Abstracts Archive - Page 2448 of 2607 - ACR Meeting Abstracts

Abstract Number: 2363 • 2012 ACR/ARHP Annual Meeting
Assessment of Disease Activity in Large Vessel Vasculitis: Initial Results of an International Delphi Exercise
Sibel Z. Aydin¹, Haner Direskeneli², Eric L. Matteson³ and Peter A. Merkel⁴, ¹Unit of Rheumatology, Medeniyet University, Goztepe Training and Research Hospital, Istanbul, Turkey, ²Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, ³Rheumatology, Mayo Clinic, Rochester, MN, ⁴University of Pennsylvania, Philadelphia, PA
Background/Purpose: Assessment of disease activity in large vessel vasculitis (LVV) is challenging. The lack of specific, validated outcome measurements for both Takayasu’s (TAK) and giant…
Abstract Number: 2364 • 2012 ACR/ARHP Annual Meeting
CROSS-Sectional Assessment of Damage in Takayasu Arteritis with A Validated Tool
Ahmet Omma¹, Burak Erer², Omer Karadag³, Neslihan Yilmaz⁴, Fatma Alibaz-Oner⁵, Fatih Yildiz⁶, Melike Kalfa⁷, Gezmis Kimyon⁸, Sedat Kiraz⁹, Haner Direskeneli⁵, Eren Erken¹⁰, Kenan Aksu¹¹, Ahmet Mesut Onat¹², Ahmet Gul², Lale Ocal², Murat Inanc² and Sevil Kamali¹³, ¹Internal Medicine Department, Rheumatology Division, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ²Department of Internal Medicine, Rheumatology Division, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ³Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, ⁴Department of Rheumatology, Bilim University Faculty of Medicine, Istanbul, Turkey, ⁵Division of Rheumatology, Department of Internal Medicine, Marmara University, Faculty of Medicine, Istanbul, Turkey, ⁶Rheumatology, Cukurova University, School of Medicine, Adana, Turkey, ⁷Dept. of Internal Medicine, Division of Rheumatology, Ege University, Faculty of Medicine, Izmir, Turkey, ⁸Department of Rheumatology, Gaziantep University School of Medicine, Gaziantep, Turkey, ⁹Division of Rheumatology, Department of Internal Medicine, Hacettepe University, Faculty of Medicine, Ankara, Turkey, ¹⁰Rheumatology, Cukurova University School of Medicine, Adana, Turkey, ¹¹Rheumatology, Ege University School of Medicine, Izmir, Turkey, ¹²Rheumatology, Gaziantep University School of Medicine, Gaziantep, Turkey, ¹³Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
Background/Purpose: Takayasu arteritis (TA) is a large vessel vasculitis with a chronic course, usually causing damage by the time of diagnosis. To our knowledge, there…
Abstract Number: 2325 • 2012 ACR/ARHP Annual Meeting
PD-1 Signaling Promotes Suppressive Function of CD4⁺ Regulatory T Cells in (New Zealand Black x New Zealand White )F₁ Lupus-Prone Mice in a Dose-Dependent Manner
Maida Wong¹, Antonio La Cava² and Bevra H. Hahn³, ¹Internal Medicine/Rheumatology, University of California, Los Angeles, Los Angeles, CA, ²Internal Medicine/Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ³Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA
Background/Purpose: Programmed death-1 (PD-1) has been regarded as a negative regulatory signal in T cells. Our laboratory has shown that PD-1 is important in T…
Abstract Number: 2326 • 2012 ACR/ARHP Annual Meeting
Discovery of a Highly Potent, Selective Reversible Covalent Inhibitor of JAK3 Kinase
Ronald J. Hill¹, Angelina Bisconte¹, J. Michael Bradshaw¹, Ken Brameld², Eun Ok Kim¹, Xiaoyan Li², Tim Owens², Erik Verner² and David M. Goldstein², ¹Biology, Principia Biopharma, South San Francisco, CA, ²Chemistry, Principia Biopharma
Background/Purpose: Targeting of the JAK-STAT pathway has been shown to be efficacious for treatment of patients with rheumatoid arthritis through the successful use of pan-JAK…
Abstract Number: 2327 • 2012 ACR/ARHP Annual Meeting
CGEN-15001, a Novel Negative Costimulatory Fusion Protein Is Effective in the Collagen-Induced Arthritis Mouse Model of Rheumatoid Arthritis
Iris Hecht¹, Kay McNamee², Ilan Vaknin³, Anat Oren³, Joseph R. Podojil⁴, Galit Rotman³, Eyal Neria³, Stephen D. Miller⁴ and Richard O. Williams², ¹R&D, Compugen Ltd., Tel Aviv, Israel, ²Kennedy Institute of Rheumatology, Oxford University, Oxford, United Kingdom, ³Compugen Ltd., Tel Aviv, Israel, ⁴Microbiology-Immunology, Northwestern University, Chicago, IL
Background/Purpose: CGEN-15001 is a recombinant Fc fusion protein consisting of the extracellular domain of CGEN-15001T, a protein predicted to be a member of the B7/CD28…
Abstract Number: 2328 • 2012 ACR/ARHP Annual Meeting
A Novel Method for Quantitative and Functional Analysis of Autophagy Using Flow Cytometry in Activated Human Primary T Cells
Ryu Watanabe¹, Hiroshi Fujii², Yukiko Kamogawa², Kyohei Nakamura¹, Tsuyoshi Shirai², Yumi Tajima², Shinichiro Saito², Tomonori Ishii¹ and Hideo Harigae¹, ¹Department of Hematology and Rheumatology, Tohoku University, Sendai, Japan, ²Tohoku University, Sendai, Japan
Background/Purpose: Autophagy is an evolutionally conserved self-degradation system. In this process, an isolation membrane engulfs cytoplasmic materials and organelles to form an autophagosome. The autophagosome…
Abstract Number: 2329 • 2012 ACR/ARHP Annual Meeting
Increase of CD4⁺CD25⁺FoxP₃⁺ T Cell in Patients with Systemic Sclerosis Could Secret IL-17 with Dysfunction of Immunosuppression
Xinjuan Liu¹, Na Gao¹, Mengtao Li¹, Dong Xu¹, Yong Hou¹, Qian Wang¹, Guohua Zhang¹, Qiuning Sun², Henghui Zhang³ and Xiaofeng Zeng⁴, ¹Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China, ²Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China, ³Hepatology Institute, Peking University, People's Hospital, Beijing, China, ⁴Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Background/Purpose: Immune unbalance between Th17 and regulatory T cells (Treg) is a characteristic of systemic sclerosis (SSc). The functional heterogeneity and differentiation dynamics can be…
Abstract Number: 2330 • 2012 ACR/ARHP Annual Meeting
Mucosal-Associated Invariant T Cells Are Inactivated by IFNα and Reduced in Systemic Lupus Erythematosus
Asako Chiba¹, Naoto Tamura², Ran Matsudaira³, Takashi Yamamura¹, Yoshinari Takasaki² and Sachiko Miyake¹, ¹Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan, ²Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ³Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Mucosal-associated invariant T (MAIT) cells are a subset of innate-like lymphocytes which are restricted by the MHC-related molecule-1 (MR1) and express an invariant TCRα…
Abstract Number: 2331 • 2012 ACR/ARHP Annual Meeting
The Effects of Anti–Tumor Necrosis Factor Agents On the Expansion of T Helper-Type 17 Cells Driven by Lipopolysaccharide-Stimulated Monocytes
Gianluca Fossati¹, Louise Healy¹ and Andrew Nesbitt², ¹UCB Pharma, Slough, United Kingdom, ²UCB Pharma, SLough, United Kingdom
Background/Purpose: T helper-type 17 (Th17) cells are proinflammatory CD4+ cells characterized by the production of Interleukin-17 (IL-17).There is evidence that IL-17 and other cytokines which…
Abstract Number: 2332 • 2012 ACR/ARHP Annual Meeting
Suppression of PP2Ac Causes DNA Hypermethylation Through Enhanced Pmek/Perk Activity in T Cells
Katsue S. Watanabe¹, Kamalpreet Nagpal² and George C. Tsokos³, ¹Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan, ²Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Medicine/Rheumatology, BIDMC, Harvard Medical School, Boston, MA
Background/Purpose: Although many reports have focused on the impaired MEK-ERK signaling pathway in T cells from systemic lupus erythematosus (SLE) patients which results in suppression…
Abstract Number: 2333 • 2012 ACR/ARHP Annual Meeting
A Novel Subset of CD4 T Cells That Provides Help for Human Memory B Cell Responses
Sang T. Kim, Jin Young Choi, Begona Lainez and Joseph E. Craft, Internal Medicine, Section of Rheumatology, Yale University School of Medicine, New Haven, CT
Background/Purpose: Follicular helper T (Tfh) cells provide help to B cells in germinal centers (GCs) of secondary lymphoid organs (SLOs) following primary antigen (Ag) challenge,…
Abstract Number: 2334 • 2012 ACR/ARHP Annual Meeting
T-Cell Cross Reactivity with Citrullinated Antigen and P. Gingivalis Membrane Antigen Following Infection with P. Gingavalis and/or Injection of Citrullinated Mouse Type II Collagen in DBA/1J Mice
Michael J. Duryee¹, Anand Dusad², Carlos D. Hunter¹, Ke Ren³, Dong Wang⁴, James R. O'Dell⁵, Lynell W. Klassen⁵, Ted R. Mikuls⁶ and Geoffrey M. Thiele⁷, ¹Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ²Rheumatology, University of Nebraska Medical Center, Omaha, NE, ³College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, ⁴Pharmaceutical Sciences, Univ of Nebraska Medical Ctr, Omaha, NE, ⁵Dept of Internal Medicine, Univ of Nebraska Med Ctr, Omaha, NE, ⁶Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁷Int Med/Sec of Rheum/Immun, Univ of Nebraska Med Ctr, Omaha, NE
Background/Purpose: Recently, periodontal disease (PD) has been associated with the risk and progression of RA. Patients with RA complicated by PD have been shown to…
Abstract Number: 2335 • 2012 ACR/ARHP Annual Meeting
Increased TSLP Expression in Joints of Rheumatoid Arthritis Patients Causes Increased Activation of Intra-Articular Myeloid Dendritic Cells with Enhanced Th1 and Th17 Cell Activity
F.M. Moret¹, C.E. Hack², T.R.D.J. Radstake³, J.W.J. Bijlsma¹, F.P.J.G. Lafeber¹ and J.A.G. van Roon⁴, ¹Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Immunology, UMC Utrecht, Utrecht, Netherlands, ³Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁴Rheumatology & Clinical Immunology/Lab Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Thymic stromal lymphopoietin (TSLP) is well known for its potent activation of myeloid dendritic cells (mDCs) to induce Th2-mediated immune responses. Administration of TSLP…
Abstract Number: 2336 • 2012 ACR/ARHP Annual Meeting
Elevated Frequency of Synovial Interleukin-21⁺ CD4⁺ T Cells Co-Expressing Tumor Necrosis Factor-a in Rheumatoid Arthritis
Maria C. Lebre¹, Pedro L. Vieira², Saïda Aarrass³, Thomas Newsom-Davis², Paul P. Tak⁴ and Gavin R. Screaton², ¹Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam The Netherlands, Amsterdam, Netherlands, ²Department of Immunology, Imperial College London, London, United Kingdom, ³Clinical Immunology and Rheumatology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam The Netherlands, Amsterdam, Netherlands, ⁴Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam and GlaxoSmithKline, Amsterdam, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting synovial tissue in multiple joints. The inflammatory process in RA is regulated by several cytokines,…
Abstract Number: 2337 • 2012 ACR/ARHP Annual Meeting
Therapeutic Promotion of CD8 CTL by CpG Oligodeoxynucleotides (ODN) in an Induced Model of Lupus
Maksym Puliaiev¹, Kateryna Soloviova¹ and Charles S. Via², ¹Pathology Department, Uniformed Services University of Health Sciences, Bethesda, MD, ²Pathology Rm B3-100, Uniformed Services University of Health Sciences, Bethesda, MD
Background/Purpose: In addition to TcR signaling and costimulation, CD8 T cells require a third signal to mature into effector cytotoxic T lymphocytes (CTL). In pathogen…

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