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  • Abstract Number: 2348 • 2012 ACR/ARHP Annual Meeting

    Plasma Fibrinogen Better Identifies Persistent Disease Activity in Polymyalgia Rheumatica Than Either ESR or CRP

    EM McCarthy1, Paul A. MacMullan1, S. Al-Mudhaffer1, Anne M. Madigan1, S. Donnelly1, C. J. McCarthy1, Dermot Kenny2, Eamonn Molloy3 and G M. McCarthy1, 1Rheumatology, Mater Misericordiae University Hospital, Dublin 7, Ireland, 2Molecular and Cellular Therapeutics, RCSI, Dublin 2, Ireland, 3Rheumatology, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland

    Background/Purpose: In PMR careful tailoring of the glucocorticoid dosage to the patients needs is crucial to avoid the risk of treatment-related adverse effects and the…
  • Abstract Number: 2349 • 2012 ACR/ARHP Annual Meeting

    Corticosterois Therapy Restaured Treg/Th17 Balance in Patients with Polimyalgia Rheumatica

    Lorena Alvarez-Rodriguez1, Marcos Lopez-Hoyos2, Jaime Calvo-Alen3, Elena Aurrecoechea4, Teresa Ruiz Jimeno4, Ignacio Villa4, Carmen Gonzalez-Vela5 and Victor M. Martinez-Taboada1, 1Rheumatology, Hospital Universitario Marques de Valdecilla. IFIMAV, Santander, Spain, 2Immunology, Hospital Universitario Marques de Valdecilla. IFIMAV, Santander, Spain, 3Rheumatology, Hospital de Sierrallana. Torrelavega. Spain, Torrelavega, Spain, 4Rheumatology, Hospital de Sierrallana, Torrelavega, Spain, 5Pathology Anatomy, Hospital Universitario Marques de Valdecilla. IFIMAV, Santander, Spain

    Background/Purpose: To characterize the levels of circulating T regulatory cells (Tregs) and Th17 cells in polymyalgia rheumatica (PMR). Methods: The study included 46 patients with…
  • Abstract Number: 2350 • 2012 ACR/ARHP Annual Meeting

    Similarities Exceeds Differences in the Pattern of Joint and Vascular Positron Emission/Computed Tomography Uptake in Polymyalgia Rheumatica and Giant Cell Arteritis

    Dario Camellino1, Silvia Morbelli2, Francesco Paparo3, Michela Massollo2, Gianmario Sambuceti4 and Marco A. Cimmino5, 1Dipartimento Medicina Interna, Clinica Reumatologica, Genova, Italy, 2Dipartimento Medicina Interna, Medicina Nucleare, Genova, Italy, 3Radiology Unit, E.O. Ospedali Galliera, Genoa, Italy, 4Dipartimento di Medicina Interna, Medicina Nucleare, Genova, Italy, 5Department of Internal Medicine, Academic Unit of Clinical Rheumatology, University of Genova, Genova, Italy

    Background/Purpose: Polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) are two frequent overlapping diseases. The purpose of this work is to examine the relationship between…
  • Abstract Number: 2351 • 2012 ACR/ARHP Annual Meeting

    Correlation Between Hypoechoic Halo of the Temporal Arteries and Clinical, Laboratory, and Temporal Artery Biopsy Findings in Patients with Giant Cell Arteritis

    Luigi Boiardi1, Giulia Pazzola2, Alberto Cavazza3, Francesco Muratore2, Giovanna Restuccia2, Alberto Nicolini4, Giuseppe Germanò2, Nicolo Pipitone2, Pierluigi Macchioni2, Niccolò Possemato2, Gianluigi Bajocchi5, Ilaria Padovano2, Olga Addimanda6, Alberto Lo Gullo2, Maria Grazia Catanoso7 and Carlo Salvarani8, 1Rheumatology service, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, 2Rheumatology Service, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, 3Pathology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 4Internal Medicine, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, 5Department of Internal Medicine, Rheumatology Unit, Arcispedale S Maria Nuova. IRCCS, Reggio Emilia, Italy, 6Rheumatolgy Service, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, 7Rheumatology Service, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 8Rheumatology, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy

    Background/Purpose: The presence of a hypoechoic halo of the temporal arteries on Color-Doppler sonography (CDS) has high specificity and acceptable sensitivity for the diagnosis of…
  • Abstract Number: 2352 • 2012 ACR/ARHP Annual Meeting

    Temporal Artery Biopsy Culture in Tridimensional Matrix. an in Vitro Model for Functional Studies in Giant-Cell Arteritis

    Marc Corbera Bellalta1, Ester Planas Rigol1, Ester Lozano1, Marco A. Alba2, Itziar Tavera-Bahillo1, Sergio Prieto-González1, Georgina Espígol Frigolé1, Montserrat Butjosa1, José Hernández-Rodríguez1, Ana García-Martínez3 and Maria C. Cid4, 1Vasculitis Research Unit, Department of Systemic Autoimmune Diseases, Hospital Clinic University Barcelona, Barcelona, Spain, 2Systemic Autoimmune Diseases, Vasculitis Research Unit. Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, 3Department of Emergency Medicine, Vasculitis Research Unit. Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, 4Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain

    Background/Purpose: GCA is the most frequent systemic vasculitis in Europe and North America. In spite of the initial response to glucocorticoid treatment more than 60%…
  • Abstract Number: 2353 • 2012 ACR/ARHP Annual Meeting

    TLR2 Activation by Acute Serum Amyloid A Induces Pro-Inflammatory Mechanisms in a Novel Ex Vivo Temporal Artery Explant Culture/Model of Giant Cell Arteritis

    Peadar Rooney1, Danielle Molloy1, Jennifer McCormick2, Mary Connolly1, Sinead M. Miggin3, Ashwini Maratha3, Douglas J. Veale4, Conor Murphy5, Eamonn Molloy6 and Ursula Fearon7, 1Rheumatology, Dublin Academic Medical Centre, Dublin, Ireland, 2Dublin Academic Medical Centre, Translational Rheumatology Research Group, Dublin, Ireland, 3Biology, Immune Signalling Laboratory, Maynooth, Ireland, 4Rheumatology, St. Vincent's University Hospital, Dublin 4, Ireland, 5Department of Ophthalmology, Royal Victoria Eye and Ear Hospital, Dublin, Ireland, 6Rheumatology, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, 7Rheumatology, Translation Research Group, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland

    Background/Purpose: Giant cell arteritis (GCA) is the most common form of primary vasculitis. The pathogenesis of this disease is characterised by disregulated angiogenesis and inflammatory…
  • Abstract Number: 2354 • 2012 ACR/ARHP Annual Meeting

    The Prevalence of Low Bone Mineral Density in Patients with New Onset Giant Cell Arteritis. Do They Get Appropriate Bone Protective Treatment?

    Andreas P. Diamantopoulos and Glenn Haugeberg, Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway

    Background/Purpose: Giant cell arteritis (GCA) is a common form of vasculitis mainly affecting individuals older than 50 years with a mean  onset age of  69…
  • Abstract Number: 2355 • 2012 ACR/ARHP Annual Meeting

    Increase in Duration and Cumulative Dose of Glucocorticoid Therapy in Recent Decades: Observations From a Population-Based Cohort of Patients with Giant Cell Arteritis

    P. Deepak Udayakumar1, Tanaz A. Kermani2, Kenneth J. Warrington3, Cynthia S. Crowson4 and Eric L. Matteson1, 1Rheumatology, Mayo Clinic, Rochester, MN, 2Rheumatology, University of California Los Angeles, Santa Monica, CA, 3Division of Rheumatology, Mayo Clinic, Rochester, MN, 4Department of Health Sciences Research, Mayo Clinic, Rochester, MN

    Background/Purpose: Systemic glucocorticoid (GC) therapy is the first line treatment for giant cell arteritis (GCA). Patients with GCA are often counseled that therapy will be…
  • Abstract Number: 2356 • 2012 ACR/ARHP Annual Meeting

    Visual Manifestations in Giant Cell Arteritis : Trend Over Five Decades

    Abha G. Singh1, Cynthia S. Crowson2, Tanaz A. Kermani3, Cornelia M. Weyand4, Eric L. Matteson1 and Kenneth J. Warrington5, 1Rheumatology, Mayo Clinic, Rochester, MN, 2Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 3Rheumatology, University of California Los Angeles, Los Angeles, CA, 4Medicine, Stanford University School of Medicine, Stanford, CA, 5Division of Rheumatology, Mayo Clinic, Rochester, MN

    Background/Purpose: Cranial ischemic complications, particularly permanent visual loss, are catastrophic complications of giant cell arteritis (GCA). Corticosteroids have been used to decrease the risk of…
  • Abstract Number: 2357 • 2012 ACR/ARHP Annual Meeting

    Relapses in Patients with Giant-Cell Arteritis: Prevalence, Characteristics and Associated Clinical Findings in a Prospectively Followed Cohort of 106 Patients

    Marco A. Alba1, Ana García-Martínez2, Itziar Tavera-Bahillo1, Sergio Prieto-González1, Montserrat Butjosa3, Georgina Espígol4, Marc Corbera4, Ester Planas4, Jose Hernandez-Rodriguez5 and Maria C. Cid6, 1Systemic Autoimmune Diseases, Vasculitis Research Unit. Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, 2Department of Emergency Medicine, Vasculitis Research Unit. Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, 3Vasculitis Research Unit, Department of Systemic Autoimmune Diseases, Hospital Clinic University Barcelona, Barcelona, Spain, 4Systemic Autoimmune Diseases, Vasculitis research unit. Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, 5Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, 6Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain

    Background/Purpose: In spite of the satisfactory initial response to glucocorticoid treatment, patients with giant cell arteritis (GCA) frequently experience relapses during follow-up. The objectives of…
  • Abstract Number: 2358 • 2012 ACR/ARHP Annual Meeting

    Large Vessel Giant Cell Arteritis: A Cohort Study

    Francesco Muratore1, Tanaz A. Kermani2, Cynthia S. Crowson3, Abigail B. Green3, Eric L. Matteson4 and Kenneth J. Warrington5, 1Rheumatology, Arcispedale S Maria Nuova, Reggio Emilia, Italy, 2Rheumatology, University of California Los Angeles, Los Angeles, CA, 3Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 4Rheumatology, Mayo Clinic, Rochester, MN, 5Division of Rheumatology, Mayo Clinic, Rochester, MN

    Background/Purpose: A subset of patients with giant cell arteritis (GCA) has large vessel (LV) involvement. We sought to identify baseline variables that distinguish patients with…
  • Abstract Number: 2359 • 2012 ACR/ARHP Annual Meeting

    Outcome of Aortic Involvement in GIANT CELL Arteritis (GCA) After 1-Year Follow-up: Prospective Study in 35 Patients Using Computed Tompography Angiography (CTA)

    Sergio Prieto-González1, Pedro Arguis2, Ana García-Martínez3, Itziar Tavera-Bahillo1, Marc Corbera-Bellalta1, Marco A. Alba1, Georgina Espígol-Frigolé1, Ester Planas-Rigol1, José Hernández-Rodríguez1 and Maria C. Cid4, 1Systemic Autoimmune Diseases, Vasculitis Research Unit. Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, 2Center for diagnostic imaging, Vasculitis Research Unit. Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, 3Department of Emergency Medicine, Vasculitis Research Unit. Hospital Clínic. University of Barcelona. IDIBAPS, Barcelona, Spain, 4Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain

    Background/Purpose: 65% of patients with newly diagnosed, biopsy-proven GCA showed radiologic finding of aortitis using CTA in a prospective study of 40 patients. By segments,…
  • Abstract Number: 2360 • 2012 ACR/ARHP Annual Meeting

    Prevalence, Management and Outcomes of PET Positive Large Vessel Vasculitis in Difficult to Treat PMR and GCA Patients

    Pravin Patil1, Shaifali Jain2, Katerina Achilleos3, Tochukwu Adizie1, Mark Williams1, Matthew Tam2 and Bhaskar Dasgupta4, 1Rheumatology, Southend University Hospital, Westcliff on sea, United Kingdom, 2Radiology, Southend University Hospital, Westcliff on sea, United Kingdom, 3Rheumatology, Southend University Hospital, Westcliff-on-sea, United Kingdom, 4Rheumatology, Southend University Hospital, Westcliff-on-Sea, United Kingdom

    Background/Purpose:  Management of PMR and GCA can be challenging in patients with persistently elevated inflammatory markers, prominent constitutional symptoms and inadequate steroid response. We undertook…
  • Abstract Number: 2361 • 2012 ACR/ARHP Annual Meeting

    Misdiagnosis of Giant Cell Arteritis Presenting As Fever of Unknown Origin

    Chiara Stagnaro1, Rosaria Talarico2, Claudia Ferrari2, Anna d'Ascanio3 and Stefano Bombardieri4, 1Rheumatology Unit, University of Pisa, Pisa, Italy, 2University of Pisa, Rheumatology Unit, Pisa, Italy, 3Department of Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, 4Department of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy

    Background/Purpose: Giant cell arteritis (GCA) represents the most common primary vasculitis of the elderly, that usually involves large and medium sized arteries. The wide spectrum…
  • Abstract Number: 2362 • 2012 ACR/ARHP Annual Meeting

    Evaluation of Disease Activity Using FDG PET-CT in Patients with Large Vessel Vasculitis

    Giulia Pazzola1, Luca Magnani1, Luigi Boiardi1, Nicolo Pipitone1, Annibale Versari2, Debora Formisano3, Olga Addimanda1, Riccardo Meliconi4, Lia Pulsatelli5, Gianluigi Bajocchi1, Pierluigi Macchioni1, Maria Grazia Catanoso1, Niccolò Possemato1, Ilaria Padovano1, Alberto Lo Gullo1 and Carlo Salvarani6, 1Rheumatology Service, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, 2Nuclear Medicine, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, 3Scientific Directorate, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, 4Rheumatology Service and Laboratory of Immuno Rheumatology, Istituto Ortopedico Rizzoli, University of Bologna, Bologna, Italy, 5Laboratory of Immuno Rheumatology,, Istituto Ortopedico Rizzoli, Bologna, Italy, 6Rheumatology, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy

    Background/Purpose: 18F-Fluorodeoxyglucose (FDG) positron emission tomography (PET)/computerized tomography (CT) [PET/CT] has been proposed as a useful tool to diagnose and monitor activity of large vessel…
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