation…
Abstract Number: 2317 • 2012 ACR/ARHP Annual Meeting
Protein Phosphatase 5 (PP5) Regulates Methylation Sensitive Gene Expression in CD4+ T Cells
Dipak R. Patel, Gabriela Gorelik and Bruce C. Richardson, Internal Medicine, University of Michigan, Ann Arbor, MI
Background/Purpose: CD4+CD28- T cells are enriched in chronic inflammatory diseases like rheumatoid arthritis (RA) and lupus. They are cytotoxic and resistant to apoptosis. Compared to…
Abstract Number: 2318 • 2012 ACR/ARHP Annual Meeting
Reduced Thymus Function and Accelerated T-Cell Aging in Patients with Axial Spondylarthritis
Christian Dejaco¹, Wolfgang Schwinger², Andrea Raicht², Rusmir Husic³, Johannes Fessler³, Christoph G. Ammann⁴, Christina Duftner⁵, Winfried B. Graninger⁶ and Michael Schirmer⁷, ¹Rheumatology, Southend University Hospital, Westcliff-on-Sea, United Kingdom, ²Division of Pediatric Hemato-Oncology, Medical University Graz, Graz, Austria, ³Rheumatology, Medical University Graz, Graz, Austria, ⁴Internal medicine, Medical Uiversity Innsbruck, Innsbruck, Austria, ⁵Internal Medicine, Hopital Kufstein, Kufstein, Austria, ⁶Internal medicine/Rheumatology and Immunology, Medical University Graz, Graz, Austria, ⁷Internal medicine, Innsbruck Medical University, Innsbruck, Austria
Background/Purpose: To investigate thymic T-cell output, senescence of circulating T-cell subsets and changes of T cell subsets in patients with axial spondylarthritis (aSpA). Results are…
Abstract Number: 2319 • 2012 ACR/ARHP Annual Meeting
T Follicular Helper Cell and Regulatory T Cell Frequencies Are Affected by B Cell Depletion in Patients with Granulomatosis with Polyangiitis
Yuan Zhao¹, Jessica Thomas¹, Shirish Sangle², Pamela M.K Lutalo³, Lee Meng Choong⁴, Jennifer R. Tyler¹, Jo Spencer⁵, Timothy Tree⁶ and David P. D'Cruz², ¹Peter Gorer Department of Immunobiology, School of Medicine, King's College London, London, United Kingdom, ²Louise Coote Lupus Unit, Louise Coote Lupus Unit, St Thomas' Hospital, London, United Kingdom, ³Louise Coote Lupus Unit, St Thomas Hospital, London, United Kingdom, ⁴Louise Coote Lupus Unit, St Thomas' Hospital, London, United Kingdom, ⁵Peter Gorer Department of Immunobiology, King's College London, School of Medicine, London, United Kingdom, ⁶national Institute of Health Research Centre at Guy's and St Thomas' NHS Trust, School of Medicine, King's College London, London, United Kingdom
Background/Purpose: Granulomatosis with polyangiitis (GPA, formerly known as Wegener's granulomatosis) is a rare and sometimes fatal systemic autoimmune disease. Anti-neutrophil cytoplasmic antibodies (ANCAs) specific for…
Abstract Number: 2320 • 2012 ACR/ARHP Annual Meeting
Superantigen Induces IL-17 Production From Extremely Polarized Th1 Clones
Kentaro Yomogida¹, Yuan K. Chou¹ and Cong-Qiu Chu², ¹Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University, Portland, OR, ²Rheumatology, Oregon Health & Science Univ and Portland VA Medical Center, Portland, OR
Background/Purpose: Differentiation of naïve CD4+ T cells is considered to be an irreversible event and, in particular, the plasticity is thought to be completely lost…
Abstract Number: 2321 • 2012 ACR/ARHP Annual Meeting
Interleukin 12 Is Involved in an Interferon Type I Signature Through Crosstalk of CD4⁺ T Cells and Plasmacytoid Dendritic Cells
Corinne Miceli-Richard¹, Nicolas Gestermann², Federico Simoneta², Saida Boudaoud³, Gaetane Nocturne⁴, Yann Lecluze⁵, Christine Bourgeois³ and Xavier Mariette⁶, ¹Université Paris-Sud, Le Kremlin Bicêtre, France, ²INSERM U1012, Le Kremlin Bicêtre, France, ³Université Paris-Sud, INSERM U1012, Le Kremlin Bicêtre, France, ⁴Université Paris-Sud, Le Kremlin Bicetre, France, ⁵Institut Gustave Roussy, Villejuif, France, ⁶Rheumatology, Université Paris-Sud, Le Kremlin Bicetre, France
Background/Purpose: STAT4 is a transcription factor involved in TH1 polarization characterized by type II interferon (IFN) (or IFN-g) secretion and specifically activated by interleukin 12…
Abstract Number: 2322 • 2012 ACR/ARHP Annual Meeting
Dynamic Regulation of T Follicular Helper Cell Differentiation Through STAT Signaling
Shingo Nakayamada¹, Yuka Kanno², Golnaz Vahedi², John J. O'Shea² and Yoshiya Tanaka¹, ¹First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, ²National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD
Background/Purpose: T follicular helper (Tfh) cells are a new subset of T cells that regulate B cell function and exert an important role in the…
Abstract Number: 2323 • 2012 ACR/ARHP Annual Meeting
A Genetic Polymorphism on New Zealand Black Chromosome 1 Is Associated with Abnormal Dendritic Cell Function Leading to Expansion of T_H1, T_H17 and T Follicular Helper (T_FH) Cells
Nafiseh Talaei¹, Carolina Landolt-Marticorena², Babak Noamani¹, Evelyn Pau³, Nan-Hua Chang⁴ and Joan E. Wither⁵, ¹Genetics and developmental biology, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada, ²Rheumatology, University Health Network, Toronto, ON, Canada, ³Toronto Western Research Institute, University Health Network, Toronto, ON, Canada, ⁴Genetics and Development, Toronto Western Research Institute, Toronto Western Hospital, Toronto, ON, Canada, ⁵1E420/Div of Rheumatology, Toronto Western Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: We have previously shown that B6 mice with an introgressed homozygous New Zealand Black chromosome (c) 1 interval (70 to 100 cM) develop high titres…
Abstract Number: 2283 • 2012 ACR/ARHP Annual Meeting
Preferential Association of Complement Receptor 2 Variants with Anti-dsDNA Autoantibodies in Systemic Lupus Erythematosus
Brendan M. Giles¹, Jian Zhao², Kara M. Lough¹, Patrick M. Gaffney on behalf of LLAS2³, Marta E. Alarcon-Riquelme on behalf of BIOLUPUS⁴, Elizabeth E. Brown on behalf of PROFILE⁵, Lindsey A. Criswell⁶, Gary S. Gilkeson⁷, Chaim O. Jacob⁸, Judith A. James⁹, Joan T. Merrill¹⁰, Kathy L. Moser¹¹, Timothy B. Niewold¹², R. Hal Scofield¹³, Timothy J. Vyse¹⁴, John B. Harley¹⁵, Kenneth M. Kaufman¹⁶, Jennifer A. Kelly¹¹, Carl D. Langefeld¹⁷, Jeffrey C. Edberg¹⁸, Robert P. Kimberly¹⁹, Daniela Ulgiati²⁰, Betty P. Tsao²¹ and Susan A. Boackle²², ¹University of Colorado School of Medicine, Aurora, CO, ²Division of Rheumatology, Department of Medicine, David Geffen School of Medicine University of California Los Angeles, Los Angeles, CA, ³Arthritis and Immunology Prog, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Center for Genomics and Oncological Research Pfizer-University of Granada-Junta de Andalucia, Oklahoma City, OK, ⁵University of Alabama at Birmingham, Birmingham, AL, ⁶Department of Medicine, University of California, San Francisco, Rosalind Russell Medical Research Center for Arthritis, San Francisco, CA, ⁷Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁸Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA, ⁹Oklahoma Medical Research Foundation and University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁰Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹²Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL, ¹³Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁴Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London, London, United Kingdom, ¹⁵Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children's Hospital Medical Center; US Department of Veterans Affairs Medical Center, Cincinnati, OH, ¹⁶Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁷Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ¹⁸Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ¹⁹Clinical Immun & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²⁰University of Western Australia, Perth, Western Australia, Australia, ²¹Medicine/Rheumatology, UCLA School of Medicine, Los Angeles, CA, ²²Medicine/Rheumatology, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Complement receptor 2 (CR2/CD21) is primarily expressed on B cells and follicular dendritic cells (FDC) and is required for normal humoral immune responses. We…
Abstract Number: 2284 • 2012 ACR/ARHP Annual Meeting
Epigenetic Profiling in Monozygotic Twins Discordant for Systemic Lupus Erythematosus Reveals Prominent Hypomethylation of Interferon-Inducible Genes
Paula S. Ramos¹, Timothy D. Howard², Miranda C. Marion³, Satria Sajuthi⁴, Jennifer A. Kelly⁵, Kathy L. Moser⁵ and Carl D. Langefeld⁴, ¹Department of Medicine, Medical University of South Carolina, Charleston, SC, ²Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, ³Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, NC, ⁴Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ⁵Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic, multisystem, autoimmune inflammatory disease. In addition to genetic and environmental influences, the discordance rate between monozygotic (MZ)…
Abstract Number: 2285 • 2012 ACR/ARHP Annual Meeting
Systemic Lupus Erythematosus RNA-Seq: Endogenous Retroviral Group K Overexpression in Monocytes
Lihua Shi¹, Zhe Zhang², Michelle Petri³ and Kate Sullivan⁴, ¹Immunology ARC 1216, The Children's Hospital of Philadelphia, Philadelphia, PA, ²Bioinformatics, Bioinformatics, Children's Hospital of Philadelphia, Philadelphia, PA, ³Johns Hopkins University School of Medicine, Baltimore, MD, ⁴Allergy Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: Gene expression studies of peripheral blood mononuclear cells in SLE have consistently shown an interferon signature. We previously examined monocytes from SLE patients to…

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