Abstracts Archive - Page 2436 of 2607 - ACR Meeting Abstracts

Abstract Number: 2544 • 2012 ACR/ARHP Annual Meeting
Widening Gap Between Cardiovascular Specific Mortality in Patients with Inflammatory Polyarthritis Compared to the General Population?
Alexander J. Warner¹, Jh Humphreys², Mark Lunt³, Tarnya Marshall⁴, Deborah P. M. Symmons⁵ and Suzanne Verstappen⁶, ¹Manchester Academic Health Sciences Centre, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom, ²Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit,, Manchester, United Kingdom, ³Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁴Rheumatology, Norfolk and Norwich University Hospitals Trust, Norwich, United Kingdom, ⁵Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom, ⁶Arthritis Research UK Epidemiology Unit,, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom
Background/Purpose: Cardiovascular (CVD) mortality rates are raised in patients with inflammatory polyarthritis (IP) but have been shown to be falling in the general population. This…
Abstract Number: 2545 • 2012 ACR/ARHP Annual Meeting
A Randomized, Double-Blind, Parallel Group Study of the Safety and Efficacy of Tocilizumab SC Versus Tocilizumab IV, in Combination with Traditional Dmards in Patients with Moderate to Severe RA
G. R. Burmester¹, Andrea Rubbert-Roth², Alain G. Cantagrel³, Stephen Hall⁴, Piotr Leszczynski⁵, Daniel Feldman⁶, Madura J. Rangaraj⁷, Georgia Roane⁸, Charles L. Ludivico⁹, Francesco Ramirez¹⁰ and Min Bao¹¹, ¹Charité-Universitätsmedizin Berlin, Berlin, Germany, ²Klinikum der Universität zu Köln, Köln, Germany, ³Dept of Rheumatology, Centre Hospitalier Universitaire de Toulouse, Toulouse, France, ⁴Cabrini Medical Centre, Malvern, Australia, ⁵Dept. of Rheumatology and Clinical Immunology, J. Strus Poznan Municipal Hospital, Poznan University of Medical Sciences, Poznan, Poland, ⁶Rheumatology, Universidade Federal de de São Paulo, Sao Paulo, Brazil, ⁷Arthritis & Diabetes Clinic, Inc., Monroe, LA, ⁸Rheumatology Associates of South Carolina, Charleston, SC, ⁹East Penn Rheumatology Assoc, Bethlehem, PA, ¹⁰Roche Products Limited, Welwyn, United Kingdom, ¹¹Genentech, South San Francisco, CA
Background/Purpose: The objective of this study was to compare the efficacy and safety of tocilizumab (TCZ) subcutaneous (SC) and TCZ intravenous (IV) regimen in patients…
Abstract Number: 2506 • 2012 ACR/ARHP Annual Meeting
Expression of Helios Facilitates Distinction Between FoxP3⁺ Treg and FoxP3⁺ Activated T Conventional Cells in Patients with Systemic Lupus Erythematosus
Amit Golding¹, Sarfaraz A. Hasni², Gabor G. Illei³ and Ethan M. Shevach⁴, ¹Medicine/Rheumatology and Clinical Immunology, Baltimore VA and University of Maryland School of Medicine, Baltimore, MD, ²Rheumatology, National Institutes of Health, Bethesda, MD, ³Sjogren's Clinic, NIDCR/ NIH, Bethesda, MD, ⁴Laboratory of Immunology, NIAID/NIH, Bethesda, MD
Background/Purpose: FoxP3 is not a reliable marker for distinguishing regulatory T (Treg) cells in humans due to the fact that FoxP3 may be up-regulated in…
Abstract Number: 2507 • 2012 ACR/ARHP Annual Meeting
Activated Cullin-Ring Ubiquitin Ligases (CRLs) Dampen T Cell Signaling and Inactivation of Crls Arrests the Progression of Inflammatory Arthritis
Leonard L. Dragone¹, Lisa K. Peterson², Allison Berger³ and Samantha F. Friend², ¹Dept of Pediatrics, National Jewish Health, Denver, CO, ²Pediatrics, National Jewish Health, Denver, CO, ³Department of Millennium Pharmaceuticals, Millennium Pharmaceuticals, Inc, Cambridge, MA
Background/Purpose: The role of Cullin-Ring ubiquitin ligase (CRL) activity in regulating T cell function is largely unexplored. Thus, we sought to determine if cullin neddylation…
Abstract Number: 2508 • 2012 ACR/ARHP Annual Meeting
miR142-3p Interfers with T Cell Proliferation by Targeting the Expression of Garp in Patients with Rheumatoid Arthritis
Qihui Zhou¹, Sonja Haupt¹, Johannes Thomas Kreuzer¹, Hendrik Schulze-Koops¹ and Alla Skapenko², ¹Division of Rheumatology and Clinical Immunology, Med.Klinik und Poliklinik IV, University of Munich, Munich, Germany, ²Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany
Background/Purpose: Rheumatoid arthritis (RA) is a systematic chronic inflammatory disorder, characterized by severe joint destruction. Regulatory T cells (Tregs) have been implicated to be important…
Abstract Number: 2509 • 2012 ACR/ARHP Annual Meeting
Cost-Effectiveness of Training Rural Providers to Perform Joint Injections
Michael J. Battistone¹, Richard E. Nelson², William D. Ashworth³, Andrea Barker³, Marissa Grotzke⁴, Timothy A. Huhtala⁵, Robert Z. Tashjian⁶ and Grant W. Cannon¹, ¹Division of Rheumatology, Salt Lake City VA and University of Utah, Salt Lake City, UT, ²Division of Epidemiology, Salt Lake City VA and University of Utah, Salt Lake City, UT, ³General Internal Medicine, Salt Lake City VA and University of Utah, Salt Lake City, UT, ⁴Division of Endocrinology, Salt Lake City VA and University of Utah, Salt Lake City, UT, ⁵Division of General Internal Medicine, Salt Lake City VA and University of Utah, Salt Lake City, UT, ⁶Division of Orthopaedics, Salt Lake City VA and University of Utah, Salt Lake City, UT
Background/Purpose: Community based outpatient clinics (CBOCs) have been established by the Department of Veteran Affairs (VA) to provide primary care services to veterans living in…
Abstract Number: 2510 • 2012 ACR/ARHP Annual Meeting
Patient and Provider Factors Associated with Compliance with Rheumatoid Arthritis Treatment Recommendations
Leslie R. Harrold¹, George W. Reed², Katherine C. Saunders³, Ying Shan¹, Tanya Spruill⁴ and Jeffrey D. Greenberg⁵, ¹Dept of Medicine, UMass Medical School, Worcester, MA, ²University of Massachusetts Medical School, Worcester, MA, ³Corrona, LLC., Southborough, MA, ⁴Center for Healthful Behavior Change, Department of Population Health, NYU School of Medicine, New York, NY, ⁵New York Hospital for Joint Disease, New York, NY
Background/Purpose: Only approximately 50% of rheumatoid arthritis (RA) patient with active disease receive care consistent with the American College of Rheumatology (ACR) recommendations for the…
Abstract Number: 2511 • 2012 ACR/ARHP Annual Meeting
Potential Barriers That Limit Access to Rheumatologists Among Patients with Early Rheumatoid Arthritis in a Universal Access Health Care System
Jessica Widdifield¹, J. Michael Paterson², Sasha Bernatsky³, Karen Tu², Nadia Gunraj², Noah Ivers¹, Debra Butt², R. Liisa Jaakkimainen⁴, J. Carter Thorne⁵, Vandana Ahluwalia⁶ and Claire Bombardier⁷, ¹University of Toronto, Toronto, ON, Canada, ²Institute for Clinical Evaluative Sciences, Toronto, ON, Canada, ³Clinical Epidemiology, Research Institute of the McGill University Health Ctre, Montreal, QC, Canada, ⁴Preventive Med and Biostatisti, University of Toronto, Toronto, ON, Canada, ⁵Southlake Regional Health Centre, Newmarket, ON, Canada, ⁶William Osler Health Center, Brampton, ON, Canada, ⁷Rheumatology, University of Toronto, Toronto, ON, Canada
Background/Purpose: Current guidelines for the optimal care of rheumatoid arthritis (RA) recommend prompt referral to a rheumatologist. In the province of Ontario, Canada all 13…
Abstract Number: 2512 • 2012 ACR/ARHP Annual Meeting
Changes in Bone Marrow Lesion Volume Relate to Changes in Knee Pain. Data From the Osteoarthritis Initiative
Jeffrey B. Driban¹, Lori Lyn Price², Grace H. Lo³, Jincheng Pang⁴, Eric Miller⁴, Charles Eaton⁵, John A. Lynch⁶ and Timothy E. McAlindon⁷, ¹Rheumatology, Tufts Medical Center, Boston, MA, ²Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ³Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, ⁴Department of Electrical and Computer Engineering, Tufts University, Medford, MA, ⁵Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Providence, RI, ⁶Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, ⁷Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Changes in bone marrow lesions (BMLs), common magnetic resonance (MR) imaging findings in osteoarthritis (OA), are predictive of OA progression. However, it is unclear…
Abstract Number: 2513 • 2012 ACR/ARHP Annual Meeting
Association of Arthritis and Joint Pain with Accelerometer-Measured Physical Activity in Adults Aged 50 and Older in the United States: Findings From the National Health and Nutrition Examination Survey (2003-2004)
Kathryn Remmes Martin¹, Dane Van Domelen¹, Matthew Pantell¹, Ming-yang Hung¹, Tamara B. Harris¹ and Kushang Patel², ¹Laboratory of Epidemiology, Demography, and Biometry, NIA/NIH, Bethesda, MD, ²Center for Pain Research on Impact, Measurement & Effectiveness, Department of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA
Background/Purpose: To compare the prevalence of meeting current public health physical activity (PA) guidelines by arthritis and knee/hip joint pain status, and to examine the…
Abstract Number: 2514 • 2012 ACR/ARHP Annual Meeting
Racial/Ethnic Trends in Incidence and Prevalence of Rheumatoid Arthritis in a Large Multi-Ethnic Managed Care Population
Aniket A. Kawatkar¹, Cecilia Portugal¹, Li-Hao Chu² and Rajan Iyer³, ¹Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, ²Department of Research and Evaluation,, Kaiser Permanente Southern California, Pasadena, ³Department of Research and Evaluation,, Kaiser Permanente Southern California, Pasadena, CA
Background/Purpose: As epidemiologic studies throughout the world have shown significant variations, we sought to characterize racial differences in longitudinal epidemiologic trends of adult rheumatoid arthritis…
Abstract Number: 2515 • 2012 ACR/ARHP Annual Meeting
Low Density Lipoprotein Receptor Deficiency Results in Osteophyte Formation During Experimental Osteoarthritis Which Is Enhanced Under High Cholesterol Conditions
Wouter de Munter, Birgitte Walgreen, Monique M. Helsen, Annet W. Sloëtjes, Wim B. van den Berg and Peter L.E.M. van Lent, Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: Synovial macrophages are involved in osteophyte formation during experimental collagenase-induced osteoarthritis (OA). Accumulated LDL can be oxidized in an inflammatory environment such as OA…
Abstract Number: 2516 • 2012 ACR/ARHP Annual Meeting
Adenosine Receptors Stimulate Bone Regeneration by Targeting Osteoclasts
Aranzazu Mediero¹, Tuere Wilder² and Bruce N. Cronstein³, ¹Medicine, Division of Translational Medicine, NYU School of Medicine, New York, NY, ²Medicine, division of Translational Medicine, NYU School of Medicine, New York, NY, ³Internal Medicine, NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: Various types of orthopedic procedures, including spinal fusion and repair of bone defects due to trauma, infection or metastatic disease, require formation of new…
Abstract Number: 2517 • 2012 ACR/ARHP Annual Meeting
Inhibition of Notch Signaling Increases the Severity of Experimental Osteoarthritis
Neng-Yu Lin¹, Alfiya Distler¹, Christian Beyer², Clara Dees³, Jingang Huang³, Francesco Dell'Accio⁴, Oliver Distler⁵, Georg A. Schett⁶ and Joerg HW Distler¹, ¹Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine 3, Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ³Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴William Harvey Research Institute, Barts and the London Queen Mary's School of Medicine and Dentistry, Centre for Experimental Medicine and Rheumatology, London, United Kingdom, ⁵Department of Rheumatology and Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁶Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Notch signaling is triggered by binding of ligands such as Jagged-1 (Jag-1) to Notch receptors, which results in cleavage of Notch receptors by the…
Abstract Number: 2518 • 2012 ACR/ARHP Annual Meeting
The Sphingosine-1-Phosphate Pathway Is a Key Regulator of Bone Substrate-Mediated Osteoclast Differentiation in Inflammatory Arthritis
P. Edward Purdue¹, Jon Hill², Steven R. Goldring³, Nikolaus, B. Binder³, Jennifer L. Swantek⁴, Zhenxin Shen⁵, Tania N. Crotti⁵, Gerald H. Nabozny⁴ and Kevin P. McHugh⁵, ¹Research, Hospital for Special Surgery, New York, NY, ²Scientific Knowledge Discovery, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, ³Hospital for Special Surgery, New York, NY, ⁴Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁵Orthopedic Surgery, Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, MA
Background/Purpose: Multiple lines of evidence have established that osteoclasts are required for physiologic bone resorption and pathological bone loss in inflammatory disorders. Isolation of differentiated…

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