Abstracts Archive - Page 2440 of 2607 - ACR Meeting Abstracts

Abstract Number: 2484 • 2012 ACR/ARHP Annual Meeting
Hepatic Steatosis in Rheumatoid Arthritis: Associations with Disease Characteristics, Pharmacotherapies, and Atherosclerosis
Jon T. Giles¹ and Joan M. Bathon², ¹Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ²Columbia University, New York, NY
Background/Purpose: Ectopic deposition of liver fat (steatosis) is associated with insulin resistance (IR), cardiovascular disease (CVD), and is a potent risk factor for cirrhosis. RA…
Abstract Number: 2485 • 2012 ACR/ARHP Annual Meeting
Tofacitinib, an Oral Janus Kinase Inhibitor: Analyses of Efficacy and Safety of 10 versus 5mg Twice Daily in a Pooled Phase 3 and Long-Term Extension Rheumatoid Arthritis Population
S. Cohen¹, S. Krishnaswami², B. Benda³, R. Riese², M.G. Boy⁴, D. Gruben⁴, G. Wallenstein⁵, C. A. Mebus⁴, S. H. Zwillich² and J. D. Bradley⁶, ¹Metroplex Clinical Research Centre, Dallas, TX, ²Pfizer Inc., Groton, CT, ³Clinical Development & Medical Affairs, Pfizer Inc., Collegeville, PA, ⁴Pfizer Inc, Groton, CT, ⁵Pfizer Inc, New York, NY, ⁶Worldwide Pharmaceutical Development, Pfizer Inc., Groton, CT
Background/Purpose: Tofacitinib is a novel, oral Janus kinase inhibitor being investigated as a targeted immunomodulator and disease-modifying therapy for RA. Phase (P) 3 studies demonstrated…
Abstract Number: 2446 • 2012 ACR/ARHP Annual Meeting
Activity Limitations Experienced by People with Rheumatoid Arthritis On Biologic Medications and Their Use of Ergonomic Methods
Alison Hammond¹ and Sarah Tyson², ¹Centre for Health Sciences Research, University of Salford, Salford, United Kingdom, ²Centre for Health Sciences Research, University of Salford, Manchester, United Kingdom
Background/Purpose: People with rheumatoid arthritis (RA) commonly have daily activity difficulties. Whilst biologics significantly improve ability, ergonomic methods (e.g. altered working methods, ergonomic equipment, activity…
Abstract Number: 2447 • 2012 ACR/ARHP Annual Meeting
Accuracy of Sensewear Mini^TM and Actigraph GT3X^TM Accelerometers for Differentiating Sedentary and Light Physical Activities in a Controlled Laboratory Setting
April Y. F. Leung¹, Lynne M. Feehan², Cynthia Macdonald¹, Jenny Leese³, Erin Carruthers⁴ and Linda C. Li⁵, ¹Physical Therapy, University of British Columbia, Vancouver, BC, Canada, ²Physical Therapy, Arthritis Research Centre of Canada and University of British Columbia, Vancouver, BC, Canada, ³Arthritis Research Centre of Canada, Vancouver, BC, Canada, ⁴Arthritis Research Centre of Canada, Richmond, BC, Canada, ⁵Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada
Background/Purpose: People living with inflammatory arthritis are likely to be less physically active due to pain and fatigue. To understand the relationship between physical inactivity…
Abstract Number: 2448 • 2012 ACR/ARHP Annual Meeting
Sustained Improvement Physical Function Following an Integrated Rehabilitation Programme for Chronic Knee Pain
Mike Hurley¹ and Dr Nicola E. Walsh², ¹School of Rehabilitation Sciences, St George's University of London, London, United Kingdom, ²Allied Health Professions, University of the West of England Bristol, Bristol, United Kingdom
Background/Purpose: Chronic knee pain causes personal suffering and impairs physical function and quality of life. Usual primary care involves prolonged drug therapy in spite of…
Abstract Number: 2449 • 2012 ACR/ARHP Annual Meeting
Head to Head Comparison of Subcutaneous Abatacept Versus Adalimumab in the Treatment of Rheumatoid Arthritis: Key Efficacy and Safety Results From the Ample (Abatacept Versus Adalimumab Comparison in Biologic-Naive RA Subjects with Background Methotrexate) Trial
Michael E. Weinblatt¹, Michael H. Schiff², Roy Fleischmann³, Robert Valente⁴, Désirée van der Heijde⁵, Gustavo Citera⁶, Cathy Zhao⁷ and Michael A. Maldonado⁸, ¹Rheumatology & Immunology, Brigham & Women's Hospital, Boston, MA, ²Rheumatology Division, University of Colorado, Denver, CO, ³Southwestern Medical Center at Dallas, University of Texas, Dallas, TX, ⁴Arthritis Center of Nebraska, Lincoln, NE, ⁵Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁶Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ⁷Bristol-Myers Squibb, Princeton, NJ, ⁸Medical Strategy, Bristol-Myers Squibb, Princeton, NJ
Background/Purpose : The availability of multiple biologic agents to treat rheumatoid arthritis (RA) has created a need for comparative assessment. AMPLE (Abatacept Versus Adalimumab Comparison…
Abstract Number: 2450 • 2012 ACR/ARHP Annual Meeting
Evoked Pain Brain Response Is Associated with Reduced μ-Opioid Receptor Binding in Fibromyalgia
Heng Wang¹, Daniel J. Clauw², Jon-Kar Zubieta³ and Richard E. Harris⁴, ¹Anesthesiology, University of Michigan, Ann Arbor, ²Anesthesiology/Internal Medicine (Rheum), University of Michigan, Ann Arbor, MI, ³Molecular and Behavioral Neuroscience Institue, Psychiatry, University of Michigan, Ann Arbor, ⁴Anesthesiology, University of Michigan, Ann Arbor, MI
Background/Purpose: Previous studies indicate that fibromyalgia (FM) patients have augmented clinical and brain responses to painful stimuli (i.e. hyperalgesia/allodynia), as well as increased production of…
Abstract Number: 2451 • 2012 ACR/ARHP Annual Meeting
Laquinimod (LAQ) Is Equivalent to Mycophenolate Mofetil (MMF) in Preventing and Suppressing Murine Lupus Nephritis and Has Greater Effects On Myeloid/Monocyte/Macrophage Cells
Bevra H. Hahn¹, Maida Wong², Elaine Lourenco² and Brian Skaggs², ¹Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ²Medicine/Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA
Background/Purpose: Lupus nephritis (LN) depends on autoAb deposition and activation of multiple cell types that infiltrate kidneys and promote inflammation – monocytes/macrophages (MM), DCs, T…
Abstract Number: 2452 • 2012 ACR/ARHP Annual Meeting
Rheumatoid Arthritis-Associated PTPN22 Modulates Toll-Like Receptor-Mediated, Type 1 Interferon-Dependent Innate Immunoregulation
Yaya Wang¹, Stephanie Stanford², Wenbo Zhou³, Jennifer L. Auger⁴, Genhong Cheng⁵, Amanda Campbell⁶, Fernanda M. Shoyama¹, Henry H. Balfour Jr.⁷, Andrew C. Chan⁸, Bryce A. Binstadt⁴, Nunzio Bottini⁶ and Erik J. Peterson³, ¹Department of Medicine, University of Minnesota, Minneapolis, MN, ²Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ³University of Minnesota, Minneapolis, MN, ⁴Center for Immunology and Department of Pediatrics, University of Minnesota, Minneapolis, MN, ⁵University of California, Los Angeles, Los Angeles, CA, ⁶La Jolla Institute for Allergy and Immunology, La Jolla, CA, ⁷University of Minnesota, Minneapolis, ⁸Immunology, Genentech Inc, South San Francisco, CA
Background/Purpose: A coding polymorphism (C1858T) in PTPN22 is strongly associated with risk of Rheumatoid Arthritis (RA) and other autoimmune diseases. PTPN22 encodes Lymphoid Phosphatase (Lyp);…
Abstract Number: 2453 • 2012 ACR/ARHP Annual Meeting
The Role of Bob1 in Rheumatoid Arthritis: Potential Implications for Autoimmunity
Nataliya Yeremenko¹, Tineke Cantaert¹, Melissa N. van Tok², Ioana Gofita¹, Juan D. Canete³, Paul P. Tak⁴, Hergen Spits⁵ and Dominique L. Baeten⁴, ¹Division of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ²Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ³Arthritis Unit. Rheumatology Department, Hospital Clínic, Barcelona, Spain, ⁴Division of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ⁵Tytgat Institute for Liver and Intestinal Research, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) is a prototypic autoimmune disease characterized by a prominent humoral autoimmunity. Of particular relevance is the local production of autoantibodies such…
Abstract Number: 2454 • 2012 ACR/ARHP Annual Meeting
Expression of TLR5 Strongly Correlates with Levels of TNF-a and DAS28 in RA Monocytes and Ligation of TLR5 Induces Angiogenesis in RA
Nathan D. Chamberlain¹, Michael Volin², Olga M. Vila³, Shiva Arami⁴, Suncica Volkov⁵ and Shiva Shahrara¹, ¹Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, ²Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine Midwestern University, Downers Grove, IL, ³University of Illinois at Chicago, Chicago, IL, ⁴Medicine - Rheumatology, University of Illinois at Chicago, Chicago, IL, ⁵Rheumatology/MC 733, University of Illinois at Chicago, Chicago, IL
Background/Purpose: This study was performed to determine whether expression of TLR5 is associated with Rheumatoid Arthritis (RA) disease activity as well as to examine the…
Abstract Number: 2455 • 2012 ACR/ARHP Annual Meeting
Establishment of Standardized International Units for IgG Anti-β₂glycoprotein Antibody Measurement
Rohan Willis¹, Claudia Grossi², Gabriella Lakos³, Pier Luigi Meroni⁴, Maria Borghi², Luis R. Lopez⁵, Corina Dima⁶, Marius C. Teodorescu⁷, Nicholas Ozarka⁷, Matthias Kast⁸, Nina Olschowka⁸, Alfredo Villarreal⁹, Maria Crisostomo¹⁰, Mike Watkins⁹, Wendy Vandam¹¹, Tony Prestigiacomo¹¹, Josep Puig¹², Kerrie Jaskal¹³, Roger Walker¹⁰, Sarah Paul⁹, T. Buckner¹⁴, Fernando S. Cavalcanti¹² and Silvia S. Pierangeli¹⁵, ¹Rheumatolgoy/Dept Int Med, University of Texas Medical Branch, Galveston, TX, ²Lab of immunology, IRCCS Istituto Auxologico Italiano, Milano, Italy, ³Research, INOVA Diagnostics, San Diego, CA, ⁴Chair and Division of Rheumatology, Gaetano Pini Institute, University of Milan, Milan, Italy, ⁵Corgenix Inc, Broomfield, CO, ⁶Microbiology, Theratest Laboratories Inc, Lombard, IL, ⁷Microbiology, TheraTest Laboratories Inc, Lombard, IL, ⁸Phadia Thermofisher, Freiburg, MN, Germany, ⁹BioPlex Division, Bio-Rad Laboratories, Benicia, CA, ¹⁰Bio-rad Laboriatories, In, Bio-Rad Laboratories, Hercules, CA, ¹¹Bio-Rad Laboratories, Hercules, CA, ¹²Biokit, Barcelona, Spain, ¹³Instrumentation Laboratories, Bedford, MA, ¹⁴Corgenix, Broomfield, CO, ¹⁵Rheumatology/Dept Int Med, University of Texas Medical Branch, Galveston, TX
Background/Purpose: Despite numerous efforts aimed at the standardization of assays for detection of anti-β2Glycoprotein I (aβ2GPI)antibodies, there are still concerns, including the type and…
Abstract Number: 2456 • 2012 ACR/ARHP Annual Meeting
Pro-Inflammatory and Pro-Thrombotic Markers in Persistently Antiphospholipid Antibody-Positive Patients with/without Systemic Lupus Erythematosus
Gurjot Basra¹, Doruk Erkan², Rohan Willis¹, JoAnn Vega³, Ana Laura Carrera Marin⁴, Patricia Ruiz Limon¹, Vijaya L. Murthy¹, Shraddha Jatwani¹, Neha Dang¹, Emilio B. Gonzalez¹ and Silvia S. Pierangeli⁴, ¹Rheumatolgoy/Dept Int Med, University of Texas Medical Branch, Galveston, TX, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³Research, Hospital for Special Surgery, New York, NY, ⁴Rheumatology/Dept Int Med, University of Texas Medical Branch, Galveston, TX
Background/Purpose: Pro-inflammatory/thrombotic biomarkers (BMR), which are associated with aPL-mediated pathogenic effects in vitro/vivo, are also increased in aPL-positive patients. Here we examined whether those BMR…
Abstract Number: 2457 • 2012 ACR/ARHP Annual Meeting
An Open-Label Prospective Pilot Mechanistic Study of Fluvastatin in Persistently Antiphospholipid Antibody-Positive Patients
Doruk Erkan¹, Rohan Willis², JoAnn Vega³, Vijaya L. Murthy², Ana Laura Carrera Marin⁴, Gurjot Basra², Patricia Ruiz Limon², Emilio B. Gonzalez² and Silvia S. Pierangeli², ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Rheumatolgoy/Dept Int Med, University of Texas Medical Branch, Galveston, TX, ³Research, Hospital for Special Surgery, New York, NY, ⁴Rheumatology/Dept Int Med, University of Texas Medical Branch, Galveston, TX
Background/Purpose: Antiphospholipid antibodies (aPL) induce a pro-inflammatory and pro-thrombotic state by upregulating various cytokines, chemokines, and tissue factor (TF). Fluvastatin reduces TF expression and decrease…
Abstract Number: 2458 • 2012 ACR/ARHP Annual Meeting
The Estimated Prevalence of Antiphospholipid Antibodies in General Population Patients with Pregnancy Loss, Stroke, Myocardial Infarction, and Deep Vein Thrombosis
Laura Andreoli¹, Alessandra Banzato², Cecilia B. Chighizola³, Guillermo J. Pons-Estel⁴, Guilherme Ramires de Jesus⁵, Michael D. Lockshin⁶, Doruk Erkan⁷ and On Behalf of APS Action⁸, ¹Rheumatology and Clinical Immunology, University of Brescia, Brescia, Italy, ²Department of Cardiac Thoracic and Vascular Sciences, Department of Cardiac Thoracic and Vascular Sciences, University of Padua, Padua, Italy, ³Rheumatology, Istituto Auxologico Italiano, University of Milan, Milan, Italy, ⁴Servicio de Enfermedades Autoinmunes, Department of Autoimmune Diseases, Institut Clìnic de Medicina i Dermatologia, Hospital Clìnic, Barcelona, Spain, ⁵Department of Obstetrics, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil, ⁶Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, ⁷Rheumatology, Hospital for Special Surgery, New York, NY, ⁸APS ACTION, New York, NY
Background/Purpose: AntiPhospholipid Syndrome Alliance For Clinical Trials and InternatiOnal Networking (APS ACTION) is an international research network that has been created specifically to design and…

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