Abstract Number: 2338 • 2012 ACR/ARHP Annual Meeting
1,25(OH)2D3 Modulates the Migration Pattern of Th17 Cells From Patients with Rheumatoid Arthritis
Background/Purpose: Vitamin D has suppressive effects on autoimmune diseases, such as rheumatoid arthritis (RA). Within these diseases, T-helper-17 (Th17) cells have been implicated to play…Abstract Number: 2339 • 2012 ACR/ARHP Annual Meeting
Lowering Fli1 Levels Decreases the Levels of Lipid Mediators in the Kidneys and T Cells of MRL/Lpr Lupus Prone Mice
Background/Purpose: The Ets factor Fli1 is implicated as a key modulator of lupus disease expression. Over-expressing Fli1 in healthy mice, results in the development of…Abstract Number: 2340 • 2012 ACR/ARHP Annual Meeting
A Numeric Expansion of Invariant Natural Killer T Cells Protects Against the Progression of Fatal Autoimmunity in Lupus-Prone Mice
Background/Purpose: Previous studies from our lab have shown that the introgression of a NZB chromosome 1 (c1) interval extending from 135 to179 Mb onto the…Abstract Number: 2341 • 2012 ACR/ARHP Annual Meeting
Exacerbation of Collagen-Induced Arthritis by an Anti-CD3 Antibody Targeting Aminoterminal-Deficient CD3ε
Background/Purpose: We have previously characterized naturally occurring forms of CD3e that lack the aminoterminal region (DNH2-CD3e) and are bound with high avidity by the YCD3-1…Abstract Number: 2342 • 2012 ACR/ARHP Annual Meeting
Synovial Tissue Analysis in the Pre-Clinical Phase of Arthritis: T-Cell Infiltration Preceding the Development of Arthritis
Background/Purpose: We have previously shown in a pilot study that there is no evident synovial inflammation in autoantibody-positive individuals who are at risk of developing…Abstract Number: 2343 • 2012 ACR/ARHP Annual Meeting
The Therapeutic Antibody Tregalizumab (BT-061) Induces Activation of Regulatory T Cells by Engaging a Unique CD4 Mediated Signaling That Strongly Differs From Signaling Events Induced by Standard Anti-CD4 Antibodies
Background/Purpose: The humanized CD4 specific monoclonal antibody (mAb) tregalizumab is currently being tested in phase II clinical trials in Rheumatoid Arthritis. In contrast to other…Abstract Number: 2344 • 2012 ACR/ARHP Annual Meeting
Transcriptional Regulation of Garp Expression
Background/Purpose: Regulatory T cells (Tregs) contribute to immune tolerance and play a pivotal role in the prevention of autoimmune diseases such as rheumatoid arthritis (RA).…Abstract Number: 2303 • 2012 ACR/ARHP Annual Meeting
Confirmation of TNIP1 As a Susceptibility Locus for Systemic Sclerosis in a Large Multicentre Study
Background/Purpose: Systemic sclerosis or scleroderma (SSc) is a complex autoimmune disorder that affects the connective tissue causing fibrosis in the skin and different internal organs.…Abstract Number: 2304 • 2012 ACR/ARHP Annual Meeting
Differential Association of IRAK1 and MECP2 with Specific Systemic Sclerosis Phenotypes
Background/Purpose: Systemic sclerosis (SSc) is a fibrotic autoimmune disease that represents a clear example of a sex biased immune disorder. The X-chromosome gene IRAK1 has…Abstract Number: 2306 • 2012 ACR/ARHP Annual Meeting
Intratracheal Instillation of Omniscan in an Adenine-Induced Model of Chronic Renal Failure: A New Model of Nephrogenic Systemic Fibrosis
Background/Purpose: Nephrogenic Systemic Fibrosis (NSF), a generalized progressive fibrotic disorder, occurs in some patients with renal insufficiency exposed to various gadolinium based contrast agents (GdBCA). …Abstract Number: 2307 • 2012 ACR/ARHP Annual Meeting
Role of Endosomal and Cell Membrane Toll-Like Receptors in Keratinocyte Activation by Systemic Sclerosis Autoantibodies
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune rare connective tissue disorder of unknown aetiology, heterogeneous clinical manifestations and an often progressive course which includes skin…Abstract Number: 2308 • 2012 ACR/ARHP Annual Meeting
CD11c+ Cells Are Necessary for Myofibroblast Maintenance in Bleomycin-Induced Cutaneous Fibrosis
Background/Purpose: Systemic sclerosis (SSc) is a heterogeneous connective tissue disease that has significant mortality and morbidity secondary to internal and cutaneous fibrosis. Though the exact…Abstract Number: 2309 • 2012 ACR/ARHP Annual Meeting
Increased Levels of Ser 181 Phosphorylated SOX9 in SSc Dermal Fibroblasts: A Novel Participant in the Pathogenesis of SSc Fibrotic Process
Background/Purpose: SOX9, a high mobility group (HMG) transcription factor is a master regulator of chondrogenesis and is essential for the maintenance of the chondrocyte-specific phenotype…Abstract Number: 2310 • 2012 ACR/ARHP Annual Meeting
Enhancement of CRACM1 Expression in Functionally Aberrant Naïve CD4+ T Cells in Active Rheumatoid Arthritis
Background/Purpose: Lymphocytes from rheumatoid arthritis (RA) patients have been reported to exhibit increased basal intracellular Ca2+ concentrations compared with the lymphocytes of healthy controls. A…Abstract Number: 2311 • 2012 ACR/ARHP Annual Meeting
Total Glucosides of Paeony Th1 and Th17 Cell Differentiation by Blocking STAT1 and STAT3 Activation in Vivo
Background/Purpose: Th1 and Th17 cells play very importent role in the lesions of human rheumatoid arthritis (RA). Total glucoside of paeony (TGP), an active compound extracted from…
ACR Meeting Abstracts